scholarly journals Features of Bone Regeneration of the Jaws Alveolar Ridge Using Hydroxyapatite-Based Material

2021 ◽  
Vol 27 (1) ◽  
pp. 9-18
Author(s):  
A. Y. Drobyshev ◽  
N. A. Redko ◽  
E. G. Sviridov ◽  
R. V. Deev
Keyword(s):  
Bone Tissue ◽  
Clinical Medicine ◽  
Maxillofacial Surgery ◽  
Titanium Implants ◽  
Alveolar Ridge ◽  
Tissue Samples ◽  
Surgical Interventions ◽  
Dental Implantation ◽  
Regeneration Of Bone Tissue ◽  
The Stability

Background. Currently, using of osteointegrated titanium implants has become a key component for restoring lost function in various areas of clinical medicine. The actual issue remains preservation or reconstruction of bone tissue for optimal use of titanium implants in traumatology and orthopedics, as well as in maxillofacial surgery. One of the most common grafts are hydroxyapatite-based material with various inclusions, for example, an antibiotic.The aim of the study is to characterize the regeneration of bone tissue of the jaws alveolar ridge using the hydroxyapatite-based material “Collapan-L” in clinical practice.Material and Methods. The study of the material “Collapan-L” (Intermedapatit, Russia) using involved 30 patients with a diagnosis “chronic periodontitis of the tooth”. Patients underwent complex surgical and orthopedic treatment to restore masticatory function. At the first stage, teeth were removed with the “Collapan-L” material used to preserve the alveolus. 4 months after extraction, dental implantation was performed with simultaneous trephine biopsy from the augmentation zone for histomorphometric analysis. At the stage of implant placement and before prosthetics the stability dynamics was measured.Results. The study involved 42 tissue samples obtained at periods from 9 to 32 weeks after removal. The morphological assessment of bone tissue from the implantation zone determined that after 4 months trabeculae from the newly formed bone, including small fragments of biomaterial, were revealed; at the same time, there were signs of biodegradation of the implanted material fragments, there was no inflammatory infiltrate. After 6 months in a significant part of cases the granules of bone material were not found, which indicates a pronounced osseointegration of the material. In its structure, the formed bone tissue differences barely noticeable from the native one, which allows us to conclude that by the time of 24 weeks, the processes of reparative osteogenesis in the alveolus are completed.Conclusion. Histological examination and assessment of changes in the stability showed that using of bone replacement material after tooth extraction can increase the regenerative potential of bone tissue, avoid additional surgical interventions to increase the volume of bone tissue in the area of future implantation, and the formed bone tissue is close in its structure to the native one.

Main Approaches to the Use of Biomaterials in Oral and Maxillofacial Surgery: A Brief Systematic Review

2021 ◽  
pp. 42-48
Author(s):  
Henrique Esteves Magalhães ◽  
Priscilla Janaína de Lima Borelli Bovo ◽  
Luciano Rodrigues Neves ◽  
Marcelo Henrique Batista Santos ◽  
Rogério Luiz de Araújo Vian ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bone Tissue ◽  
Dental Implants ◽  
Bone Growth ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Success Rates ◽  
Dental Implantation ◽  
Regeneration Of Bone Tissue ◽  
Regeneration Of Bone

Introduction: In recent years, procedures with the use of dental implants have increased worldwide, reaching approximately one million dental implants per year. In recent years, a platelet concentrate called FRP (fibrin-rich plasma) has been the subject of clinical studies. Associated with this, the biomaterial Bio-Oss® (Geistlich), as it is biodegradable, biocompatible, non-toxic, and has low immunogenicity, and bio stimulators can act in the regeneration of bone tissue, as it establishes with the cells the appropriate biological niche (favorable microenvironment) for bone growth. Objective: Therefore, the present study aimed to evaluate, through a brief systematic review, the results that involve bone formation for dental implantation, with the use of biomaterials such as fibrin-rich plasma and Bio-Oss®. Methods: The model used for the review was PRISMA. Was used databases such as Scopus, Scielo, Lilacs, Google Scholar, PubMed. Results: Fibrin-rich plasma (FRP) as an autologous biomaterial for use in oral and maxillofacial surgery presents most leukocytes, platelets, and growth factors, forming a fibrin matrix, with three-dimensional architecture. The Bio-Oss® biomaterial (Geistlich), as it is biodegradable, biocompatible, non-toxic, and has low immunogenicity and bio stimulators can act in the regeneration of bone tissue, since it establishes with the adenomatous mesenchymal stem cells the appropriate biological niche for bone growth and, thus, allowing the dental implant to be as effective as possible. Conclusion: The use of FRP associated with Bio-Oss® seems to illustrate high success rates with minimal costs, which may reduce the amount of bone graft needed to fill the sinus cavity, reducing the costs of the procedure.

