scholarly journals Low Total Lymphocyte Count as the Risk of Hospital Acquired Malnutrition in Children

2021 ◽  
Vol 5 (2) ◽  
pp. 68
Author(s):  
Dian Sulistya Ekaputri ◽  
I Gusti Lanang Sidiartha ◽  
I Gusti Ayu Eka Pratiwi
Keyword(s):  
Multivariate Analysis ◽  
Lymphocyte Count ◽  
Prognostic Value ◽  
Nutritional Therapy ◽  
Total Lymphocyte Count ◽  
Exclusion Criteria ◽  
Hospital Malnutrition ◽  
Cohort Design ◽  
Total Lymphocyte ◽  
Hospital Acquired

Background: Hospital Acquired Malnutrition (HAM) is characterized by inadequate nutritional therapy and the risk of developing malnutrition during the hospital stay. In clinical practice, there are many measurements to determine nutritional status. Total lymphocyte count (TLC) is associated with impaired function of immune system in malnutrition. The purpose of this study was to evaluate the prognostic value of TLC to the occurrence of HAM in pediatric patients.Materials and Methods: This an observational study with a prospective cohort design. Subjects were assessed for weight at the first day of hospitalization, then the subjects were followed until they were discharged. Body weight was re-measured on discharge to determine the presence or absence of HAM. This research was conducted at Sanglah Hospital from May-December 2019. Subjects who met the inclusion and exclusion criteria were enrolled in the study.Results: Among 120 subjects, 55 subjects or 45.8% were malnourished on admission. Subjects with a low TLC compared to a normal TLC had a 3.9-fold risk of experiencing hospital acquired malnutrition (95% Confidence Interval: 1.59 to 7.19, p=0.001). Subjects who had a low TLC had HAM of 61.8%, while subjects who had a normal TLC had HAM of 32.3%. In multivariate analysis, low TLC was the only risk factor for HAM in this research.Conclusion: This study proved that low TLC is the risk of HAM. Total lymphocyte count could be used as predictor of the risk of HAM in hospitalization children.Keywords: hospital malnutrition, total lymphocyte, children

scholarly journals Prognostic value of total lymphocyte count in cardiac surgery

2015 ◽  
Vol 17 (2) ◽  
pp. 41
Author(s):  
V. V. Lomivorotov ◽  
S. M. Yefremov ◽  
V. A. Boboshko ◽  
V. A. Shmyrev
Keyword(s):  
Intensive Care Unit ◽  
Cardiac Surgery ◽  
Intensive Care ◽  
Postoperative Complications ◽  
Hospital Stay ◽  
Peripheral Blood ◽  
Lymphocyte Count ◽  
Prognostic Value ◽  
Total Lymphocyte Count ◽  
Total Lymphocyte

The aim of this study retrospective cohort was to investigate the prognostic value of preoperative total lymphocyte count in peripheral blood as a predictor of postoperative complications and mortality in cardiac surgery. All adults undergoing cardiopulmonary bypass in 2009. The cohort size was 1 368 patients. Patient characteristics, hospital mortality, postoperative complications, ventilation period, intensive care unit and hospital stay were analysed. Preoperative total lymphocyte count <1 611 cells/L was assotiated with significantly higher mortality by univariate (p<0,0001) and multivariate (p<0,022) analisys. Low preoperative total lymphocyte count was associated with more frequent inotropic support (p<0,001); postoperative heart arrhythmia (p<0,001); hemodialysis-dependent acute renal failure (p<0,001); and a prolonged ventilation period (p=0,001), intensive care unit stay (p<0,001), and hospital stay (p=0,007). Low preoperative total lymphocyte count in peripheral blood is a useful prognostic criterion for evaluation of a complicated postoperative period in cardiosurgical patients.

scholarly journals Medical Nutrition Therapy in Ascendens Colon Perforation Due to Intestinal Tuberculosis With Severe Malnutrition: A Case Report

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 864-864
Author(s):  
Emy Pramita Utami ◽  
Nurpudji Astuti Taslim ◽  
Mardiana Madjid ◽  
Nurbaya Syam ◽  
Devintha Virani
Keyword(s):  
Lymphocyte Count ◽  
Intestinal Tuberculosis ◽  
Nutritional Therapy ◽  
Nutrition Therapy ◽  
Total Lymphocyte Count ◽  
Severe Malnutrition ◽  
Medical Nutrition Therapy ◽  
Total Lymphocyte ◽  
Operative Complications ◽  
Medical Nutrition

