scholarly journals Evaluation of calcium-fortified municipal water as a public health intervention to mitigate lead burdens

2021 ◽  
Author(s):  
Mozhgon Rajaee ◽  
Ernest Dubovitskiy ◽  
Victoria C. Brown
Keyword(s):  
Serum Calcium ◽  
Lead Exposure ◽  
Calcium Intake ◽  
Public Health Intervention ◽  
Blood Lead ◽  
The Body ◽  
High Calcium Intake ◽  
Lead Absorption ◽  
High Calcium ◽  
Lead Levels

Abstract Lead has adverse effects on health, society, and the economy. Lead exposure results in increased blood lead levels and storage in bones. Calcium and lead are competitively absorbed and as such calcium can be used to mitigate the body lead burden. Twenty-eight quantitative research studies were reviewed that examined lead exposure (in blood, bone, or breastmilk) and calcium intake or serum calcium to evaluate the efficacy and safety of fortifying potable water supplies with calcium to mitigate lead absorption or resorption. Eighteen of the studies reported a significant inverse relationship between biomarker lead levels and calcium intake or serum calcium. The relationship was most evident with high calcium intake, suggesting a dose-dependent relationship. An intervention with calcium-fortified water could offer an accessible source of supplemental calcium to help meet the recommended dietary allowance (RDA) and mitigate lead absorption. A concentration of 60 mg-Ca/L can supply 22.0 and 16.3% of a 1,000 mg-Ca RDA for men and women, respectively, at the recommended daily water intake.

scholarly journals The Modifying Factor of Lead Exposure Time with Blood Lead Levels on Adulterated Paint Worker

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Diah Lestari ◽  
Angki Purwanti
Keyword(s):  
Exposure Time ◽  
Lead Exposure ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
The Body ◽  
Blood Lead Levels ◽  
Lead Levels ◽  
Spearman Test ◽  
The Relationship

The modifying factor for exposure time for paint workers who work more than 8 hours / day have abnormal blood lead levels> 10 μg / dl. Lead exposure to paint workers occurs when mixing paints, mostly through air, skin, through food and drinks. The longer the work, the more the amount of lead exposure received, although the amount of lead absorbed by the body is only small, this metal turns out to be very dangerous and can cause health problems due to the buildup of lead in the body. The presence of lead (Pb) in the blood can cause severe and dangerous effects including interfering with the hematopoietic system, a long exposure can disrupt the gastrointestinal system, central nervous system, immune system, kidneys. The purpose of this research was to determine the relationship and closeness of the relationship between the modification factors of exposure time with blood lead levels of adulterated paint workers in the area of East Jakarta. The research method uses primary data through an analytic observational cross-sectional design approach. Sampling is done by non-probability sampling with consecutive sampling techniques. The correlation test used was the Spearman test with a confidence level of 95%. The results of the research found that the average exposure time of adulterated paint workers was 48.9 hours/week exceeding the permissible work time, and the exposure time >40 hours/week was 77.5% of the number of respondents. The average blood lead level was 0.15 mg/L, with the highest blood lead level 0.45 mg/L and workers with exposure times> 40 hours/week obtained blood lead levels exceeding the safe reference limit (40 mg/L) of 19.4%. The conclusion is that there is a significant relationship between duration of exposure and lead level of adulterated paint workers (p-value = 0.029) and shows the moderate closeness of the relationship with the direction of a positive relationship. The value of r = 0.346, means that the longer the person is exposed to lead, the higher the level of lead in the blood of adulterated paint  workers. The discussion of modification factors of exposure time in adulterated paint workers can influence lead exposure continuously, in the long term, absorption of lead in the body 99% which is bound to erythrocytes will accumulate in the blood, then it is distributed into the blood which is 90% binding to cells red blood cells (erythrocytes), and the rest are bound to blood plasma. Once absorbed, the lead will be stored in the blood for 35 days. For 8 hours, a worker can absorb up to 400 μg and add 20 - 30 μg / day from food, drinks, and air. The presence of lead in blood represents a reflection of the dynamic continuity between exposure, absorption, distribution, and excretion, so that it is one indicator to know and follow ongoing exposure. Keywords : Modifying Effect, Exposure Time, Relationship Strength, Blood Lead Levels

scholarly journals Calcium Intake Is Inversely Related to the Risk of Obesity Among American Young Adults over a 30-Year Follow-Up

