Resveratrol and Colorectal Cancer: A Molecular Approach to Clinical Researches

2021 ◽  
Vol 21 ◽  
Author(s):  
Eisa Kaveh Vernousfaderani ◽  
Negin Akhtari ◽  
Sara Rezaei ◽  
Yasaman Rezaee ◽  
Saba Shiranirad ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Pentose Phosphate Pathway ◽  
Clinical Studies ◽  
Pentose Phosphate ◽  
Pharmacological Effects ◽  
Molecular Approach ◽  
Prevention And Treatment ◽  
Cox 2

: Phytochemicals are the most valuable and comprehensive structures, which may have a broad range of protective benefits, from reducing inflammation and speeding healing to preventing infection and fighting cancer. Resveratrol (RSV) is a natural phenolic compound from the oligomeric stilbenoid group, which is usually found in human daily diets such as grape, peanut, berries and grains. It exhibits anti-inflammatory, neuroprotection, antioxidant and cancer prevention and treatment effects. RSV is thought to have an impressive outcome in colorectal cancer (CRC) treatment through the vital molecules and cancer signaling pathways, including SIRT1, P53, P21, AMPK, ROS, BMP7, COX-2, NO, Caspases, Wnt, TNFs, NF-κB, EMT, and pentose phosphate pathway. Therefore, this paper reviews the current researches on resveratrol pharmacological effects and pharmacokinetic and drug delivery system, as well as clinical studies in CRC.

scholarly journals Protection Effect of Self-Nanoemulsifying Drug Delivery System (SNEDDS) Piroxicam as Ulcerogenic Agent towards Malondialdehid Level and Protein Expression of Caspase-3, COX-1, COX-2 at Rat Gastric

2020 ◽  
pp. 273-283
Author(s):  
Iis Wahyuningsih ◽  
Kurnia Ambarwati ◽  
Erninda Ayu Hapsari ◽  
Afifah Fauziyyah ◽  
Azis Ikhsanudin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Protein Expression ◽  
Drug Delivery System ◽  
Delivery System ◽  
Caspase 3 ◽  
Thiobarbituric Acid Reactive Substance ◽  
Sprague Dawley ◽  
Protection Effect ◽  
Cox 2 ◽  
Cox 1

The aim of this study was to determine the protection effect of SNEDDS piroxicam ulcerogenic agent against malondialdehyde (MDA) level and protein expression of caspase-3, COX-1, COX-2. The research was conducted using the test animals as much as 30 male white Sprague dawley (SD) rats aged 1-2 months with a weight of 100-200 grams divided into 5 groups. Treatment was given for 28 days orally. On the 29th day blood samples were also taken for the determination of MDA (Malondialdehid) levels by Thiobarbituric Acid Reactive Substance (TBARs) method using a visible spectrophotometer. Rats were sacrificed, then gastric organs were taken for immunohistochemical testing of caspase-3 and COX-1 expression, COX-2. The statistical analysis showed that the piroxicam SNEDDS group and the piroxicam suspension group decreased expression of the caspase-3 protein, increased COX-1 expression, decreased COX-2 and significantly decreased MDA levels. The piroxicam-containing SNEDDS (Self-Nanoemulsifying Drug Delivery System) form has protection against ulcogenic piroxicam.

Abstract 236: Therapeutic targeting of the pentose phosphate pathway in colorectal cancer

2020 ◽  
Author(s):  
Noorhan Ghanem ◽  
Chirine El Baba ◽  
Lara Al Saleh ◽  
Berthe Hayar ◽  
Patrick Aouad ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Pentose Phosphate Pathway ◽  
Pentose Phosphate ◽  
Therapeutic Targeting

scholarly journals Self-Nanoemulsifying Drug Delivery System of Genkwanin: A Novel Approach for Anti-Colitis-Associated Colorectal Cancer

2021 ◽  
Vol Volume 15 ◽  
pp. 557-576
Author(s):  
Hua-Feng Yin ◽  
Chun-Ming Yin ◽  
Ting Ouyang ◽  
Shu-Ding Sun ◽  
Wei-Guo Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Novel Approach

scholarly journals Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System

2020 ◽  
Vol Volume 14 ◽  
pp. 4387-4405
Author(s):  
Nasrul Wathoni ◽  
An Ny Nguyen ◽  
Agus Rusdin ◽  
Abd Kakhar Umar ◽  
Ahmed Fouad Abdelwahab Mohammed ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
System P ◽  
Nanoparticle Drug Delivery ◽  
Enteric Coated

scholarly journals Preparation and Characterization of Self Nano-Emulsifying Drug Delivery System Loaded with Citraland Its Antiproliferative Effect on Colorectal Cells In Vitro

Nanomaterials ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 1028 ◽  
Author(s):  
Mira Nadiah Mohd Izham ◽  
Yazmin Hussin ◽  
Muhammad Nazirul Mubin Aziz ◽  
Swee Keong Yeap ◽  
Heshu Sulaiman Rahman ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Average Particle Size ◽  
Physicochemical Characterization ◽  
Average Particle ◽  
Colorectal Cancer Cells

Citral is an active compound naturally found in lemongrass, lemon, and lime. Although this pale-yellow liquid confers low water solubility, the compound has been reported to possess good therapeutic features including antiproliferative and anticancer modalities. The self nano-emulsifying drug delivery system (SNEDDS) is a type of liquid-lipid nanocarrier that is suitable for the loading of insolubilized oil-based compound such as Citral. This study reports the design and optimization of a SNEDDS formulation, synthesis and characterization as well as loading with Citral (CIT-SNEDDS). Further assessment of theantiproliferative effects of CIT-SNEDDS towards colorectal cancer cells was also conducted. SNEDDS composed of coconut oil, dimethyl sulfoxide (DMSO) and Tween 80. CIT-SNEDDS was prepared via gentle agitation of SNEDDS with 0.5% Citral for 72 h at room temperature. Physicochemical characterization was performed using several physicochemical analyses. The average particle size of CIT-SNEDDS was16.86 ± 0.15 nm, zeta potential of 0.58 ± 0.19 mV, and polydispersity index (PDI) of 0.23 ± 0.01. In vitro drug release of Citral from CIT-SNEDDS was 79.25% of release, and for Citral the release percentage was 93.56% over 72 h. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was done to determine the cytotoxicity effect of CIT-SNEDDS in human colorectal cancer cell lines HT29 and SW620. The half maximal inhibitory concentrations (IC50) for 72 hof CIT-SNEDDS and Citral on SW620 were 16.50 ± 0.87 µg/mL and 22.50 ± 2.50 µg/mL, respectively. The IC50 values of CIT-SNEDDS and Citral after 72 h of treatment on HT29 were 34.10 ± 0.30 µg/mL and 21.77 ± 0.23 µg/mL, respectively. This study strongly suggests that CIT-SNEDDS has permitted the sustained release of Citral and that CIT-SNEDDS constitutes a potential soluble drug nanocarrier that is effective against colorectal cancer cells.

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