Applications of Selectfluor for the oxidation of Sulfides, urazoles and alcohols under the solvent-free conditions

2020 ◽  
Vol 07 ◽  
Author(s):  
Gholamabbas Chehardoli ◽  
Mohammad Ali Zolfigo ◽  
Shadpour Mallakpour
Keyword(s):  
Reaction Time ◽  
Oxidation Reaction ◽  
Room Temperature ◽  
Lone Pair ◽  
Solvent Free ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Lone Pair Electron ◽  
Work Up ◽  
Efficient Reagent

: Selectfluor acts as a safe and efficient reagent for the oxidation of urazoles, alcohols and also sulfides via releasing the electrophile F under the solvent-free conditions. In room temperature, this reagent cannot oxidize the substrates alone and requires KBr as the catalyst. In the proposed mechanism, Selectfluor converts the Br- to the Br-F and the lone-pair electron of substrates attack to Br-F to perform the oxidation reaction. This procedure offers some advantages; for example short reaction time, simple work-up, good yield and matching with some green chemistry approaches.

One-Pot, Regioselective Synthesis of Homopropargyl Alcohols using Propargyl Bromide and Carbonyl Compound by the Mg-mediated Reaction under Solvent-free Conditions

2020 ◽  
Vol 17 (6) ◽  
pp. 438-442
Author(s):  
Xiaofang Ma ◽  
Shunxi Li ◽  
Samrat Devaramani ◽  
Guohu Zhao ◽  
Daqian Xu
Keyword(s):  
Reaction Time ◽  
Organic Synthesis ◽  
Carbonyl Compounds ◽  
Solvent Free ◽  
Propargyl Bromide ◽  
Important Goal ◽  
One Pot ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Volatile Organic

The elimination of volatile organic solvents in organic synthesis is the most important goal in “Green” chemistry. We report a simple, efficient and facile method for the addition of progargyl bromide to carbonyl compounds using Mg metal as a mediator under solvent-free conditions which could regioselectively generate homopropargyl alcohols efficiently in good to excellent yields. The procedure has advantages such as short reaction time, operationally simple, excellent product yields, high regioselectivity and organic solvent-free.

scholarly journals A Facile Solvent-Free Route for One-Pot Multicomponent Synthesis of Benzylpyrazolyl Coumarins Derivatives in Presence of Effective Synergetic Catalytic System

2019 ◽  
Vol 31 (6) ◽  
pp. 1357-1361 ◽  
Author(s):  
NARENDRA R. KAMBLE ◽  
VINOD T. KAMBLE
Keyword(s):  
Room Temperature ◽  
Silver Salt ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Niobium Pentachloride ◽  
Solvent Free Conditions ◽  
Work Up ◽  
Solvent Free Reaction

A combinatorial library of benzylpyrazolyl coumarin derivatives have been synthesized by a green one-pot four-component reaction between aryl hydrazine/hydrazine hydrate (1), ethyl acetoacetate (2), aromatic aldehydes (3) and 4-hydroxycoumarin (4) catalyzed by niobium pentachloride with silver salt under solvent-free conditions has been developed. Experimental simplicity, simple work-up procedure and solvent-free reaction condition at room temperature are important features of the present protocol.

Synthesis of 1H-Chromeno[2,3-d]Pyrimidine-5-Carboxamides under Solvent-Free Conditions at Ambient Temperature

2017 ◽  
Vol 41 (2) ◽  
pp. 85-87 ◽  
Author(s):  
Ghodsyeh Keykha ◽  
Mohammad R. Hosseini-Tabatabaei ◽  
Alireza Hassanabadi
Keyword(s):  
Ambient Temperature ◽  
Present Method ◽  
Barbituric Acid ◽  
Condensation Product ◽  
Solvent Free ◽  
One Pot ◽  
Short Reaction Time ◽  
Alkyl Isocyanide ◽  
Solvent Free Conditions ◽  
Work Up

Good yields of six 1H-chromeno[2,3-d]pyrimidine-5-carboxamides were obtained via the two-stage, one-pot reaction of an alkyl isocyanide with the initially formed condensation product of 1,3-dimethyl barbituric acid and a salicylaldehyde under solvent-free conditions at ambient temperature. This procedure has a number of advantages, such as short reaction time and easy work-up. Also, the present method does not involve any hazardous organic solvent.

