Fast Dissolving Oral Films

The aim of the review was to explore the necessity, advantages and different techniques of oral films for enhancing solubility of poorly soluble drugs with an emphasis on the newer, state-of the art technologies, such as 3D printing and hot-melt extrusion (HME). The historical background of oral films is presented along with the regularly used techniques. The modern approach of quality-by-design (QbD) is unravelled, identifying appropriate critical process parameters (CPP) and applied to oral films. A section is devoted modern technologies such as 3D printing and HME of oral films. Oral films are innovative formulations by which poorly soluble drugs have been founds to give positive results in enhancing their solubility and dissolution characteristics. With modern sophisticated techniques, precise mass production of oral films has been given a thrust. Oral films have better patient compliance, improved biopharmaceutical properties, improved efficacy, and better safety. By applying QbD and implementation of modern technologies the newer generation of oral films are yielding promising results

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Design, Optimization and Evaluation of Fast-Dissolving Oral Films of Ropinirole

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2018.11.1.3 ◽

2018 ◽

Vol 11 (1) ◽

pp. 3958-3967

Author(s):

Bhikshapathi D. V. R. N. ◽

Srinivas A

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Good Alternative ◽

In Vitro Dissolution ◽

Content Uniformity ◽

Onset Of Action ◽

Disintegration Time ◽

Peg 4000 ◽

Oral Films

The main objective of this study was to develop fast dissolving oral films of ropinirole HCl to attain quick onset of action for the better management of Parkinson’s disease. Twenty-seven formulations (F1-F27) of ropinirole oral dissolving films by solvent-casting method using 33 response surface method by using HPMC E15, Maltodextrin PEG 4000 by using Design of experiment software. Formulations were evaluated for their physical characteristics, thickness, folding endurance, tensile strength, disintegration time, drug content uniformity and drug release characteristics and found to be within the limits. Among the prepared formulations F4 showed minimum disintegration time 11 sec, maximum drug was released i.e. 99.68 ± 1.52% of drug within 10 min when compared to the other formulations and finalized as optimized formulation. FTIR data revealed that no interactions takes place between the drug and polymers used in the optimized formulation. The in vitro dissolution profiles of marketed product and optimized formulation was compared and found to be the drug released was 92.77 ± 1.52 after 50 min. Therefore, it can be a good alternative to conventional ropinirole for immediate action. In vitro evaluation of the ropinirole fast dissolving films confirmed their potential as an innovative dosage form to improve delivery and quick onset of action of ropinirole. The oral dissolving film is considered to be potentially useful for the treatment of Parkinson’s disease where quick onset of action is desired

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Pressure-assisted microsyringe 3D printing of oral films based on pullulan and hydroxypropyl methylcellulose

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2021.120197 ◽

2021 ◽

Vol 595 ◽

pp. 120197

Author(s):

M. Elbadawi ◽

D. Nikjoo ◽

T. Gustafsson ◽

S. Gaisford ◽

A.W. Basit

Keyword(s):

3D Printing ◽

Hydroxypropyl Methylcellulose ◽

Oral Films

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Development of fast dissolving oral films containing lercanidipine HCl nanoparticles in semicrystalline polymeric matrix for enhanced dissolution and ex vivo permeation

European Journal of Pharmaceutics and Biopharmaceutics ◽

10.1016/j.ejpb.2016.04.001 ◽

2016 ◽

Vol 103 ◽

pp. 179-191 ◽

Cited By ~ 28

Author(s):

Ankita D. Chonkar ◽

J. Venkat Rao ◽

Renuka S. Managuli ◽

Srinivas Mutalik ◽

Swapnil Dengale ◽

...

