Human health management and life/disease risk assessment: A review

2020 ◽  
Vol 14 ◽  
Author(s):  
Hui-Zhong Li ◽  
Xiang-Dong Liu ◽  
Xin Shi
Keyword(s):  
Risk Assessment ◽  
Human Health ◽  
Population Health ◽  
Health Management ◽  
Disease Risk ◽  
Residual Life ◽  
Economic Status ◽  
Health Assessment ◽  
Research Progress ◽  
Future Research

Background: Modern medical researches show that population health is closely related to population behavior, environmental factors, social and economic conditions, aging and genetic susceptibility. Therefore, it is very important to study the relationship between these factors and population health. Objective: It reviews the latest research progress in population health management and life/disease risk assessment, analyzes the existing problems in relevant researches, and proposes some improvement plans to solve the problems. Methods: It introduces the general methods of human health management and life/disease risk assessment, analyzes the defects of these methods in practical application, and then draws lessons from the methods of industrial system equipment health management and residual life prediction, and puts forward some new ideas to solve the problems. Results: In the study of health assessment, although self-assessment of health is a common method of health variables, its subjectivity and inaccuracy is a problem that cannot be ignored. In life/disease risk assessment studies, medical effect and efficacy are mainly evaluation subjects, and little consideration is given to other factors, such as behaviour, environment, socio-economic status. In the construction of statistical graphs, great individual differences, internal symbiotic variables and external impact variables are seldom considered. Conclusion: This study helps to understand the basic ideas and methods in health management and life/disease risk assessment, and proposes some future research programs based on the author's knowledge background.

scholarly journals Implementing a Population Health Management Intervention to Control Cardiovascular Disease Risk Factors

2020 ◽  
Vol 35 (6) ◽  
pp. 1931-1933
Author(s):  
Shelley A. Jazowski ◽  
Hayden B. Bosworth ◽  
Karen M. Goldstein ◽  
Courtney White-Clark ◽  
Felicia McCant ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Population Health ◽  
Health Management ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cardiovascular Disease Risk Factors ◽  
Population Health Management ◽  
Management Intervention

scholarly journals Myeloproliferative Neoplasms: Emerging Treatment Options for Myelofibrosis

2020 ◽  
Vol 18 (12.5) ◽  
pp. 1788-1791
Author(s):  
Aaron T. Gerds
Keyword(s):  
Risk Assessment ◽  
Stem Cells ◽  
Disease Risk ◽  
Myeloproliferative Neoplasms ◽  
Treatment Options ◽  
Future Research ◽  
Treatment Algorithms ◽  
Epigenetic Regulators ◽  
Special Case ◽  
Proliferative Signaling

Myelofibrosis (MF) is a symptom-forward disease, and its treatment focuses on alleviating those symptoms, as well as improving survival. An initial disease risk assessment is critical for deciding on a course of therapy (and a number of models can be used depending on the available patient information), and anemia can be considered a special case within the treatment algorithms for MF. JAK-STAT inhibition is currently the cornerstone of treatment for MF, but these inhibitors are not perfect. Future research will focus on the microenvironment in reversing fibrosis, immunotherapies, proliferative signaling pathways, epigenetic regulators, and stem cells.

scholarly journals The Law Aspects in Health Management: A Bibliometric Analysis of Issues on the Injury, Damage and Harm in Criminal Law

2020 ◽  
pp. 293-305
Author(s):  
Zamina Aliyeva
Keyword(s):  
Substance Abuse ◽  
Criminal Justice ◽  
Human Health ◽  
Criminal Law ◽  
Government Regulation ◽  
Health Care Policy ◽  
Health Management ◽  
Mental Disease ◽  
Future Research ◽  
Government Control

The paper presents the analysis of the approaches to define the areas of research on the injury, damage and harm to human health in criminal law. The obtained results proved that crimes, connected to drugs abuse, their legislation become an essential part of the issues. At the same, developing of government control, medical standards, improving quality of medical education balancing the «medical mistake – injury to human’s health – jurisprudence consequences» triangle in the tendency of the injury, damage and harm in criminal laware becoming very important to the healthcare system due to increasing requirements of regulators, customers and shareholders. The paper aimed to analyse the tendency in the literature on the injury, damage and harm in criminal law, which published in books, journals, conference proceedings etc. to identify future research directions. The methodological tools are VOSviewer, Scopus and Web of Science (WoS) software. This study covers 1072 papers from Scopus and WoS database. The time for analysis were 1970-2020. The Scopus and WoS analyse showed that in 2012-2019 the numbers of papers on the injury, damage and harm in criminal law issues began to increase. However, the topics changed from general issues to the problem of decriminalisation of drug trafficking, and the corresponding paradigm shift in the punishment of some crimes, increasing interest in punishing corporations for violating environmental regulations. In 2017 the number of documents dedicated to injury, damage and harm in criminal law was increased by 667% compared to 2012. The main subject areas of analyses of the injury, damage and harm in criminal law were the next: Law, Public environmental, occupational health, Criminology penology, Substance abuse, Psychiatry, Medicine. The biggest amount of investigations of the injury, damage and harm in criminal law was published by the scientists from the USA, United Kingdom, Australia and Canada. In 2019 such journals with high impact factor as International Journal of Drug Policy, International Journal of Law and Psychiatry, The Lancet etc. published the number of issues, which analysed of the injury, damage and harm to human health in criminal law. Such results proved that theme on the injury, damage and harm to human health in criminal law is actually in the ongoing trends of the modern jurisprudence and regulation. The findings from VOSviewer defined 6 clusters of the papers which analysed the injury, damage and harm to human health in criminal law from the different points of views. The first biggest cluster (with the biggest number of connections) merged the keywords as follows: criminal justice, law enforcement, public health, health care policy, harm reduction, drug legislation, drug and narcotic control, substance abuse, homelessness etc. The second significant cluster integrated the keywords as follows: criminal behaviour, crime victim, adolescent, violence, mental health, mental disease, prisoner, young people, rape, police etc. The third biggest cluster concentrated on criminal aspects of jurisprudence, criminal law, human right, legal liability, social control, government regulation etc. The obtained results allow concluding that balancing the triangles «medical mistakes – criminal – education» and «drugs – criminal – justice» and «abortion – criminal – women/children» form an important part of the injury, damage and harm in criminal law issues. Keywords injury, damage, harm, human health, criminal law, management, governance.