Rapid synthesis of homoallylic alcohol from aldehyde with allyltributylstannane under solvent-free conditions

2012 ◽  
Vol 90 (2) ◽  
pp. 167-172 ◽  
Author(s):  
Pranjal P. Bora ◽  
H. Atoholi Sema ◽  
Barisha Wahlang ◽  
Ghanashyam Bez
Keyword(s):  
Reaction Time ◽  
Phosphotungstic Acid ◽  
Catalytic Amount ◽  
Solvent Free ◽  
Reaction Conditions ◽  
Rapid Synthesis ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Solvent Free Reaction

A catalytic amount (2 mol %) of phosphotungstic acid (PTA) is sufficient to synthesize homoallylic alcohol in excellent yields from aldehyde with allyltributylstannane upon grinding under solvent-free reaction conditions. Easy handling, very short reaction time, solvent-free reaction conditions, and aqueous workup free isolation protocol may make our method very useful for synthetic chemists.

scholarly journals A Green, Expeditious, One-Pot Synthesis of 3, 4-Dihydropyrimidin-2(1H)-ones Using a Mixture of Phosphorus Pentoxide-Methanesulfonic Acid at Ambient Temperature

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Amulrao Borse ◽  
Mahesh Patil ◽  
Nilesh Patil ◽  
Rohan Shinde
Keyword(s):  
Reaction Time ◽  
Ambient Temperature ◽  
Room Temperature ◽  
Simple Procedure ◽  
Methanesulfonic Acid ◽  
Phosphorus Pentoxide ◽  
One Pot ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
High Yields

An expeditious, one-pot method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones using a mixture of phosphorus pentoxide-methanesulfonic acid (Eaton’s reagent) at room temperature under solvent-free conditions is described. The salient features of this method include short reaction time, green aspects, high yields, and simple procedure.

scholarly journals Montmorillonite K10-Catalyzed Solvent-Free Conversion of Furfural into Cyclopentenones

Catalysts ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 301 ◽  
Author(s):  
Sonia Bonacci ◽  
Monica Nardi ◽  
Paola Costanzo ◽  
Antonio De Nino ◽  
Maria Di Gioia ◽  
...  
Keyword(s):  
Reaction Time ◽  
Heterogeneous Catalysis ◽  
Heterogeneous Catalyst ◽  
Environmentally Friendly ◽  
Solvent Free ◽  
Short Reaction Time ◽  
Montmorillonite K10 ◽  
Solvent Free Conditions

A simple and eco-friendly montmorillonite K10 (MK10)-catalyzed method for the synthesis of cyclopentenone derivatives from biomass-produced furfural has been developed. The versatility of this protocol is that the reactions were performed under solvent-free conditions and in a short reaction time under heterogeneous catalysis. Montmorillonite K10 is mostly explored as a heterogeneous catalyst since it is inexpensive and environmentally friendly.

Efficient Synthesis of Novel Quinolinone Derivatives via Catalyst-free Multicomponent Reaction

2020 ◽  
Vol 17 (5) ◽  
pp. 403-407
Author(s):  
Rui Du ◽  
Liangliang Han ◽  
Zhongqiang Zhou ◽  
Victor Borovkov
Keyword(s):  
Reaction Time ◽  
Multicomponent Reaction ◽  
Room Temperature ◽  
Reaction Rates ◽  
Solvent Free ◽  
Hydroxyl Group ◽  
Efficient Synthesis ◽  
Catalyst Free ◽  
Solvent Free Conditions ◽  
Substituted Benzaldehydes

The synthesis of 3-(aryl(piperidin-1-yl)methyl)-4-hydroxyquinolin-2(1H)-one derivatives via catalyst-free multicomponent reaction is described. The reaction of 4-hydroxyquinolin-2(1H)-one, piperidine, and 4-chlorobenzaldehyde was carried out in different solvents and under solvent-free conditions at room temperature. The best solvent in terms of the yield and reaction time was found to be dichloromethane. Most substituted benzaldehydes reacted with 4-hydroxyquinolin-2(1H)-one and piperidine to afford corresponding products in good-to-excellent yields. Aldehydes with electronwithdrawing groups were more reactive to exhibit higher reaction rates. However, 2-substituted benzaldehydes did not react with 4-hydroxyquinolin-2(1H)-one and piperidine under the reaction condition. Aldehydes bearing a hydroxyl group failed to produce the corresponding products.

