Assessment of Thyroid Function in Type 1 Diabetic Pediatric Patients And It's Relation to Diabetes Severity

2020 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Ayman Shuhoub ◽  
Zainab Aldrawani ◽  
Faika Arab
Keyword(s):  
Thyroid Function ◽  
Pediatric Patients ◽  
Diabetes Severity

Practice Variance in Thyroid Screening of Youth with Type 1 Diabetes Mellitus

2018 ◽  
Vol 90 (4) ◽  
pp. 266-269
Author(s):  
Peter M. Wolfgram ◽  
Bhavana Narala ◽  
David T. Wyatt
Keyword(s):  
Type 1 Diabetes ◽  
Thyroid Function ◽  
North American ◽  
Pediatric Patients ◽  
Screening Tests ◽  
Antibody Testing ◽  
Endocrine Society ◽  
Multicenter Observational Study ◽  
Thyroid Screening

Background: Variance between current American Diabetes Association (ADA) and International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines and in clinical practice exists for the use of thyroid antibody and thyroid function screening in pediatric patients with new-onset type 1 diabetes (T1D). Methods: North American Pediatric Endocrine Society (PES) members were surveyed regarding their thyroid screening practices of euthyroid youth with T1D. An institutional analysis of the ability of antithyroid peroxidase (aTPO) and antithyroglobulin antibodies (aTG) to predict the subsequent use of levothyroxine was performed. Results: Forty-eight percent of 374 survey respondents tested both aTPO and aTG at diagnosis of T1D, but 35% performed no baseline antibody testing. If antibodies were positive, 89% of the respondents would perform annual thyroid function testing, but if antibodies were negative, 62% would follow thyroid function annually and 29% biannually. Institutionally, aTPO had significantly greater sensitivity (p = 0.04) but lower specificity (p = 0.008) than aTG for predicting the use of levothyroxine. Conclusions: Variance exists among North American PES members regarding thyroid disease screening for pediatric patients diagnosed with T1D, and this appears to reflect differences between ADA and ISPAD guidelines. A prospective multicenter observational study which shares electronic medical record data and compares aTPO and TSH as primary screening tests may allow for more uniform guidelines and address the possibility of using TSH alone.

Arginine metabolism and gut microbiota changes in pediatric patients with type 1 diabetes

2020 ◽  
Author(s):  
Elena Aghajanova ◽  
Arthur Melkonyan ◽  
Nina Alchujyan ◽  
Bayburdyan Gayane ◽  
Margarita Hovhannisyan ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Gut Microbiota ◽  
Pediatric Patients ◽  
Arginine Metabolism

1290-P: Gut Microbiota in New-Onset Pediatric Patients with Type 1 Diabetes: Machine Learning Algorithms to Classify Microorganisms Disease-Linked

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1290-P
Author(s):  
GIUSEPPE D’ANNUNZIO ◽  
ROBERTO BIASSONI ◽  
MARGHERITA SQUILLARIO ◽  
ELISABETTA UGOLOTTI ◽  
ANNALISA BARLA ◽  
...  
Keyword(s):  
Machine Learning ◽  
Type 1 Diabetes ◽  
Gut Microbiota ◽  
Pediatric Patients ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
New Onset

scholarly journals Investigation of TAGAP gene polymorphism (rs1738074) in Turkish pediatric celiac patients

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Melek Pehlivan ◽  
Tülay K. Ayna ◽  
Maşallah Baran ◽  
Mustafa Soyöz ◽  
Aslı Ö. Koçyiğit ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Disease Risk ◽  
Polymerase Chain Reaction Method ◽  
Control Group ◽  
Healthy Children ◽  
Single Nucleotide ◽  
Significant Difference ◽  
Allele Specific ◽  
And Control

Abstract Objectives There are several hypotheses on the effects of the rs1738074 T/C single nucleotide polymorphism in the TAGAP gene; however, there has been no study on Turkish pediatric patients. We aimed to investigate the association of celiac disease (CD) and type 1 diabetes mellitus (T1DM) comorbidity with the polymorphism in the TAGAP gene of Turkish pediatric patients. Methods Totally, 127 pediatric CD patients and 100 healthy children were included. We determined the polymorphism by the allele-specific polymerase chain reaction method. We used IBM SPSS Statistics version 25.0 and Arlequin 3.5.2 for the statistical analyses. The authors have no conflict of interest. Results It was determined that 72% (n=154) of only CD patients had C allele, whereas 28% (n=60) had T allele. Of the patients with celiac and T1DM, 42.5% (n=17) and 57.5% (n=23) had T and C alleles, respectively. Of the individuals in control group, 67% (n=134) had C allele, whereas 33% (n=66) had T allele. Conclusions There was no significant difference in the genotype and allele frequencies between the patient and control groups (p>0.05). There was no significant association between the disease risk and the polymorphism in our study group.

