scholarly journals Stimulation of Distraction Osteogenesis in Limb Lengthening: Our Concept

2021 ◽  
Vol 27 (1) ◽  
pp. 75-85
Author(s):  
V. I. Shevtsov ◽  
S. S. Leonchuk
Keyword(s):  
Soft Tissue ◽  
Distraction Osteogenesis ◽  
Treatment Time ◽  
Experimental Studies ◽  
Limb Lengthening ◽  
Duration Of Treatment ◽  
Slowing Down ◽  
Intramedullary Rod ◽  
Using Data ◽  
Stimulation Of

Background. Currently, limb lengthening is a widespread operation used in clinical and cosmetic practice. However, in the process of implementing this technology, its main drawbacks were revealed: the duration of treatment and the slowing down of the process of osteogenesis in the elongation zone. Rapid distraction in the external fixator or with an intramedullary rod can lead to a slowdown in osteogenesis and soft tissue complications, including neuropathy and soft tissue eruption.The aim — to develop a present its own concept of stimulating distraction osteogenesis in limb elongation, based on many years of clinical experience.Materials and Methods. This study is based on the long-term experience of the Ilizarov Center in limb lengthening (using data from clinical and experimental studies performed in the institution: more than 200 animals and 8000 patients), as well as literature data.Results. The introduction of the considered methods of stimulation of osteogenesis made it possible to significantly reduce the treatment time of patients and thereby reduce the number of possible complications characteristic of transosseous osteosynthesis. Systemic diseases, congenital malformation of the segment can negatively affect the quality of the new bone.Conclusions. The use of methods of stimulation of osteogenesis allows to reduce treatment time and increase osteogenesis when limb lengthening, which allows, if necessary, to provide re-lengthening of the segment without increasing treatment time.

Diagnostics of metal samples using the results of experimental and theoretical study of positively charged microparticles formed upon sample destruction

2018 ◽  
Vol 84 (10) ◽  
pp. 23-28
Author(s):  
D. A. Golentsov ◽  
A. G. Gulin ◽  
Vladimir A. Likhter ◽  
K. E. Ulybyshev
Keyword(s):  
Experimental Data ◽  
Early Stage ◽  
Experimental Studies ◽  
Material Model ◽  
Total Charge ◽  
Cross Sectional ◽  
Practical Applications ◽  
Mechanical And Electrical Properties ◽  
Order Of Magnitude ◽  
Using Data

Destruction of bodies is accompanied by formation of both large and microscopic fragments. Numerous experiments on the rupture of different samples show that those fragments carry a positive electric charge. his phenomenon is of interest from the viewpoint of its potential application to contactless diagnostics of the early stage of destruction of the elements in various technical devices. However, the lack of understanding the nature of this phenomenon restricts the possibility of its practical applications. Experimental studies were carried out using an apparatus that allowed direct measurements of the total charge of the microparticles formed upon sample rupture and determination of their size and quantity. The results of rupture tests of duralumin and electrical steel showed that the size of microparticles is several tens of microns, the particle charge per particle is on the order of 10–14 C, and their amount can be estimated as the ratio of the cross-sectional area of the sample at the point of discontinuity to the square of the microparticle size. A model of charge formation on the microparticles is developed proceeding from the experimental data and current concept of the electron gas in metals. The model makes it possible to determine the charge of the microparticle using data on the particle size and mechanical and electrical properties of the material. Model estimates of the total charge of particles show order-of-magnitude agreement with the experimental data.

scholarly journals Intermolar Mandibular Distraction Osteogenesis—A Preliminary Report

2021 ◽  
Vol 11 (9) ◽  
pp. 4118
Author(s):  
Suen A. N. Lie ◽  
Britt H. B. T. Engelen ◽  
Veronique C. M. L. Timmer ◽  
Nico M. P. Vrijens ◽  
Paolo Asperio ◽  
...  
Keyword(s):  
Distraction Osteogenesis ◽  
Treatment Time ◽  
Average Length ◽  
Case Series ◽  
Growth Spurt ◽  
Overall Treatment Time ◽  
Mandibular Distraction ◽  
Mandibular Distraction Osteogenesis ◽  
Root Fractures

