scholarly journals The Need for New Microbiological Water Quality Criteria

1991 ◽  
Vol 24 (2) ◽  
pp. 43-48 ◽  
Author(s):  
Helmy T. El-Zanfaly
Keyword(s):  
Public Health ◽  
Water Quality ◽  
Drinking Water ◽  
Plate Count ◽  
Resistant Bacteria ◽  
Water Quality Criteria ◽  
Antibiotic Resistant Bacteria ◽  
Gram Positive ◽  
Antibiotic Resistant ◽  
Gram Negative

The microbiological criteria for water quality have been directed towards protection of consumers from possible microbial pollution which may cause public health hazards. Therefore, the bacteriological standards for drinking water are based mainly on bacterial indicators. Another problem of prime concern to public health is the presence of antibiotic-resistant bacteria in drinking water Antibiotic–resistant bacteria were found among standard plate count populations of Chlorinated drinking water from two districts in Cairo. Most strains appeared to be ampicillin resistant (89%). Those were followed by sulfaguanidine (78%) and streptomycin (57%). The majority of the tested strains (62.4 to 98%) were multiple antibiotic resistant (MAR). Identification of 363 MAR strains revealed that Gram-positive rods were dominant, while Gram-negative fermentative rods, Gram-positive cocci and Gram-negative nonfermentative rods represent the second, third and fourth group. A total of 101 strains isolated from underground water pumped from three water works in Cairo were classified and tested for their resistance towards four commonly used antibiotics; chloramphenicol, tetracycline, neomycin, penicillin and one chemotherapeutic agent namely sulfanilamide pyrimidine. Results showed that 77, 64 and 32 isolates have resistance towards penicillin, sulfanilamide pyrimidine and tetracycline, respectively. Only 18 and 8 isolates were resistant to chloramphenicol and neomycin, respectively. It was also found that 19 isolates belonging to 6 genera or groups were sensitive towards all of the tested compounds. Therefore, any source of antibiotic~resistant bacteria must be viewed with concern and use of data on MAR bacteria should be made in future water quality deliberations and in regulating effluent quality discharges.

scholarly journals Beyond fecal microbiota transplantation: Developing drugs from the microbiome

2020 ◽  
Author(s):  
Ylaine Gerardin ◽  
Sonia Timberlake ◽  
Jessica R Allegretti ◽  
Mark B Smith ◽  
Zain Kassam
Keyword(s):  
Public Health ◽  
Drug Discovery ◽  
Infectious Diseases ◽  
Health Outcomes ◽  
Patient Care ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant

Abstract The transfer of live gut microbes may transform patient care across a range of autoimmune, metabolic, hepatic and infectious diseases. One early approach, fecal microbiota transplantation, has shown promise in Clostridiodes difficile infection and the potential for improving clinical and public health outcomes for other antibiotic-resistant bacteria. These clinical successes have motivated the development of microbiome drugs, which will need to address challenges in safety, uniformity, and delivery while seeking to preserve the benefits of using whole microbiome communities as novel therapeutics and an innovative platform for drug discovery.

Isolation of Gram-Positive, Antibiotic-Resistant Bacteria from Tactile Mobile Phones in a Northwestern Mexican City

2020 ◽  
Vol 45 (5) ◽  
pp. 1050-1060
Author(s):  
Samuel Campista-León ◽  
Joel Tohevaris Garcia-Guerrero ◽  
Vicente Olimón-Andalón ◽  
Luz Isela Peinado-Guevara
Keyword(s):  
Mobile Phones ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Gram Positive ◽  
Antibiotic Resistant

PCR Targeting of Antibiotic Resistant Bacteria in Public Drinking Water of Lahore Metropolitan, Pakistan

2009 ◽  
Vol 22 (6) ◽  
pp. 458-463 ◽  
Author(s):  
Zahoor Qadir SAMRA ◽  
Mariam NASEEM ◽  
Sumaria Javed KHAN ◽  
Nadia DAR ◽  
Muhammad Amin ATHAR
Keyword(s):  
Drinking Water ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Public Drinking Water ◽  
Public Drinking ◽  
Pcr Targeting

scholarly journals Antibiotic-resistant bacteria in drinking water.