Keyword(s):

Ex Vivo ◽

Polymeric Matrix ◽

Enhanced Dissolution ◽

Ex Vivo Permeation ◽

Oral Films

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FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILMS OF PROCHLORPERAZINE MALEATE

INDIAN DRUGS ◽

10.53879/id.52.12.10351 ◽

2015 ◽

Vol 52 (12) ◽

pp. 23-33

Author(s):

R. Kanekar ◽

◽

P. M. Dandagi ◽

A. P. Gadad

Keyword(s):

Ex Vivo ◽

Rapid Onset ◽

Drug Release Profile ◽

Onset Of Action ◽

In Vitro Drug Release ◽

Physico Chemical ◽

Film Forming ◽

Oral Films ◽

Ex Vivo Study

The objective of the present study was to prepare and evaluate fast-dissolving oral films of prochlorperazine maleate (PCM), in order to enhance the bioavailability of the drug and to provide rapid onset of action thereby improving patient compliance. The solubility of the drug was increased by preparing inclusion complex with 2-hydroxypropyl-β-cyclodextrin (2HPβCD) and then incorporating it into the fast dissolving films. The fast-dissolving films of PCM were prepared by solvent casting method using different film forming polymers such as HPMC E15 and HPMC E5, either as single polymer or combination of the two. The film formulations were evaluated for various physico-chemical parameters. All formulations released more than 85% of the drug within 15 minutes. Formulation F4 showed best in vitro drug release profile. From the ex vivo study it was found that 94.79% of drug permeated through the porcine oral mucosa from the optimized formulation F4 within 60 mins.

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FABRICATION AND CHARACTERIZATION OF FAST DISSOLVING FILMS OF ECLIPTA PROSTRATE LEAVES EXTRACT TO TREAT MOUTH ULCERS

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2021v13i5.41597 ◽

2021 ◽

pp. 263-271

Author(s):

MANIKIRAN S. S. ◽

NAGAM SANTHI PRIYA ◽

B. AUBINE MOLLY ◽

LAKSHMI PRASANTHI NORI

Keyword(s):

Drug Release ◽

Moisture Loss ◽

Disintegration Time ◽

Weight Variation ◽

Eclipta Prostrata ◽

Release Studies ◽

Study Results ◽

The Stability ◽

Oral Films

Objective: This research focused on the design of fast dissolving herbal film of Eclipta Prostrate leaves extract for mouth ulcers. Methods: The extract of Eclipta Prostrata leaves was formulated as films by solvent casting method using various polymers viz., HPMC E5, HPMC E15, sodium alginate and PVA. The films were designed by using propylene glycol as a plasticizer, SSG as super disintegrate and honey as a sweetener. Furthermore, the films were evaluated for thickness, folding endurance, weight variation, % elongation, surface pH, % moisture uptake, % moisture loss, disintegration and in vitro drug release study. Results: The revealed that all the films were good in appearance and had a smooth texture. Out of all ten formulations, F3 and F5 disintegrated rapidly with a disintegration time of 27 and 32 seconds. The drug release studies revealed that all the formulations had a good release profile, but the F3 formulation showed rapid release i.e. 83.57% in 4 min. The stability studies revealed that the formulations F3 and F5 were found good with non-tackiness, easily separable and disintegrated at 29 and 33 sec respectively with no appearance and drug release. Conclusion: The research revealed that Eclipta prostrate leaves extract can be formulated into oral films for the treatment of mouth ulcers with improved bioavailability and expected patient compliance.

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Phospholipid-containing films for improved drug release

INFORM International News on Fats Oils and Related Materials ◽

10.21748/inform.09.2021.30 ◽

2021 ◽

pp. 30-33

Author(s):

Jiahao Huang ◽

◽

Shawn Wettig

Keyword(s):

Water Solubility ◽

Aqueous Media ◽

Active Pharmaceutical Ingredients ◽

Natural Sources ◽

Pharmaceutical Ingredients ◽

Alternative Approach ◽

Poor Water Solubility ◽

Dissolution Efficiency ◽

Oral Films ◽

Liquid Liquid Phase Separation

Phospholipids from natural sources can delay liquid-liquid phase separation and improve supersaturation for active pharmaceutical ingredients with poor water-solubility in aqueous media. Researchers have developed oral films containing phospholipids to enhance the dissolution efficiency of hydrophobic pharmaceutical ingredients. Phospholipid-based oral films provide an alternative approach for compounding pharmacies to formulate drugs with poor water solubility.

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