Interpenetrating Polymer Network: Biomedical Applications

2020 ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Eltjani-Eltahir Hago ◽  
Xinsong Li

In this work, a new approach was introduced to prepare interpenetrating polymer network PVA/GE hydrogels by cross-linking of various concentration gelatin in the presence of transglutaminase enzyme by using the freezing-thawing cycles technique. The effects of freezing-thawing cycles on the properties of morphological characterization, gel fraction, swelling, mechanical, and MTT assay were investigated. The IPN PVA/GE hydrogels showed excellent physical and mechanical Properties. MTT assay data and the fibroblasts culture also showed excellent biocompatibility and good proliferation. This indicates that the IPN hydrogels are stable enough for various biomedical applications.


Author(s):  
Junaid Khan ◽  
Amit Alexander ◽  
Ajazuddin ◽  
Swarnlata Saraf ◽  
Shailendra Saraf

2015 ◽  
Vol 2 (1) ◽  
pp. 21-30 ◽  
Author(s):  
Mohd Fuzail Qadri ◽  
Rishabha Malviya ◽  
Pramod Kumar Sharma

Interpenetrating polymer network (IPN) has been regarded as one of the novel technology in recent years showing the superior performances over the conventional techniques. This system is designed for the delivery of drugs at a predetermined rate and thus helps in controlled drug delivery. Due to its enhanced biological and physical characteristics like biodegradability, biocompatibility, solubility, specificity and stability, IPN has emerged out to be one of the excellent technologies in pharmaceutical industries. This article focuses mainly on the biomedical applications of IPN along with its future applicability in pharmaceutical research. It summarizes various aspects of IPN, biomedical applications and also in-cludes the different dosage forms based on IPN.


2011 ◽  
Vol 6 (4) ◽  
pp. 263-270 ◽  
Author(s):  
Neelam Jain ◽  
Pramod Kumar Sharma ◽  
Arunabha Banik ◽  
Amit Gupta ◽  
Vineet Bhardwaj

2012 ◽  
Vol 466-467 ◽  
pp. 229-233
Author(s):  
Nai Yan Zhang ◽  
Jiang Yu ◽  
Shou Jun Cai

A series of temperature- and pH-responsive poly(vinyl alcohol)/poly(N, N-diethylacrylamide-co-methacrylic acid) PVA/P(DEA-co-MAA) intelligent semi-IPN hydrogels were synthesized by free-radical copolymerization techniques and semi-interpenetrating polymer network techniques. The effects of the feed components, temperature and pH on the swelling behavior of the hydrogels were studied in detail. This unique property makes them very useful for biomedical applications such as on-off switches for modulated drug delivery and tissue engineering. With the increase of PVA content, the thermo- and pH-responsive of the semi-IPN hydrogel improved.


RSC Advances ◽  
2021 ◽  
Vol 11 (37) ◽  
pp. 22544-22555
Author(s):  
Atefeh Safaei-Yaraziz ◽  
Shiva Akbari-Birgani ◽  
Nasser Nikfarjam

The interlacing of biopolymers and synthetic polymers is a promising strategy to fabricate hydrogel-based tissue scaffolds to biomimic a natural extracellular matrix for cell growth.


Sign in / Sign up

Export Citation Format

Share Document