Main Approaches to the Use of Biomaterials in Oral and Maxillofacial Surgery: A Brief Systematic Review

2021 ◽  
pp. 42-48
Author(s):  
Henrique Esteves Magalhães ◽  
Priscilla Janaína de Lima Borelli Bovo ◽  
Luciano Rodrigues Neves ◽  
Marcelo Henrique Batista Santos ◽  
Rogério Luiz de Araújo Vian ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bone Tissue ◽  
Dental Implants ◽  
Bone Growth ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Success Rates ◽  
Dental Implantation ◽  
Regeneration Of Bone Tissue ◽  
Regeneration Of Bone

Introduction: In recent years, procedures with the use of dental implants have increased worldwide, reaching approximately one million dental implants per year. In recent years, a platelet concentrate called FRP (fibrin-rich plasma) has been the subject of clinical studies. Associated with this, the biomaterial Bio-Oss® (Geistlich), as it is biodegradable, biocompatible, non-toxic, and has low immunogenicity, and bio stimulators can act in the regeneration of bone tissue, as it establishes with the cells the appropriate biological niche (favorable microenvironment) for bone growth. Objective: Therefore, the present study aimed to evaluate, through a brief systematic review, the results that involve bone formation for dental implantation, with the use of biomaterials such as fibrin-rich plasma and Bio-Oss®. Methods: The model used for the review was PRISMA. Was used databases such as Scopus, Scielo, Lilacs, Google Scholar, PubMed. Results: Fibrin-rich plasma (FRP) as an autologous biomaterial for use in oral and maxillofacial surgery presents most leukocytes, platelets, and growth factors, forming a fibrin matrix, with three-dimensional architecture. The Bio-Oss® biomaterial (Geistlich), as it is biodegradable, biocompatible, non-toxic, and has low immunogenicity and bio stimulators can act in the regeneration of bone tissue, since it establishes with the adenomatous mesenchymal stem cells the appropriate biological niche for bone growth and, thus, allowing the dental implant to be as effective as possible. Conclusion: The use of FRP associated with Bio-Oss® seems to illustrate high success rates with minimal costs, which may reduce the amount of bone graft needed to fill the sinus cavity, reducing the costs of the procedure.

Vitamin D Effects on Guided Bone Regeneration and Osseointegration of Dental Implants (Literature Review)

2020 ◽  
Vol 75 (5) ◽  
pp. 552-560
Author(s):  
Sergey Yu. Ivanov ◽  
Svetlana Yu. Kalinchenko ◽  
Nidjat A. Guseynov ◽  
Aleksander A. Muraev ◽  
Aigul Т. Safi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Tissue ◽  
Dental Implants ◽  
Scientific Data ◽  
Reparative Regeneration ◽  
Jaw Bone ◽  
Dental Implantation ◽  
Oral Reconstruction ◽  
Phosphate Exchange ◽  
Regeneration Of Bone

Background.Due to the prevalence of Vitamin D deficiency as well as the frequency of reconstructive surgical interventions followed by dental implantation, the issue arises concerning the effect of Vitamin D on reparative regeneration of bone and osseointegration of dental implants.The purpose using literature data we are conducting an impact assessment of vitamin D on reparative regeneration of bone tissue, in particular, after oral reconstruction surgeries and dental implantation.Methods.Retrieval, systematization and analysis of scientific data on application of vitamin D supplementation and its effect on reparative regeneration of jaw bone tissue.The conclusions.For the most part, the positive effect exerted on reparative regeneration of jaw bone tissue and osseointegration of dental implants is due to the role of vitamin D in physiological processes evolving in bone tissue, namely maintenance of calcium and phosphate exchange through intestinal absorption and TNF, RANKL (Receptor activator of nuclear factor kappa-B ligand) and consequently differentiation of precursors to osteoclasts into osteoclasts through VDR stimulation (VitaminD Receptor) receptors for further osteogenesis. Also, according to literature data, FGF23 (Fibroblast Growth Factor) protein is a marker of osteoblasts differentiation into osteocytes, it is also known that FGF23 and 1,25(ОН)2D3 are genetically related. FGF23 is the main regulator of both phosphate exchange in bones and metabolism of vitamin D and its metabolites. Besides, indirect anti-inflammatory effect has been observed thanks to inhibition of pro-inflammatory cytokine secretion. Taking into account the abovementioned data, of particular relevance is the definition of serum concentration 25(ОН)D and development of schemes of vitamin D level pre-surgery correction in patients, who have to undergo oral reconstruction surgeries and dental implantation. Mass spectrometry is a promising diagnostic method for determining the level of vitamin D in a body, as it allows to identify the actual amount of vitamin D free from admixture of other steroid hormones. The introduction of this method into clinical practice will allow to monitor the level of vitamin D in patients, receiving reconstructive and rehabilitative treatment.

