Physical Activity as a Moderator of Alzheimer Pathology: A Systematic Review of Observational Studies

2019 ◽  
Vol 16 (4) ◽  
pp. 362-378 ◽  
Author(s):  
Kristian Steen Frederiksen ◽  
Le Gjerum ◽  
Gunhild Waldemar ◽  
Steen Gregers Hasselbalch
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Healthy Subjects ◽  
Observational Studies ◽  
Hippocampal Volume ◽  
Csf Biomarkers ◽  
Amyloid Pet ◽  
The Relationship ◽  
Alzheimer Pathology

Introduction: Observational studies have found that physical activity is associated with a reduced risk of cognitive decline and dementia. Whether physical activity may also reduce the level of AD pathology, remains undetermined. Objective: To examine the relationship between physical activity and AD biomarkers (beta-amyloid1- 42, total tau and phosphorylated tau in CSF, amyloid PET, hippocampal atrophy on MRI and parietotemporal hypometabolism on brain 18F-FDG-PET). Methods: We carried out a systematic review of the observational studies of physical activity and AD biomarkers in healthy subjects, subjective cognitive complaints, mild cognitive impairment (MCI) and AD dementia. Results: We identified a total of 40 papers, which were eligible for inclusion. Thirty-four studies were conducted on healthy subjects, 3 on MCI and healthy subjects, 1 on MCI, and 2 on AD and healthy controls. Six studies reported on CSF biomarkers, 9 on amyloid PET, 29 on MRI and 4 on brain 18FFDG- PET. The majority of studies did not find a significant association between physical activity and AD biomarkers Conclusion: The quality of included studies with only a few longitudinal studies, limits the conclusions which may be drawn from the present findings especially regarding the biomarkers other than hippocampal volume. However, the majority of the identified studies did not find a significant association.

Physical Activity and Quality of Life in People With Visual Impairments: A Systematic Review

2022 ◽  
pp. 0145482X2110725
Author(s):  
Eduardo L. Caputo ◽  
Rafael B. Porcellis da Silva ◽  
Larissa Leal da Cunha ◽  
Gabriele R. Krüger ◽  
Felipe F. Reichert
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Systematic Review ◽  
Visual Impairments ◽  
World Health ◽  
Life Questionnaire ◽  
Cross Sectional ◽  
World Health Organization Quality ◽  
The Relationship

Objective This systematic review aimed to investigate the relationship between physical activity and quality of life (QOL) in people with visual impairments. Methods: Electronic searches were performed in PubMed, SPORTdiscus, CINAHL, Embase, and Web of Science. Observational studies describing the relationship between physical activity and QOL in adults with visual impairments were included. The Newcastle-Ottawa Scale (NOS) adapted for cross-sectional studies was used to assess the quality of the studies. Results: Overall, 327 studies were identified, and eight met the inclusion criteria. All studies had cross-sectional designs and seven were performed in developed countries. Physical activity was assessed objectively by one study, and five studies used the International Physical Activity Questionnaire. The World Health Organization Quality of Life Questionnaire was the most used instrument to measure QOL. Six studies reported a positive relationship between physical activity and QOL domains, as follows: life satisfaction, activity limitation, fair or poor health, physically and mentally unhealthy days, psychological health, and overall QOL. Conclusion: People with visual impairments who are engaged in physical activity are more likely to have better QOL outcomes.

scholarly journals The Association between Energy Balance-Related Behavior and Burn-Out in Adults: A Systematic Review

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 397
Author(s):  
Yanni Verhavert ◽  
Kristine De Martelaer ◽  
Elke Van Hoof ◽  
Eline Van Der Linden ◽  
Evert Zinzen ◽  
...  
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Energy Balance ◽  
Observational Studies ◽  
Experimental Studies ◽  
Dietary Behavior ◽  
Negative Association ◽  
High Quality Research ◽  
Burn Out ◽  
The Relationship

Although it is believed that physical activity, sedentary, and dietary behavior (i.e., energy balance-related behavior) may decrease the risk of burn-out, the association between both is currently not well understood. Therefore, the aim of this systematic review was to synthesize studies investigating the relationship between energy balance-related behavior and burn-out risk. A systematic literature search was conducted in four databases, resulting in 25 included studies (ten experimental and 15 observational studies). Nine out of ten experimental studies showed that exercise programs were effective in reducing burn-out risk. Fourteen out of fifteen observational studies found a negative association between physical activity and burn-out risk, whereas one study did not find a relation. Two of the 15 observational studies also showed that being more sedentary was associated with a higher burn-out risk, and two other studies found that a healthier diet was related to a lower burn-out risk. No experimental studies were found for the latter two behaviors. It can be concluded that physical activity may be effective in reducing burn-out risk. The few observational studies linking sedentary and dietary behavior with burn-out risk suggest that being more sedentary and eating less healthy are each associated with higher burn-out risk. More high-quality research is needed to unravel the causal relationship between these two behaviors and burn-out risk.

scholarly journals Light-intensity physical activity and mental ill health: a systematic review of observational studies in the general population

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Mireia Felez-Nobrega ◽  
Judit Bort-Roig ◽  
Ruimin Ma ◽  
Eugenia Romano ◽  
Matthew Faires ◽  
...  
Keyword(s):  
Mental Health ◽  
Physical Activity ◽  
Systematic Review ◽  
General Population ◽  
Observational Studies ◽  
Age Groups ◽  
Cross Sectional ◽  
Intensity Physical Activity ◽  
The Relationship

