SERPINs in Macrophage May Be Key Inflammation Regulator and Relevant to Poor Prognosis in Adamantinomatous Craniopharyngioma

Craniopharyngioma is one of the most prevalent sellar tumors in children. Though normally, gross resection might be reached, while the prognosis and outcome of the patient is much more worse than any other benign tumor. Inflammation in tumor is of essential in tumor growth and progression. We found that inflammation was relevant to patient outcome and macrophages in adamantinomatous craniopharyngioma were activated in an interesting pattern. We then evaluated immune microenvironment in adamantinomatous craniopharyngioma and intended to screen out potential functional molecules for therapeutic targets and predicting prognosis. The results showed that SERPINs family, especially SERPINE1 and SERPING1 were up-regulated in adamantinomatous craniopharyngioma and might be related to patient outcome in malignant tumor. At the same time, the immune environment of adamantinomatous craniopharyngioma was similar with glioma rather than other benign brain tumors. The study firstly proposes the view that ACP might share the same characteristics with malignant brain tumor, and meanwhile preliminarily demonstrates SERPINs, especially SERPINE1 might also play a critical role in ACP, just like other aggressive cancer.

Gallstone Formation Follows a Different Trajectory in Bariatric Patients Compared to Nonbariatric Patients

Since obese patients form cholesterol gallstones very rapidly after bariatric surgery, in patients who did not form gallstones during preceding years, we hypothesized that gallstone formation follows a different trajectory in bariatric patients compared to nonbariatric patients. We therefore analyzed the lipid composition of gallbladder bile derived from 18 bariatric gallstone patients and 17 nonbariatric gallstone patients (median (IQR) age, 46.0 (28.0–54.0) years; 33 (94%) female) during laparoscopic cholecystectomy using an enzymatic and lipidomics approach. We observed a higher concentration of total lipids (9.9 vs. 5.8 g/dL), bile acids (157.7 vs. 81.5 mM), cholesterol (10.6 vs. 5.4 mM), and phospholipids (30.4 vs. 21.8 mM) in bariatric gallstone patients compared to nonbariatric gallstone patients. The cholesterol saturation index did not significantly differ between the two groups. Lipidomics analysis revealed an interesting pattern. Enhanced amounts of a number of lipid species were found in the gallbladder bile of nonbariatric gallstone patients. Most striking was a fivefold higher amount of triglyceride. A concomitant ninefold increase of apolipoprotein B was found, suggesting secretion of triglyceride-rich lipoproteins (TRLs) at the canalicular pole of the hepatocyte in livers from nonbariatric gallstone patients. These findings suggest that gallstone formation follows a different trajectory in bariatric patients compared to nonbariatric patients. Impaired gallbladder emptying might explain the rapid gallstone formation after bariatric surgery, while biliary TRL secretion might contribute to gallstone formation in nonbariatric patients.

2-Variable Fubini-degenerate Apostol-type polynomials

This work deals with the mathematical inspection of a hybrid family of the degenerate polynomials of the Apostol-type. The inclusion of the derivation of few series expansion formulas, explicit representations and difference equations for this hybrid family brings a novelty to the existing literature. Moreover, certain connection formulas and several novel identities for these polynomials are established and investigated. The graphical representations of certain degenerate polynomials are explored and several new interesting pattern of the zeros are observed.

Sex and Culture Differences in Cultural Intelligence: A Study Comparing Saudi Arabians and Egyptians

Cultural Intelligence (CI) refers to the motivation and ability to understand and deal with cultural differences. As such, it is assumed to play a role in the effectiveness of social contact and communication between people from different cultures. Given its relevance to international relations, it is imperative to test which individual and group factors are associated with CI. Therefore, in the present study we examine cross-cultural and gender differences in CI. In one of their classes at their university, students ( N = 829) from Egypt and Saudi Arabia completed a multidimensional measure of CI. The results showed an interesting pattern of interactions between country and gender, which indicated that Egyptian men did not significantly differ from co-national women, but Saudi men scored significantly lower than women. We suggest that the different patterns of results in the two countries may partly arise from different levels of exposure to different cultures and partly from subtle differences in the constitution of the samples. Knowledge of individual and group differences in cultural intelligence may potentially contribute to explaining differential levels of success in individuals or countries in dealing with cultural differences.

exture Oriented Scene Generation from Natural Language Text Description using 3D Coloured Objects

To understand language, we need an understanding of the world around us. Language describes the world and provides symbols with which we represent meaning. Still, much knowledge about the world is so obvious that it is rarely explicitly stated. It is uncommon for people to state that chairs are usually on the floor and upright, and that you usually eat a cake from a plate on a table. Knowledge of such common facts provides the context within which people communicate with language. Therefore, to create practical systems that can interact with the world and communicate with people, we need to leverage such knowledge to interpret language in context. Scene generation can be used to achieve an ability to generate 3D scenes on basis of text description. A model capable of learning natural language semantics or interesting pattern to generate abstract idea behind scene composition is interesting [1].Scene generation from text involves several fields like NLP, artificial intelligence, computer vision and machine learning. This paper focuses on optimally arranging objects in a room with focus on the orientation of the objects with respect to the floor, wall and ceiling of a room along with textures. Our model suggest a novel framework which can be used as a tool to generate scene where anyone without 3D Modeling.

