Endocrine-Disrupting Compounds in Fish Physiology, with Emphasis on their Effects on the Arginine Vasotocin/Isotocin System

2021 ◽  
Vol 21 ◽  
Author(s):  
Hanna Kalamarz-Kubiak
Keyword(s):  
Round Goby ◽  
Endocrine Disrupting Compounds ◽  
Well Being ◽  
Arginine Vasotocin ◽  
Fish Model ◽  
Physiological Processes ◽  
Slow Progression ◽  
Endocrine Disrupting ◽  
Fish Habitats ◽  
Harmful Effects

: The purposes of this review are to promote better use of existing knowledge of marine pollutants especially endocrine-disrupting compounds (EDCs) and to draw attention to the slow progression of the research on the influence of those compounds on arginine vasotocin/isotocin system (AVT/IT) in fish. EDCs are leading to the degradation of fish habitats, reducing their spawning potential and possibly their population parameters (e.g. growth, maturation), by preventing fish from breeding and rebuilding their populations. Therefore, searching for new welfare indicators such as AVT and IT and developing research procedures mimicking environmental conditions using a versatile fish model is extremely important. Fish species such as Zebrafish (Daniorerio) and round goby (Neogobiusmelanostomus) can be recommended as very suitable modelsfor studying estrogenic EDCs on the AVT/IT system and other hormones involved in the neuroendocrine regulation of physiological processes in fish.These studies would not only improve our understanding of the effects of EDCs on vertebrates but could also help safeguard the well-being of aquatic and terrestrial organisms from the harmful effects of these compounds.

Nanofiltration of endocrine disrupting compounds

2003 ◽  
Vol 3 (5-6) ◽  
pp. 321-327 ◽  
Author(s):  
M. Gallenkemper ◽  
T. Wintgens ◽  
T. Melin
Keyword(s):  
Wastewater Treatment ◽  
Municipal Wastewater ◽  
Wastewater Treatment Plants ◽  
Endocrine Disrupting Compounds ◽  
Municipal Wastewater Treatment ◽  
Water And Wastewater Treatment ◽  
Wide Range ◽  
Endocrine Disrupting ◽  
Municipal Wastewater Treatment Plants ◽  
Set Up

Endocrine disrupting compounds can affect the hormone system in organisms. A wide range of endocrine disrupters were found in sewage and effluents of municipal wastewater treatment plants. Toxicological evaluations indicate that conventional wastewater treatment plants are not able to remove these substances sufficiently before disposing effluent into the environment. Membrane technology, which is proving to be an effective barrier to these substances, is the subject of this research. Nanofiltration provides high quality permeates in water and wastewater treatment. Eleven different nanofiltration membranes were tested in the laboratory set-up. The observed retention for nonylphenol (NP) and bisphenol A (BPA) ranged between 70% and 100%. The contact angle is an indicator for the hydrophobicity of a membrane, whose influence on the permeability and retention of NP was evident. The retention of BPA was found to be inversely proportional to the membrane permeability.

scholarly journals Effects of the Hedgehog signalling inhibitor itraconazole on developing rat ovaries

2021 ◽  
Author(s):  
Hanna Katarina Lilith Johansson ◽  
Camilla Taxvig ◽  
Gustav Peder Mohr Olsen ◽  
Terje Svingen
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Endocrine Disrupting Compounds ◽  
Perinatal Period ◽  
Endocrine Function ◽  
Ovary Development ◽  
Knock Out ◽  
Female Reproductive Health ◽  
Endocrine Disrupting ◽  
Hh Signaling ◽  
Knock Out Mice

