scholarly journals Acute ST elevation myocardial infarction (STEMI) in Young Male with Nephrotic Syndrome: A case report

2021 ◽  
Vol 2 (3) ◽  
pp. 31-34
Author(s):  
Ratna Pancasari ◽  
Cholid Tri Tjahjono ◽  
Anna Fuji Rahimah ◽  
Indra Prasetya
Keyword(s):  
Myocardial Infarction ◽  
Nephrotic Syndrome ◽  
Coronary Thrombosis ◽  
Laboratory Data ◽  
Young Patients ◽  
Young Male ◽  
Young Males ◽  
History Of ◽  
St Elevation ◽  
Electrocardiogram Ecg

Background: In young males, an acute myocardial infarction is an uncommon event. Thrombolism caused by nephrotic syndrome (NS) is one of the pathophysiologies of their infarctions. Case Illustration: A-24-y.o male patient, presenting with prolong typical chest pain since 72 hours before admission. The chest leads on an electrocardiogram (ECG) indicated ST-Elevation. Cardiac troponin was significantly raised. Since the previous two weeks, he has been experiencing nephrotic syndrome symptoms including anasarca edema.It was supported by laboratory data which is obtained proteinuria, hyperlipidemia and hypoalbuminemia. A complete acute occlusion of the proximal portion of the left anterior descending artery was revealed by coronary angiography. Increased fibrinogen levels appeared to be a contributing factor for hypercoagulable state in this patient, implying a correlation between coronary thrombosis and nephrotic syndrome. Discussion: Myocardial infarction (MI) is rare in young males, but it occurs 8 times more often in patients with NS than in the general population. Clinicians should pay closer attention to the history of previous diseases with a high risk of thromboembolism in young patients with MI, and they should specifically promote thromboembolism prevention and care in patients with renal disease to decrease the incidence of thromboembolism complications. Conclusion: Nephrotic syndrome should be considered as a contributing factor in any patient presenting with acute STEMI, particularly in young males.

scholarly journals Acute anterior myocardial infarction in a 22-year-old male nephrotic patient along with familial hyperlipidaemia

2018 ◽  
Vol 28 (11) ◽  
pp. 1348-1352 ◽  
Author(s):  
Junzhong Zeng ◽  
Jinhua Li ◽  
Jiyu Zhang
Keyword(s):  
Myocardial Infarction ◽  
Nephrotic Syndrome ◽  
Young Patients ◽  
Acute Chest Pain ◽  
Anterior Myocardial Infarction ◽  
Coronary Syndrome ◽  
Increased Risk ◽  
Nephrotic Patient ◽  
History Of ◽  
St Elevation

AbstractWe report a case of acute myocardial infarction in a nephrotic male patient. A 22-year-old man with a 1-year history of nephrotic syndrome due to membranous nephropathy presented with acute chest pain and was admitted to our emergency room. An electrocardiogram showed ST elevation in leads consistent with anterior and inferior myocardial infarction. Subsequent cardiac catheterisation showed evidence of thrombotic occlusion of the anterior descending coronary artery. The patient had no long history of hypercholesterolaemia or hypertriglyceridaemia. The case suggests that young patients with a short-term nephrotic syndrome may be at an increased risk for acute coronary syndrome owing to hypercoagulability state.

The E27 β2-adrenergic Receptor Polymorphism Reduces the Risk of Myocardial Infarction in Dyslipidemic Young Males

2001 ◽  
Vol 85 (02) ◽  
pp. 231-233 ◽  
Author(s):  
Gianluca Sala ◽  
Augusto Di Castelnuovo ◽  
Laura Cuomo ◽  
Marinella Gattone ◽  
Pantaleo Giannuzzi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Relative Risk ◽  
Adrenergic Receptor ◽  
Young Male ◽  
First Episode ◽  
Control Group ◽  
Entire Study ◽  
Young Males ◽  
History Of ◽  
Β2 Adrenergic Receptor