Multi-component synthesis of highly substituted imidazoles catalyzed by nanorod vanadatesulfuric acid

2015 ◽  
Vol 69 (11) ◽  
Author(s):  
Masoud Nasr-Esfahani ◽  
Morteza Montazerozohori ◽  
Tooba Abdizadeh
Keyword(s):  
Reaction Time ◽  
High Purity ◽  
Ammonium Acetate ◽  
Chlorosulfonic Acid ◽  
Solvent Free ◽  
One Pot ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
High Yields ◽  
Tetrasubstituted Imidazoles

AbstractNanorod vanadatesulfuric acid (VSA NRs), as a recyclable and eco-benign catalyst, was used for one-pot synthesis of 2,4,5-trisubstituted imidazoles and 1,2,4,5-tetrasubstituted imidazoles using aldehydes, benzil, benzoin or 9,10-phenanthrenequinone and ammonium acetate or aniline under solvent-free conditions providing high to excellent yields. VSA is easily prepared by a simple reaction of chlorosulfonic acid and sodium metavanadate in high purity. As compared with the conventional procedures, the present protocol offers several advantages such as simplicity of procedure, short reaction time, high yields, easy workup, recoverability and reusability of the catalyst and simple purification of the products.

Zinc Mediated Selective Acylation of Ferrocene under Solvent-Free Conditions

2007 ◽  
Vol 2007 (7) ◽  
pp. 426-428 ◽  
Author(s):  
Vishal H. Purecha ◽  
Nitin S. Nandurkar ◽  
Bhalchandra M. Bhanage ◽  
Jayashree M. Nagarkar
Keyword(s):  
Reaction Time ◽  
Carboxylic Acid ◽  
Environmentally Friendly ◽  
Operating Conditions ◽  
Solvent Free ◽  
Acyl Chloride ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Selective Acylation ◽  
Environmentally Friendly Method

A simple, convenient and environmentally-friendly method for selective acylation of ferrocene to monoacylferrocene in the presence of Zn metal under solvent-free conditions is described. The protocol requires mild operating conditions, affording higher yields of desired products both with acyl chloride/carboxylic acid within a short reaction time (15–30 min).

Facile Synthesis of 1,8-dioxooctahydro Xanthenes by Reusable Zinc Sulfide based Ternary Nanocomposite via Hydrothermal Route

2020 ◽  
Vol 9 (1) ◽  
pp. 72-79
Author(s):  
Jhansi R. Sunkara ◽  
Sathish M. Botsa
Keyword(s):  
Catalytic Activity ◽  
Reaction Time ◽  
Metal Oxide ◽  
Solvent Free ◽  
Hydrothermal Route ◽  
One Pot ◽  
Co Catalyst ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Xanthene Derivatives

Background: Metal oxide or metal oxide composite nanoparticles are attaining tremendous importance due to their catalytic activities for various organic transformations. Objective: To report the one-pot synthesis of xanthene derivatives prepared by ZnS-Fe2O3-Ag composite under solvent-free conditions. Method: To prepare nanocomposite by a facile and simple hydrothermal approach. Results: The prepared composite is smaller (17.56 nm) in size and can be easily separable, recycled and reused six times without any significant loss of catalytic activity with excellent yields. In short reaction time, great catalytic activity was perceived with no co-catalyst and any other activator. Conclusion: In conclusion, ZnS-Fe2O3-Ag composite provides a simple, economical, efficient and greener method for the synthesis of one-pot multicomponent reaction of aldehyde with 1,3-diketones under solvent free conditions for the synthesis of 1,8-dioxooctahydro xanthenes. In short reaction time, great catalytic activity was perceived with no co-catalyst and any other activator.

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