scholarly journals Role of Th17-cell related cytokines in geriatric asthma

2018 ◽  
Vol 47 (2) ◽  
pp. 580-590 ◽  
Author(s):  
Zhang Quan-san ◽  
Xu Xiaohong ◽  
Li ying ◽  
Sun Zhaojia
Keyword(s):  
Pulmonary Function ◽  
Geriatric Patients ◽  
Immunoglobulin E ◽  
Airway Remodeling ◽  
Normal Population ◽  
Young Patients ◽  
Young Male ◽  
Asthma Control Test ◽  
Young Males ◽  
Male Patients

Objective This study aimed to investigate the pathogenesis of geriatric asthma through immunoglobulin E (IgE), interleukin-17A (IL-17A), IL-17F, and glucocorticoid receptor-β (GR-β) expression. Methods We studied 51 geriatric male patients with asthma and 50 young male patients with asthma. We also included 21 normal geriatric males and 21 normal young males. All geriatric and young patients were divided into groups according to pulmonary function. Levels of cytokines, such as IgE, IL-17A, IL-17F, and GR-β, were measured. Pulmonary function was assessed. The results from patients were compared with those from the 42 healthy subjects. Results Serum IgE, IL-17A, IL-17F, and GR-β levels in geriatric patients with moderate or severe asthma were significantly higher than those in young patients with moderate asthma and in the normal population. Geriatric patients with asthma had higher asthma control test scores than did young patients with asthma. Conclusion Hormone resistance in geriatric male patients with asthma is more serious than that in young male patients with asthma. Airway inflammation and airway remodeling in geriatric male patients with asthma may be more serious than those in young male patients with asthma, even when there is similar pulmonary function.

scholarly journals HUBUNGAN TGF-β1 DAN ESTROGEN DENGAN VOLUME PROSTAT PADA PASIEN BPH, PASIEN TUA NON BPH, DAN PASIEN MUDA

1970 ◽  
Vol 16 (1) ◽  
Author(s):  
Boyke Soebhali ◽  
Soetojo Soetojo ◽  
Doddy M Soebadi ◽  
Hendromartono Hendromartono ◽  
Widodo J P
Keyword(s):  
Patient Group ◽  
Strong Correlation ◽  
Prostate Volume ◽  
Young Patients ◽  
Young Male ◽  
Old Patients ◽  
Estrogen Level ◽  
Male Patients ◽  
Tgf Β1

Objective: To determine the correlation of TGF-b1 and estrogen with prostate volume in BPH patients, old patients without BPH and young patients. Materials and methods: We enrolled 30 patients and allocated them into three groups. First group consists of BPH patients, second group consists of old male patients with more than 55 years of age, and third group consists of young male patients with less than 40 years of age. We analyzed the level of TGF-b1 and estrogen in these patients. Transrectal USG was used to measure the prostate volume. We analyzed the correlations of TGF-b1 and estrogen level with prostate volume. Results: We found a positive strong correlation between estrogen and prostate volume in the BPH patient group (p=0,021; r coeff=0,786). Other group showed no significant correlations. Conclusion: Estrogen plays an important role in BPH pathophysiology. Further research on the influence of estrogen in BPH patients is recommended.

scholarly journals Acute ST elevation myocardial infarction (STEMI) in Young Male with Nephrotic Syndrome: A case report

2021 ◽  
Vol 2 (3) ◽  
pp. 31-34
Author(s):  
Ratna Pancasari ◽  
Cholid Tri Tjahjono ◽  
Anna Fuji Rahimah ◽  
Indra Prasetya
Keyword(s):  
Myocardial Infarction ◽  
Nephrotic Syndrome ◽  
Coronary Thrombosis ◽  
Laboratory Data ◽  
Young Patients ◽  
Young Male ◽  
Young Males ◽  
History Of ◽  
St Elevation ◽  
Electrocardiogram Ecg