scholarly journals Сучасні підходи до хірургічного лікування хворих на генералізова- ний пародонтит із використанням дентальних імплантатів

2017 ◽  
Author(s):  
H. B. Prots ◽  
V. P. Piuryk
Keyword(s):  
Postoperative Complications ◽  
Bone Tissue ◽  
Surgical Intervention ◽  
Positive Development ◽  
Duration Of Treatment ◽  
Surgical Interventions ◽  
Periodontal Tissues ◽  
Dental Implantation ◽  
Simultaneous Surgery

The main postulate of periodontal treatment is the elimination of factors injuring periodontal disease, creating conditions for the normalization of its properties. Structures with additional supports on the intraosseous implants are optimal for orthopaedic treatment. The possibilities and conditions for surgical intervention on periodontal tissues and implantation in patients with varying severity of chronic GP were generally poorly understood.The aim of the study – to improve the treatment of patients with partial edentia and chronic generalized periodontitis by including dental implantation to the complex of therapeutic measures.Materials and Methods. There are presented the results of 360 patients with varying severity degrees of generalized periodontitis who underwent surgery on periodontal tissues with dental implantation.Results and Discussion. Our research showed that implantation in patients with mild generalized periodontitis can achieve consistently good results regardless the method of treatment. Simultaneous surgery on periodontal tissues and the dental implantation shortens treatment duration in 1.5–2 times without compromising its quality. It is shown that in patients with moderate and severe degrees of generalized periodontitis it is appropriate to perform periodontal surgery separately followed by dental implantation to prevent postoperative complications and implant loss. When planning for dental implants and periodontal surgical intervention it is necessary to determine the quality of bone remodeling to assess the structural and functional state of bone tissue and differentiated destination osteotropic drugs that promote positive postoperative period.Conclusions. Therefore, in order to increase the effectiveness of dental implantation and surgical periodontal intervention, bone remodelling markers should be determined to assess the structural and functional status of bone tissue and for the differentiated use of osteotropic drugs, which will contribute to the positive development of the postoperative period. Simultaneous surgical intervention on periodontal tissues and dental implantation in 1.5–2 times reduces the duration of treatment without reducing its quality. In patients with moderate to severe degrees, it is expedient to carry out surgical interventions with subsequent dental implantation in order to prevent postoperative complications and loss of implants.

scholarly journals Rehabilitation of the alveolar bone after tooth extraction. Analysis of methods

2020 ◽  
Vol 18 (3) ◽  
pp. 87-92
Author(s):  
Yu. A. Bakaev ◽  
I. A. Voronov ◽  
Yu. A. Generalova ◽  
Ya. A. Negorelova ◽  
M. E. Balashova ◽  
...  
Keyword(s):  
Literature Review ◽  
Bone Tissue ◽  
Bone Remodeling ◽  
Tooth Extraction ◽  
Irreversible Process ◽  
Treatment Process ◽  
Alveolar Bone ◽  
Alveolar Ridge ◽  
Dental Implantation

Resorption of the alveolar bone after tooth extraction is an irreversible process due to biological bone remodeling. It will greatly complicate the further treatment of patients for dental implantation, since for the latter a prerequisite is a sufficient volume of bone tissue. It leads to a protracted treatment process: the volume and timing of interventions increases. The literature review has shown possible methods of preservation of the alveolar ridge after tooth extraction and the results of their application.

scholarly journals Структура и физико-химические механизмы взаимодействия костной ткани с титановыми имплантатами в условиях туберкулезного остита

2019 ◽  
Vol 89 (12) ◽  
pp. 1997
Author(s):  
О.Н. Мусская ◽  
В.К. Крутько ◽  
А.А. Гайдаш ◽  
А.И. Кулак ◽  
Н.С. Чекан ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Bone Matrix ◽  
Titanium Implants ◽  
Mineral Phase ◽  
Apatite Phase ◽  
Phase Synthesis ◽  
X Ray ◽  
Regeneration Of Bone Tissue ◽  
Regeneration Of Bone ◽  
Scanning Electron

The structure and physicochemical mechanisms of interaction of bone tissue with titanium implants in tuberculous osteitis have been studied by scanning electron microscopy, X-ray phase analysis, IR spectroscopy and thermal analysis methods. It has been found that the physiological regeneration of bone tissue is accompanied by growth of organic components, embrittlement of the mineral phase of the bone matrix, and its fine disintegration during the treatment of tuberculosis osteitis. The presence of titanium implants during a physiologically normal state contributes to the activation of apatite phase synthesis in the regenerating bone. The main mechanism of implantation osteogenesis in tuberculous osteitis is the formation of the inorganic phase of hydroxyapatite mainly in the areas of destruction of the titanium alloy.

