Application of regression analysis and classification trees in calculating additional population risk of ischemic heart disease

Nonenzymatic reactions between glucose and proteins yield advanced glycation end products (AGE) such as pentosidine. AGE accumulate in diabetic patients, alter the structure and function of tissue proteins, stimulate cellular response, and have thus been implicated in diabetic tissue damage. The present study was undertaken to assess the factors determining plasma total pentosidine level in diabetic patients and the possible relation between plasma pentosidine level and diabetic complications. In diabetic patients, including patients with renal failure, plasma pentosidine levels, assessed by HPLC assay, were correlated with serum creatinine (P < 0.0001). In patients with normal renal function, pentosidine levels were correlated with blood glucose control (hemoglobin Alc: P = 0.0028; fructoselysine: P = 0.0133), serum creatinine (P = 0.029), patient age (P = 0.0416), duration of diabetes (P = 0.0431), and total cholesterol (P = 0.0056) and LDL-cholesterol (P = 0.0208). Multiple regression analysis revealed an independent influence of hemoglobin Alc and serum creatinine on pentosidine levels (r2 = 0.216, P = 0.0026). Pentosidine levels were higher in patients with than in those without hypertension (P = 0.043) or ischemic heart diseases (P = 0.0061). No such differences were observed between patients with and without albuminuria or retinopathy. Multiple regression analysis revealed an independent influence of plasma pentosidine on the presence of hypertension (r2 = 0.129, P = 0.0382) and of plasma pentosidine and HDL-cholesterol on the presence of ischemic heart disease (r2 = 0.326, P = 0.0012). The present study demonstrated that plasma pentosidine level was significantly influenced by the quality of glycemic control and renal function. Pentosidine level was also correlated with hypertension and ischemic heart disease, and might be taken as a biomarker of diabetic cardiovascular risk.

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SAT-541 Difference in Aldosterone Dependency Between Cardiovascular Diseases and Renal Impairments in Patients with Primary Aldosteronism

Journal of the Endocrine Society ◽

10.1210/jendso/bvaa046.475 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

Author(s):

Masakatsu Sone ◽

Youichi Ohno ◽

Akiyuki Kawashima ◽

Nobuya Inagaki ◽

Mitsuhide Naruse ◽

...

Keyword(s):

Logistic Regression ◽

Regression Analysis ◽

Heart Disease ◽

Renal Impairment ◽

Ischemic Heart Disease ◽

Logistic Regression Analysis ◽

Primary Aldosteronism ◽

Odds Ratio ◽

Plasma Aldosterone ◽

Ischemic Heart

Abstract BACKGROUND: There have been several clinical studies examining the factors associated with cardiovascular disease (CVD) and renal impairment in patients with primary aldosteronism (PA); however, their results have left it unclear as to whether they are affected by the plasma aldosterone concentration (PAC) itself. Method: This is a retrospective cross-sectional study. We assessed the PA database established by the multicenter JPAS (Japan Primary Aldosteronism Study) and compared the prevalences of CVD (stroke, ischemic heart disease, and heart failure) and renal impairment (proteinuria and lowered eGFR) among patients with PA and those with essential hypertension (EHT). We also performed logistic regression analysis to determine which parameters significantly increased the odds ratio for these complications. Results: The prevalence of CVD was significantly higher among 2814 patients with PA than among matched patients with EHT. The prevalence of proteinuria was also significantly higher among PA than EHT patients, whereas there was no significant difference in the prevalence of lowered eGFR. Multivariable logistic regression analysis showed that the PAC significantly increases the adjusted odds ratios for proteinuria and lowered eGFR independent of other known risk factors. By contrast, the PAC was not linearly related to the adjusted odds ratio for CVD. Conclusion: Plasma aldosterone levels are closely associated with renal impairment in patients with PA. This is contrast to our finding that the PAC was not, itself, linearly associated with CVDs, such as stroke or ischemic heart disease. The mechanism underlying the kidney damage in patients with PA may thus differ from that affecting the cardiovascular system.

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A Logistic Regression Analysis of the Ischemic Heart Disease Risk

Journal of Applied Sciences ◽

10.3923/jas.2006.785.788 ◽

2006 ◽

Vol 6 (4) ◽

pp. 785-788 ◽

Cited By ~ 7

Author(s):

Irfana P. Bhatti ◽

Heman D. Lohano . ◽

Zafar A. Pirzado . ◽

Imran A. Jafri .

