scholarly journals Analgesic Efficiency of Tramadol Administered Prior to Hysteroscopy Procedure

2016 ◽  
pp. 4
Author(s):  
Pınar Kadiroğulları ◽  
Kerem Doğa Seçkin ◽  
Burak Yücel ◽  
Berna Aslan Çetin ◽  
Sibel Arslan Barut ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Visual Analogue Scale ◽  
Prospective Study ◽  
Analogue Scale ◽  
The Other ◽  
Office Hysteroscopy ◽  
Pain Scores ◽  
Vas Scores ◽  
Group 2 ◽  
Group 1

<p><strong>OBJECTIVE:</strong> In this study, our objective was to assess the pain scores using the Visual Analogue Scale (VAS) in patients who were given tramadol prior to office hysteroscopy in order to demonstrate its analgesic activity when given before this procedure. <br /><strong>STUDY DESIGN:</strong> This prospective study conducted in year 2015 included two group of patients undergoing office hysteroscopy that were defined on the basis of the type of analgesia. Patients in the first group (Group 1, n=44) received oral tramadol prior to the procedure, while patients in the other group (Group 2, n=44) received placebo. VAS scores were determined during (0 minutes) and after (15 minutes) the procedure. <br /><strong>RESULTS:</strong> There were no significant differences between groups in terms of age, parity and body mass index (p&gt;0.05). Comparison of VAS scores at 0 and 15 minutes, lower values were observed in tramadol patients at 0 minutes (p&lt;0.05), while scores at 15 minutes were not significantly different between the groups (p&gt;0.05). <br /><strong>CONCLUSION:</strong> Although oral tramadol given prior to office hysteroscopy was effective and safe in reducing pain during the procedure, it is not useful for the pain that occurs after processing.</p>

Pain scores and recovery post tonsillectomy: intracapsular versus extracapsular coblation

2019 ◽  
Vol 133 (09) ◽  
pp. 775-781 ◽  
Author(s):  
M Junaid ◽  
S Sood ◽  
H Walijee ◽  
J Dorgham ◽  
S De
Keyword(s):  
Primary Care ◽  
General Practitioner ◽  
Visual Analogue Scale ◽  
Prospective Study ◽  
Analogue Scale ◽  
Normal Fluid ◽  
Pain Scores ◽  
Average Pain ◽  
A Prospective Study ◽  
Intracapsular Tonsillectomy

AbstractObjectiveThis study compared post-tonsillectomy pain scores and recovery using the coblation-only technique, comparing extracapsular versus intracapsular approaches.MethodsA prospective study was performed in our paediatric ENT department. Pain scores were recorded on days 0, 2, 4 and 8, using a visual analogue scale ranging from 0 (no pain) to 10 (extreme pain). Information was also collected on: return to normal fluid and solid intake, and any post-operative visits to primary care.ResultsIn total, 101 patients were included in the analysis. Average pain scores were statistically lower on days 2, 4 and 8 in the intracapsular group compared to the extracapsular cohort. The intracapsular cohort also returned sooner to normal fluid and solids intake. The extracapsular group were more likely to visit the general practitioner post-operatively.ConclusionIntracapsular tonsillectomy appears to result in reduced morbidity overall and should be considered as a viable alternative in relevant cases.

scholarly journals NEUROTRANSMITTER IMBALANCES AND PSYCHOLOGICAL DYSFUNCTIONS AS PREDICATIVE FACTORS OF POSTOPERATIVE CHRONIC PAIN SYNDROME IN OPERATIVE GYNECOLOGY CENTER

2020 ◽  
pp. 48-56
Author(s):  
L.N. Gumenyuk ◽  
L.I. Seytumerova ◽  
A.A. Serafimova ◽  
A.V. Yatsiv
Keyword(s):  
Chronic Pain ◽  
Postoperative Pain ◽  
Visual Analogue Scale ◽  
Analogue Scale ◽  
Depressive Disorders ◽  
Pain Syndrome ◽  
Chronic Pain Syndrome ◽  
Chronic Postoperative Pain ◽  
Group 2 ◽  
Group 1