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1445-1445
Author(s):  
Liping Lu ◽  
Cheng Chen ◽  
Wenjing Tang ◽  
David Jacobs ◽  
James Shikany ◽  
...  
Keyword(s):  
Young Adults ◽  
Coronary Artery ◽  
Serum Calcium ◽  
Calcium Intake ◽  
Dietary Quality ◽  
Inverse Association ◽  
High Calcium Intake ◽  
High Calcium ◽  
American Young Adults

Abstract Objectives It has been suggested that high calcium intake may promote weight reduction and prevent obesity, but data from longitudinal studies investigating the potential long-term associations of calcium with weight maintenance are limited and the findings are inconsistent. Therefore, we prospectively examined dietary calcium and serum calcium concentrations in relation to the incidence of obesity in a cohort of American young adults. Methods This study includes 4097 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study who were age 18–30 years at baseline in 1985–86. Participants were reexamined in 8 follow-ups over 30 years. Calcium intake from diet and supplements was estimated by the CARDIA diet history questionnaire at baseline and two re-exams (year 7 and 20). Serum calcium concentrations were measured at baseline. Incident obesity was defined as a body mass index ≥30 kg/m2. Multivariable-adjusted Cox proportional hazards regression models were used to examine the associations between calcium levels (intake and serum concentrations) and the incidence of obesity. Results During 30 years of follow-up, a total of 1675 participants became obese. Both calcium intake and serum calcium concentrations were inversely associated with obesity incidence independent of sociodemographics, major lifestyle factors, medical history, dietary quality and clinical measurements (blood pressure, lipid profiles, and fasting insulin) [hazard ratio (95% confidence interval) of quintile 5 (highest) vs. quintile 1 (lowest) calcium intake from diet and supplements: 0.76 (0.62, 0.93), P for trend = 0.02; serum calcium: 0.83 (0.71, 0.97), P for trend = 0.04]. A similar inverse association was observed between the consumption of dairy products, a major food source of calcium, and obesity incidence. Conclusions Calcium intake and serum calcium concentration are longitudinally and inversely associated with incidence of obesity among American young adults. Funding Sources The Coronary Artery Risk Development in Young Adults Study is supported by grants from the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham, Northwestern University, University of Minnesota, and Kaiser Foundation Research Institute. This study is also partially supported by the NIH grants.

The effects of lead on GABAergic interneurons in rodents

2017 ◽  
Vol 33 (11) ◽  
pp. 867-875 ◽  
Author(s):  
Yifei Duan ◽  
Leiwen Peng ◽  
Hua Shi ◽  
Yongmei Jiang
Keyword(s):  
Dna Methylation ◽  
Cell Line ◽  
Lead Exposure ◽  
Dose Group ◽  
Blood Lead ◽  
The Body ◽  
Blood Lead Levels ◽  
Gabaergic Interneurons ◽  
Lead Levels

Lead is a heavy metal that affects various systems and organs in the body, especially the nervous system. In this study, the in vivo and in vitro effects of lead on neurons were analyzed. We divided mouse pups into three groups based on the concentration of lead exposure: the control group, the low-dose group, and the high-dose group. Changes in behavior (measured by an open-field test and a tail suspension test), blood lead levels (measured by atomic absorption spectrophotometry), the number of GABAergic interneurons (measured by immunohistochemistry), gene expression (measured by qRT-PCR), and DNA methylation (measured by pyrosequencing) were determined in the three groups. The lead-exposed pups showed significantly higher blood lead levels ( p < 0.001). Lead exposure caused hyperactivity and reduced the body weight of the exposed mice compared with that of the controls. The lead-exposed groups showed significantly lower numbers of parvalbumin and neuropeptide Y interneurons and lower expression levels of distal-less homeobox ( Dlx) 1, 2, 5, and 6 genes in the cerebral cortex. To further clarify the mechanism of Dlx gene downregulation, we selected the GE6 cell line, which can differentiate into various subtypes of GABAergic interneurons, for in vitro experiments. We found that high levels of lead also inhibited the expression of Dlx 1/ 2/ 5/ 6 in vitro, but DNA methylation levels were not changed in the GE6 cell line. Furthermore, lead exposure significantly decreased the expression of Olig1 and Ki67 and increased that of Tubb3 in vitro. The present study revealed that lead exposure can alter behaviors, reduce the number of GABAergic interneurons, and change the expression of some important genes in neuronal cells.