Keyword(s):

Logistic Regression ◽

Regression Analysis ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Logistic Regression Analysis ◽

Disease Risk ◽

Ischemic Heart ◽

Ischemic Heart Disease Risk ◽

Heart Disease Risk

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The Blood Cytokine Profile of Young People with Early Ischemic Heart Disease Comorbid with Abdominal Obesity

Journal of Personalized Medicine ◽

10.3390/jpm10030087 ◽

2020 ◽

Vol 10 (3) ◽

pp. 87

Author(s):

Yulia I. Ragino ◽

Veronika I. Oblaukhova ◽

Yana V. Polonskaya ◽

Natalya A. Kuzminykh ◽

Liliya V. Shcherbakova ◽

...

Keyword(s):

Regression Analysis ◽

Heart Disease ◽

Relative Risk ◽

Ischemic Heart Disease ◽

Abdominal Obesity ◽

Ischemic Heart ◽

Flt3 Ligand ◽

Blood Concentrations ◽

Gm Csf ◽

Elisa Testing

Objective: The aim was to study the blood cytokine/chemokine profile of 25–44-year-old people with early ischemic heart disease (IHD) comorbid with abdominal obesity (AO). Methods: A cross-sectional medical examination of subjects in Novosibirsk, Russia, was conducted after random sampling of the above age group. A total of 1457 subjects, 804 females and 653 males, were analyzed. The epidemiological diagnosis of IHD was made in accordance with 17 validated and functional criteria, employing exercise ECG for confirmation. Simultaneous quantitative analyses of 41 cytokines/chemokines in blood serum were performed by a multiplex assay using the HCYTMAG-60K-PX41 panel (MILLIPLEX MAP) on a Luminex 20 MAGPIX flow cytometer, with additional ELISA testing. Results: Flt3 ligand, GM-CSF, and MCP-1 were significantly associated with the relative risk of early IHD. In the presence of AO, GM-CSF, MCP-1 and IL-4 also significantly correlated with the relative risk of early IHD. By univariate regression analysis, the relative risk of early IHD was associated with lowered blood concentrations of Flt3 ligand, whereas the relative risk of early IHD in the presence of AO was associated with lowered blood concentrations of GM-CSF. Employing multivariable regression analysis, only lower blood levels of Flt3 ligand were associated with a relative risk of early IHD, whereas the relative risk of early IHD in the presence of AO was limited to lower levels of IL-4. Conclusion: Findings related to Flt3 ligand, GM-CSF, and IL-4 are consistent with the international literature. Results from the present study are partly confirmative and partly hypothesis generating.

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Investigation of Epidemiological Characteristics of Patients over Age 65 with Covid-19 ın a City

European Journal of Public Health ◽

10.1093/eurpub/ckab165.182 ◽

2021 ◽

Vol 31 (Supplement_3) ◽

Author(s):

A Gokce ◽

A Ozer ◽

V Soyiler ◽

ME Gundogdu

Keyword(s):

Regression Analysis ◽

Heart Disease ◽

Chronic Disease ◽

Mortality Rate ◽

Ischemic Heart Disease ◽

Chronic Diseases ◽

Hospital Setting ◽

Mortality Rates ◽

Ischemic Heart ◽

Epidemiological Characteristics

Abstract Background The population aged ≥65 is important because of the higher mortality rate and a riskier clinical course of COVID-19 in this patient group. This study aimed to examine the epidemiological characteristics, clinical conditions and factors affecting the clinical status of patients over 65 with COVID-19 in the Bingol province. Methods Study was conducted between March and December 2020 in the Bingol province using the data of 3,521 patients over age 65 who were positive for SARS-CoV-2 as per RT-PCR results. The study commenced after obtaining necessary institutional permissions and the ethics committee approval. In the study, independent variables were age, gender, presence of chronic diseases whereas dependent variables were mortality status, presence of pneumonia. Chi-square test and binominal logistic regression analysis were used for statistical analysis. In all evaluations, p < 0.05 was considered significant. Results The median age of the patients participating in the study was 72(65-102) and the case fatality rate was 2%. The mortality rates were significantly higher in patients aged between 75-84 and those aged >85 as well as patients who had a chronic disease, diabetes and ischemic heart disease compared to the other groups (p < 0.05). According to the regression analysis, mortality rate was 2.6-fold higher in males than in females and 24.3-fold higher in patients with pneumonia than in those without pneumonia (p < 0.05). Conclusions Among the patients in the study group, mortality rate was found to be higher in males, those in the advanced age group and those with pneumonia and chronic diseases. Therefore, if possible, patients with these characteristics should be followed more closely in a hospital setting during the pandemic. Key messages Mortality rates are higher in patients with COVID-19 who have a chronic disease, diabetes or ischemic heart disease. Age, gender and presence of pneumonia are among the important factors in the course of COVID-19.

