Inhibition of Tumor Cell Invasiveness by Chemically Modified Tetracyclines

2001 ◽  
Vol 8 (3) ◽  
pp. 261-270 ◽  
Author(s):  
Y. Gu ◽  
M. Lee ◽  
J. Roemer ◽  
L. Musacchia ◽  
M. Golub ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Chemically Modified ◽  
Cell Invasiveness ◽  
Chemically Modified Tetracyclines

scholarly journals Regulation of CD44 Alternative Splicing by SRm160 and Its Potential Role in Tumor Cell Invasion

2006 ◽  
Vol 26 (1) ◽  
pp. 362-370 ◽  
Author(s):  
Chonghui Cheng ◽  
Phillip A. Sharp
Keyword(s):  
Alternative Splicing ◽  
Tumor Cell ◽  
Cell Invasion ◽  
Rna Splicing ◽  
Tumor Cell Invasion ◽  
Dependent Manner ◽  
Cd44 Isoforms ◽  
Transmembrane Glycoprotein ◽  
Cell Invasiveness ◽  
Interfering Rna

ABSTRACT The multiple isoforms of the transmembrane glycoprotein CD44 are produced by alternative RNA splicing. Expression of CD44 isoforms containing variable 5 exon (v5) correlates with enhanced malignancy and invasiveness of some tumors. Here we demonstrate that SRm160, a splicing coactivator, regulates CD44 alternative splicing in a Ras-dependent manner. Overexpression of SRm160 stimulates inclusion of CD44 v5 when Ras is activated. Conversely, small interfering RNA (siRNA)-mediated silencing of SRm160 significantly reduces v5 inclusion. Immunoprecipitation shows association of SRm160 with Sam68, a protein that also stimulates v5 inclusion in a Ras-dependent manner, suggesting that these two proteins interact to regulate CD44 splicing. Importantly, siRNA-mediated depletion of CD44 v5 decreases tumor cell invasion. Reduction of SRm160 by siRNA transfection downregulates the endogenous levels of CD44 isoforms, including v5, and correlates with a decrease in tumor cell invasiveness.

Bullet for periodontal disease in future: Chemically modified tetracyclines

2021 ◽  
pp. 1-7
Author(s):  
Shivani Sachdeva ◽  
Ameet Mani ◽  
Harish Saluja
Keyword(s):  
Chronic Periodontitis ◽  
Periodontal Ligament ◽  
Host Response ◽  
Alveolar Bone ◽  
Gastrointestinal Toxicity ◽  
Collagenolytic Activity ◽  
Periodontal Pathogens ◽  
Oral Biofilm ◽  
Chemically Modified ◽  
Chemically Modified Tetracyclines

Chronic periodontitis is nowadays popularly regarded as Dysbiosis, [1] which causes destruction of tissues rich in collagen like periodontal ligament, alveolar bone and gingival connective tissue. The oral biofilm comprises many periodontal pathogens better regarded as ‘triggers’ in causing chronic periodontitis. Since, not everyone will be affected in the same manner due to periodontal pathogens. Some might not elicit a host response while, the others might have exaggerated response. So, host modulation therapy came into existence to counteract the exaggerated host response. The chemically modified tetracyclines (CMTs) have emerged to inhibit the inflammatory response or to reduce the collagenolytic activity of host. Though a derivative of tetracyclines, it still lacks an antimicrobial action and hence, can be used for periodontitis for longer duration with no adverse effects of gastrointestinal toxicity which parent tetracyclines have.

Abstract 3070: Suppression of tumor cell invasiveness andin vivotumor growth by microRNA-874 in non-small cell lung cancer.

2013 ◽  
Author(s):  
Divya Kesanakurti ◽  
Dilip Maddirela ◽  
Subramanyam Chittivelu ◽  
Jasti S. Rao ◽  
Chandramu Chetty
Keyword(s):  
Lung Cancer ◽  
Tumor Cell ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Invasiveness

scholarly journals L1 cell adhesion molecules as regulators of tumor cell invasiveness

2009 ◽  
Vol 3 (3) ◽  
pp. 275-277 ◽  
Author(s):  
Priscila F. Siesser ◽  
Patricia F. Maness
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Cell Invasiveness

scholarly journals Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia

2009 ◽  
Vol 28 (1) ◽  
pp. 129 ◽  
Author(s):  
Alexandra Szalad ◽  
Mark Katakowski ◽  
Xuguang Zheng ◽  
Feng Jiang ◽  
Michael Chopp
Keyword(s):  
Transcription Factor ◽  
Tumor Cell ◽  
Transcription Factor Sp1 ◽  
Cell Invasiveness

Fisetin Inhibits Matrix Metalloproteinases and Reduces Tumor Cell Invasiveness and Endothelial Cell Tube Formation

2013 ◽  
Vol 65 (8) ◽  
pp. 1192-1199 ◽  
Author(s):  
Jun Hyoung Park ◽  
Yoon-Jung Jang ◽  
Yu Jung Choi ◽  
Jin Wook Jang ◽  
Joo-Hyon Kim ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Matrix Metalloproteinases ◽  
Tumor Cell ◽  
Tube Formation ◽  
Cell Invasiveness
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