The Bethe-Ansatz approach to the $$ \mathcal{N} $$ = 4 superconformal index at finite rank

We investigate the Bethe-Ansatz approach to the superconformal index of $$ \mathcal{N} $$ N = 4 supersymmetric Yang-Mills with SU(N) gauge group in the context of finite rank, N. We explicitly explore the role of the various types of solutions to the Bethe-Ansatz Equations in recovering the exact index for N = 2, 3. We classify the Bethe-Ansatz Equations solutions as standard (corresponding to a freely acting orbifold T2/ℤm× ℤn) and non-standard. For N = 2, we find that the index is fully recovered by standard solutions and displays an interesting pattern of cancellations. However, for N ≥ 3, the standard solutions alone do not suffice to reconstruct the index. We present quantitative arguments in various regimes of fugacities that highlight the challenging role played by the continuous families of non-standard solutions.

METEOROLOGICAL GNSS APPLICATION FOR HEAVY RAIN ON DECEMBER 31, 2019 IN THE JAKARTA AND SURROUNDING AREAS

This study aims to utilize GNSS for meteorology in Indonesia. With the "goGPS" software, the zenith troposphere delay (ZTD) value is estimated. Calculations in rainy conditions, the ZTD value is converted into a water vapor value (PWV). The research area for the phenomenon of heavy rain occurred at the end of 2019 in Jakarta and its surroundings, which caused flooding on January 1, 2020. According to the Geophysical Meteorology and Climatology Agency (BMKG), the flood's primary cause was high rainfall. Meanwhile, the rainfall at Taman Mini and Jatiasih stations was 335 mm/day and 260 mm/day, respectively. We get an interesting pattern of PWV values for this rain phenomenon. GNSS data processing, the PWV value at five GNSS stations around Jakarta, shows the same pattern even though the average distance between GNSS stations is ~ 30 km. The PWV value appears to increase at noon on December 30, 2019, and the peak occurs in the early hours of December 31, 2019. The PWV value suddenly decreases at noon on January 1, 2020. Next, the PWV value increases again but not as high as at the previous peak. Since January 2, 2020, the PWV value has decreased and remained almost constant until January 4, 2020. In that period, there were two events that the PWV value increased. The PWV value at the first peak is ~ 70 mm, and at the second peak ~ 65 mm. The most significant increase in PWV value was recorded at CJKT stations.

Instagram and intermodal configurations of value

This paper explores how ideological positions associated with food are construed multimodally in Instagram posts produced by everyday social media users. Discourse about food choices is an important site for revealing syndromes of values that characterise the ideological positions that are embedded in everyday life. An example of a highly valued food is the avocado which is an important bonding icon in semantic domains from veganism, clean eating, keto/low-carb eating, ethical/sustainable eating to fitness. We explore how values associated with avocado toast are enacted intermodally through the interplay of meanings made in the images, captions, and tags in a corpus of 64,585 Instagram posts tagged #avotoast. The study draws on previous social semiotic work on visual intersubjectivity and everyday aesthetics in social photography (Zhao and Zappavigna 2018a) to interpret the visual meanings made in these posts. It also draws on research into intermodal coupling (image-text relations) and ambient affiliation (online social bonding) (Zappavigna 2018) to understand how different values are construed in these texts. A modified grounded theory approach is used to isolate and exemplify the visual and textual features at stake, and then to explore ideological positionings through close multimodal analysis. A particularly interesting pattern in the corpus is the interaction of aesthetic and moralising discourses. For instance, a regulative metadiscourse realised through hashtags is used to project an instructional discourse about how to eat and what is considered ethical, sustainable, and nutritious food consumption. Rather than being directly encoded as judgement of behaviour these assessments tended to be expressed as appreciation of food items and their aesthetics or worth (e.g., clean, healthy, etc.).

COVID-19 Stay-at-home Orders Result in a Decrease in the Number of Missing Daily Precipitation Observations

The number of missing daily climate data observations reported by U.S. stations in the Global Historical Climate Network (GHCN) is assessed since mid-March 2020 when most states implemented lock-down requirements in response to the COVID-19 pandemic. Compared to the same period March15-April 30 in previous years, an interesting pattern of missing data emerges. For stations in the citizen-science Community Collaborative Rain, Hail and Snow Network (CoCoRaHS) the percentage of missing data declined by approximately 5%, with the largest declines typically in states most affected by the pandemic. Conversely, at NWS Observer Network stations, missing data observations did not show a systematic increase or decrease. Presumably the as a result of stay-at-home orders CoCoRaHS observers were away from home less frequently and thus were able to maintain a series of uninterrupted observations. At CoCoRaHs stations, a reduction in the number of missing weekend observations was noted during the stay-at-home period.