1981 ◽  
Vol 42 (2) ◽  
pp. 277-283 ◽  
Author(s):  
J L Armstrong ◽  
D S Shigeno ◽  
J J Calomiris ◽  
R J Seidler
Keyword(s):  
Drinking Water ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant

scholarly journals Deferasirox (ExJade): A Fluorescent Pro-Chelator Active Against Antibiotic Resistant Bacteria

2020 ◽  
Author(s):  
Adam Sedgwick ◽  
Kai-Cheng Yan ◽  
Daniel N. Mangel ◽  
Ying Shang ◽  
Axel Steinbrueck ◽  
...  
Keyword(s):  
Iron Overload ◽  
Therapeutic Response ◽  
A549 Cells ◽  
Fluorescent Imaging ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Gram Positive ◽  
Antibiotic Resistant

<p>Deferasirox,<b> ExJade</b>, an FDA-approved treatment for iron overload disorders has been shown to inhibit the growth of both gram-positive and -negative bacteria through iron (Fe(III)) chelation. Modification of the <b>ExJade</b> framework led to the identification of a new fluorescent platform <b>ExPh </b>and <b>ExBT</b>. Functionalization of the phenol moieties on <b>ExBT</b> with phosphate units afforded a ratiometric fluorescent pro-chelator (<b>ExPhos</b>), which was effective in the inhibition of two clinically relevant antibiotic-resistant bacteria, (MRSA (ATCC 43300) and VRE (ATCC 51299)), and allowed the fluorescent imaging of MRSA. <a>Remarkably, this pro-chelation strategy proved selective towards bacteria with no cytotoxicity observed for <b>ExPhos</b> treated A549 cells (72 h incubation). This work represents a new pro-chelator antibiotic strategy that </a><a>can be modified with a chosen reactive chemical trigger to provide a diagnostic signal in conjunction with a therapeutic response</a> with a potential of minimal off-target toxicities.</p>

scholarly journals Synergism between Outer Membrane Proteins and Antimicrobials

2011 ◽  
Vol 55 (5) ◽  
pp. 2206-2211 ◽  
Author(s):  
P. Veiga-Crespo ◽  
E. Fusté ◽  
T. Vinuesa ◽  
M. Viñas ◽  
T. G. Villa
Keyword(s):  
Outer Membrane ◽  
Outer Membrane Proteins ◽  
Bactericidal Effect ◽  
Resistant Bacteria ◽  
Logarithmic Phase ◽  
Permeability Barrier ◽  
Gram Negative Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Gram Negative

ABSTRACTAntibiotic-resistant bacteria are becoming one of the most important problems in health care because of the number of resistant strains and the paucity of new effective antimicrobials. Since antibiotic-resistant bacteria will continue to increase, it is necessary to look for new alternative strategies to fight against them. It is generally accepted that Gram-negative bacteria are intrinsically less susceptible than Gram-positive bacteria to antimicrobials. The main reason is that Gram-negative bacteria are surrounded by a permeability barrier known as the outer membrane (OM). Hydrophilic solutes most often cross the OM through water-filled channels formed by a particular family of proteins known as porins. This work explores the possibility of using exogenous porins to lower the required amounts of antibiotics (ampicillin, ciprofloxacin, cefotaxime, clindamycin, erythromycin, and tetracycline). Porins had a bactericidal effect onEscherichia colicultures, mainly in the logarithmic phase of growth, when combined with low antibiotic concentrations. The use of different antibiotic-porin mixtures showed a bactericidal effect greater than those of antibiotics and porins when used separately. It was possible to observe different behaviors according to the antibiotic type used.

Incidence of antibiotic resistant bacteria in drinking water in Cairo

1987 ◽  
Vol 32 (1-2) ◽  
Author(s):  
HelmyTawfik El-Zanfaly ◽  
El-SaiedAbd-Aziz Kassim ◽  
SamirM. Badr-Eldin
Keyword(s):  
Drinking Water ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant

scholarly journals Occurrence of Multiple Antibiotic Resistant Bacteria in Aquatic Environments in Central Minnesota

2015 ◽  
Vol 12 (3) ◽  
Author(s):  
Megan Bollin ◽  
Ellen Jensen ◽  
David Mitchell
Keyword(s):  
Aquatic Ecosystems ◽  
Resistant Bacteria ◽  
Aquatic Environments ◽  
Gram Negative Bacteria ◽  
Drug Resistant ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Gram Negative ◽  
Density Values ◽  
Resistance Coefficients

The purpose of this study was to investigate the possibility that antibiotic resistant bacteria could be isolated and identified in aquatic ecosystems in the lakes on the campus of Saint John’s University and the nearby Sauk and Watab Rivers. A total of 125 isolates were collected. Seventy-nine percent of the isolates were gram negative rods. Twenty-six isolates that were resistant to seven or more antibiotics were selected for further investigation. The 26 isolates were all gram negative and members of seven different genera with Flavobacterium and Acinetobacter being the most common. Resistance coefficients were calculated based on optical density values relative to cells grown without antibiotics. Multi-drug resistant, gram negative bacteria were shown to be common in aquatic environments in central Minnesota.

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