Abstract Background Most of theevidence has focused on examining the influence of moderate-to-vigorous intensity physical activity on mental health, but he role of light intensity physical activity (LIPA) is less understood. The purpose of this systematic review was to assess the relationship between time spent in LIPA and mental ill health across the lifespan. Methods Data were obtained from online databases (Medline, Embase, Scopus, PsychInfo and CINAHL). The search and collection of eligible studies was conducted up to May 28, 2020. Observational studies conducted in the general population and reporting on the association between LIPA (1.6–2.9 metabolic equivalents; either self-reported or device-based measured) and mental ill health were included. Results Twenty-two studies were included in the review (16 cross-sectional and 6 longitudinal). In older adults (≥ 65 years) and adults (18–64 years), the evidence examining the relationship between LIPA and depressive symptoms is mixed. Data on anxiety, psychological distress and overall mental health are scarce, and results are inconclusive. There is no evidence suggesting favorable associations between LIPA and anxiety in college students. Finally, very limited data was found in adolescents (11–17 years) (n = 2 studies) and children (6–10 years) (n = 2 studies), but the evidence suggests that LIPA does not influence mental health outcomes in these age groups. Conclusions This review provided mostly cross-sectional evidence indicating that LIPA may not be associated with mental health outcomes across age groups. Future research efforts employing prospective research designs are warranted to better understand the role of LIPA on mental ill health across age groups.

Adverse Quality of Life Style and Risk of Infertility: A Systematic Review Study

2020 ◽  
Vol 16 (3) ◽  
pp. 169-181
Author(s):  
Sara Abdoli ◽  
Seyedeh Zahra Masoumi ◽  
Farideh Kazemi
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Systematic Review ◽  
High Body Mass Index ◽  
Cross Sectional ◽  
Review Study ◽  
The Impact ◽  
The Relationship ◽  
Reproductive Indices

Background: Infertility and mental, social, and economic issues associated with it endanger some relationships. Adverse quality of lifestyle is a threat to reproductive health and can lead to infertility problems. Objective: The present systematic review study was conducted to investigate the impact of the adverse quality of lifestyle on increased risks of infertility. Methods: After selecting electronic databases, namely Scopus, Pub Med, SID, and Web of Science, we searched the total population of available and published observational studies [cohort, casecontrol and cross-sectional] in Persian and English, examining the impact of lifestyle on reproductive and infertility parameters. The employed keywords were infertility, sub-fertility, male infertility, female infertility, couple infertility, lifestyle, and quality of life and their equivalent Persian words from 2007 to January 2019 regardless of gender. Out of 1211 studies, 60 were finally included in the study after excluding unrelated and duplicate papers and animal samples. Results: In the present study, older age, inadequate diet and nutrient intake, high body mass index and abdominal fat, smoking and alcohol drinking, inadequate physical activity, intense physical activity, stress, and sexual dysfunction were observed to affect reproductive indices; however, some researchers did not find any relationship between the foregoing factors and fertility. Conclusion: Individuals with dysfunctions in reproductive indices had more adverse quality of lifestyle indices compared with others, possibly reducing their chances of fertility. However, more studies are required to determine the relationship between lifestyle and infertility.

scholarly journals The relationship between physical activity and low back pain outcomes: a systematic review of observational studies

2010 ◽  
Vol 20 (3) ◽  
pp. 464-474 ◽  
Author(s):  
Paul Hendrick ◽  
S. Milosavljevic ◽  
L. Hale ◽  
D. A. Hurley ◽  
S. McDonough ◽  
...  
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Low Back Pain ◽  
Back Pain ◽  
Observational Studies ◽  
Low Back ◽  
Pain Outcomes ◽  
The Relationship

scholarly journals Customary physical activity and odds of depression: a systematic review and meta-analysis of 111 prospective cohort studies

2021 ◽  
pp. bjsports-2020-103140
Author(s):  
Rodney K Dishman ◽  
Cillian P McDowell ◽  
Matthew Payton Herring
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Depressive Symptoms ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Observational Studies ◽  
Meta Analysis ◽  
Vigorous Physical Activity ◽  
Prospective Cohort Studies ◽  
Over Time

ObjectiveTo explore whether physical activity is inversely associated with the onset of depression, we quantified the cumulative association of customary physical activity with incident depression and with an increase in subclinical depressive symptoms over time as reported from prospective observational studies.DesignSystematic review and meta-analysis.Data sourcesMEDLINE, PsycINFO, PsycARTICLES and CINAHL Complete databases, supplemented by Google Scholar.Eligibility criteriaProspective cohort studies in adults, published prior to January 2020, reporting associations between physical activity and depression.Study appraisal and synthesisMultilevel random-effects meta-analysis was performed adjusting for study and cohort or region. Mixed-model meta-regression of putative modifiers.ResultsSearches yielded 111 reports including over 3 million adults sampled from 11 nations in five continents. Odds of incident cases of depression or an increase in subclinical depressive symptoms were reduced after exposure to physical activity (OR, 95% CI) in crude (0.69, 0.63 to 0.75; I2=93.7) and adjusted (0.79, 0.75 to 0.82; I2=87.6) analyses. Results were materially the same for incident depression and subclinical symptoms. Odds were lower after moderate or vigorous physical activity that met public health guidelines than after light physical activity. These odds were also lower when exposure to physical activity increased over time during a study period compared with the odds when physical activity was captured as a single baseline measure of exposure.ConclusionCustomary and increasing levels of moderate-to-vigorous physical activity in observational studies are inversely associated with incident depression and the onset of subclinical depressive symptoms among adults regardless of global region, gender, age or follow-up period.

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