Novel Interpenetrating Polymer Matrix Network Microparticles for Intestinal Drug Delivery

Nanocomposites are a class of materials in which one or more phases with nanoscale dimensions are embedded in a metal, ceramic, or polymer matrix. The properties of nanocomposites depend on matrix, loading, degree of dispersion, size, shape, and orientation of the nanoscale phase and interaction between the matrix and the nanoscale phase. Nanocomposites are generally prepared using direct melt intercalation. The formation of nanocomposite is ascertained by XRD pattern, FTIR spectra, electron microscopy, and thermal analysis like DSC and TGA. Nanocomposites have properties of nanoparticles, multifunctional capabilities, chemical functionalization, huge interphase zone. Novel nanomaterials offer a new chemotherapeutic route for cancer treatment by combining cell imaging and hyperthermia in a synergistic way. In spite of toxicity and safety concerns, multifunctional nanocomposite still interest the researchers because of emergence of versatile properties, better understanding of disease biomarkers, and quest for ways to improve biocompatibility.

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Comparison of the drug delivery properties of different biocompatible polymer–matrix materials with potential as intra-oral devices

Composite Interfaces ◽

10.1163/156855408786778447 ◽

2008 ◽

Vol 15 (7-9) ◽

pp. 687-696

Author(s):

Jun Li ◽

David A. Barrow ◽

Padma Tallury ◽

David Paquette ◽

Sid Kalachandra

Keyword(s):

Drug Delivery ◽

Polymer Matrix ◽

Biocompatible Polymer

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Development and Characterization of Novel Freeze-thawed Polyvinyl Alcohol/ Halloysite Hydrogels. An approach for drug delivery application

Materiale Plastice ◽

10.37358/mp.17.1.4774 ◽

2017 ◽

Vol 54 (1) ◽

pp. 8-13

Author(s):

Adi Ghebaur ◽

Sorina Alexandra Garea ◽

Sergiu Cecoltan ◽

Horia Iovu

Keyword(s):

Drug Delivery ◽

Gastrointestinal Tract ◽

Drug Release ◽

Polyvinyl Alcohol ◽

Acetylsalicylic Acid ◽

Polymer Matrix ◽

Swelling Degree ◽

Model Drug ◽

Thawing Procedure

The influence of aluminosilicates on the structure and drug release profiles of polyvinyl alcohol (PVA) - halloysite (HNT) hydrogels containing acetylsalicylic acid (ASA) as a model drug was monitored. The hydrogels were synthesized using a three cycle freeze - thawing procedure and were characterized by FTIR, XRD and SEM. The swelling degree and cytotoxicity were also determined. All hydrogels properties were influenced by HNT concentration from the polymer matrix. The release of ASA, from PVA - HNT hydrogels was monitored in the gastrointestinal tract conditions.

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Anisotropy Influences on the Drug Delivery Mechanisms by Means of Joint Invariant Functions

Computational and Mathematical Methods in Medicine ◽

10.1155/2017/5748273 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

G. Cioca ◽

E. S. Bacaita ◽

M. Agop ◽

C. Lupascu Ursulescu

Keyword(s):

Drug Delivery ◽

Polymer Matrix ◽

Invariant Functions ◽

Delivery Mechanism ◽

New Equation ◽

Joint Invariant

In the frame of Higuchi’s type functionality, this paper presents the anisotropy influences on the drug delivery mechanisms through the joint invariant functions to the simultaneous actions of the two SL(2R) isomorphic groups. Then, a new equation for drug delivery mechanism, independent of the type of polymer matrix and/or drug, is proposed.

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Spectroscopic Investigation of Chlorin-Based Photosensitizers in Polymer Matrix

International Journal of Polymer Science ◽

10.1155/2021/8842052 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Antonina Naumenko ◽

Nataliya Kutsevol

Keyword(s):

Drug Delivery ◽

Photodynamic Therapy ◽

Optical Absorption ◽

Tumor Cells ◽

Polymer Matrix ◽

Spectroscopic Investigation ◽

Chlorin E6 ◽

Optical Absorption Spectra ◽

Trimethyl Ether ◽

Derivatives Of

Chlorin e6 and its derivatives are the basis of a number of drugs used in medicine in the treatment of various diseases, including cancer, by photodynamic therapy. Nonpolar derivatives of Chlorin e6—dimethyl ether of Chlorin e6 (DME Ce6) and trimethyl ether of Chlorin e6 (TME Ce6)—are actively studied for application during photodynamic therapy. In this work, based on the electron optical absorption spectra, the interaction of photosensitizer molecules with branched star-like copolymer dextran-graft-polyacrylamide in anionic form was investigated and the possibility of using the latter as a carrier for drug delivery to tumor cells was suggested.

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