Background: Dental Class II is the most common indication for combined orthodontic-orthognathic treatment. Intermolar mandibular distraction osteogenesis (IMDO) treatment was performed during the growth spurt, to avoid surgery at a later age. The aim of this study is to present our first experience with IMDO. Methods: This is a retrospective case series of patients who underwent an IMDO. All patients showed mandibular retrognathism, and orthodontic treatment with functional appliances was not successful. Results: In total, 20 patients (mean age of 14.8 years (SD = 0.9 ys) were included. All patients achieved a Class I occlusion. An average length gain of 9.6 mm (SD = 3.7 mm) was reached. In one patient an abscess occurred. Nine patients presented with root fractures of the second molar; three were lost, one treated endodontically. The average time between insertion and removal of the distractors was 4.6 months (SD = 1.5 mths). In one case a premature consolidation was seen. Conclusion: We achieved satisfactory results with IMDO, although undesirable effects occurred. An advantage is the manageable overall treatment time. Open questions concern the occurrence of root fractures. Furthermore, the question of long-term stability is open. The question of dynamic distraction treatment in relation to temporomandibular joint changes can only be answered in the long term.

scholarly journals Automating Skeletal Expansion: An Implant for Distraction Osteogenesis of the Mandible

2009 ◽  
Vol 3 (1) ◽  
Author(s):  
John C. Magill ◽  
Marten F. Byl ◽  
Batya Goldwaser ◽  
Maria Papadaki ◽  
Roger Kromann ◽  
...  
Keyword(s):  
Distraction Osteogenesis ◽  
Treatment Time ◽  
Patient Activation ◽  
Latency Period ◽  
Bone Lengthening ◽  
Loop Control ◽  
New Device ◽  
Distraction Device ◽  
Component Failures ◽  
Natural Healing

Distraction osteogenesis is a technique of bone lengthening that makes use of the body’s natural healing capacity. An osteotomy is created, and a rigid distraction device is attached to the bone. After a latency period, the device is activated two to four times per day for a total of 1 mm/day of bone lengthening. This technique is used to correct a variety of congenital and acquired deformities of the mandible, midface, and long bones. To shorten the treatment period and to eliminate the complications of patient activation of the device, an automated continuous distraction device would be desirable. It has been reported that continuous distraction generates adequate bone with lengthening at a rate of 2 mm/day, thereby reducing the treatment time. The device we describe here uses miniature high-pressure hydraulics, position feedback, and a digital controller to achieve closed-loop control of the distraction process. The implanted actuator can produce up to 40 N of distraction force on linear trajectories as well as curved distraction paths. In this paper we detail the spring-powered hydraulic reservoir, controller, and user interface. Experiments to test the new device design were performed in a porcine cadaver head and in live pigs. In the cadaver head, the device performed an 11 day/11 mm distraction with a root-mean-squared position error of 0.09 mm. The device functioned for periods of several days in each of five live animals, though some component failures occurred, leading to design revisions. The test series showed that the novel design of this system provides the capabilities necessary to automate distraction of the mandible. Further developments will focus on making the implanted position sensor more robust and then on carrying out clinical trials.

Late Stage Decomposition of Embalmed Cadavers

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Pilar Mata Tutor ◽  
Catherine Villoria Rojas ◽  
María Benito Sánchez
Keyword(s):  
Soft Tissue ◽  
Late Stage ◽  
Good Condition ◽  
Experimental Studies ◽  
The Body ◽  
Health Law ◽  
External Appearance ◽  
Intrinsic Factors ◽  
Preservation Technique ◽  
Extrinsic And Intrinsic Factors

