Advances in Electrochemical Methods for the Analysis of Pharmaceuticals

Clemmer and Beebe have pointed out that surface structures on graphite substrates can be misinterpreted as biopolymer images in STM experiments. We have been using electrochemical methods to react DNA fragments onto gold electrodes for STM and AFM imaging. The adsorbates produced in this way are only homogeneous in special circumstances. Searching an inhomogeneous substrate for ‘desired’ images limits the value of the data. Here, we report on a reversible method for imaging adsorbates. The molecules can be lifted onto and off the substrate during imaging. This leaves no doubt about the validity or statistical significance of the images. Furthermore, environmental effects (such as changes in electrolyte or surface charge) can be investigated easily.

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Reduction potentials determination of some biochemically important free radicals. Pulse radiolysis and electrochemical methods

Journal de Chimie Physique ◽

10.1051/jcp/1993900711 ◽

1993 ◽

Vol 90 ◽

pp. 711-744 ◽

Cited By ~ 6

Author(s):

M Faraggi ◽

MH Klapper

Keyword(s):

Free Radicals ◽

Pulse Radiolysis ◽

Electrochemical Methods ◽

Reduction Potentials

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SEPARATION AND CHARACTERIZATION OF ANTHOCYANINS BY ANALYTICAL AND ELECTROCHEMICAL METHODS

Environmental Engineering and Management Journal ◽

10.30638/eemj.2011.093 ◽

2011 ◽

Vol 10 (5) ◽

pp. 697-701 ◽

Cited By ~ 1

Author(s):

Firuta Fitigau ◽

Claudia Popescu ◽

Adina-Elena Segneanu ◽

Ionel Balcu ◽

Raluca Martagiu ◽

...

Keyword(s):

Electrochemical Methods

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Studies and Research on the Corrosion Behavior of Ni-Al2O3 Compound Coatings Obtained by Electrochemical Methods

The Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science ◽

10.35219/mms.2020.3.04 ◽

2020 ◽

Vol 43 (3) ◽

pp. 21-25

Author(s):

Simona BOICIUC ◽

◽

Keyword(s):

Corrosion Resistance ◽

Corrosion Behavior ◽

Corrosion Behaviour ◽

Composite Coatings ◽

Point Of View ◽

Electrochemical Methods ◽

Dispersed Phase ◽

Nickel Matrix ◽

Technical Alumina ◽

Compound Coatings

The undertaken research which is described in this paper aims at the corrosion behaviour of composite coatings in nickel matrix using as dispersed phase technical alumina with dimensions of 5 μm and their characterization from a microstructural point of view. The corrosion resistance in the saline fog of the coatings is influenced by the microstructure, the stresses developed in the layer and the roughness.

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Recent Progress in the Analysis of Captopril Using Electrochemical Methods: A Review

Current Analytical Chemistry ◽

10.2174/1573411014666180510151528 ◽

2019 ◽

Vol 15 (3) ◽

pp. 198-206 ◽

Cited By ~ 1

Author(s):

Sarfaraz Ahmed Mahesar ◽

Saeed Ahmed Lakho ◽

Syed Tufail Hussain Sherazi ◽

Hamid Ali Kazi ◽

Kamran Ahmed Abro ◽

...

Keyword(s):

Enzyme Inhibitor ◽

Modified Electrodes ◽

High Sensitivity ◽

Pharmaceutical Formulations ◽

Inorganic Materials ◽

Electrochemical Methods ◽

Nano Particles ◽

Moderate Heart Failure ◽

Analytical Instrumentation

Background: Captopril is the synthetic dipeptide used as an angiotensin converting enzyme inhibitor. Captopril is used to treat hypertension as well as for the treatment of moderate heart failure. Analytical instrumentation and methodology plays an important role in pharmaceutical analysis. Methods: This review presents some important applications of electrochemical modes used for the analysis of captopril. So far captopril has been analyzed by using different bare and modified working electrodes with a variety of modifiers from organic and inorganic materials to various types of nano particles/materials. Results: This paper presents some of the methods which have been published in the last few years i.e. from 2003 to 2016. This review highlights the role of the analytical instrumentation, particularly electrochemical methods in assessing captopril using various working electrodes. Conclusion: A large number of studies on voltammetry noted by means of various bare and modified electrodes. Among all of the published voltammetric methods, DPV, SWV, CV and miscellaneous modes were trendy techniques used to analyze captopril in pharmaceutical formulations as well as biological samples. Electrodes modified with nanomaterials are promising sensing tools as this showed high sensitivity, good accuracy with precision as well as selectivity. In comparison to chromatographic methods, the main advantages of electrochemical methods are its cheaper instrumentation, lower detection limit and minimal or no sample preparation.

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Electroanalysis of Catecholamine Drugs using Graphene Modified Electrodes

Current Analytical Chemistry ◽

10.2174/1573411014666180917113206 ◽

2019 ◽

Vol 15 (4) ◽

pp. 443-466 ◽

Cited By ~ 1

Author(s):

Mahya Karami Mosammam ◽

Mohammad Reza Ganjali ◽

Mona Habibi-Kool-Gheshlaghi ◽

Farnoush Faridbod

Keyword(s):

Electrochemical Sensors ◽

Modified Electrodes ◽

Electrochemical Methods ◽

High Signal ◽

Signal To Noise ◽

Low Level ◽

Biological Studies

Background: Catecholamine drugs are a family of electroactive pharmaceutics, which are widely analyzed through electrochemical methods. However, for low level online determination and monitoring of these compounds, which is very important for clinical and biological studies, modified electrodes having high signal to noise ratios are needed. Numerous materials including nanomaterials have been widely used as electrode modifies for these families during the years. Among them, graphene and its family, due to their remarkable properties in electrochemistry, were extensively used in modification of electrochemical sensors. Objective: In this review, working electrodes which have been modified with graphene and its derivatives and applied for electroanalyses of some important catecholamine drugs are considered.

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