Features of application of Collapan-L in dental implantation (clinical example)

2019 ◽  
Vol 1 (5) ◽  
pp. 8-10
Author(s):  
I. N. Kolganov ◽  
A. V. Ivaschenko ◽  
A. E. Yablokov ◽  
I. M. Fedyaev ◽  
V. Ya. Arkhipov
Keyword(s):  
Bone Tissue ◽  
Tissue Repair ◽  
Tomographic Images ◽  
Computed Tomographic ◽  
Dental Implantation ◽  
Regeneration Of Bone Tissue ◽  
The Moment ◽  
Osteoplastic Material ◽  
Bone Structures ◽  
Regeneration Of Bone

A high percentage of patients with a diagnosis of partial absence of teeth often have a deficiency in the bone tissue of the alveolar ridge, which, in turn, makes it difficult, and in some cases makes it impossible, to impose dental implants. At the moment there are a number of materials involved in the restoration of bone tissue. These include osteoinductive, osteoconductive and indifferent materials. The authors note that osteoconductive materials are the most effective of these groups for bone tissue repair. A prominent representative is the drug Collapan-L. Purpose. To determine the features of the clinical use of the drug Collapan-L during dental implantation. Materials and methods. Patient P., 49 years old, complained of partial absence of teeth in the upper jaw. After examining the computed tomographic images, it was decided to perform a closed sinus lift operation with the use of osteoplastic material Collapan-L. Conclusion. In the course of our research, it was found that the effect of Collapan-L on the defects of bone structures allows to reduce the postoperative effects, such as pain, swelling, allows for quick and high-quality regeneration of bone tissue.

Regeneration of bone tissue under implantation of sapphire with titanium coating

2014 ◽  
Vol 0 (3) ◽  
pp. 24 ◽  
Author(s):  
Volodymyr Filipenko ◽  
Inna Batura ◽  
Anatoliy Andreyev ◽  
Оleksey Marushchak
Keyword(s):  
Bone Tissue ◽  
Titanium Coating ◽  
Regeneration Of Bone Tissue ◽  
Regeneration Of Bone

Vitamin D Effects on Guided Bone Regeneration and Osseointegration of Dental Implants (Literature Review)

2020 ◽  
Vol 75 (5) ◽  
pp. 552-560
Author(s):  
Sergey Yu. Ivanov ◽  
Svetlana Yu. Kalinchenko ◽  
Nidjat A. Guseynov ◽  
Aleksander A. Muraev ◽  
Aigul Т. Safi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Tissue ◽  
Dental Implants ◽  
Scientific Data ◽  
Reparative Regeneration ◽  
Jaw Bone ◽  
Dental Implantation ◽  
Oral Reconstruction ◽  
Phosphate Exchange ◽  
Regeneration Of Bone

Background.Due to the prevalence of Vitamin D deficiency as well as the frequency of reconstructive surgical interventions followed by dental implantation, the issue arises concerning the effect of Vitamin D on reparative regeneration of bone and osseointegration of dental implants.The purpose using literature data we are conducting an impact assessment of vitamin D on reparative regeneration of bone tissue, in particular, after oral reconstruction surgeries and dental implantation.Methods.Retrieval, systematization and analysis of scientific data on application of vitamin D supplementation and its effect on reparative regeneration of jaw bone tissue.The conclusions.For the most part, the positive effect exerted on reparative regeneration of jaw bone tissue and osseointegration of dental implants is due to the role of vitamin D in physiological processes evolving in bone tissue, namely maintenance of calcium and phosphate exchange through intestinal absorption and TNF, RANKL (Receptor activator of nuclear factor kappa-B ligand) and consequently differentiation of precursors to osteoclasts into osteoclasts through VDR stimulation (VitaminD Receptor) receptors for further osteogenesis. Also, according to literature data, FGF23 (Fibroblast Growth Factor) protein is a marker of osteoblasts differentiation into osteocytes, it is also known that FGF23 and 1,25(ОН)2D3 are genetically related. FGF23 is the main regulator of both phosphate exchange in bones and metabolism of vitamin D and its metabolites. Besides, indirect anti-inflammatory effect has been observed thanks to inhibition of pro-inflammatory cytokine secretion. Taking into account the abovementioned data, of particular relevance is the definition of serum concentration 25(ОН)D and development of schemes of vitamin D level pre-surgery correction in patients, who have to undergo oral reconstruction surgeries and dental implantation. Mass spectrometry is a promising diagnostic method for determining the level of vitamin D in a body, as it allows to identify the actual amount of vitamin D free from admixture of other steroid hormones. The introduction of this method into clinical practice will allow to monitor the level of vitamin D in patients, receiving reconstructive and rehabilitative treatment.