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Intestinal Alkaline Phosphatase Deficiency Is Associated with Ischemic Heart Disease

Disease Markers ◽

10.1155/2019/8473565 ◽

2019 ◽

Vol 2019 ◽

pp. 1-11 ◽

Cited By ~ 1

Author(s):

Jagannath Malo ◽

Md. Jahangir Alam ◽

Munjareen Shahnaz ◽

Kanakaraju Kaliannan ◽

Gopal Chandra ◽

...

Keyword(s):

Alkaline Phosphatase ◽

Regression Analysis ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Strong Association ◽

Multiple Logistic Regression Analysis ◽

Ischemic Heart ◽

Intestinal Alkaline Phosphatase ◽

The Metabolic Syndrome ◽

High Level

Background. We have previously shown that the deficiency of the gut enzyme intestinal alkaline phosphatase (IAP) is associated with type 2 diabetes mellitus (T2DM) in humans, and mice deficient in IAP develop the metabolic syndrome, a precipitant of T2DM and ischemic heart disease (IHD). We hypothesized that IAP deficiency might also be associated with IHD in humans. We aimed to determine the correlation between the IAP level and IHD in humans. Methods and Results. The IHD patients were recruited from the National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh, and the control healthy participants were recruited from a suburban community of Dhaka. We determined the IAP level in the stools of 292 IHD patients (187 males, 105 females) and 331 healthy control people (84 males, 247 females). We found that compared to controls, IHD patients have approx. 30% less IAP (mean±SEM: 63.7±3.5 vs. 44.9±2.1 U/g stool, respectively; p<0.000001), which indicates that IAP deficiency is associated with IHD, and a high level of IAP is probably protective against IHD in humans. The adjusted generalized linear model (GLM) of regression analysis predicted a strong association of IAP with IHD (p=0.0035). Multiple logistic regression analysis showed an independent inverse relationship between the IAP level and the IHD status (odds ratio, OR=0.993 with 95% CI 0.987-0.998; p<0.01). Conclusions. IAP deficiency is associated with IHD, and a high level of IAP might be protective against IHD.

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Could Cardiovascular Health Metrics Account for Age and Sex Disparities in Self-Reported Ischemic Heart Disease Prevalence?

Journal of Clinical Medicine ◽

10.3390/jcm7100369 ◽

2018 ◽

Vol 7 (10) ◽

pp. 369

Author(s):

Yang Peng ◽

Zhiqiang Wang

Keyword(s):

Regression Analysis ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Cardiovascular Health ◽

Age Groups ◽

Heart Association ◽

Core Sample ◽

Ischemic Heart ◽

Age Variations ◽

Age Disparities

The American Heart Association has outlined seven modifiable cardiovascular health (CVH) metrics. However, the sex and age disparities in the association between those CVH metrics and ischemic heart disease (IHD) prevalence are unclear. Our study sought to examine the possible sex and age variations in the association between CVH metrics and IHD prevalence using an Australian nationally representative survey. We used the core sample of the 2011–2012 Australian Health Survey, and 7499 adults with fasting plasma glucose (FPG) and total cholesterol values were included. We used Poisson regression analysis to measure the associations between individual metrics and IHD prevalence. Our study used both stratification and interaction analyses to compare the magnitude of associations between sex and age groups. Then, we calculated the population attributable fractions to measure the contribution of each metric to IHD prevalence. In addition, we applied logistic regression analysis to examine the influences of ideal CVH metrics number on IHD prevalence and used stratification and interaction analyses. Body mass index, physical activity, blood pressure, and FPG have greater effects on IHD prevalence in young adults compared to older adults. We failed to detect the sex variations in CVH metrics and IHD prevalence. The ideal CVH metrics number was inversely correlated to IHD prevalence and it has similar effects in four subgroups. These CVH metrics do not explain the sex and age disparities in IHD prevalence and the topic need further explorations.

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