CHANGES IN BLOOD PROTEOME OF COSMONAUTS WITH MICRO- AND MACROVASCULAR INJURIES DUE TO G-LOADS AT THE FINAL STAGE OF LONG-DURATION SPACE MISSIONS

2020 ◽  
Vol 54 (5) ◽  
pp. 5-14
Author(s):  
L.Kh. Pastushkova ◽  
◽  
K.S. Kireev ◽  
I.M. Larina ◽  
◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Soft Tissues ◽  
Blood Rheology ◽  
Landing Site ◽  
Space Missions ◽  
Vascular Injuries ◽  
New Approach ◽  
Long Duration ◽  
Integrated Response

The integrated response of the human proteome to re-entry g-loads following long-term space missions was studied in 13 male cosmonauts at the age of 44 ± 6 years. Examination at the landing site discovered local petechial hemorrhages into soft tissues of the back and lower legs. The paper presents a new approach to evaluation of petechia and soft tissue hemorrhages in cosmonauts on return to Earth. Proteomic analysis was performed with the use of LC-MS. Bioinformation analysis was made using Perseus, PubMed, Uniprot and ANDSystem software. Nine out of 19 significantly different (p < 0.05) proteins were related to vascular injuries directly. We described proteins with a primarily protecting effect against endothelial cells apoptosis and augmentation of vascular permeability, proteins that are responsible for blood rheology and proteins antagonistic to the main triggers of ischeamia-reperfusion injuries of the lungs, liver and other parenchymal organs.

scholarly journals Short-term variations in Be stars observed by the CoRoT and Kepler space missions

2010 ◽  
Vol 6 (S272) ◽  
pp. 451-456 ◽  
Author(s):  
Juan Gutiérrez-Soto ◽  
Coralie Neiner ◽  
Juan Fabregat ◽  
Antonino Francesco Lanza ◽  
Thierry Semaan ◽  
...  
Keyword(s):  
Active Regions ◽  
Space Missions ◽  
Be Stars ◽  
Short Term ◽  
Long Duration ◽  
Term Variation ◽  
Be Star ◽  
Preliminary Study ◽  
Very High

AbstractThe corot and kepler space missions are collecting very high-precision long-duration photometric data of many Be stars, allowing us to better understand the origin of their short-term variability and the link between these variations and the Be phenomenon. In this paper, we present a brief summary of the results obtained in the analysis of several Be stars observed with corot in terms of pulsations. In addition, we show that variations of the Be star HD 175869 can be explained as two active regions separated by 150 degrees or as unstable pulsating modes in a star with an extensive mixing in radiative layers corresponding to a core overshooting of 0.35Hp. A preliminary study of the photometric and spectroscopic variability seen in the B1.5IVe star HD 51193 is performed. Currently the kepler satellite is observing the only confirmed Be star in its field of view, namely KIC 6954726. From low-resolution spectra we derived a spectral type of B2.5Ve for this star and we studied the long-term variation of the emission in the Hα line. The 3.5-year kepler light curve will allow us to detect even more close frequencies than with corot and to perform a detailed analysis of the amplitude variations in a Be star.

The Nutriss Study: A New Approach to Calibrate Diet and Exercise in Long-Term Space Missions to Maintain Body Fat, Muscle and Fluid Homeostasis

2020 ◽  
Vol 99 (2) ◽  
pp. 121-125
Author(s):  
F. G. Di Girolamo ◽  
G. Biolo ◽  
N. Fiotti ◽  
R. Situlin ◽  
C. Piacenza ◽  
...  
Keyword(s):  
Body Fat ◽  
Space Missions ◽  
New Approach ◽  
Fluid Homeostasis ◽  
Diet And Exercise

THE NUTRISS STUDY: A NEW APPROACH TO CALIBRATE DIET AND EXERCISE IN LONG-TERM SPACE MISSIONS

Nutrition ◽  
2021 ◽  
Vol 87-88 ◽  
pp. 111320
Author(s):  
F.G. Di Girolamo ◽  
R. Situlin ◽  
N. Fiotti ◽  
G. Valentini ◽  
E. Carrubba ◽  
...  
Keyword(s):  
Space Missions ◽  
New Approach ◽  
Diet And Exercise

Reduction of major amputations in the diabetic ischaemic foot: A strategy to "take control" with conservative care as well as revascularisation

VASA ◽  
2001 ◽  
Vol 30 (Supplement 58) ◽  
pp. 6-14 ◽  
Author(s):  
Edmonds ◽  
Foster
Keyword(s):  
Natural History ◽  
Treatment Plan ◽  
Staging System ◽  
Vascular Control ◽  
New Approach ◽  
Conservative Care ◽  
Arterial Bypass ◽  
Therapeutic Footwear ◽  
Frequent Problem

The diabetic ischaemic foot has become an increasingly frequent problem over the last decade. However, we report a new approach consisting of a basic classification, a simple staging system of the natural history and a treatment plan for each stage, within a multi-disciplinary framework. This approach of "taking control" consists of two parts: 1. long-term conservative care including debridement of ulcers (to obtain wound control), eradication of sepsis (micribiological control), and provision of therapeutic footwear (mechanical control), and 2. revascularisation by angioplasty and arterial bypass (vascular control). This approach has led to a 50% reduction in the rate of major amputations in patients attending with ischaemic ulceration and absent foot pulses from 1989 to 1999 (from 4.6% to 2.3% per year). Patients who underwent angioplasty increased from 6% to 13%. Arterial bypass similarly increased from 3% to 7% of cases. However, even with an increased rate of revascularisation, 80% of patients responded to conservative care alone. This,we conclude, is an essential part of the management of all patients with ischaemic feet.