Abstract Objectives Intestinal tuberculosis (TB) cases increased with the increase in TB cases in general. Intestinal TB was found in 11% of extrapulmonary TB patients. Severe malnutrition was associated with poor outcome in TB patients. Due to inflammation process, TB patients were in hypermetabolic conditions which caused increase in nutritional requirements. Intestinal TB with severe malnutrition need spesific nutritional therapy, tailored to each patient based on their nutritional status and clinical condition. Methods A 41-year old male patient with severe malnutrition (body mass index 17,9 kg/m2) diagnosed with post laparotomy due to perforation of ascending colon due to Intestinal TB. Oral intake decreased due to loss of appetite and abdominal pain. Patient showed pale in conjunctival, loss of subcutaneous fat, wasting and edema in extremities. Laboratory findings were anemia (7.5 g/dL), hypoalbuminemia (2.4 g/dL), hyponatremia (130 mmol/L), hypokalemia (3.0 mmol/L) and severe depletion of total lymphocyte count (477/mL). Patient suffered from post-operative complications in the form of post-operative ileus, low output enterocutaneous fistula and suspected an anastomoses leakage. Results Medical nutrition therapy was given with a total calorie of 1175 kcal and increased gradually to 2000 kcal, protein 0.8–2 g/Ideal Body Weight/day using high protein formula and amino acids parenteral nutrition, including glutamine infussion. We administered suplementations which were zinc, multivitamins, curcuma and snakehead fish extract. Patient was discharged after 37 days with clinical and functional capacity improvement assessed with handgrip dynamometer from 11.2 to 23.4 kg. Laboratory improvement were Hemoglobin 10.1 g/dL, Albumin 2.8 mg/dL, Sodium 143 mmol/L, Potassium 4.2 mmol/L and Total lymphocyte count 904/mL. Post-operative complications were improved. Conclusions Malnourished patient with intestinal TB who undergoing surgery had an increased risk of nutritional deficiencies and postoperative complications. Specific nutritional therapy to reduce inflammation or hypermetabolic, and to treat post surgical complications, proper monitoring and nutritional education results in a good outcome for patient. Funding Sources The author(s) received no financial support for the research, autorship and/or publication of this article.

Are albumin and total lymphocyte count significant and reliable predictors of mortality in fractured neck of femur patients?

2013 ◽  
Vol 24 (7) ◽  
pp. 1193-1196 ◽  
Author(s):  
Vishwajeet Kumar ◽  
Avinash Alva ◽  
Sudheer Akkena ◽  
Morgan Jones ◽  
Philip N. Murphy ◽  
...  
Keyword(s):  
Lymphocyte Count ◽  
Total Lymphocyte Count ◽  
Fractured Neck Of Femur ◽  
Neck Of Femur ◽  
Predictors Of Mortality ◽  
Total Lymphocyte

Correlation between total and CD4 lymphocyte counts in HIV infection: not making the good an enemy of the not so perfect

1996 ◽  
Vol 7 (6) ◽  
pp. 422-428 ◽  
Author(s):  
E J Beck ◽  
E J Kupek ◽  
M M Gompels ◽  
A J Pinching
Keyword(s):  
T Cell ◽  
Hiv Infection ◽  
Lymphocyte Count ◽  
Cell Subset ◽  
Total Lymphocyte Count ◽  
Aids Patients ◽  
T Cell Subset ◽  
Total Lymphocyte ◽  
Asymptomatic Patients ◽  
Cd4 Lymphocyte

The aim of this study was to assess the correlation and average cost of total lymphocyte count compared with CD4 count as a broad estimate of immunosuppression in HIV-1 infected individuals. Spearman's partial rank correlation were calculated between total lymphocyte count, absolute CD4 count and CD4 per cent stratified by stage of HIV-1 infection for routinely collected samples. Data were collected prospectively from a T cell-subset register combined with clinical data obtained retrospectively from case notes of HIV-infected patients managed at St Mary's Hospital, London 1982-1991. Costing data were obtained through a survey of the departments of haematology and immunology 1989 90 prices . The correlation between 1534 paired absolute lymphocyte count and CD4 lymphocyte count was found to be high R 0.76 . When analysed by stage of HIV infection, the correlation increased from R 0.64 for asymptomatic patients, to R 0.72 for patients with symptomatic non-AIDS HIV infection and R 0.73 for AIDS patients. Correlations between absolute lymphocyte count and CD4 per cent were considerably weaker: R 0.41 all paired counts; R 0.32 for asymptomatic patients; R 0.25 for symptomatic non-AIDS patients; R 0.32 for AIDS patients. Average cost was 8 per full blood count compared with 38 per T-cell subset analysis. The high correlation between total and CD4 lymphocyte counts, especially for patients with symptomatic HIV disease, demonstrates the suitability of the use of total lymphocyte count in the absence of CD4 counts. Given the considerably lower prices of total lymphocyte counts compared with T-cell subset analysis, this is particularly relevant for developing countries.