Background: In young males, an acute myocardial infarction is an uncommon event. Thrombolism caused by nephrotic syndrome (NS) is one of the pathophysiologies of their infarctions. Case Illustration: A-24-y.o male patient, presenting with prolong typical chest pain since 72 hours before admission. The chest leads on an electrocardiogram (ECG) indicated ST-Elevation. Cardiac troponin was significantly raised. Since the previous two weeks, he has been experiencing nephrotic syndrome symptoms including anasarca edema.It was supported by laboratory data which is obtained proteinuria, hyperlipidemia and hypoalbuminemia. A complete acute occlusion of the proximal portion of the left anterior descending artery was revealed by coronary angiography. Increased fibrinogen levels appeared to be a contributing factor for hypercoagulable state in this patient, implying a correlation between coronary thrombosis and nephrotic syndrome. Discussion: Myocardial infarction (MI) is rare in young males, but it occurs 8 times more often in patients with NS than in the general population. Clinicians should pay closer attention to the history of previous diseases with a high risk of thromboembolism in young patients with MI, and they should specifically promote thromboembolism prevention and care in patients with renal disease to decrease the incidence of thromboembolism complications. Conclusion: Nephrotic syndrome should be considered as a contributing factor in any patient presenting with acute STEMI, particularly in young males.

Case report of a 27-year-old male with DCIS

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e11635-e11635
Author(s):  
C. Hamm ◽  
C. Coroneos
Keyword(s):  
Family History ◽  
Ductal Carcinoma ◽  
Young Male ◽  
Strong Family History ◽  
Brca1 And Brca2 ◽  
Young Males ◽  
History Of ◽  
Male Patients ◽  
History Of Cancer

e11635 DCIS in a young male is rarely reported. Our patient is a 25 year old male who presented with symptomatic unilateral gynecomastia. He presented with a strong family history of cancer on both maternal and paternal sides of his family including breast, lung (maternal) and melanoma, colon and pancreatic (paternal). His mother tested negative for BRCA1 and BRCA2. There is no information on the paternal genetic testing. He was treated with left subcutaneous mastectomy. Upon histologic review of the sample, concurrent gyecomastia and ductal carcinoma in situ was discovered. To date, only four cases of gynecomastia and DCIS have been described in younger male patients. Since only 30 - 50% of patients with DCIS eventually develop invasive cancer in the subsequent 10 - 20 years, this figure in the general population may be higher. This case underscores the importance of family history in any patient presenting with a breast mass. Patients must be made aware of the risk, however small it may be and physicians must remain cautious of malignancy in young males with gynecomastia. No significant financial relationships to disclose.

scholarly journals Immunologic Pathophysiology and Airway Remodeling Mechanism in Severe Asthma: Focused on IgE-Mediated Pathways

Diagnostics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 83
Author(s):  
Shih-Lung Cheng
Keyword(s):  
Severe Asthma ◽  
Immunoglobulin E ◽  
Airway Remodeling ◽  
Real Life ◽  
Allergic Diseases ◽  
Proinflammatory Mediators ◽  
Small Subgroup ◽  
Humanized Monoclonal Antibody ◽  
Severe Allergic Asthma ◽  
Ige Mediated

Despite the expansion of the understanding in asthma pathophysiology and the continual advances in disease management, a small subgroup of patients remains partially controlled or refractory to standard treatments. Upon the identification of immunoglobulin E (IgE) and other inflammatory mediators, investigations and developments of targeted agents have thrived. Omalizumab is a humanized monoclonal antibody that specifically targets the circulating IgE, which in turn impedes and reduces subsequent releases of the proinflammatory mediators. In the past decade, omalizumab has been proven to be efficacious and well-tolerated in the treatment of moderate-to-severe asthma in both trials and real-life studies, most notably in reducing exacerbation rates and corticosteroid use. While growing evidence has demonstrated that omalizumab may be potentially beneficial in treating other allergic diseases, its indication remains confined to treating severe allergic asthma and chronic idiopathic urticaria. Future efforts may be bestowed on determining the optimal length of omalizumab treatment, seeking biomarkers that could better predict treatment response and as well as extending its indications.

scholarly journals Relating Reactive and Proactive Aggression to Trait Driving Anger in Young and Adult Males: A Pilot Study Using Explicit and Implicit Measures

2021 ◽  
Vol 13 (4) ◽  
pp. 1850
Author(s):  
Veerle Ross ◽  
Nora Reinolsmann ◽  
Jill Lobbestael ◽  
Chantal Timmermans ◽  
Tom Brijs ◽  
...  
Keyword(s):  
Pilot Study ◽  
Cognitive Biases ◽  
Young Male ◽  
Proactive Aggression ◽  
Implicit Measures ◽  
Adult Males ◽  
Young Males ◽  
Targeted Interventions ◽  
Driving Anger ◽  
Reactive And Proactive Aggression