Towards the Affective Cognition Approach to Human Performance in Space

2020 ◽  
Vol 91 (6) ◽  
pp. 532-534
Author(s):  
Nicola Mammarella
Keyword(s):  
Cognitive Performance ◽  
Cognitive Processing ◽  
Human Performance ◽  
Space Missions ◽  
Cognition And Emotion ◽  
Dynamic Relation ◽  
Interesting Pattern

INTRODUCTION: In recent decades, there has been investigation into the effects of microgravity and microgravity-like environments on cognition and emotion separately. Here we highlight the need of focusing on emotion-cognition interactions as a framework for explaining cognitive performance in space. In particular, by referring to the affective cognition hypothesis, the significant interplay between emotional variables and cognitive processing in space is briefly analyzed. Altogether, this approach shows an interesting pattern of data pointing to a dynamic relation that may be sensitive to microgravity. The importance of examining interactions between emotion and cognition for space performance remains fundamental (e.g., stress-related disorders) and deserves further attention. This approach is ultimately interesting considering the potential effects that microgravity may play on human performance during long-term space missions and on return to Earth.Mammarella N. Towards the affective cognition approach to human performance in space. Aerosp Med Hum Perform. 2020; 91(6):532–534.

Infections and use of antibiotics in residents of long-term care facilities in Hungary

2014 ◽  
Vol 155 (23) ◽  
pp. 911-917 ◽  
Author(s):  
Rita Szabó ◽  
Karolina Böröcz
Keyword(s):  
Urinary Tract ◽  
Long Term Care ◽  
Soft Tissues ◽  
Good Practice ◽  
Antibiotic Use ◽  
Prevalence Survey ◽  
Term Care ◽  
Care Facilities ◽  
Tract Infections

Introduction: Healthcare associated infections and antimicrobial use are common among residents of long-term care facilities. Faced to the lack of standardized data, the European Centre for Disease Prevention and Control funded a project with the aim of estimating prevalence of infections and antibiotic use in European long-term care facilities. Aim: The aim of the authors was to present the results of the European survey which were obtained in Hungary. Method: In Hungary, 91 long-term care facilities with 11,823 residents participated in the point-prevalence survey in May, 2013. Results: The prevalence of infections was 2.1%. Skin and soft tissues infections were the most frequent (36%), followed by infections of the respiratory (30%) and urinary tract (21%). Antimicrobials were mostly prescribed for urinary tract infections (40.3%), respiratory tract infections (38.4%) and skin and soft tissue infections (13.2%). The most common antimicrobials (97.5%) belonged to the ATC J01 class of “antibacterials for systemic use”. Conclusions: The results emphasise the need for a national guideline and education for good practice in long-term care facilities. Orv. Hetil., 2014, 155(23), 911–917.

Жизнеобеспечение экипажа пилотируемого космического объекта, проблемы управления

2019 ◽  
pp. 109-120
Author(s):  
Boris F. ZARETSKIY ◽  
Arkadiy S. GUZENBERG ◽  
Igor A. SHANGIN
Keyword(s):  
Control System ◽  
Life Support ◽  
Support Systems ◽  
Space Missions ◽  
Automated System ◽  
Deep Space ◽  
Automated Control ◽  
Life Support Systems ◽  
Long Duration ◽  
Space Life Support

Life support for first manned spaceflights was based on supplies of consumables. Crew life support systems based on supplies of water and oxygen, in spite of their simplicity, are extremely inefficient in orbital space missions and are unfeasible in deep space missions because of mass and volume constraints. Therefore, there are currently developed and are to be used on space stations the life support systems that are based on chemical and physical regeneration of water and oxygen extracted from human waste. In view of further advances in long-duration orbital stations, and the prospects of establishment of planetary outposts and deep space exploration, the problem of constructing an automated system for controlling a suite of regenerative LSS becomes urgent. The complexity of solving the problem of constructing an efficient control system in this case owes to the existence of a large number of effectiveness criteria. The paper proposes a system of consolidated global efficiency criteria, which allows to break up this problem into a series of sub-problems of optimization in order to solve this problem. The proposed criteria are longevity, cost, comfort. The paper presents a series of specific examples of using the proposed principles with necessary generalizations. Key words: space life support systems, atmosphere revitalization equipment, automated control system, global generalized efficiency criteria, longevity, cost, comfort.

Attention To Music In The Years Of Independence: A New Approach To Scientific Research

2020 ◽  
Vol 2 (09) ◽  
pp. 395-398
Author(s):  
Sultanov A. ◽  
Tajiboev E.
Keyword(s):  
Music Education ◽  
Education System ◽  
Scientific Research ◽  
Educational Technologies ◽  
New Approach ◽  
Modern Methods

This article reveals the attention paid to music education in Uzbekistan, the new approach implemented in the education system, the development of pedagogical educational technologies and modern methods based on long-term independence.

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