Chronic postoperative pain is one of the urgent medical and social problems of operative gynecology. The problem is preconditioned by a high prevalence rate, a significant impact on the outcomes of operative therapy and, as a consequence, patients’ quality of life. The goal of the paper is to study the role of preoperative neurotransmitter and psychoemotional dysfunctions in the development of postoperative chronic pain syndrome in an operative gynecology center. Materials and Methods. The study enrolled 156 patients aged 18–45 years who underwent planned surgical treatment for gynecological pathology. Patients were subsequently divided into 2 groups: Group 1 – women with postoperative chronic pain syndrome; Group 2 – women without chronic postoperative pain syndrome. The authors conducted general clinical examination, and also determined the levels of g-aminobutyric acid and β-endorphin in serum of patients using enzyme-linked immunosorbent assay. A visual analogue scale was used to assess quantitative characteristics of pain syndrome. Qualitative characteristics of pain syndrome were assessed according to the McGill Pain Questionnaire. HAM-A and HDRS were used to assess psychoemotional state. Results. Postoperative chronic pain was observed in 39.7 % of patients 12 months after surgery. In the preoperative period, a pain syndrome was registered in all patients. However, there were no significant intergroup differences in its severity. Statistically significant predominance of the affective scale indicators was revealed in the pain syndrome structure in Group 1, while Group 2 demonstrated predominance of the sensory scale indicators (p=0.003). Group 1 demonstrated more pronounced changes in GABA and β-endorphin levels. An inverse correlation was found between the level of β-endorphin and the affective and evaluative McGill questionnaire scales. Various affective pathologies were verified in Group 1. However, depressive disorders dominated. Group 2 demonstrated only subdepression and individual clinically unformed anxiety symptoms. The authors found out depressive disorder correlation with the severity of preoperative pain syndrome according to visual-analogue scale, McGill questionnaire affective scale, and β-endorphin concentration. Conclusion. Neurotransmitter disorders and psychological dysfunctions affect the formation of postoperative chronic pain syndrome. There is a correlation between chronic postoperative pain syndrome, preoperative β-endorphin concentration (r=-0.70; p=0.028), and the severity of depressive disorders (r=0.65; p=0.012), which confirms their role as non-specific prognostic markers while monitoring the postoperative chronic pain syndrome. Keywords: gynecological pathology, postoperative chronic pain syndrome, neurotransmitters, affective disorders. Хроническая послеоперационная боль – одна из актуальных медико-социальных проблем оперативной гинекологии, что обусловлено высоким уровнем распространенности, значительным влиянием на исходы хирургического лечения и, как следствие, качество жизни пациентов. Цель – изучение роли предоперационных нейромедиаторных и психоэмоциональных дисфункций в формировании хронического послеоперационного болевого синдрома в клинике оперативной гинекологии. Материалы и методы. В исследовании приняли участие 156 больных в возрасте от 18 до 45 лет, которым выполнено плановое хирургическое лечение по поводу гинекологической патологии. Пациенты в последующем были разделены на 2 группы: 1-я – женщины с хроническим послеоперационным болевым синдромом; 2-я – пациентки без хронического послеоперационного болевого синдрома. Наряду с общеклиническим обследованием c помощью иммуноферментного анализа определяли уровень кислоты и β-эндорфина в сыворотке крови. С целью оценки количественной характеристики боли применяли визуальную аналоговую шкалу, качественной – болевой опросник McGill, для оценки психоэмоционального статуса – клиническую шкалу HAM-A и HDRS. Результаты. Спустя 12 мес. после оперативного вмешательства хронический послеоперационный болевой синдром наблюдался у 39,7 % обследованных. В предоперационном периоде у всех обследованных отмечался болевой синдром, при этом достоверных межгрупповых различий его интенсивности не выявлено. В структуре болевого синдрома у пациенток 1-й группы выявлено статистически значимое преобладание показателей аффективной шкалы, у женщин 2-й группы – сенсорной (p=0,003). У пациенток 1-й группы изменения уровней ГАМК и β-эндорфина носили более выраженный характер. Установлена обратная корреляционная связь уровня β-эндорфина с показателями аффективной и эвалюативной шкал опросника McGill. Аффективная патология различной степени выраженности верифицирована у всех больных 1-й группы. В структуре преобладали депрессивные нарушения. У пациенток 2-й группы наблюдались лишь субдепрессивные состояния и отдельные, клинически не оформленные симптомы тревоги. Установлены корреляции депрессивных расстройств c выраженностью предоперационного болевого синдрома по визуально-аналоговой шкале, аффективной шкалой опросника McGill, концентрацией β-эндорфина. Выводы. Нейромедиаторные и психологические дисфункции влияют на формирование послеоперационного хронического болевого синдрома. Установлена связь между хроническим послеоперационным болевым синдромом и предоперационными значениями концентрации β-эндорфина (r=-0,70; p=0,028), выраженностью депрессивных расстройств (r=0,65; p=0,012), что подтверждает их роль как неспецифических прогностических маркеров при мониторинге формирования послеоперационного хронического болевого синдрома. Ключевые слова: гинекологическая патология, хронический послеоперационный болевой синдром, нейромедиаторы, аффективные расстройства.