Driving anger and aggressive driving are main contributors to crashes, especially among young males. Trait driving anger is context-specific and unique from other forms of anger. It is necessary to understand the mechanisms of trait driving anger to develop targeted interventions. Although literature conceptually distinguished reactive and proactive aggression, this distinction is uncommon in driving research. Similar, cognitive biases related to driving anger, measured by a combination of explicit and implicit measures, received little attention. This pilot study related explicit and implicit measures associated with reactive and proactive aggression to trait driving anger, while considering age. The sample consisted of 42 male drivers. The implicit measures included a self-aggression association (i.e., Single-Target Implicit Association Test) and an attentional aggression bias (i.e., Emotional Stroop Task). Reactive aggression related positively with trait driving anger. Moreover, a self-aggression association negatively related to trait driving anger. Finally, an interaction effect for age suggested that only in young male drivers, higher proactive aggression related to lower trait driving anger. These preliminary results motivate further attention to the combination of explicit and implicit measures related to reactive and proactive aggression in trait driving anger research.

scholarly journals Compartment Syndrome: an Acute Femoral Stress Fracture in a Young Male Athlete

2021 ◽  
Author(s):  
Amelie Kanovsky ◽  
Ernst J. Mueller
Keyword(s):  
Compartment Syndrome ◽  
Muscle Mass ◽  
Stress Fracture ◽  
Acute Stress ◽  
Young Male ◽  
Young Males ◽  
Fatigued Muscle ◽  
Fracture Osteosynthesis ◽  
Initial Fracture ◽  
The Right

AbstractThe incidence of an acute compartment syndrome (ACS) of the thigh is less than 1%. It is most common in the setting of muscle overuse or muscle injury, as well as secondary to trauma, such as a femoral fracture. We present a case of an ACS in a young, healthy, and semiprofessional athlete with normal coagulation who sustained an acute stress fracture of the distal femur. After the initial fracture osteosynthesis, the patient suffered from a compartment syndrome in the right anterior aspect of the distal thigh. Following rapid surgical fasciotomy, the case was uneventful, and he returned to his preinjury sport level without any neurological consequences. This case confirms that ACS in the thigh is rare, but mainly occurs in young males with a large muscle mass due to participation in various athletic programs. We hypothesize that constant muscle over-usage primes for a larger amount of contused and protruding muscle mass in the small femoral compartment. Hence, the fatigued muscle subjects the bone to an increased mechanical force resulting in an overloading process. This ensues the accumulation of femoral microfractures and primes for the occurrence of an increased rate of stress fractures and an ACS in the thigh.

68 – Neurophysiological profile (EEG, auditory ERP) in the first episode young male patients

2008 ◽  
Vol 98 ◽  
pp. 61-62
Author(s):  
I. Lebedeva ◽  
V. Kaleda ◽  
A. Barkhatova ◽  
M. Omelchenko ◽  
S. Golubev
Keyword(s):  
Young Male ◽  
First Episode ◽  
Male Patients ◽  
Auditory Erp

Lumbar epidural hematoma associated with spondylolyses

2008 ◽  
Vol 8 (2) ◽  
pp. 174-180 ◽  
Author(s):  
Chima O. Ohaegbulam ◽  
Ian F. Dunn ◽  
Pierre d'Hemecourt ◽  
Mark R. Proctor
Keyword(s):  
Epidural Hematoma ◽  
Surgical Intervention ◽  
Relevant Literature ◽  
Young Male ◽  
Active Patient ◽  
Male Patients

✓ This report describes 3 young male patients with multiple lumbar spondylolyses in combination with a symptomatic epidural hematoma. The records of all 3 patients were reviewed for clinical details. All patients were successfully treated without surgical intervention. Initial neuroimaging results for all patients revealed epidural hematomas, and follow-up imaging confirmed resolution of the hematomas. The relevant literature is briefly reviewed to examine the rarity of this combination. Spontaneous epidural hematomas may occur in the setting of spondylolysis, and this diagnosis should be considered when imaging reveals an unusual epidural lesion in a young active patient.

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