SummaryIn the present study we evaluated whether two polymorphisms of β2-adrenergic receptors (β2-AR) gene (R16G and Q27E) could modify the risk of myocardial infarction (MI).Using a case-control design, we analyzed the data from 125 male patients who had experienced a first episode of MI before the age of 45 years and 108 male controls matched for age. The allele frequencies for R16G and Q27E were: G16=0.56 and E27=0.36 in patients with MI and G16=0.61 and E27=0.42 in the control group. There was a trend (not statistically significant) of decreasing MI risk according to E27 or G16 alleles. Combined effect between E27 allele and history of dyslipidemia has been observed. Whereas dyslipidemia conferred a relative risk of MI of 4.8 (P<0.001) compared with normolipidemia in the entire study population, the relative risk increased to 9.0 (P<0.001) in Q27 homozygotes with dyslipidemia, and decreased to 1.8 (P=0.36) in E27 homozygotes.Our results show that the E27 allele of the β2-adrenergic receptor has a significant protective effect on MI in dyslipidemic young male.

scholarly journals Recurrent Episodes of ST-Elevation Myocardial Infarction in a 19-Year-Old Male with Fontan Circulation

2021 ◽  
Vol 7 (2) ◽  
Author(s):  
Alghammass MA ◽  
◽  
Drakos SG ◽  
Lal AK ◽  
Martinez HD ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Single Ventricle ◽  
Fontan Procedure ◽  
Young Patients ◽  
Coronary Intervention ◽  
St Segment Elevation ◽  
St Segment ◽  
Percutaneous Coronary ◽  
History Of ◽  
St Elevation

We describe a case of a 19-year-old male with history of single ventricle physiology status post-Fontan procedure at the age of two who developed thromboembolic phenomena involving his splenic, renal and coronary arteries resulting in multiple infarcts and recurrent in-hospital acute ST-Segment Elevation Myocardial Infarction (STEMI) treated by emergent Percutaneous Coronary Intervention (PCI). This case highlights multiple aspects and challenges of managing young patients with congenital heart disease.

C0347 Thrombin binding to platelets of young patients with a history of acute myocardial infarction

2012 ◽  
Vol 130 ◽  
pp. S104
Author(s):  
Grazia Loredana Mendolicchio ◽  
Monica Bacci ◽  
Dennis Zavalloni ◽  
Lidia Rota ◽  
Zaverio Marcello Ruggeri
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Young Patients ◽  
History Of

scholarly journals Role of Th17-cell related cytokines in geriatric asthma

2018 ◽  
Vol 47 (2) ◽  
pp. 580-590 ◽  
Author(s):  
Zhang Quan-san ◽  
Xu Xiaohong ◽  
Li ying ◽  
Sun Zhaojia
Keyword(s):  
Pulmonary Function ◽  
Geriatric Patients ◽  
Immunoglobulin E ◽  
Airway Remodeling ◽  
Normal Population ◽  
Young Patients ◽  
Young Male ◽  
Asthma Control Test ◽  
Young Males ◽  
Male Patients

Objective This study aimed to investigate the pathogenesis of geriatric asthma through immunoglobulin E (IgE), interleukin-17A (IL-17A), IL-17F, and glucocorticoid receptor-β (GR-β) expression. Methods We studied 51 geriatric male patients with asthma and 50 young male patients with asthma. We also included 21 normal geriatric males and 21 normal young males. All geriatric and young patients were divided into groups according to pulmonary function. Levels of cytokines, such as IgE, IL-17A, IL-17F, and GR-β, were measured. Pulmonary function was assessed. The results from patients were compared with those from the 42 healthy subjects. Results Serum IgE, IL-17A, IL-17F, and GR-β levels in geriatric patients with moderate or severe asthma were significantly higher than those in young patients with moderate asthma and in the normal population. Geriatric patients with asthma had higher asthma control test scores than did young patients with asthma. Conclusion Hormone resistance in geriatric male patients with asthma is more serious than that in young male patients with asthma. Airway inflammation and airway remodeling in geriatric male patients with asthma may be more serious than those in young male patients with asthma, even when there is similar pulmonary function.

scholarly journals Elderly Asian Patients Have Lower Revascularisation Rates and Poorer Outcomes for ST-Elevation Myocardial Infarction Compared to Younger Patients