scholarly journals 1359 Everyone Deserves to Smile: An Audit on The Success Rate of Dental Implants in Complex Maxillofacial Patients

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
P Lugaric ◽  
C Frezzini ◽  
A Patterson
Keyword(s):  
Dental Implants ◽  
Maxillofacial Surgery ◽  
Survival Rates ◽  
Oral And Maxillofacial Surgery ◽  
Head And Neck Reconstruction ◽  
Success Rates ◽  
Native Bone ◽  
Local Standard ◽  
Edentulous Patients ◽  
Surgery Department

Abstract Aim To determine the success rates of dental implants in complex patients treated in the Oral and Maxillofacial Surgery Department at Rotherham General Hospital (RGH). Method All patients who received dental implants in the period January 2010 – March 2017 at RGH were included in the audit. Standards 90% local standard Results 68 dental implants were placed in 22 patients: 15 patients head and neck reconstruction, 5 atrophic edentulous patients, 2 trauma. Conclusions Survival rates for dental implants in the literature is variable ranging from 91 -96% in native bone and mucosa and 46 - 98% in irradiated tissue.

scholarly journals Features of Bone Regeneration of the Jaws Alveolar Ridge Using Hydroxyapatite-Based Material

2021 ◽  
Vol 27 (1) ◽  
pp. 9-18
Author(s):  
A. Y. Drobyshev ◽  
N. A. Redko ◽  
E. G. Sviridov ◽  
R. V. Deev
Keyword(s):  
Bone Tissue ◽  
Clinical Medicine ◽  
Maxillofacial Surgery ◽  
Titanium Implants ◽  
Alveolar Ridge ◽  
Tissue Samples ◽  
Surgical Interventions ◽  
Dental Implantation ◽  
Regeneration Of Bone Tissue ◽  
The Stability

Background. Currently, using of osteointegrated titanium implants has become a key component for restoring lost function in various areas of clinical medicine. The actual issue remains preservation or reconstruction of bone tissue for optimal use of titanium implants in traumatology and orthopedics, as well as in maxillofacial surgery. One of the most common grafts are hydroxyapatite-based material with various inclusions, for example, an antibiotic.The aim of the study is to characterize the regeneration of bone tissue of the jaws alveolar ridge using the hydroxyapatite-based material “Collapan-L” in clinical practice.Material and Methods. The study of the material “Collapan-L” (Intermedapatit, Russia) using involved 30 patients with a diagnosis “chronic periodontitis of the tooth”. Patients underwent complex surgical and orthopedic treatment to restore masticatory function. At the first stage, teeth were removed with the “Collapan-L” material used to preserve the alveolus. 4 months after extraction, dental implantation was performed with simultaneous trephine biopsy from the augmentation zone for histomorphometric analysis. At the stage of implant placement and before prosthetics the stability dynamics was measured.Results. The study involved 42 tissue samples obtained at periods from 9 to 32 weeks after removal. The morphological assessment of bone tissue from the implantation zone determined that after 4 months trabeculae from the newly formed bone, including small fragments of biomaterial, were revealed; at the same time, there were signs of biodegradation of the implanted material fragments, there was no inflammatory infiltrate. After 6 months in a significant part of cases the granules of bone material were not found, which indicates a pronounced osseointegration of the material. In its structure, the formed bone tissue differences barely noticeable from the native one, which allows us to conclude that by the time of 24 weeks, the processes of reparative osteogenesis in the alveolus are completed.Conclusion. Histological examination and assessment of changes in the stability showed that using of bone replacement material after tooth extraction can increase the regenerative potential of bone tissue, avoid additional surgical interventions to increase the volume of bone tissue in the area of future implantation, and the formed bone tissue is close in its structure to the native one.

