scholarly journals Biomedical Applications of Interpenetrating Polymer Network System

2015 ◽  
Vol 2 (1) ◽  
pp. 21-30 ◽  
Author(s):  
Mohd Fuzail Qadri ◽  
Rishabha Malviya ◽  
Pramod Kumar Sharma
Keyword(s):  
Biomedical Applications ◽  
Polymer Network ◽  
Pharmaceutical Research ◽  
Controlled Drug Delivery ◽  
Dosage Forms ◽  
Interpenetrating Polymer Network ◽  
Network System ◽  
The Novel ◽  
Novel Technology ◽  
Pharmaceutical Industries

Interpenetrating polymer network (IPN) has been regarded as one of the novel technology in recent years showing the superior performances over the conventional techniques. This system is designed for the delivery of drugs at a predetermined rate and thus helps in controlled drug delivery. Due to its enhanced biological and physical characteristics like biodegradability, biocompatibility, solubility, specificity and stability, IPN has emerged out to be one of the excellent technologies in pharmaceutical industries. This article focuses mainly on the biomedical applications of IPN along with its future applicability in pharmaceutical research. It summarizes various aspects of IPN, biomedical applications and also in-cludes the different dosage forms based on IPN.

scholarly journals Interpenetrating Polymer Network Hydrogels Based on Gelatin and PVA by Biocompatible Approaches: Synthesis and Characterization

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Eltjani-Eltahir Hago ◽  
Xinsong Li
Keyword(s):  
Mechanical Properties ◽  
Mtt Assay ◽  
Biomedical Applications ◽  
Polymer Network ◽  
Physical And Mechanical Properties ◽  
Morphological Characterization ◽  
Interpenetrating Polymer Network ◽  
Synthesis And Characterization ◽  
Cross Linking ◽  
New Approach

In this work, a new approach was introduced to prepare interpenetrating polymer network PVA/GE hydrogels by cross-linking of various concentration gelatin in the presence of transglutaminase enzyme by using the freezing-thawing cycles technique. The effects of freezing-thawing cycles on the properties of morphological characterization, gel fraction, swelling, mechanical, and MTT assay were investigated. The IPN PVA/GE hydrogels showed excellent physical and mechanical Properties. MTT assay data and the fibroblasts culture also showed excellent biocompatibility and good proliferation. This indicates that the IPN hydrogels are stable enough for various biomedical applications.

scholarly journals Current Approaches on Gastroretentive Drug Delivery systems

2020 ◽  
Vol 10 (1) ◽  
pp. 139-146 ◽  
Author(s):  
Aniket Uttam Pund ◽  
Raosaheb Sopanrao Shendge ◽  
Ajinkya Kailas Pote
Keyword(s):  
Extended Release ◽  
Dosage Forms ◽  
Oral Dosage ◽  
The Novel ◽  
Novel Technologies ◽  
Novel Technology ◽  
The Many ◽  
Floating Systems ◽  
Acidic Region ◽  
Gastro Retentive

Over recent years, there have been many efforts to develop the absorption rate of medications and the therapeutic efficacy of oral dosage types. GRDDS for strengthen the pharmacological effects of drugs with a small uptake site, are unbalanced at pH greater than 7, are dissolved under acidic region, and are effective local region in the stomach. The gastro retentive systems that have the different evaluation parameter that according to the dosage forms. There are many criteria for the choosing of the drug used in the gastro-retardant systems as the drug should be sparingly stable, it should be compatible with the gastric region, and narrow absorption. In this review, we have summarized the information related to the various approaches for enhancing and prolonging of the dosage forms in the stomach for their extended-release of action. Also talking about the many natural and synthetic polymers is used in the formulation with their different grade and their ratio that affects on the release action. The many scientist and inventors have increased their interest in developing the novel dosage forms and they staying in the stomach for showing the prolonged period action. We have also discussed the novel technology are involved in the gastric retention many companies has been developed the polymer grades for using it in the formulation for showing the retention action. Keywords: Introduction, Approaches, Novel technologies, Polymer used in floating systems.

Advances in interpenetrating polymer network hydrogels and their applications

2014 ◽  
Vol 86 (11) ◽  
pp. 1707-1721 ◽  
Author(s):  
Ecaterina Stela Dragan
Keyword(s):  
Mechanical Properties ◽  
Drug Loading ◽  
Polymer Network ◽  
Mesh Size ◽  
Ionic Species ◽  
Interpenetrating Polymer Network ◽  
The Novel ◽  
Artificial Cornea ◽  
Separation Processes ◽  
Highly Stretchable

Abstract Interpenetrating polymer network (IPN) hydrogels brought distinct benefits compared to single network hydrogels like more widely controllable physical properties, and (frequently) more efficient drug loading/release. However, IPN strategy is not sufficient to design hydrogels with enhanced mechanical properties required for regenerative medicine like replacement of natural cartilage or artificial cornea. Some of the novel techniques promoted last decade for the preparation of IPN hydrogels which fulfill these requirements are discussed in the review. Among them, “double network” strategy had a strong contribution in the development of a large variety of hydrogels with spectacular mechanical properties at water content up to 90 %. Using cryogelation in tandem with IPN strategy led to composite cryogels with high mechanical properties and high performances in separation processes of ionic species. Highly stretchable and extremely tough hydrogels have been obtained by combining a covalently cross-linked synthetic network with an ionically cross-linked alginate network. IPN hydrogels with tailored mesh size have been also reported.

Biomedical Applications of Interpenetrating Polymer Network Gels

2020 ◽  
pp. 289-312
Author(s):  
Junaid Khan ◽  
Amit Alexander ◽  
Ajazuddin ◽  
Swarnlata Saraf ◽  
Shailendra Saraf
Keyword(s):  
Biomedical Applications ◽  
Polymer Network ◽  
Interpenetrating Polymer Network
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