2020 ◽  
Vol 49 (1) ◽  
pp. 3-14
Author(s):  
James X Cai ◽  
Jonathan Yap ◽  
Fei Gao ◽  
Tian Hai Koh ◽  
Khim Leng Tong ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Elderly Patients ◽  
Young Patients ◽  
Coronary Intervention ◽  
St Elevation Myocardial Infarction ◽  
Younger Patients ◽  
Asian Patients ◽  
Percutaneous Coronary ◽  
St Elevation

Introduction: There is limited information on elderly patients presenting with ST elevation myocardial infarction (STEMI). This study aimed to study the outcomes of elderly Asian patients with STEMI compared to younger patients. Materials and Methods: The study utilised data from 2007 to 2012 from the Singapore Myocardial Infarction Registry, a mandatory national population-based registry. Elderly patients were defined as ≥80 years of age, middle-aged to old (MAO) patients were defined as 45–80 years of age and young patients were defined as ≤45 years of age. The primary outcome of the study was 1-year mortality and secondary outcomes included in-hospital complications and mortality. Results: There were 12,409 STEMI patients with 1207 (9.7%) elderly patients, 10,093 (81.3%) MAO patients and 1109 (8.9%) young patients. Elderly patients had more cardiovascular risk factors and lower rates of total percutaneous coronary intervention (26.0% vs 72.4% vs 85.5%, respectively; P <0.0001) compared to MAO and young patients. They had higher 1-year mortality (60.6% vs 18.3% vs 4.1%, respectively; P <0.0001) when compared to MAO and young patients. Conclusion: Elderly patients with STEMI have poorer outcomes than MAO and young patients. This is potentially attributable to a myriad of factors including age, higher burden of comorbidities and a lesser likelihood of receiving revascularisation and guideline-recommended medical therapy. Keywords: Coronary artery bypass graft, Percutaneous coronary intervention

scholarly journals Younger age of patients with myocardial infarction correlates with higher number of relatives with history of premature atherosclerosis

2020 ◽  
Author(s):  
Michał Ambroziak ◽  
Katarzyna Niewczas-Wieprzowska ◽  
Agnieszka Maicka ◽  
Andrzej Budaj
Keyword(s):  
Myocardial Infarction ◽  
Family History ◽  
Young Patients ◽  
Significant Risk ◽  
Control Group ◽  
Premature Coronary Artery Disease ◽  
Premature Atherosclerosis ◽  
Global Issues ◽  
Younger Age ◽  
History Of

Abstract Background. Premature coronary artery disease belongs to the most pressing global issues in a modern cardiology. Family history appears to be one of the most important and significant risk factors in young patients with myocardial infarction (MI). The aim of the study was to investigate the role of family history of premature cardiovascular disease (CVD) in patients <50 years with myocardial infarction (MI) compared to patients ≥ 50 years with MI and to young healthy people.Methods. The studied group (MI<50) consisted of 240 patients aged 26-49 years with MI. The control groups consisted of 240 patients (MI≥50) with MI aged 50-92 years and 240 healthy people aged 30-49 years.Results. There were statistically significant differences between the MI<50 and MI≥50 and young healthy groups regarding family history of premature MI/ischaemic stroke and percent of patients with of ≥2 relatives affected including parents, children, siblings, siblings of parents and grandparents (10.8%, 2.9%, 3.7%, respectively; p<0.0001). There was a statistically significant negative correlation between the age of the first episode of MI and the number of relatives with a history of premature MI/stroke (r=0.249, p<0.05) within all MI patients. Statistically significant differences between MI<50 and MI≥50 groups as well as young healthy control group were revealed regarding prevalence of smoking, body mass index (BMI), LDL, HDL, triglycerides (TG) and glucose levels.Conclusions. Younger age of patients with myocardial infarction correlates with a higher number of relatives with a history of premature MI/ischemic stroke. Thus, the family history of premature atherosclerosis involving not only the first-, but also the second-degree relatives, seems to be valuable and could be considered in an individual CVD risk evaluation in young people.

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