scholarly journals Top 100 Cited Systematic Reviews and Meta-Analyses in The Major Journals of Oral and Maxillofacial Surgery: A Bibliometric Analysis

2020 ◽  
Author(s):  
Essam Al-Moraissi ◽  
Endi Lanza Galvão ◽  
Nikolaos Christidis ◽  
Saulo Gabriel Falci
Keyword(s):  
Systematic Review ◽  
Bibliometric Analysis ◽  
Systematic Reviews ◽  
Cosmetic Surgery ◽  
Oral Surgery ◽  
Maxillofacial Surgery ◽  
Oral Pathology ◽  
Oral And Maxillofacial Surgery ◽  
Success Rates ◽  
Oral Radiology

Abstract Background : The aim of this bibliometric research was to identify and analyze the top 100 cited systematic reviews in the field of oral and maxillofacial surgery. Methods : Using the Web of Science-database without restrictions on publication year or language, a bibliometric analysis was performed for the five major journals of oral and maxillofacial surgery: International Journal of Oral and Maxillofacial Surgery, Journal of Oral and Maxillofacial Surgery, Journal of Cranio-maxillofacial Surgery, British Journal of Oral & Maxillofacial Surgery and Oral Surgery Oral medicine Oral pathology Oral radiology. Discussion : The most top-cited systematic review was published in 2015 with a total of 200 citations on survival and success rates of dental implants, consistent with the finding that “pre- and peri-implant surgery and dental implantology”, and “craniomaxillofacial deformities and cosmetic surgery” were the most frequently-cited topics (22% each). The International Journal of Oral and Maxillofacial Surgery displayed both most citations in total and in average per publication. The outcome of this article can be used as a source of information not just for researchers but also for clinicians and students, and of which areas have a large impact on the field of oral and maxillofacial surgery but cannot reflect the quality of the included systematic reviews.Systematic review registration: not applicable

scholarly journals Autogenous Platelet Rich Plasma in Healing of Bone Defects

JMS SKIMS ◽  
2013 ◽  
Vol 16 (2) ◽  
pp. 90-94 ◽  
Author(s):  
Altaf H Malik ◽  
Ajaz A Shah ◽  
Rubeena Tabasum ◽  
Irshad Ahmad ◽  
Manzoor Ahmad
Keyword(s):  
Bone Growth ◽  
Platelet Rich Plasma ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Maxillofacial Region ◽  
Group A ◽  
Oral And Maxillofacial Region ◽  
Group B ◽  
Regeneration Of Bone

Purpose: To evaluate the efficacy of PRP in regeneration of bone in defects of the oral and maxillofacial region. Methods: A comparative nonrandomized study including 40 patients with bony defects of cystic origin   in the maxillofacial region was carried out in the Department of Oral and Maxillofacial Surgery. Patients were divided into two groups: group A received PRP and in group B PRP was not used. Postoperatively, the patients were monitored regularly by radiographs to evaluate new bone growth at 1st  ,3rd and 6th month clinically and radiographically. Results: Faster bone healing in was observed in the patients in whom PRP was used at every follow up. Conclusion: Defects filled with PRP showed comparatively earlier and faster bone regeneration. JMS 2013;16(2):90-94

scholarly journals Advance on Resveratrol Application in Bone Regeneration: Progress and Perspectives for Use in Oral and Maxillofacial Surgery

Biomolecules ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 94 ◽  
Author(s):  
Denise Murgia ◽  
Rodolfo Mauceri ◽  
Giuseppina Campisi ◽  
Viviana De Caro
Keyword(s):  
Biological Effects ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Positive Effects ◽  
Natural Polyphenol ◽  
Regeneration Of Bone Tissue ◽  
Experimental Findings ◽  
Regeneration Of Bone

The natural polyphenol Resveratrol (RSV) claims numerous positive effects on health due to the well documented biological effects demonstrating its potential as a disease-preventing agent and as adjuvant for treatment of a wide variety of chronic diseases. Since several studies, both in vitro and in vivo, have highlighted the protective bone aptitude of RSV both as promoter of osteoblasts’ proliferation and antagonist of osteoclasts’ differentiation, they could be interesting in view of applications in the field of dentistry and maxillofacial surgery. This review has brought together experimental findings on the use of RSV in the regeneration of bone tissue comprising also its application associated with scaffolds and non-transfusional hemocomponents.

