Efficacy and Safety of Mesenchymal Stromal cells Therapy for COVID-19 Infection: A Systematic Review and Meta-analysis

2021 ◽  
Vol 16 ◽  
Author(s):  
Yaxin Li ◽  
Ziyang Wei ◽  
Xinyu Ma ◽  
Jing Xu ◽  
Xia Zhao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mortality Rate ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
High Mortality ◽  
Meta Analysis ◽  
Fixed Effect Model ◽  
Control Group ◽  
Safety And Efficacy ◽  
And Control

Background: Coronavirus disease 2019 (COVID-19) is an infectious respiratory disease prevalent worldwide with a high mortality rate, and there is currently no specific medicine to treat patients. Objective: We aimed to assess the safety and efficacy of stem cell therapy for COVID-19 by providing references for subsequent clinical treatments and trials. Method: We systematically searched PubMed, Embase, Cochrane, and Web of Science, using the following keywords: “stem cell” or “stromal cell” and “COVID-19.” Controlled clinical trials published in English until 24th August 2021 were included. We followed the PRISMA guidelines and used Cochrane Collaboration’s tool for assessing the risk of bias. We analysed the data using a fixed-effect model. Results: We identified 1779 studies, out of which eight were eligible and included in this study. Eight relevant studies consisted of 156 patients treated with stem cells and 144 controls (300 individuals in total). There were no SAEs associated with stem cell therapy in all six studies, and no significant differences in AEs (p = 0.09, I2 = 40%, OR = 0.53, 95% CI: 0.26 to 1.09) between the experimental group and control group were observed. Moreover, the meta-analysis found that stem cell therapy effectively reduced the high mortality rate of COVID-19 (14/156 vs. 43/144; p<0.0001, I2 =0%, OR=0.18, 95% CI: 0.08 to 0.41). Conclusion: This study suggests that MSCs therapy for COVID-19 has shown some promising results in safety and efficacy. It effectively reduces the high mortality rate of COVID-19 and does not increase the incidence of adverse events. 

scholarly journals Stem Cells Therapy for COVID-19: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Erfan Arabpour ◽  
Sina Khoshdel ◽  
Negin Tabatabaie ◽  
Ali Akhgarzad ◽  
Moein Zangiabadian ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Large Scale ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Control Group ◽  
Remarkable Effect

Introduction: Vaccination seems to be a good solution for preventing and controlling coronavirus disease (COVID-19) pandemic, but still there are some challenges in COVID-19 vaccination. Investigating new therapeutic options for COVID-19 is necessary. The current study aimed to evaluate the safety and efficacy of stem cells in treating patients with COVID-19.Methods: We reviewed the relevant scientific literature published up to April 1, 2021. The pooled risk ratio (RR) with 95% CI was assessed using a fixed or random-effect model. We considered P &lt; 0.05 as statistically significant for publication bias. Data were analyzed by Comprehensive Meta-Analysis software, Version 2.0 (Biostat, Englewood, NJ).Results: After reviewing 1,262 records, we identified 10 studies that met the inclusion criteria. The analysis showed that stem cell therapy could significantly reduce the mortality rate (RR 0.471, 95% CI: 0.270–0.821) and morbidity (RR 0.788, 95% CI: 0.626–0.992) in patients with COVID-19; compared with the control group.Conclusions: The present study suggests that stem cell therapy has a remarkable effect on reducing mortality and morbidity of patients with COVID-19. Further large-scale studies are needed to approve these results. Defining a protocol for stem cell therapy in patients with COVID-19 can lead to achieving the best clinical outcomes.

