scholarly journals Anisotropy Influences on the Drug Delivery Mechanisms by Means of Joint Invariant Functions

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
G. Cioca ◽  
E. S. Bacaita ◽  
M. Agop ◽  
C. Lupascu Ursulescu
Keyword(s):  
Drug Delivery ◽  
Polymer Matrix ◽  
Invariant Functions ◽  
Delivery Mechanism ◽  
New Equation ◽  
Joint Invariant

In the frame of Higuchi’s type functionality, this paper presents the anisotropy influences on the drug delivery mechanisms through the joint invariant functions to the simultaneous actions of the two SL(2R) isomorphic groups. Then, a new equation for drug delivery mechanism, independent of the type of polymer matrix and/or drug, is proposed.

Exosomes: Structure, Biogenesis, Types and Application in Diagnosis and Gene and Drug Delivery

2020 ◽  
Vol 20 (3) ◽  
pp. 195-206 ◽  
Author(s):  
Shriya Agarwal ◽  
Vinayak Agarwal ◽  
Mugdha Agarwal ◽  
Manisha Singh
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Immune Responses ◽  
Biological Membrane ◽  
Gene Isolation ◽  
Delivery Vehicle ◽  
Scientific Communities ◽  
Therapeutic Regime ◽  
Targeted Gene Therapy ◽  
Delivery Mechanism

Abstract: In recent times, several approaches for targeted gene therapy (GT) had been studied. However, the emergence of extracellular vesicles (EVs) as a shuttle carrying genetic information between cells has gained a lot of interest in scientific communities. Owing to their higher capabilities in dealing with short sequences of nucleic acid (mRNA, miRNA), proteins, recombinant proteins, exosomes, the most popular form of EVs are viewed as reliable biological therapeutic conveyers. They have natural access through every biological membrane and can be employed for site-specific and efficient drug delivery without eliciting any immune responses hence, qualifying as an ideal delivery vehicle. Also, there are many research studies conducted in the last few decades on using exosome-mediated gene therapy into developing an effective therapy with the concept of a higher degree of precision in gene isolation, purification and delivery mechanism loading, delivery and targeting protocols. This review discusses several facets that contribute towards developing an efficient therapeutic regime for gene therapy, highlighting limitations and drawbacks associated with current GT and suggested therapeutic regimes.

Novel Interpenetrating Polymer Matrix Network Microparticles for Intestinal Drug Delivery

2014 ◽  
Vol 11 (2) ◽  
pp. 191-199 ◽  
Author(s):  
Jagadeeswara Reddy ◽  
B. Nagashubha ◽  
Mahesh Reddy ◽  
Afrasim Moin ◽  
H.G. Shivakumar
Keyword(s):  
Drug Delivery ◽  
Polymer Matrix

scholarly journals Multilayered drug delivery coatings composed of daidzein-loaded PHBV microspheres embedded in a biodegradable polymer matrix by electrophoretic deposition

2016 ◽  
Vol 4 (29) ◽  
pp. 5035-5045 ◽  
Author(s):  
Qiang Chen ◽  
Wei Li ◽  
Qingqing Yao ◽  
Ruifang Liang ◽  
Rosalina Pérez-Garcia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymer Matrix ◽  
Electrophoretic Deposition ◽  
Biodegradable Polymer ◽  
Drug Encapsulation

Drug encapsulation with predetermined loading, and the fabrication of multilayered drug delivery coatings by a combination of EPD and LbL deposition.

Imaging the Cytosolic Drug Delivery Mechanism of HDL-Like Nanoparticles

2013 ◽  
Vol 31 (6) ◽  
pp. 1438-1449 ◽  
Author(s):  
Qiaoya Lin ◽  
Juan Chen ◽  
Kenneth K. Ng ◽  
Weiguo Cao ◽  
Zhihong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Delivery Mechanism

Nanocomposites in Drug Delivery and Imaging Applications

2021 ◽  
pp. 1539-1554
Author(s):  
Dimple Sethi Chopra
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Thermal Analysis ◽  
Cancer Treatment ◽  
Polymer Matrix ◽  
Cell Imaging ◽  
Xrd Pattern ◽  
Chemical Functionalization ◽  
Disease Biomarkers ◽  
The Matrix