Abstract Early ovary development is considered to be largely hormone independent, yet there are associations between fetal exposure to endocrine disrupting chemicals and reproductive disorders in women. This can potentially be explained by perturbations to establishment of ovarian endocrine function rather than interference with an already established hormone system. In this study we explore if Hedgehog (HH) signaling, a central pathway for correct ovary development, can be disrupted by exposure to HH-disrupting chemicals, using the antifungal itraconazole as model compound. In the mouse Leydig cell line TM3, used as a proxy for ovarian theca cells, itraconazole exposure had a suppressing effect on genes downstream of HH signaling, such as Gli1. Exposing explanted rat ovaries (gestational day 22 or postnatal day 3) to 30 µM itraconazole for 72 h induced significant suppression of genes in the HH signaling pathway with altered Ihh, Gli1, Ptch1, and Smo expression similar to those previously observed in Ihh/Dhh knock-out mice. Exposing rat dams to 50 mg/kg bw/day in the perinatal period did not induce observable changes in the offspring’s ovaries. Overall, our results suggest that HH signal disruptors may affect ovary development with potential long-term consequences for female reproductive health. However, potent HH inhibitors would likely cause severe teratogenic effects at doses lower than those causing ovarian dysgenesis, so the concern with respect to reproductive disorder is for the presence of HH disruptors at low concentration in combination with other ovary or endocrine disrupting compounds.

scholarly journals New Frontiers in Caregiving Research: Biopsychosocial Perspectives and Interventions

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 615-615
Author(s):  
Jyoti Savla ◽  
Karen Roberto ◽  
Mamta Sapra
Keyword(s):  
Family Caregivers ◽  
Memory Loss ◽  
Well Being ◽  
Psychoeducational Intervention ◽  
Loved One ◽  
Daily Diary Study ◽  
Physiological Processes ◽  
And Coping ◽  
With Memory ◽  
Health And Well Being

Abstract Although families embrace the opportunity to care for a loved one, caregiving is stressful and takes a toll on the caregiver’s health and well-being. Earlier studies of stress and coping among family caregivers focused on psychological outcomes and emotional well-being. In the last decade, stress researchers have broadened their focus to include biomarkers and health outcomes. Data from two studies of caregivers of persons with memory loss will be used to discuss two new frontiers of caregiving research. First, a daily-diary study will be used to identify the mechanism by which stress disrupts the physiological processes and proliferates into serious psychopathology and pre-clinical and clinical health conditions. Second, a mindfulness-based psychoeducational intervention study will be utilized to identify malleable factors that can be harnessed to lower stress and improve the well-being of family caregivers. Next steps for caregiving research in the context of demographic and technological trends will be discussed.

When history perpetuates stereotypes and narratives: The burden of historical representations on well-being

2021 ◽  
Author(s):  
Raymond Boateng
Keyword(s):  
Social Identity ◽  
Well Being ◽  
Self Esteem ◽  
Social Identification ◽  
Potential Impact ◽  
Historical Representations ◽  
The Relationship ◽  
Harmful Effects

Previous research outlined that historical representations of different groups underlie stereotypes and prejudice. Considering the gap in the literature on historical representations and their potential impact on the well-being of Africans, we hypothesised that historical representations of Africans and perceptions of these representations among Africans (N = 225 in Europe relate to well-being outcomes in that population. Furthermore, we predicted that the relationship between historical representations and well-being is mediated by stereotype confirmation concerns and social identification. Consistent with our predictions, historical representations were associated with poorer well-being. Particularly, historical representations were related to increased anxiety and low self-esteem through their relationship with stereotype confirmation concerns. Social identity mitigated the harmful effects of historical representations on self-esteem. However, social identity did not mediate the association between historical representations and anxiety. Our findings highlight the effects of historical representations on well-being.

Automatic flow-through system for exploration of the human bioaccessibility of endocrine disrupting compounds from microplastics

The Analyst ◽  
2021 ◽  
Author(s):  
Manuel Miro ◽  
Alexandra Sixto ◽  
Bilal El-Morabit ◽  
María José Trujillo-Rodríguez ◽  
Enrique Javier Carrasco-Correa
Keyword(s):  
Endocrine Disrupting Compounds ◽  
Gi Tract ◽  
Endocrine Disrupting ◽  
Flow Through

This article reports on the first attempt towards investigating the leaching rates in the human gastrointestinal (GI) tract of plastic-borne contaminants that can be ingested accidentally using physiologically relevant body...

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