scholarly journals Nitrogen-nitrate exposure from drinking water and colorectal cancer risk for rural women in Wisconsin, USA

2008 ◽  
Vol 6 (3) ◽  
pp. 399-409 ◽  
Author(s):  
Jane A. McElroy ◽  
Amy Trentham-Dietz ◽  
Ronald E. Gangnon ◽  
John M. Hampton ◽  
Andrew J. Bersch ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Drinking Water ◽  
Cancer Risk ◽  
Rural Women ◽  
Nitrate Nitrogen ◽  
Fold Increase ◽  
Proximal Colon ◽  
Nitrate Contamination ◽  
Colorectal Cancer Risk

One unintentional result of widespread adoption of nitrogen application to croplands over the past 50 years has been nitrate contamination of drinking water with few studies evaluating the risk of colorectal cancer. In our population-based case-control study of 475 women age 20–74 years with colorectal cancer and 1447 community controls living in rural Wisconsin, drinking water nitrate exposure were interpolated to subjects residences based on measurements which had been taken as part of a separate water quality survey in 1994. Individual level risk factor data was gathered in 1990–1992 and 1999–2001. Logistic regression models estimated the risk of colorectal cancer for the study period, separately and pooled. In the pooled analyses, an overall colorectal cancer risk was not observed for exposure to nitrate-nitrogen in the highest category (≥10 ppm) compared to the lowest category (<0.5 ppm). However, a 2.9 fold increase risk was observed for proximal colon cancer cases in the highest compared to the lowest category. Statistically significant increased distal colon or rectal cancer risk was not observed. These results suggest that if an association exists with nitrate-nitrogen exposure from residential drinking water consumption, it may be limited to proximal colon cancer.

scholarly journals Colorectal cancer risk and nitrate exposure through drinking water and diet

2016 ◽  
Vol 139 (2) ◽  
pp. 334-346 ◽  
Author(s):  
Nadia Espejo-Herrera ◽  
Esther Gràcia-Lavedan ◽  
Elena Boldo ◽  
Nuria Aragonés ◽  
Beatriz Pérez-Gómez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drinking Water ◽  
Cancer Risk ◽  
Colorectal Cancer Risk

scholarly journals In vitro DNA adduct profiling to mechanistically link red meat consumption to colon cancer promotion

2016 ◽  
Vol 5 (5) ◽  
pp. 1346-1358 ◽  
Author(s):  
Lieselot Y. Hemeryck ◽  
Caroline Rombouts ◽  
Thomas Van Hecke ◽  
Lieven Van Meulebroek ◽  
Julie Vanden Bussche ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Cancer Risk ◽  
Meat Consumption ◽  
Red Meat ◽  
Dna Adduct ◽  
Colorectal Cancer Risk

Red meat digestion may contribute to colorectal cancer risk.

Long-Term Exposure to Nitrate in Drinking Water and Colorectal Cancer Risk (MCC-SPAIN STUDY)

2014 ◽  
Vol 2014 (1) ◽  
pp. 2369
Author(s):  
Nadia Espejo-Herrera* ◽  
Manolis Kogevinas ◽  
Esther Gràcia-Lavedan ◽  
Nuria Aragonés ◽  
Elena Boldo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drinking Water ◽  
Cancer Risk ◽  
Colorectal Cancer Risk

scholarly journals Genetic Variations in SMAD7 Are Associated with Colorectal Cancer Risk in the Colon Cancer Family Registry

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e60464 ◽  
Author(s):  
Xuejuan Jiang ◽  
J. Esteban Castelao ◽  
David Vandenberg ◽  
Angel Carracedo ◽  
Carmen M. Redondo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Cancer Risk ◽  
Genetic Variations ◽  
Colorectal Cancer Risk ◽  
Cancer Family ◽  
Colon Cancer Family Registry

Abstract 36: Genetic variability in MRP4 (ABCC4), ibuprofen use, and colorectal cancer risk in the Colon Cancer Family Registry.