Clinical application of stem cell therapy in neurogenic bladder: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Hanieh Salehi-pourmehr ◽  
Ozra Nouri ◽  
Amirreza Naseri ◽  
Leila Roshangar ◽  
Reza Rahbarghazi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Cell Therapy ◽  
Neurogenic Bladder ◽  
Clinical Application ◽  
Stem Cell Therapy ◽  
Meta Analysis

Application Effect Analysis of Nursing Intervention in Stem Cell Therapy for Stroke Patients

2021 ◽  
Vol 7 (4) ◽  
pp. 392-399
Author(s):  
Jing Zhao ◽  
Lili Fu ◽  
Juan Zhu ◽  
Yan Liu ◽  
Xiaoqian Sun
Keyword(s):  
Quality Of Life ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Daily Living ◽  
Nursing Intervention ◽  
Control Group ◽  
Observation Group ◽  
Stroke Patients

To study and analyze the actual clinical effect of nursing intervention in stem cell therapy for stroke patients. A total of 9 stroke patients treated with stem cell therapy in our hospital from September 2018 to September 2019 were selected as the research and analysis objects. All patients were divided into observation group 5 stroke patients and control group 4 stroke patients by random number method. Both groups of patients were treated with stem cell therapy. Patients in the control group were treated with conventional nursing methods, and patients in the observation group were treated with nursing intervention methods. The treatment compliance, psychological status, quality of life and daily living ability before and after intervention were compared between the two groups. There were no significant differences in exercise training, disease monitoring and compliance with regular life between the two groups before intervention (P > 0.05), and the patients in observation group were significantly better than those in control group after intervention (P < 0.05), with significant differences. There was no significant difference in anxiety and depression scores between the two groups before intervention (P > 0.05), and after intervention, the patients in the observation group were significantly lower than those in the control group (P < 0.05), and the difference was statistically significant. There was no significant difference in quality of life and ability of daily living between the two groups before intervention (P > 0.05), and the patients in the observation group were significantly better than those in the control group after intervention (P < 0.05), the difference was statistically significant. The application of nursing intervention in stem cell therapy for stroke patients has a significant effect, which significantly improves the patient's compliance with the treatment, alleviates the negative emotions of patients, improves the psychological status of patients, improves the quality of life and daily living ability of patients, and is worthy of popularization and application in clinical nursing.

scholarly journals Therapeutic effect and safety of stem cell therapy for chronic liver disease: a systematic review and meta-analysis of randomized controlled trials

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Guang-Peng Zhou ◽  
Yi-Zhou Jiang ◽  
Li-Ying Sun ◽  
Zhi-Jun Zhu
Keyword(s):  
Stem Cell ◽  
Liver Disease ◽  
Adverse Events ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Meta Analysis ◽  
Chronic Liver ◽  
Controlled Trials ◽  
Therapeutic Effects ◽  
Term Survival

Abstract Background Stem cell therapy is becoming an emerging therapeutic option for chronic liver disease (CLD). However, whether stem cell therapy is more effective than conventional treatment remains questionable. We performed a large-scale meta-analysis of randomized controlled trials (RCTs) to evaluate the therapeutic effects and safety of stem cell therapy for CLD. Methods We systematically searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov databases for the period from inception through March 16, 2020. Primary outcomes were all-cause mortality and adverse events related to stem cell therapy. Secondary outcomes included the model for end-stage liver disease score, total bilirubin, albumin, alanine aminotransferase, prothrombin activity, and international normalized ratio. The standardized mean difference (SMD) and odds ratio (OR) with 95% confidence interval (CI) were calculated using a random-effects model. Results Twenty-four RCTs were included and the majority of these studies showed a high risk of bias. The meta-analysis indicated that compared with conventional treatment, stem cell therapy was associated with improved survival and liver function including the model of end-stage liver disease score, total bilirubin, and albumin levels. However, it had no obvious beneficial effects on alanine aminotransferase level, prothrombin activity, and international normalized ratio. Subgroup analyses showed stem cell therapy conferred a short-term survival benefit for patients with acute-on-chronic liver failure (ACLF), a single injection was more effective than multiple injections, hepatic arterial infusion was more effective than intravenous infusion, and bone marrow-derived stem cells were more effective than those derived from the umbilical cord. Thirteen trials reported adverse events related to stem cell therapy, but no serious adverse events were reported. Conclusions Stem cell therapy is a safe and effective therapeutic option for CLD, while patients with ACLF benefit the most in terms of improved short-term survival. A single injection administration of bone marrow-derived stem cells via the hepatic artery has superior therapeutic effects.

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