scholarly journals EMLA- AN EFFECTIVE TOOL FOR TOPICAL ANALGESIA IN SPLIT SKIN GRAFT HARVEST

2020 ◽  
pp. 1-4
Author(s):  
Lalit Agrawal ◽  
Fahud Khurram ◽  
Naveen Khubchandani
Keyword(s):  
Visual Analogue Scale ◽  
Skin Graft ◽  
Analogue Scale ◽  
Skin Grafting ◽  
Split Skin Graft ◽  
Emla Cream ◽  
Graft Harvest ◽  
Group 2 ◽  
Split Skin ◽  
Group 1

Background: Many patients require general anesthesia merely for skin grafting. EMLA cream which is aeutectic mixture of Lignocaine and Prilocaine provides surface anesthesia when applied on intact skin. Its role in venepuncture or IV cannula insertion in children is well documented. Aim and Objective: To compare effectiveness of EMLA over inltrative local anaesthesia in split skin graft harvest. Method: A prospective study was conducted on 64 patients who required skin grafting. Various indications for grafting were noted. The patients were randomly allocated to two groups. In one group 32 patients, graft was harvested after application of EMLA cream whereas in another group of 32 patients, graft was harvested by inltrating local anesthesia. Pain perceived during donor area preparation, graft harvesting and post-operative pain was recorded and compared between the two groups on Visual analogue scale and Likert scale. Results: Total 64 patients were included in the study with 32 patients in either group. Traumatic loss of skin was the most common indication in either group for skin graft harvest. As per visual analogue scale during the graft harvest, most of the patients were in the range of 4-7 score in either group (71.87% vs 53.12%). 75% of the patients were in the 4-7 score in both groups. As per likert scale during the graft harvest score of 4 was noted in 62.5% in group 1 vs 53.12% in group 2 patients. 81.25% patients in group 1 reported procedure as excellent versus 53.12% patients in group 2. Patients experienced more pain during inltration of local anesthesia. Whereas more bleeding was noted in EMLA group immediately after harvest of graft. Conclusions: EMLA cream can be effectively used as an alternative to local anaesthetic inltration for harvest of split thickness skin graft

scholarly journals Comparison of Four Different Pain Relief Methods during Hysterosalpingography: A Randomized Controlled Study

2015 ◽  
Vol 20 (2) ◽  
pp. 107-111 ◽  
Author(s):  
Bekir Serdar Unlu ◽  
Mehmet Yilmazer ◽  
Gulengul Koken ◽  
Dagistan Tolga Arioz ◽  
Ebru Unlu ◽  
...  
Keyword(s):  
Pain Relief ◽  
Visual Analogue Scale ◽  
Analogue Scale ◽  
Cervix Uteri ◽  
Controlled Study ◽  
Group 4 ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

BACKGROUND: Hysterosalpingography (HSG) is the most commonly used method for evaluating the anatomy and patency of the uterine cavity and fallopian tubes, and is an important tool in the evaluation of infertility. The most frequent side effect is the pain associated with the procedure.OBJECTIVES: To evaluate four analgesic methods to determine the most useful method for reducing discomfort associated with HSG.METHODS: In the present prospective study, 75 patients undergoing HSG for evaluation of infertility were randomly assigned to four groups: 550 mg of a nonsteroidal anti-inflammatory drug (NSAID) (group 1); 550 mg NSAID + paracervical block (group 2); 550 mg NSAID + paracervical analgesic cream (group 3); or 550 mg NSAID + intrauterine analgesic instillation (group 4). A visual analogue scale was used to assess the pain perception at five predefined steps.RESULTS: Instillation of the liquids used for HSG was found to be the most painful step of HSG, and this step was where the only significant difference among groups was observed. When comparing visual analogue scale scores, group 2 and group 3 reported significantly less pain than the other groups. Group 1 reported significantly higher mean ( ± SD) scores (7.2 ± 1.6) compared with groups 2 and 3 (4.7 ± 2.5 and 3.8 ± 2.4, respectively) (P<0.001). In addition, group 2 reported significantly less pain than group 4 (4.7 ± 2.5 versus 6.7 ± 1.8, respectively) (P<0.02).CONCLUSIONS: For effective pain relief during HSG, in addition to 550 mg NSAID, local application of lidocaine cream to the posterior fornix of the cervix uteri and paracervical lidocaine injection into the cervix uteri appear to be the most effective methods.