2012 ◽  
Vol 21 (11 Supplement) ◽  
pp. 36-36
Author(s):  
Laura M. Heath ◽  
Karen W. Makar ◽  
Alexa J. Resler ◽  
Brenna L. Seufert ◽  
Elizabeth M. Poole ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Genetic Variability ◽  
Cancer Risk ◽  
Colorectal Cancer Risk ◽  
Cancer Family ◽  
Colon Cancer Family Registry

scholarly journals Nitrate in drinking water and colorectal cancer risk: A nationwide population-based cohort study

2018 ◽  
Vol 143 (1) ◽  
pp. 73-79 ◽  
Author(s):  
Jörg Schullehner ◽  
Birgitte Hansen ◽  
Malene Thygesen ◽  
Carsten B. Pedersen ◽  
Torben Sigsgaard
Keyword(s):  
Colorectal Cancer ◽  
Drinking Water ◽  
Cohort Study ◽  
Cancer Risk ◽  
Population Based ◽  
Colorectal Cancer Risk

scholarly journals Genetic variation in prostaglandin synthesis and related pathways, NSAID use and colorectal cancer risk in the Colon Cancer Family Registry

2014 ◽  
Vol 35 (9) ◽  
pp. 2121-2126 ◽  
Author(s):  
Alexa J. Resler ◽  
Karen W. Makar ◽  
Laura Heath ◽  
John Whitton ◽  
John D. Potter ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Genetic Variation ◽  
Cancer Risk ◽  
Prostaglandin Synthesis ◽  
Colorectal Cancer Risk ◽  
Cancer Family ◽  
Colon Cancer Family Registry

scholarly journals Coffee consumption and risk of colorectal cancer: a meta-analysis of observational studies

2012 ◽  
Vol 16 (2) ◽  
pp. 346-357 ◽  
Author(s):  
Guowei Li ◽  
Defu Ma ◽  
Yumei Zhang ◽  
Wei Zheng ◽  
Peiyu Wang
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Cancer Risk ◽  
Cohort Studies ◽  
Meta Analysis ◽  
Coffee Consumption ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Case Control Studies ◽  
The Relationship

AbstractObjectiveSeparate meta-analyses based on case–control and cohort studies have reported different results on the relationship between coffee consumption and colorectal cancer risk. To clarify the effect of coffee intake on colorectal cancer risk, we performed a meta-analysis based on both case–control and cohort studies.DesignReview study.SettingWe identified case–control and cohort studies related to coffee consumption and colorectal cancer risk listed on MEDLINE, the Cochrane Controlled Trials Register, EMBASE, Science Citation Index and PubMed (until May 2011).SubjectsResearch literature on the relationship between coffee consumption and colorectal cancer risk.ResultsTwenty-five case–control (15 522 cases) and sixteen cohort studies (10 443 cases) were included in the meta-analysis. Comparing the highest v. the lowest/non category of coffee consumption, the combined results from case–control studies showed a significant relationship with colorectal cancer (OR = 0·85, 95 % CI 0·75, 0·97) and colon cancer (OR = 0·79, 95 % CI 0·67, 0·95), but not rectal cancer (OR = 0·95, 95 % CI 0·79, 1·15). For cohort studies, there was a slight suggestion of an inverse association with colorectal cancer (relative ratio = 0·94; 95 % CI 0·88, 1·01) and colon cancer (OR = 0·93, 95 % CI 0·86, 1·01), rather than rectal cancer (OR = 0·98, 95 % CI 0·88, 1·09). In subgroup analyses using case–control studies, significant inverse associations were found in females for colorectal cancer and in Europe for colorectal and colon cancer, while the subgroup analyses of cohort studies found that coffee drinks substantially decreased risk of colon cancer only in Asian women.ConclusionsResults from case–control studies suggest coffee consumption can significantly decrease the risks of colorectal cancer and colon cancer, especially in Europe and for females.

scholarly journals Association between known risk factors and colorectal cancer risk among Indigenous people participating in the Ontario Familial Colon Cancer Registry

2020 ◽  
Vol 27 (4) ◽  
Author(s):  
S. Jamal ◽  
A.J. Sheppard ◽  
M. Cotterchio ◽  
S. Gallinger
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Colon Cancer ◽  
Risk Factor ◽  
Cancer Risk ◽  
Cigarette Smoking ◽  
Cancer Registry ◽  
Colorectal Cancer Risk ◽  
Indigenous Populations ◽  
Familial Colon Cancer