Accountable Care: Building Systems for Population Health Management

2014 ◽  
Author(s):  
Sarah Klein Klein ◽  
Douglas McCarthy McCarthy ◽  
Alexander Cohen Cohen
Keyword(s):  
Population Health ◽  
Health Management ◽  
Accountable Care ◽  
Population Health Management ◽  
Building Systems

Human health risk assessment: application of the NORISC-HRA and ROME models at two test sites

2006 ◽  
Vol 14 (2) ◽  
pp. 559-570 ◽  
Author(s):  
F. Quercia ◽  
A. Vecchio ◽  
M. Falconi ◽  
L. Togni ◽  
E. Wcislo ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Health Risk ◽  
Human Health ◽  
Health Risk Assessment ◽  
Human Health Risk ◽  
Human Health Risk Assessment

Metabolism and Distribution of Novel Tumor Targeting Drugs In Vivo

2020 ◽  
Vol 21 (13) ◽  
pp. 996-1008
Author(s):  
Mengli Wang ◽  
Qiuzheng Du ◽  
Lihua Zuo ◽  
Peng Xue ◽  
Chao Lan ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Small Molecule ◽  
High Efficiency ◽  
Tumor Therapy ◽  
Research Progress ◽  
Future Research ◽  
Pharmacokinetic Parameters ◽  
Molecular Characteristics ◽  
Targeted Drugs

Background: As a new tumor therapy, targeted therapy is becoming a hot topic due to its high efficiency and low toxicity. Drug effects of targeted tumor drugs are closely related to pharmacokinetics, so it is important to understand their distribution and metabolism in vivo. Methods: A systematic review of the literature on the metabolism and distribution of targeted drugs over the past 20 years was conducted, and the pharmacokinetic parameters of approved targeted drugs were summarized in combination with the FDA's drug instructions. Targeting drugs are divided into two categories: small molecule inhibitors and monoclonal antibodies. Novel targeting drugs and their mechanisms of action, which have been developed in recent years, are summarized. The distribution and metabolic processes of each drug in the human body are reviewed. Results: In this review, we found that the distribution and metabolism of small molecule kinase inhibitors (TKI) and monoclonal antibodies (mAb) showed different characteristics based on the differences of action mechanism and molecular characteristics. TKI absorbed rapidly (Tmax ≈ 1-4 h) and distributed in large amounts (Vd > 100 L). It was mainly oxidized and reduced by cytochrome P450 CYP3A4. However, due to the large molecular diameter, mAb was distributed to tissues slowly, and the volume of distribution was usually very low (Vd < 10 L). It was mainly hydrolyzed and metabolized into peptides and amino acids by protease hydrolysis. In addition, some of the latest drugs are still in clinical trials, and the in vivo process still needs further study. Conclusion: According to the summary of the research progress of the existing targeting drugs, it is found that they have high specificity, but there are still deficiencies in drug resistance and safety. Therefore, the development of safer and more effective targeted drugs is the future research direction. Meanwhile, this study also provides a theoretical basis for clinical accurate drug delivery.

Mix Networks: Existing Scenarios and Future Directions on Security and Privacy

2019 ◽  
Vol 14 ◽  
Author(s):  
Khaleel Ahmad ◽  
Afsar Kamal
Keyword(s):  
Security And Privacy ◽  
Research Progress ◽  
Future Research ◽  
Future Directions ◽  
Practical Solution ◽  
Research Gap ◽  
The Web ◽  
Privacy Enhancing Techniques

Background: Privacy enhancing techniques are developed in order to provide strong protection to cyberspace. These techniques aim to allow users to keep their identities hidden during the communication when they are sending email, making payments online, browsing the Web or posting to newsgroups. MixNet is the most practical solution for concealing identities of message and sender’s identities. Objective: It provides sender and receiver anonymity as well as message security. The main goal of MixNet is to overcome vulnerability and enhance the performance of communication. It can efficiently handle the messages of various length and produce desirable results with privacy. The main objective of this paper is to acquire information and concepts regarding MixNet. We also provide guidelines for future research and references. Methods : The designing of MixNet depends on what cryptosystem method is used. Symmetric and Asymmetric both are used. Other methods could be also used such as PIR, CSP and FDR model, RPC, Token-based approach or others. Result: In this paper we provide an overview of MixNet approaches and presented a survey on MixNet based techniques and different models. We also constructed the comparison tables as per our requirements for better understanding. For this purpose, we found a total of 120 articles related to the MixNet published between 1990 and 2018 from the most relevant scientific resources. However, only 86 papers were analyzed due to comprehensiveness and relevancy to this article. Conclusion: Focused on the security and privacy of communication and how it can be achieved. This survey also reveals research progress and research gap on MixNet.

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