Decomposition is a natural process that begins approximately four minutes after death and continues until the body is degraded to simpler biochemical components which are gradually recycled back to the environment. This process is dependent on extrinsic and intrinsic factors. Embalming is a chemical preservation technique that aims to preserve the external appearance of the body in good condition for an indeterminate period. In Spain, there is a lack of experimental studies carried out to analyse the variables that affect decomposition in embalmed bodies, therefore, in accordance with the conclusions reached by previous authors, it is hypothesised that embalmed bodies show quantifiable characteristics during the late stage decomposition which distinguish them from control, unembalmed, cadavers. An anthropological and statistical analysis was performed on 14 individuals from Cementerio Sur de Madrid exhumed after ten years according to the Mortuary Health Law of the Autonomous Region of Madrid. The preliminary results obtained showed that there is a qualitative and statistically significant relationship between the variables evaluated, being the presence or absence of soft tissue the most notable difference. The mortuary or thanatopraxy treatments performed before the burial and the microenvironmental conditions of the burial positively influence the soft tissue preservation on embalmed bodies. These results contribute to the understanding about the decomposition rate of an embalmed cadavers in cemeteries, and the related extrinsic variables.

scholarly journals The Impact of the Interaction of Financial and Industrial Structure on Economic Growth – Evidence from China

2021 ◽  
Vol 251 ◽  
pp. 01101
Author(s):  
Yiqian Tan ◽  
Fan Jiang
Keyword(s):  
Economic Growth ◽  
Industrial Structure ◽  
Financial Structure ◽  
Growth Speed ◽  
Matching Effect ◽  
Industrial Upgrading ◽  
Slowing Down ◽  
Using Data ◽  
The Impact ◽  
The Relationship

In recent years, China’s economic growth speed has been slowing down, leading to the problems of overcapacity and unbalanced regional economic development, and the mismatch between industrial and financial structure is becoming intense. This paper, starting with the relationship among economic growth, industrial structure and financial structure, summarizes the research by the former scholars. On this basis, by using data of 31 provincial panel data in China from 2007 to 2016, the article aims to find out the relationship between the industrial structure and economic growth, the relationship between the financial structure and economic growth and the relationship between the interaction of financial and industrial structure and economic growth. Finally, the conclusions of this paper are obtained that the interaction between the financial structure and the industrial structure can promote the economic growth significantly. However, the matching effect of the financial structure and industrial structure in China has not been completely formed, and the industrial upgrading should be guided to be structurally reformed through the policy.

scholarly journals Stimulasi Kesantunan Berbahasa Anak Usia Dini di PAUD Hauriyah Halum, Padang

2019 ◽  
Vol 4 (2) ◽  
pp. 127-136
Author(s):  
Imam Muthie ◽  
Yaswinda Yaswinda
Keyword(s):  
Early Childhood ◽  
Analysis Technique ◽  
Language Research ◽  
Beam Center ◽  
Descriptive Approach ◽  
Development Of Language ◽  
Using Data ◽  
Teachers And Parents ◽  
Practice Methods ◽  
Stimulation Of

The purpose of this study was to describe how the stimulation of early childhood language politeness in class B1 children at Hauriyah Halum PAUD Padang was carried out. This research is a descriptive approach with qualitative methods. The research was conducted from April 19 to May 19 2019. Researchers used teachers and parents as informants. The way to collect data that the researcher uses is observation, interview, and documentation, while the data analysis technique is done using data triangulation techniques. This study found that the development of children's language politeness in Hauriyah Halum PAUD was carried out through the application of donated duo baleh in accordance with Minangkabau culture and integrated in the learning process, the center. Every activity of developing language politeness is carried out through the process of habituation until it is finally embedded properly for the child. The center which is the focus of politeness-language research is the beam center, natural center, Islamic center, arts center and preparation center. The teacher carries out the development of language politeness by providing simulations through various types of activities in the classroom and outside the classroom. The teacher uses a variety of methods in implementing the development of children's language politeness, namely using, direct practice methods, demonstration methods, and methods of assigning assignments. Then it can be concluded from this study that the implementation of stimulation of speaking politeness in early childhood at PAUD Hauriyah Halum Padang has gone well in accordance with the principles of Minangkabau cultural politeness.