scholarly journals Chronic pain in children with oncopathology: ways of solving the problem

2020 ◽  
pp. 6-7
Author(s):  
N.M. Adamchuk ◽  
O.Yu. Sorokina
Keyword(s):  
Blood Pressure ◽  
Gastrointestinal Tract ◽  
Visual Analogue Scale ◽  
Acute Leukemia ◽  
Emotional Disorders ◽  
Analogue Scale ◽  
Face Scale ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Objective. Pain is one of the complications in children with acute leukemia, which requires timely and effective analgesic therapy. We decided to determine the effectiveness and tolerability of analgesia in children with acute leukemia depending on the method of analgesia. Materials and methods. There was a survey of 60 children (3 groups of 20 children each). In group 1 conducted morphine analgesia, in group 2 – morphine in combination with gabapentin, in group 3 – paracetamol with gabapentin. Investigated performance of the cardiovascular system, gastrointestinal tract. The questionnaire “Feeling. Activity. Mood” was used to determine psycho-emotional disorders, visual-analogue scale and face scale was used to determine the intensity of pain. Results and discussion. In group 1, all children had dysfunction of the gastrointestinal tract and lability of blood pressure. In group 2, only 11 children had disorders of the digestive system, there were no cardiovascular complications. In group 3, only 5 children had lability of blood pressure. Averages activity in all three groups are almost identical and reflect favorable condition. The average health indicators are the lowest in the 1st group – 3.78±0.11 (p<0.05), in the 2nd group – 3.84±0.06 (p<0.05), and in the 3rd group – 4.01±0.09 (p<0.05). Mood indicators in groups 2 and 3 are almost the same – 4.04±0.12 (p<0.05) and 4.42±0.04 (p<0.05), respectively, and the worst in 1st group – 3.94±0.07 (p<0.05). The pain intensity according to visual-analogue scale on day 30 was in the 1st group ≤5 points, in the 2nd group ≤4 points and in the 3rd group ≤3 points. On day 78, the intensity of pain in group 1 was ≤5 points, in 2nd and 3rd groups – ≤3 points. Severe asthenia was observed only in 6 children (10 %) of the group 1, moderate asthenia – in 45 children (75 %) and the fatigue reaction – in 9 children (25 %). Conclusions. The best tolerability of analgesia in children, receiving paracetamol with gabapentin, the worst – in children receiving only opiates. Children who combined opiates with gabapentin had better health and significantly fewer complications than children who received opiates alone.

scholarly journals THE DIFFERENCES OF PROPRIOCEPTIVE NEUROMUSCULAR FACILITATION (PNF) STRETCHING AND ICE MASSAGE IN PREVENTING DELAYED ONSET MUSCLE SORENESS (DOMS) IN ADOLESCENT IN DENPASAR

2018 ◽  
Vol 6 (3) ◽  
pp. 37
Author(s):  
Made Wahyu Cahyadi ◽  
Ni Wayan Tianing ◽  
I Made Krisna Dinata
Keyword(s):  
Visual Analogue Scale ◽  
Analogue Scale ◽  
Muscle Soreness ◽  
Hypothesis Test ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Significant Difference ◽  
Proprioceptive Neuromuscular Facilitation ◽  
Group 2 ◽  
Group 1