Clinical characteristics and outcome of hospitalized children and adolescent patients with type 1 diabetes during the COVID-19 pandemic: data from a single center surveillance study in Egypt

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Eman Monir Sherif ◽  
Yasmine Ibrahim Elhenawy ◽  
Randa Mahmoud Matter ◽  
Hanan Hassan Aly ◽  
Rasha Adel Thabet ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Pediatric Patients ◽  
Surveillance Study ◽  
Single Center ◽  
Children And Adolescent ◽  
Mean Delay ◽  
Patients With Diabetes ◽  
Constant Feature ◽  
Inflammatory Syndrome

Abstract Objectives COVID-19 pandemic significantly impacted the diagnosis of type 1 diabetes and its acute complications. Thus, the study aimed to evaluate the characteristics of pediatric patients with type 1 diabetes hospitalized during the first wave of the pandemic and the prevalence of new onset diabetes among patients with evidence of COVID-19 infection. Methods A single-center surveillance study included all patients with diabetes admitted to Children’s Hospital, Ain Shams University, in Egypt between May to August 2020. Data were collected to evaluate patients’ clinical and laboratory characteristics as well as their outcomes. Results Thirty-six patients were admitted during the study period. The mean age was 8.4 ± 3.8 years. Patients presented late to the emergency department with a mean delay of 3.05 ± 1.19 days from onset of symptoms. 34/36 patients presented in diabetic ketoacidosis (DKA), 50% presenting in severe DKA. Almost 81% of the patients were newly diagnosed. During the study period, SARS-CoV-2 PCR was found positive in four patients, COVID Ig M antibodies were positive in another two patients; all were symptomatic requiring ICU admission. Four patients showed a picture suggestive of the multi-inflammatory syndrome (MIS-C); cardiac affection was a constant feature. Conclusions The pandemic affected both the prevalence and severity of DKA among pediatric patients. The increased prevalence of severe DKA could be partly related to delayed hospital admission or the effect of COVID-19 in triggering DKA. Efforts should be done to continuously raise awareness about diabetes in children as well as the importance of seeking timely medical guidance.

scholarly journals Association between Physical Activity and Sport Participation on Hemoglobin A1c Among Children and Adolescents with Type 1 Diabetes

2021 ◽  
Vol 18 (14) ◽  
pp. 7490
Author(s):  
Kristi M. King ◽  
Jason R. Jaggers ◽  
Lindsay J. Della ◽  
Timothy McKay ◽  
Sara Watson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 1 Diabetes ◽  
Medical Records ◽  
Hemoglobin A1c ◽  
Pediatric Patients ◽  
Sport Participation ◽  
Multiple Linear Regression Model ◽  
Significant Difference ◽  
Hba1c Levels

Purpose: To determine associations between physical activity (PA) and sport participation on HbA1c levels in children with type 1 diabetes (T1D). Method: Pediatric patients with T1D were invited to complete a PA and sport participation survey. Data were linked to their medical records for demographic characteristics, diabetes treatment and monitoring plans, and HbA1c levels. Results: Participants consisted of 71 females and 81 males, were 13 ± 3 years old with an average HbA1c level of 8.75 ± 1.81. Children accumulating 60 min of activity 3 days or more a week had significantly lower HbA1c compared to those who accumulated less than 3 days (p < 0.01) of 60 min of activity. However, there was no significant difference in HbA1c values based on sport participation groups. A multiple linear regression model indicated that PA, race, age, duration of diagnosis, and CGM use all significantly predicted HbA1c (p < 0.05). Conclusion: This study demonstrated the significant relationship between daily PA and HbA1c. Those in this sample presented with lower HbA1c values even if accumulating less than the recommended number of days of activity. Further, it was shown that sport participation alone may not be adequate enough to impact HbA1c in a similar manner.

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