scholarly journals Olanzapine Increases Neural Chemorepulsant—Draxin Expression in the Adult Rat Hippocampus

2021 ◽  
Vol 14 (4) ◽  
pp. 298
Author(s):  
Artur Pałasz ◽  
Aleksandra Suszka-Świtek ◽  
Jacek Francikowski ◽  
Marek Krzystanek ◽  
Katarzyna Bogus ◽  
...  
Keyword(s):  
Adult Neurogenesis ◽  
Neuronal Migration ◽  
Neurite Growth ◽  
Rat Hippocampus ◽  
The Novel ◽  
Adult Rat ◽  
Second Generation Antipsychotics ◽  
The Family ◽  
First Time

Draxin belongs to the family of inhibitory axon-guiding factors that regulate neuronal migration and axonal spreading in the developing brain. This glycoprotein has recently been considered to play an important role both in hippocampal differentiation and adult neurogenesis in the dentate gyrus. Given that it has been reported that antipsychotic drugs may affect neurite growth and neurogenesis, we have therefore investigated whether chronic treatment with olanzapine modulates draxin immunoreactivity in the adult rat hippocampus. After analysis of local fluorescence intensity, we found a significant increase of draxin immunoexpression both in the subgranular zone (SGZ) and granular zone of the rat hippocampus following long-term olanzapine administration. This study reveals, for the first time, the modulatory effect of the atypical antipsychotic medication olanzapine on expression of the novel chemorepulsive protein draxin in the context of adult neurogenesis regulation. Moreover, this is the first report dealing with pharmacological aspects of draxin signaling. An elevated draxin expression may indirectly support a recently formulated hypothesis that olanzapine may drive adult neurogenesis via paracrine draxin-related signaling. This action of draxin is a new element in the neurogenesis mechanism that may be part of the action of second-generation antipsychotics in the treatment of schizophrenia, indicating more detailed molecular studies are urgently required to fully investigate these potential novel mechanisms of neurogenesis.

Buried Narratives: Exhuming the Mother's Story in Oliver Twist

2018 ◽  
Vol 8 (3) ◽  
pp. 247-266
Author(s):  
Michelle L. Wilson
Keyword(s):  
Social Change ◽  
Maternal Inheritance ◽  
The Novel ◽  
Poor Law ◽  
The Family ◽  
The Law ◽  
First Time ◽  
Critical Consideration

Initially, Oliver Twist (1839) might seem representative of the archetypal male social plot, following an orphan and finding him a place by discovering the father and settling the boy within his inheritance. But Agnes Fleming haunts this narrative, undoing its neat, linear transmission. This reconsideration of maternal inheritance and plot in the novel occurs against the backdrop of legal and social change. I extend the critical consideration of the novel's relationship to the New Poor Law by thinking about its reflection on the bastardy clauses. And here, of course, is where the mother enters. Under the bastardy clauses, the responsibility for economic maintenance of bastard children was, for the first time, legally assigned to the mother, relieving the father of any and all obligation. Oliver Twist manages to critique the bastardy clauses for their release of the father, while simultaneously embracing the placement of the mother at the head of the family line. Both Oliver and the novel thus suggest that it is the mother's story that matters, her name through which we find our own. And by containing both plots – that of the father and the mother – Oliver Twist reveals the violence implicit in traditional modes of inheritance in the novel and under the law.

scholarly journals PLOT ELEMENTS AND MOTIVES OF THE NOVEL “CHEVENGUR” IN PLATONOV’S SHORT STORY “POTUDAN RIVER”

2021 ◽  
Vol 26 (1) ◽  
pp. 44-55
Author(s):  
N. Mikhaylovna Malygina ◽  
Keyword(s):  
Short Story ◽  
The Novel ◽  
Love Story ◽  
Planetary Scale ◽  
The Family ◽  
Analytical Review ◽  
Eugene Onegin ◽  
Intertextual Connections ◽  
First Time

