Effects of Capsosiphon fulvescens Extracts on Anti-oxidant Activity and anti-inflammatory action

Resveratrol (3,4′,5-trihy- droxystilbene), a natural phytoalexin polyphenol, exhibits anti-oxidant, anti-inflammatory, and anti-carcinogenic properties. This phytoalexin is well-absorbed and rapidly and extensively metabolized in the body. Inflammation is an adaptive response, which could be triggered by various danger signals, such as invasion by microorganisms or tissue injury. In this review, the anti-inflammatory activity and the mechanism of resveratrol modulates the inflammatory response are examined. Multiple experimental studies that illustrate regulatory mechanisms and the immunomodulatory function of resveratrol both in vivo and in vitro. The data acquired from those studies are discussed.

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Bioguided determination of the anti-inflammatory action of STW 5 and STW 6

Planta Medica ◽

10.1055/s-0028-1084154 ◽

2008 ◽

Vol 74 (09) ◽

Author(s):

K Nieber ◽

S Michael ◽

K Grötzinger ◽

JW Rauwald ◽

SN Okpanyi ◽

...

Keyword(s):

Anti Inflammatory ◽

Inflammatory Action

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The anti-inflammatory action of the herbal preparation STW5-II in normal human colonic mucosal cells

Planta Medica ◽

10.1055/s-0035-1565713 ◽

2015 ◽

Vol 81 (16) ◽

Author(s):

MJ Schmidt ◽

H Abdel-Aziz ◽

T Efferth

Keyword(s):

Herbal Preparation ◽

Mucosal Cells ◽

Normal Human ◽

Anti Inflammatory ◽

Inflammatory Action

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Evaluation of anti-pyretic activity of Dracaena sanderiana by Brewer’s yeast method

International Journal of Novel Trends in Pharmaceutical Sciences ◽

10.26452/ijntps.v9i2.1200 ◽

2020 ◽

Vol 9 (2) ◽

pp. 32-34

Author(s):

Pavani C H

Keyword(s):

Herbal Remedies ◽

Standard Drug ◽

Chemical Substances ◽

Beneficial Effects ◽

Potential Value ◽

Plant Effects ◽

Therapeutic Properties ◽

Dracaena Sanderiana ◽

Anti Inflammatory ◽

Inflammatory Action

These medicinal plants are used to develop a therapy for the disease. To improve the science, investigate the scientific proof and activities validation, therefore the use of various herbal remedies for their pain-relieving and anti-inflammatory action in these current days. includes influence, anti-inflammatory, anti effect, analgesia, effects and some beneficial effects on the GI system. show the potential value of pain relief, cancer prevention and weight loss. According to these plant effects, consider that this present study was mainly based on to investigate and likely to reduce the fever caused by the outdoor and indoor. potential of is evidenced in leave studies. The medicinal plant produces a variety of chemical substances which shows significant therapeutic properties with the standard drug paracetamol.

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Pharmacologically potentials of different substituted coumarin derivatives

10.31221/osf.io/w6hdg ◽

2019 ◽

Cited By ~ 1

Author(s):

Chem Int

Keyword(s):

Benzene Ring ◽

Bioactive Compounds ◽

Biological Activities ◽

Pharmacological Properties ◽

Coumarin Derivatives ◽

Wide Range ◽

Anti Oxidant ◽

Anti Inflammatory ◽

Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

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Pentoxifylline and Oxypurinol: Potential Drugs to Prevent the “Cytokine Release (Storm) Syndrome” Caused by SARS-CoV-2?

Current Pharmaceutical Design ◽

10.2174/1381612826666200811180232 ◽

2020 ◽

Vol 26 (35) ◽

pp. 4515-4521

Author(s):

Francisco J. López-Iranzo ◽

Ana M. López-Rodas ◽

Luis Franco ◽

Gerardo López-Rodas

Keyword(s):

Lung Parenchyma ◽

Interstitial Tissue ◽

Cytokine Release ◽

Phase I Clinical Trials ◽

Infected People ◽

Tnf Α ◽

Transient Loss ◽

Anti Inflammatory ◽

And Control ◽

Inflammatory Action

Background: COVID-19, caused by SARS-CoV-2, is a potentially lethal, rapidly-expanding pandemic and many efforts are being carried out worldwide to understand and control the disease. COVID-19 patients may display a cytokine release syndrome, which causes severe lung inflammation, leading, in many instances, to death. Objective: This paper is intended to explore the possibilities of controlling the COVID-19-associated hyperinflammation by using licensed drugs with anti-inflammatory effects. Hypothesis: We have previously described that pentoxifylline alone, or in combination with oxypurinol, reduces the systemic inflammation caused by experimentally-induced pancreatitis in rats. Pentoxifylline is an inhibitor of TNF-α production and oxypurinol inhibits xanthine oxidase. TNF-α, in turn, activates other inflammatory genes such as Nos2, Icam or IL-6, which regulate migration and infiltration of neutrophils into the pulmonary interstitial tissue, causing injury to the lung parenchyma. In acute pancreatitis, the anti-inflammatory action of pentoxifylline seems to be mediated by the prevention of the rapid and presumably transient loss of PP2A activity. This may also occur in the hyperinflammatory -cytokine releasing phase- of SARS-CoV-2 infection. Therefore, it may be hypothesized that early treatment of COVID-19 patients with pentoxifylline, alone or in combination with oxypurinol, would prevent the potentially lethal acute respiratory distress syndrome. Conclusion: Pentoxifylline and oxypurinol are licensed drugs used for diseases other than COVID-19 and, therefore, phase I clinical trials would not be necessary for the administration to SARS-CoV-2- infected people. It would be worth investigating their potential effects against the hyperinflammatory response to SARS-CoV-2 infection.

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Effects of Gentiana lutea root on vascular diseases

Current Vascular Pharmacology ◽

10.2174/1570161118666200529111314 ◽

2020 ◽

Vol 18 ◽

Author(s):

Gordana Joksic ◽

Djordje Radak ◽

Emina Sudar-Milovanovic ◽

Milan Obradovic ◽

Jelena Radovanovic ◽

...

Keyword(s):

Recent Literature ◽

Vascular Diseases ◽

Lipid Lowering ◽

Primary Data ◽

Electronic Database ◽

Active Components ◽

Gentiana Lutea ◽

Search Terms ◽

Anti Oxidant ◽

Anti Inflammatory

Background: Gentiana lutea (GL), commonly known as yellow gentian, bitter root, and bitterwort, belongs to family Gentianaceae. GL belongs to genus Gentiana, which is a rich natural source of iridoids, secoiridoids, xantones, flavonoids, triterpenoids, and carbohydrates. Medicinal plants from Gentiana species have anti-oxidant, anti-inflammatory, anti-mitogenic, anti-proliferative, and lipid-lowering effects, as well as a cardioprotective, hypotensive, vasodilator and anti-platelet activities. Objective: We reviewed the recent literature related to the effects of Gentiana species, and their active components on vascular diseases. Methods: Data used for this review were obtained by searching the electronic database [PUBMED/MEDLINE 1973 - February 2020]. The primary data search terms of interest were: Gentiana lutea, Gentienacea family, phytochemistry, vascular diseases, treatment of vascular diseases, anti-oxidant, anti-inflammatory, anti-atherogenic. Conclusion: Gentiana species and their constituents affect many different factors related to vascular disease development and progression. Therefore, Gentiana-based therapeutics represent potentially useful drugs for the management of vascular diseases.

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