Introduction: Colorectal cancer is one of the most common cancers in Ontario and poses a high burden among many Indigenous populations. There are two aims for this short communication: (1) highlight colorectal risk factor findings from a population-based case-control study, (2) highlight trends and challenges of colorectal cancer research among Indigenous populations in Ontario.Methods: Prevalence of cigarette smoking, obesity, diet  and family history of colorectal cancer were estimated using the Indigenous identifier in the Ontario Familial Colon Cancer Registry (OFCCR) from 1999-2007 and then compared using age-adjusted odds ratio (with 95% confidence intervals) between cases and controls.Results: There were 66 Indigenous cases and 23 Indigenous controls. Cigarette smoking and obesity were higher in cases, but not statistically significant.Discussion and Conclusions: Findings were consistent with previous literature among Indigenous populations. Colorectal cancer risk factor and screening uptake information is limited among Indigenous populations; however, self-reported screening data suggest low colorectal screening uptake. Small sample size and poor Indigenous identification questions make it challenging to comprehensively understand cancer risk factors and burden in these populations.

scholarly journals Association of dietary insulinemic potential and colorectal cancer risk in men and women

2018 ◽  
Vol 108 (2) ◽  
pp. 363-370 ◽  
Author(s):  
Fred K Tabung ◽  
Weike Wang ◽  
Teresa T Fung ◽  
Stephanie A Smith-Warner ◽  
NaNa Keum ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Colon Cancer ◽  
Cancer Risk ◽  
Insulin Response ◽  
Distal Colon ◽  
Proximal Colon ◽  
Cancer Development ◽  
Men And Women

ABSTRACT Background Insulin response may be important in colorectal cancer development. Diet modulates insulin response and may be a modifiable factor in colorectal cancer prevention. Objective We examined associations between hyperinsulinemic diets and colorectal cancer risk with the use of an empirical dietary index for hyperinsulinemia (EDIH), a food-based index that characterizes dietary insulinemic potential on the basis of circulating C-peptide concentrations. Design Diet was assessed every 4 y with food-frequency questionnaires in 46,210 men (Health Professionals Follow-Up Study, 1986–2012) and 74,191 women (Nurses’ Health Study, 1984–2012) to calculate EDIH scores. Multivariable-adjusted Cox regression was used to calculate HRs and 95% CIs for colorectal, proximal/distal colon, and rectal cancer risk. Results During 26 y of follow-up, we documented 2683 incident colorectal cancer cases. Comparing participants in the highest with those in the lowest quintiles, higher EDIH scores were associated with 33% (men: HR: 1.33; 95% CI: 1.11, 1.61; P-trend = 0.0005), 22% (women: HR: 1.22; 95% CI: 1.03, 1.45; P-trend = 0.01), and 26% (men and women: pooled HR: 1.26; 95% CI: 1.12, 1.42; P-trend <0.0001) higher risk of developing colorectal cancer. The positive associations were limited to the distal colon and rectum in men and to the distal and proximal colon in women; however, combined risk estimates were significant for all anatomic locations except for the rectum. For example, comparing participants in extreme EDIH quintiles, there was no significant association for proximal colon cancer in men (HR: 1.15; 95% CI: 0.84, 1.57; P-trend = 0.32), but the risk was elevated for distal colon (HR: 1.63; 95% CI: 1.14, 2.32; P-trend = 0.002) and rectal (HR: 1.63; 95% CI: 1.09, 2.44; P-trend = 0.01) cancer. Among women, the risk was elevated for proximal (HR: 1.28; 95% CI: 1.00, 1.63; P-trend = 0.03) and distal (HR: 1.46; 95% CI: 1.05, 2.03; P-trend = 0.03) colon cancer but not for rectal cancer (HR: 0.88; 95% CI: 0.60, 1.29; P-trend = 0.61). Conclusion The findings suggest that the insulinemic potential of diet may partly underlie the influence of dietary intake on colorectal cancer development. This observational study was registered at www.clinicaltrials.gov as NCT03364582.

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