ABSTRACT             The purpose of this study was to determine the aim of this research the difference between proprioceptive neuromuscular facilitation (PNF) stretching and ice massage in preventing the occurrence of delayset onset muscle soreness (DOMS). This research is an experimental study with post test two group desaign and using simple random sampling technique. The sample of the study were 20 male students selected based on the inclusion and exclusion criteria, which were then divided into two groups. Group 1 was given treatment of pnf stretching and group 2 was given ice massage treatment. DOMS pain was measured using visual analogue scale (VAS) at 48 h after treatment. Hypothesis test of this research using Mann-Whitney U-test, where got result p = 0,027 (p <0,05). These results show that there is a significant difference between pnf stretching and ice massage. Mean of DOMS pain value in group 1 was 2,560 and mean of DOMS pain value in group 2 was 1,200. This shows that ice massage group results in lower DOMS pain value compared to pnf stretching group. Based on the results of this study, it is concluded that ice massage is better than pnf stretching in preventing DOMS.   Keyword: delayet onset muscle soreness (DOMS), PNF Stretching, Ice Massage, visual analogue scale (VAS)

scholarly journals Percutaneous resonance stimulation in complex correction of intraabdominal hypertension and dynamic intestinal obstruction in patients with severe acute pancreatitis

2018 ◽  
Vol 23 (3) ◽  
pp. 23-30
Author(s):  
O. K. Khalidov ◽  
V. S. Fomin ◽  
A. N. Gudkov ◽  
G. O. Zayratyants ◽  
G. P. Dmitrienko ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Visual Analogue Scale ◽  
Intestinal Obstruction ◽  
Severe Acute Pancreatitis ◽  
Analogue Scale ◽  
Disease Onset ◽  
Abdominal Pressure ◽  
Abdominal Hypertension ◽  
Group 2 ◽  
Group 1

Aim. To evaluate an effectiveness of non-invasive stimulation of gastrointestinal peristaltic activity in complex correction of motor-evacuation disorders and intra-abdominal hypertension in patients with severe acute pancreatitis.Material and methods. There were 85 patients with severe acute pancreatitis. Patients were divided into two groups: group 1 (n = 43) – percutaneous resonance stimulation; group 2 (n = 42) – routine treatment of acute pancreatitis with intraperitoneal hypertension syndrome and dynamic intestinal obstruction according to normative documents. Intra-abdominal pressure was measured in 1, 3, 5, 7 days after disease onset. Abdominal perfusion pressure and filtration gradient were additionally calculated. Moreover, outcomes were assessed after 1, 3, 5, and 7 days according to visual-analogue scale.Results. There were faster regression of intraperitoneal hypertension followed by normalization of abdominal pressure after 7 days in group 1 compared with group 2 (p ≤ 0.05). Data of visual-analogue scale confirmed patients’ good tolerability of resonance stimulation including absent local discomfort during electrodes deployment and better state of health compared with group 2 (p ≤ 0.05). Infectious complications rate was 20.9% in group 1, 38.1% – in group 2. Sepsis developed in 3 (7%) patients of group 1 and in 7 (16.6%) patients of group 2. Overall mortality was 7% and 14.3% in both groups, respectively. Сonclusion. Percutaneous resonance stimulation is able to improve outcomes in patients with severe acute pancreatitis.

scholarly journals Influence of Body Mass Index on Mechanical Properties in People With Obesity

2021 ◽  
Author(s):  
Serkan Usgu ◽  
Engin Ramazanoğlu ◽  
Yavuz Yakut
Keyword(s):  
Mechanical Properties ◽  
Body Mass Index ◽  
Body Mass ◽  
The Other ◽  
Positive Correlation ◽  
Weak Positive Correlation ◽  
Group 3 ◽  
Group 2 ◽  
The Right ◽  
Group 1

Abstract Background: The study was to determine influence of body mass index on muscular mechanical properties in people with obesity.Methods: A total of 300 individuals (mean age: 27.31±7.21 years) were participated. The participants were assigned in groups base on BMI classification (Group 1 (BMI=18.50-24.99 kg/m2), Group 2 (BMI=25.00-29.99 kg/m2), and Group 3 (BMI≥30 kg/m2)). The biceps brachii (BB), biceps femoris (BF) were measured bilaterally using the "MyotonPRO" device. Results: All mechanical properties of the right and left BB muscle, left BF tone and stiffness were found significantly difference between groups (p<0.05). The bilateral BB tone in Group 3 was lower than the other two groups. The right BB stiffness of Group 2 was found to be higher compared to the other two groups (p<0.05). While the right and left BB elasticity was similar in Groups 2 and 3, it was lower compared to Group 1 (p<0.05). The left BF tone and stiffness of Group 3 were found to be significantly higher than Groups 1 and 2 (p<0.05).The right BB tone showed a weak negative correlation with BMI in females, and for left side in males. A weak positive correlation was found between the right and left BB elasticity and BMI in males and females. The left-right BF tone and left BF stiffness showed a weak positive correlation in males. Conclusions: The bilateral BB tone and elasticity decreased, and the left BF stiffness increased as BMI increased. Different mechanical properties were observed in sex comparasion base on BMI clasification. The BB and BF mechanical properties were affected more in males than females.