The relevance of the article is determined by the researcher of the semantic poetics of Platonov’s story “Potudan River”. We carry out an analytical review of the lifetime criticism and articles of modern researchers about the story, on the basis of which we formulate the purpose of the study, due to the need for a new approach to the interpretation of the work and the identification of the principles of its poetics. The novelty of the article is determined by the identification of the multilayered symbolism of the title of the story, which allows to establish the insufficiency of the conclusions that the content of the “Potudan River” is limited to the family theme. At the level of micropoetics we reveal symbolic details that connect the content of the story with the motive of love for the distant, medical and construction subjects and revealing the planetary scale of the author’s thinking. For the first time, it was established that Platonov’s story “Potudan River” was written based on part of the plot of the novel “Chevengur” – the love story of Alexander Dvanov and Sonya Mandrova. We show that the heroes of the story “Potudan River” Nikita Firsov, Lyuba Kuznetsova and Nikita’s father are doubles of the characters in the novel “Chevengur” by Sasha Dvanov, Sonya Mandrova, and Zakhar Pavlovich. The connection of the image of Lyuba with the archetype of the bride is considered. The paper reveals for the first time the intertextual connections of the story “Potudan River” with the poem “The Bronze Horseman” and the novel in verse “Eugene Onegin” by A. Pushkin, in the texts of which the writer found material for modeling the ordinary fate of the hero. Multi-level connections of the content of the story “Potudan River” with Platonov’s artistic world, which is a complete metatext, are found, which opens up new opportunities for determining the role of the editing technique and the principles of returning to the plots and motives of the works of the 1920s, as well as their transformation in the writer’s work of the 1930s.

scholarly journals Ectoparasites of the bats from karst caves of the nature reserve «Ichalkovsky Bor» (Nizhny Novgorod Region)

2018 ◽  
Vol 7 (4) ◽  
pp. 122-126
Author(s):  
Galina Anatolievna Fadeeva ◽  
Elena Evgenievna Boryakova
Keyword(s):  
Natural Habitats ◽  
Karst Caves ◽  
Central Russia ◽  
The Family ◽  
Volga Upland ◽  
The Stability ◽  
The One ◽  
Parasitic Mites ◽  
First Time

The fauna of parasitic mites of bats from the karst caves in the region of the Volga Upland was studied in 2004-2005. Six species of bats such as Daubentons water bat, Brandts bat, whiskered bat, pond bat, northern bat and long-eared bat were examined. 18 species of arthropods were detected, among them there are gamasid mites (10 species) and harvest mites (2 species). Leptotrombidium russicum (Oud., 1902) and Myotrombicula sp. were found for the first time in Central Russia. Spinturnix acuminatus (Koch, 1836), Steatonyssus spinosus (Willmann, 1936), Steatonyssus periblepharus (Kolenati, 1858), Macronyssus flavus (Kolenati, 1856) turned out to be the main group of parasites in this study. As for the insects flies of the family Nycteribiidae and fleas of the family Ischnopsyllidae were found. The cluster analysis of ectoparasite fauna has showed that they are more or less evenly distributed among all members of mixed colonies of bats, while there is no violation of specificity in the choice of hosts. Low values of the Berger-Parker index marked a lack of competition between species, which indicates the stability of parasitic communities formed on bats in mixed colonies and in natural habitats. This fact indicates a complex relationship between the parasites in the community on the one hand, and long-term existence of the community on the other hand. This, in its turn, shows that in long-evolving communities competitive relationships between parasites are obliterated, which gives them stability. Herewith the bat colony is used as an integral whole, although some parasitic species prefer certain types of hosts.

scholarly journals Present state of knowledge on the family Begoniaceae CA Agardh (Magnoliopsida) of Bangladesh

2018 ◽  
Vol 4 (1) ◽  
pp. 35-46
Author(s):  
PK Deb ◽  
MA Rahman
Keyword(s):  
Species Diversity ◽  
New Records ◽  
Herbarium Specimens ◽  
Field Investigations ◽  
The Family ◽  
First Time ◽  
Generic Family ◽  
Term Field