Microbial contamination dynamics in surgical treatment of patients using dental implants in a limited bone tissue volume

2019 ◽  
pp. 52-58
Author(s):  
A.M. Tsitsiashvili ◽  
A.M. Panin ◽  
Ye.N. Nikolayeva ◽  
A.A. Arutyunyan ◽  
M.S. Podporin ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Dental Implants ◽  
Bacteriological Study ◽  
Number Of Species ◽  
Dental Implantation ◽  
Multi Stage ◽  
Short Implants ◽  
Amoxicillin Clavulanate ◽  
Pure Cultures ◽  
Step Therapy

The aim of the study was to evaluate the effectiveness of antibiotic chemotherapy regimens and the dynamics of the nature of microbial associations of the operating area at the surgical stages of treatment of patients using dental implants in conditions of limited bone tissue. The study involved 37 patients (17 m and 20 w, from 32 to 68 years). According to the tactics of the treatment and the type of antibacterial effect, the patients were divided into 3 groups. Per os was prescribed antibiotics as a step therapy: amoxicillin (flemoxin 500 mg 1 tablet 2 per day for 7 days) and amoxicillin / clavulanate (flemoclav 625 mg 1 table 2 per day 7 days), doxycycline (unidox 100 mg 1 table 1 per day 5 days). The 1st group of patients (n1=12; 31.9%) — a multi-stage approach (MA), where the 1st operation is bone grafting (BG) (Flemoxin 500 mg), after 6—9 months, the 2nd dental implantation (DI) (flemoklav 625 mg), after 3—6 months the 3rd — installation of gingival formers (GF) (unidox 100 mg). The 2nd group of patients (n2=14; 36.2%) — a one-stage approach (OA), where the 1st operation is BG with simultaneous DI (flemoxin 500 mg), after 6—9 months — the 2nd — installation of GF (flemoklav 625 mg). 3rd group — narrow/short implants (N/S) without BG were installed (n3=11; 31.9%). The 1st operation — DI (Flemoxin 500 mg), the 2nd — installation of GF (Flemoklav 625 mg). A bacteriological study with the identification of pure cultures of bacteria and determination of sensitivity to antibacterial drugs was performed for all patients before treatment and in dynamics. In MA, there was a suppression of the growth of certain types of bacteria and an increase in the number of species resistant to this antibiotic. In the framework of the OA, when prescribing antibiotics, the results were comparable. With N/S implants, growth inhibition of a number of species present at the beginning of treatment was noted. In multi-stage operations, we consider it reasonable to use beta-lactamase-protected drugs, or drugs of another group that include representatives of parodontopathogenic species and potential carriers of multiple resistance genes in their spectrum of action.

scholarly journals Dual Network Composites of Poly(vinyl alcohol)-Calcium Metaphosphate/Alginate with Osteogenic Ions for Bone Tissue Engineering in Oral and Maxillofacial Surgery

2021 ◽  
Vol 8 (8) ◽  
pp. 107
Author(s):  
Lilis Iskandar ◽  
Lucy DiSilvio ◽  
Jonathan Acheson ◽  
Sanjukta Deb
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Vinyl Alcohol ◽  
Maxillofacial Surgery ◽  
Bone Defects ◽  
Bone Tissue Regeneration ◽  
Poly Vinyl Alcohol ◽  
Oral And Maxillofacial Surgery

Despite considerable advances in biomaterials-based bone tissue engineering technologies, autografts remain the gold standard for rehabilitating critical-sized bone defects in the oral and maxillofacial (OMF) region. A majority of advanced synthetic bone substitutes (SBS’s) have not transcended the pre-clinical stage due to inferior clinical performance and translational barriers, which include low scalability, high cost, regulatory restrictions, limited advanced facilities and human resources. The aim of this study is to develop clinically viable alternatives to address the challenges of bone tissue regeneration in the OMF region by developing ‘dual network composites’ (DNC’s) of calcium metaphosphate (CMP)—poly(vinyl alcohol) (PVA)/alginate with osteogenic ions: calcium, zinc and strontium. To fabricate DNC’s, single network composites of PVA/CMP with 10% (w/v) gelatine particles as porogen were developed using two freeze–thawing cycles and subsequently interpenetrated by guluronate-dominant sodium alginate and chelated with calcium, zinc or strontium ions. Physicochemical, compressive, water uptake, thermal, morphological and in vitro biological properties of DNC’s were characterised. The results demonstrated elastic 3D porous scaffolds resembling a ‘spongy bone’ with fluid absorbing capacity, easily sculptable to fit anatomically complex bone defects, biocompatible and osteoconductive in vitro, thus yielding potentially clinically viable for SBS alternatives in OMF surgery.

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