Nanocomposites are a class of materials in which one or more phases with nanoscale dimensions are embedded in a metal, ceramic, or polymer matrix. The properties of nanocomposites depend on matrix, loading, degree of dispersion, size, shape, and orientation of the nanoscale phase and interaction between the matrix and the nanoscale phase. Nanocomposites are generally prepared using direct melt intercalation. The formation of nanocomposite is ascertained by XRD pattern, FTIR spectra, electron microscopy, and thermal analysis like DSC and TGA. Nanocomposites have properties of nanoparticles, multifunctional capabilities, chemical functionalization, huge interphase zone. Novel nanomaterials offer a new chemotherapeutic route for cancer treatment by combining cell imaging and hyperthermia in a synergistic way. In spite of toxicity and safety concerns, multifunctional nanocomposite still interest the researchers because of emergence of versatile properties, better understanding of disease biomarkers, and quest for ways to improve biocompatibility.

scholarly journals Towards Stochasticity through Joint Invariant Functions of Two Isomorphic Lie Algebras of SL(2R) Type

Symmetry ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 226
Author(s):  
Maricel Agop ◽  
Mitică Craus
Keyword(s):  
Complex System ◽  
Fractal Theory ◽  
Invariant Function ◽  
Hydrodynamic Type ◽  
Simultaneous Action ◽  
Systems Dynamics ◽  
Invariant Functions ◽  
Scale Relativity ◽  
The One ◽  
Joint Invariant

In the motion fractal theory, the scale relativity dynamics of any complex system are described through various Schrödinger or hydrodynamic type fractal “regimes”. In the one dimensional stationary case of Schrödinger type fractal “regimes”, synchronizations of complex system entities implies a joint invariant function with the simultaneous action of two isomorphic groups of the S L ( 2 R ) type as solutions of Stoka type equations. Among these joint invariant functions, Gaussians become in the Jeans’s sense, probability density (i.e., stochasticity) whenever the information on the complex system analyzed is fragmentary. In the two-dimensional case of hydrodynamic type fractal “regimes” at a non-differentiable scale, the soliton and soliton-kink of fractal type of the velocity field generate the minimal vortex of fractal type that becomes the source of all turbulences in the complex systems dynamics. Some correlations of our model to experimental data were also achieved.

scholarly journals RECENT NANOCOCHLEATE DRUG DELIVERY SYSTEM FOR CANCER TREATMENT: A REVIEW

2019 ◽  
pp. 28-32
Author(s):  
SUJIT NAYEK ◽  
ABHIRAMI VENKATACHALAM ◽  
SANGEETA CHOUDHURY
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Divalent Cation ◽  
Technology Use ◽  
Oral Bioavailability ◽  
Anticancer Agent ◽  
Low Permeability ◽  
Delivery Mechanism ◽  
Low Solubility

Nanocochleates are at the forefront of the fast-growing nanotechnology sector in the delivery of drugs for cancer. This nanotechnology is the use of the cationic and anionic encapsulated drug that has poor oral bioavailability. Nanocochleate is a lipid-based drug delivery in the liposomal vesicles that is converted by calcium divalent cation into nanocochleate. Nanocochleates technology use encapsulations of the anticancer agent, which have low solubility, oral bioavailability and low permeability. This paper shows and provides an overview of the benefits of nanocochleates, drug delivery mechanism, choice of prevalent components (Phospholipids and Cations), various ways of producing nanocochleates and nanocochleate stability. Nanocochleates have far fewer constraints than other traditional carriers. To characterize nanocochleates, the suitable analytical methods are required. Therefore, in the therapy of cancer, nanocochleate becomes commonly applied and more prospective drug delivery system.

Lysine-Specific Demethylase 1-Selective Inactivators: Protein-Targeted Drug Delivery Mechanism

2013 ◽  
Vol 125 (33) ◽  
pp. 8782-8786 ◽  
Author(s):  
Daisuke Ogasawara ◽  
Yukihiro Itoh ◽  
Hiroki Tsumoto ◽  
Taeko Kakizawa ◽  
Koshiki Mino ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Lysine Specific Demethylase ◽  
Targeted Drug ◽  
Delivery Mechanism
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