The inventory and assessment of species diversity in the mono-generic family Begoniaceae C. A. Agardh of Bangladesh were made through long term field investigations, collections, identification, survey and examination of preserved herbarium specimens and review of relevant taxonomic and floristic literature. The family is recognized to be represented in the flora of Bangladesh by 19 species under the genus Begonia L. Of these, 11 species were known to be previously recorded from the area of Bangladesh, hence additional 8 species of the present account are being reported here for the first time as new records from Bangladesh, these are: Begonia grandis Dryand. ssp. holostylla Irmsch. , B. heracleifolia Cham. and Schltdl. Cult., B. maculata Raddi Cult. B. modestiflora Kurz, B. muliensis T. T. Yu. Cult., B. scintillans Dunn, B. surculigera Kurz and B. thomsonii A. DC. An enumeration of these 19 species is prepared, and each species is cited with detailed taxonomic data. All species of the Begonia L. are herbaceous in nature and possess potential economic values, viz. 11 (52%) medicinal, 5 (24%) ornamental, 3 (14%) beverage, 1 (5%) food and 1 (5%) poisonous. Determination of status of occurrence showed that 2 (10.53%) species are common, 5 (26.32%) cultivated, 9 (47.36%) threatened and 3 (15.79%) possibly extinct in Bangladesh. Field photographs and hand drawings of recorded taxa are provided.J. Biodivers. Conserv. Bioresour. Manag. 2018, 4(1): 35-46

scholarly journals Local resources of polyribosomes and SER promote synapse enlargement and spine clustering after long-term potentiation in adult rat hippocampus

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Michael A. Chirillo ◽  
Mikayla S. Waters ◽  
Laurence F. Lindsey ◽  
Jennifer N. Bourne ◽  
Kristen M. Harris
Keyword(s):  
Long Term Potentiation ◽  
Rat Hippocampus ◽  
Adult Rat ◽  
Local Resources ◽  
Term Potentiation

Long-Term Effects of Intracerebroventricular Streptozotocin Treatment on Adult Neurogenesis in the Rat Hippocampus

2015 ◽  
Vol 12 (8) ◽  
pp. 772-784 ◽  
Author(s):  
Ping Sun ◽  
Ana Knezovic ◽  
Milena Parlak ◽  
Jacqueline Cuber ◽  
Margherita Karabeg ◽  
...  
Keyword(s):  
Adult Neurogenesis ◽  
Rat Hippocampus ◽  
Long Term Effects

Three Proposals for Interdisciplinary Study

1998 ◽  
Vol 11 (3) ◽  
pp. 267-274 ◽  
Author(s):  
Henry C. Krasnow ◽  
Robin L. Wolkoff
Keyword(s):  
Family Business ◽  
Business Owners ◽  
Minority Shareholders ◽  
Legal Advice ◽  
The Family ◽  
Tax Savings ◽  
Long Term Impact ◽  
Interdisciplinary Study ◽  
First Time

This article suggests research to determine whether more valuable legal advice can be given in three areas. The emotional distress caused by prenuptial agreements to people under 30 years old who are marrying for the first time is not justified because these agreements often do not accomplish their intended goals. Regarding estate planning, business owners and their lawyers often focus primarily on tax savings without considering the long-term impact of the estate plan on the family business. Finally, the advantages to the family business of agreements for the buyout of disgruntled minority shareholders are discussed.

Two new records of the family Lobariaceae (Lichenized Ascomycota: Peltigerales) from Argentina.

2018 ◽  
Vol 53 (1) ◽  
pp. 5-8
Author(s):  
Alfredo Passo ◽  
Romina Vidal-Russell ◽  
Jose Martín Scervino ◽  
María Inés Messuti
Keyword(s):  
New Records ◽  
Southern Chile ◽  
The Family ◽  
Distribution And Ecology ◽  
First Time ◽  
Long Term Studies

As part of long term studies focused in the lichenized mycobiota diversity from southern Argentina, two species of the family Lobariaceae (Peltigerales), Pseudocyphellaria pluvialis and Sticta longipes, are registered for the first time in Argentina. These species were previously reported as endemic from southern Chile. Brief descriptions, illustrations and information about the distribution and ecology of the species are provided.

Sign in / Sign up

Export Citation Format

Share Document