scholarly journals Blood lead level and risk of hypertension in the United States National Health and Nutrition Examination Survey 1999–2016

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Man Fung Tsoi ◽  
Chris Wai Hang Lo ◽  
Tommy Tsang Cheung ◽  
Bernard Man Yung Cheung
Keyword(s):  
Blood Pressure ◽  
Lead Exposure ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
The United States ◽  
Study Data ◽  
Blood Lead Levels ◽  
Environmental Lead ◽  
Lead Levels

AbstractLead is a heavy metal without a biological role. High level of lead exposure is known to be associated with hypertension, but the risk at low levels of exposure is uncertain. In this study, data from US NHANES 1999–2016 were analyzed. Adults with blood lead and blood pressure measurements, or self-reported hypertension diagnosis, were included. If not already diagnosed, hypertension was defined according to the AHA/ACC 2017 hypertension guideline. Results were analyzed using R statistics version 3.5.1 with sample weight adjustment. Logistic regression was used to study the association between blood lead level and hypertension. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated. Altogether, 39,477 participants were included. Every doubling in blood lead level was associated with hypertension (OR [95%CI] 1.45 [1.40–1.50]), which remained significant after adjusting for demographics. Using quartile 1 as reference, higher blood lead levels were associated with increased adjusted odds of hypertension (Quartile 4 vs. Quartile 1: 1.22 [1.09–1.36]; Quartile 3 vs. Quartile 1: 1.15 [1.04–1.28]; Quartile 2 vs. Quartile 1: 1.14 [1.05–1.25]). In conclusion, blood lead level is associated with hypertension in the general population with blood lead levels below 5 µg/dL. Our findings suggest that reducing present levels of environmental lead exposure may bring cardiovascular benefits by reducing blood pressure.

Low-Level Lead Exposure and Blood Lead Levels in Children: A Cross-Sectional Survey

2001 ◽  
Vol 56 (6) ◽  
pp. 501-505 ◽  
Author(s):  
Aysha Habib Khan ◽  
Amanullah Khan ◽  
Farooq Ghani ◽  
Muhammad Khurshid
Keyword(s):  
Lead Exposure ◽  
Blood Lead ◽  
Blood Lead Levels ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Low Level ◽  
Lead Levels

scholarly journals Dietary Calcium Intake and Calcium Supplementation in Hungarian Patients with Osteoporosis

2013 ◽  
Vol 2013 ◽  
pp. 1-8
Author(s):  
Gábor Speer ◽  
Pál Szamosujvári ◽  
Péter Dombai ◽  
Katalin Csóré ◽  
Kinga Mikófalvi ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Calcium Intake ◽  
Calcium Supplementation ◽  
Dietary Calcium ◽  
Dietary Calcium Intake ◽  
Current Recommendation ◽  
High Calcium Intake ◽  
Osteoporosis Therapy ◽  
Average Intake ◽  
High Calcium

Purpose. Adequate calcium intake is the basis of osteoporosis therapy—when this proves insufficient, even specific antiosteoporotic agents cannot exert their actions properly.Methods. Our representative survey analyzed the dietary intake and supplementation of calcium in 8033 Hungarian female and male (mean age: 68 years) (68.01 (CI95: 67.81–68.21)) patients with osteoporosis.Results. Mean intake from dietary sources was665±7.9 mg (68.01 (CI95: 67.81–68.21)) daily. A significant positive relationship could be detected between total dietary calcium intake and lumbar spine BMD (P=0.045), whereas such correlation could not be demonstrated with femoralT-score. Milk consumption positively correlated with femur (P=0.041), but not with lumbar BMD. The ingestion of one liter of milk daily increased theT-score by 0.133. Average intake from supplementation was558±6.2 mg (68.01 (CI95: 67.81–68.21)) daily. The cumulative dose of calcium—from both dietary intake and supplementation—was significantly associated with lumbar (r=0.024,P=0.049), but not with femur BMD (r=0.021,P=0.107). The currently recommended 1000–1500 mg total daily calcium intake was achieved in 34.5% of patients only. It was lower than recommended in 47.8% of the cases and substantially higher in 17.7% of subjects.Conclusions. We conclude that calcium intake in Hungarian osteoporotic patients is much lower than the current recommendation, while routinely applied calcium supplementation will result in inappropriately high calcium intake in numerous patients.

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