Serum albumin and total lymphocyte count as predictors of outcome in hip fractures

2010 ◽  
Vol 29 (1) ◽  
pp. 89-93 ◽  
Author(s):  
Brendan J. O'Daly ◽  
James C. Walsh ◽  
John F. Quinlan ◽  
Gavin A. Falk ◽  
Robert Stapleton ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Hip Fractures ◽  
Lymphocyte Count ◽  
Total Lymphocyte Count ◽  
Predictors Of Outcome ◽  
Total Lymphocyte

scholarly journals Perbandingan Efek Pemberian Emulsi Kedelai dan Emulsi Tempe Terhadap Hitung Limfosit Total pada Tikus Putih yang Telah Diberi Prednison

2017 ◽  
Vol 5 (1) ◽  
pp. 56
Author(s):  
Rizka Bekti Nurcahyani ◽  
Imelda T Pardede ◽  
Huriatul Masdar
Keyword(s):  
Lymphocyte Count ◽  
Total Lymphocyte Count ◽  
Distilled Water ◽  
Adequate Nutrition ◽  
White Rats ◽  
Total Lymphocyte ◽  
Significant Difference ◽  
Group A ◽  
Group B

Adequate nutrition is one of important factors in immunodeficiency repairment. Soybean and tempeh contains proteins,zinc, ferrum, vitamins and isoflavon. Fermentation in tempeh makes it having better nutrients digestion and absorptionthan soybean. The objective of this study was to compare the effects of soy and tempeh emulsions on total lymphocytecount in rats treated with prednisone. The test was done on 24 male white rats divided into four groups. Group A wasgiven distilled water and group B, C and D had prednisone 2.5 mg/day for 6 days. After that, group A and B werecontinued having distilled water while groups C or D was fed with soy or tempeh emulsion 0.71 mL/day for 10 days,respectively. The results shown that soy and tempeh emulsion could increase total lymphocyte count significantly (p <0,05) but there was no significant difference of total lymphocyte count between soy and tempeh emulsion groups (p >0,05).

scholarly journals Low serum albumin and total lymphocyte count as predictors of 30 day hospital readmission in patients 65 years of age or older

2015 ◽  
Author(s):  
Robert Robinson
Keyword(s):  
Risk Factor ◽  
Serum Albumin ◽  
Hospital Readmission ◽  
Lymphocyte Count ◽  
Protein Energy Malnutrition ◽  
Total Lymphocyte Count ◽  
Total Lymphocyte ◽  
Protein Energy ◽  
Patients At Risk ◽  
Low Serum

Introduction: Hospital readmission within 30 days of discharge is a target for health care cost savings through the medicare Value Based Purchasing initiative. Because of this focus, hospitals and health systems are investing considerable resources into the identification of patients at risk of hospital readmission and designing interventions to reduce the rate of hospital readmission. Malnutrition is a known risk factor for hospital readmission. Materials and Methods: All medical patients 65 years of age or older discharged from Memorial Medical Center from January 1, 2012 to March 31, 2012 who had a determination of serum albumin level and total lymphocyte count on hospital admission were studied retrospectively. Admission serum albumin levels and total lymphocyte counts were used to classify the nutritional status of all patients in the study. Patients with a serum albumin less than 3.5 grams/dL and/or a TLC less than 1,500 cells per mm3 were classified as having protein energy malnutrition. The primary outcome investigated in this study was hospital readmission for any reason within 30 days of discharge. Results: The study population included 1,683 hospital discharges with an average age of 79 years. The majority of the patients were female (55.9%) and had a DRG weight of 1.22 (0.68). 219 patients (13%) were readmitted within 30 days of hospital discharge. Protein energy malnutrition was common in this population. Low albumin was found in 973 (58%) patients and a low TLC was found in 1,152 (68%) patients. Low albumin and low TLC was found in 709 (42%) of patients. Kaplan-Meier analysis shows any laboratory evidence of PEM is a significant (p < 0.001) predictor of hospital readmission. Low serum albumin (p < 0.001) and TLC (p = 0.018) show similar trends. Cox proportional-hazards regression analysis showed low serum albumin (Hazard Ratio 3.27, 95% CI: 2.30-4.63) and higher DRG weight (Hazard Ratio 1.19, 95% CI: 1.03-1.38) to be significant independent predictors of hospital readmission within 30 days. Discussion: This study investigated the relationship of PEM to the rate of hospital readmission within 30 days of discharge in patients 65 years of age or older. These results indicate that laboratory markers of PEM can identify patients at risk of hospital readmission within 30 days of discharge. This risk determination is simple and identifies a potentially modifiable risk factor for readmission: protein energy malnutrition.

scholarly journals Utility of total lymphocyte count as a surrogate marker for CD4 counts in HIV-1 infected children in Kenya

2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Nyawira Githinji ◽  
Elizabeth Maleche-Obimbo ◽  
Moses Nderitu ◽  
Dalton C Wamalwa ◽  
Dorothy Mbori-Ngacha
Keyword(s):  
Lymphocyte Count ◽  
Surrogate Marker ◽  
Total Lymphocyte Count ◽  
Cd4 Counts ◽  
Total Lymphocyte ◽  
Hiv 1
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