Reconstruction of Soft Tissue Defects and Bone Loss in the Tibia by Flap Transfer and Bone Transport by Distraction Osteogenesis

2020 ◽  
Vol 84 (5S) ◽  
pp. S202-S207 ◽  
Author(s):  
Abulaiti Abula ◽  
Maimaiaili Yushan ◽  
Peng Ren ◽  
Alimujiang Abulaiti ◽  
Chuang Ma ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Bone Loss ◽  
Distraction Osteogenesis ◽  
Bone Transport ◽  
Soft Tissue Defects ◽  
Flap Transfer ◽  
Tissue Defects

scholarly journals Experimental studies on vegetable marrow seeds ozonation using laboratory equipment

2019 ◽  
Vol 126 ◽  
pp. 00002
Author(s):  
Andrey V. Bogdanov ◽  
Victoria V. Evchenko ◽  
Svetlana Yu. Popova
Keyword(s):  
Seed Treatment ◽  
Treatment Time ◽  
Experimental Studies ◽  
Plant Diseases ◽  
Agricultural Crop ◽  
The Urals ◽  
Laboratory Equipment ◽  
Ozone Concentrations ◽  
Vegetable Marrow ◽  
Sowing Seed

A set of measures is taken to protect plants against various diseases and to prevent yield losses. One of the components of such actions is a pre-sowing seed treatment. One of the effective ways of pre-sowing treatment is seeds ozonization, which stimulates their germination and provides the prevention of plant diseases, hence this process increases the germination and the yield of agricultural crops. Our laboratory equipment was made to substantiate the ozonation regimes. Experimental studies on seeds ozonation were carried out for agricultural crop (the zucchini variety Zebra), which is widely used in Russia, particularly in the natural-climatic areas of the Urals. Taking into account that high ozone concentrations are dangerous to human health and life (to service personnel), pre-sowing seeds treatment was carried out at relatively safe concentrations (up to 10 mg/m3), paying attention to the tightness of the equipment. Ozone concentrations of 3 mg/m3, 6 mg/m3 and 9 mg/m3 and seed treatment time of 120 min, 240 min, 360 min and 480 min were chosen. The experimental studies have shown, that a rational regime of seeds treatment for obtaining the maximum germination (79.1%), is observed when ozone concentration is 9 mg/m3 and treatment time is 247.7 min. Thus, the developed laboratory equipment helps to determine the rational ozonation regimes for zucchini seeds. It can also be used to determine the rational ozonation regimes for seeds of other crops.

scholarly journals Quipazine Elicits Swallowing in the Arterially Perfused Rat Preparation: A Role for Medullary Raphe Nuclei?

2020 ◽  
Vol 21 (14) ◽  
pp. 5120
Author(s):  
Victor Bergé-Laval ◽  
Christian Gestreau
Keyword(s):  
Therapeutic Option ◽  
Experimental Studies ◽  
Raphe Nuclei ◽  
Excitatory Effect ◽  
Motor Patterns ◽  
Systemic Injection ◽  
Medullary Raphe ◽  
Raphé Nuclei ◽  
Stimulation Of

Pharmacological neuromodulation of swallowing may represent a promising therapeutic option to treat dysphagia. Previous studies suggested a serotonergic control of swallowing, but mechanisms remain poorly understood. Here, we investigated the effects of the serotonergic agonist quipazine on swallowing, using the arterially perfused working heart-brainstem (in situ) preparation in rats. Systemic injection of quipazine produced single swallows with motor patterns and swallow-breathing coordination similar to spontaneous swallows, and increased swallow rate with moderate changes in cardiorespiratory functions. Methysergide, a 5-HT2 receptor antagonist, blocked the excitatory effect of quipazine on swallowing, but had no effect on spontaneous swallow rate. Microinjections of quipazine in the nucleus of the solitary tract were without effect. In contrast, similar injections in caudal medullary raphe nuclei increased swallow rate without changes in cardiorespiratory parameters. Thus, quipazine may exert an excitatory effect on raphe neurons via stimulation of 5-HT2A receptors, leading to increased excitability of the swallowing network. In conclusion, we suggest that pharmacological stimulation of swallowing by quipazine in situ represents a valuable model for experimental studies. This work paves the way for future investigations on brainstem serotonergic modulation, and further identification of neural populations and mechanisms involved in swallowing and/or swallow-breathing interaction.

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