Is Expanded Hemodialysis an Option to Online Hemodiafiltration for Small- and Middle-Sized Molecules Clearance?

2018 ◽  
Vol 47 (1-3) ◽  
pp. 126-131 ◽  
Author(s):  
Javier Reque ◽  
Alejandro Pérez Alba ◽  
Nayara Panizo ◽  
Juan José Sánchez-Canel ◽  
Maria Jose Pascual ◽  
...  
Keyword(s):  
Prospective Study ◽  
Reduction Rate ◽  
Hemodialysis Patients ◽  
Reduction Ratio ◽  
The Other ◽  
Second Phase ◽  
Middle Molecules ◽  
Group 2 ◽  
To Receive ◽  
Group 1

Background: Recent evidence suggests a better reduction rate of some uremic toxins with expanded hemodialysis (HDx). Methods: Prospective study including 8 hemodialysis patients. We divided the study in 2 phases; within the first one, we assigned 4 patients (group 1) to undergo online hemodiafiltration with a PF 210H dialyzer, and the other 4 patients (group 2) to undergo HDx with the high retention onset Theranova 500 dialyzer during 24 sessions. Later, during the second phase and after a washout period, the same patients were switched to receive HDx (group 1) and HDF (group 2). Results: No differences were found in the Urea and β2-microglobulin reduction ratio. However, in the case of myoglobin, the reduction ratio with HDF was 35 vs. 60% with HDx (p < 0.001). Similarly, in the case of prolactin, the reduction ratio with HDF was 45 and 61% with HDx (p < 0.001). Conclusions: We conclude that HDx is not inferior to online hemodiafiltration in the clearance of small and middle molecules and could be superior in the clearance of larger middle molecules.

scholarly journals Appetite-related hormone levels in obese women with and without binge eating behavior

2011 ◽  
Vol 24 (5) ◽  
pp. 667-677
Author(s):  
Paula Paraguassú Brandão ◽  
Érica Patrícia Garcia-Souza ◽  
Fabiana Alves Neves ◽  
Mário José dos Santos Pereira ◽  
Rosely Sichieri ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Binge Eating ◽  
Normal Weight ◽  
The Other ◽  
Obese Women ◽  
Before And After ◽  
Total Ghrelin ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

OBJECTIVE: The aim of this study was to evaluate serum levels of appetite-related hormones (peptide YY3-36, total ghrelin, leptin and insulin) before and after consumption of a meal in obese women with and without binge eating episodes and normal weight women. METHODS: Twenty-five women aged 32-50 years were invited to participate in this study, including 9 normal weight women without binge eating episodes (20-25kg/m², group 1), 9 obese women with binge eating episodes (³30kg/m², group 2), and 7 obese women without binge eating episodes (group 3). Four blood samples were collected from each participant, one being 60 minutes before and three being 15, 45 and 90 minutes after a meal. The composition of the meal was 55% carbohydrates, 15% protein and 30% lipids. RESULTS: Group 3 presented increased HOMA-IR (M=2.5, SD=1.04) when compared with group 1 (M=1.5, SD=0.53) and group 2 (M=1.8, SD=0.58), p=0.04. Body mass index (p<0.0001), leptin (p<0.0001) and insulin (p=0.01) were higher in group 3 than in the other groups before and after the meal. Additionally, total ghrelin (p=0.003) and PYY3-36 (p=0.02) levels were lower in group 2 than in the other groups before and after the meal. After adjustment for body mass index, only the lower PYY3-36 level of group 2 remained statistically different from the other groups (p=0.01). CONCLUSION: Our study suggests that lower levels of PYY 3-36 are associated with binge eating in obese women.

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