Features of application of Collapan-L in dental implantation (clinical example)

2019 ◽  
Vol 1 (5) ◽  
pp. 8-10
Author(s):  
I. N. Kolganov ◽  
A. V. Ivaschenko ◽  
A. E. Yablokov ◽  
I. M. Fedyaev ◽  
V. Ya. Arkhipov
Keyword(s):  
Bone Tissue ◽  
Tissue Repair ◽  
Tomographic Images ◽  
Computed Tomographic ◽  
Dental Implantation ◽  
Regeneration Of Bone Tissue ◽  
The Moment ◽  
Osteoplastic Material ◽  
Bone Structures ◽  
Regeneration Of Bone

A high percentage of patients with a diagnosis of partial absence of teeth often have a deficiency in the bone tissue of the alveolar ridge, which, in turn, makes it difficult, and in some cases makes it impossible, to impose dental implants. At the moment there are a number of materials involved in the restoration of bone tissue. These include osteoinductive, osteoconductive and indifferent materials. The authors note that osteoconductive materials are the most effective of these groups for bone tissue repair. A prominent representative is the drug Collapan-L. Purpose. To determine the features of the clinical use of the drug Collapan-L during dental implantation. Materials and methods. Patient P., 49 years old, complained of partial absence of teeth in the upper jaw. After examining the computed tomographic images, it was decided to perform a closed sinus lift operation with the use of osteoplastic material Collapan-L. Conclusion. In the course of our research, it was found that the effect of Collapan-L on the defects of bone structures allows to reduce the postoperative effects, such as pain, swelling, allows for quick and high-quality regeneration of bone tissue.

Regeneration of bone tissue under implantation of sapphire with titanium coating

2014 ◽  
Vol 0 (3) ◽  
pp. 24 ◽  
Author(s):  
Volodymyr Filipenko ◽  
Inna Batura ◽  
Anatoliy Andreyev ◽  
Оleksey Marushchak
Keyword(s):  
Bone Tissue ◽  
Titanium Coating ◽  
Regeneration Of Bone Tissue ◽  
Regeneration Of Bone

Microbial contamination dynamics in surgical treatment of patients using dental implants in a limited bone tissue volume

2019 ◽  
pp. 52-58
Author(s):  
A.M. Tsitsiashvili ◽  
A.M. Panin ◽  
Ye.N. Nikolayeva ◽  
A.A. Arutyunyan ◽  
M.S. Podporin ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Dental Implants ◽  
Bacteriological Study ◽  
Number Of Species ◽  
Dental Implantation ◽  
Multi Stage ◽  
Short Implants ◽  
Amoxicillin Clavulanate ◽  
Pure Cultures ◽  
Step Therapy

The aim of the study was to evaluate the effectiveness of antibiotic chemotherapy regimens and the dynamics of the nature of microbial associations of the operating area at the surgical stages of treatment of patients using dental implants in conditions of limited bone tissue. The study involved 37 patients (17 m and 20 w, from 32 to 68 years). According to the tactics of the treatment and the type of antibacterial effect, the patients were divided into 3 groups. Per os was prescribed antibiotics as a step therapy: amoxicillin (flemoxin 500 mg 1 tablet 2 per day for 7 days) and amoxicillin / clavulanate (flemoclav 625 mg 1 table 2 per day 7 days), doxycycline (unidox 100 mg 1 table 1 per day 5 days). The 1st group of patients (n1=12; 31.9%) — a multi-stage approach (MA), where the 1st operation is bone grafting (BG) (Flemoxin 500 mg), after 6—9 months, the 2nd dental implantation (DI) (flemoklav 625 mg), after 3—6 months the 3rd — installation of gingival formers (GF) (unidox 100 mg). The 2nd group of patients (n2=14; 36.2%) — a one-stage approach (OA), where the 1st operation is BG with simultaneous DI (flemoxin 500 mg), after 6—9 months — the 2nd — installation of GF (flemoklav 625 mg). 3rd group — narrow/short implants (N/S) without BG were installed (n3=11; 31.9%). The 1st operation — DI (Flemoxin 500 mg), the 2nd — installation of GF (Flemoklav 625 mg). A bacteriological study with the identification of pure cultures of bacteria and determination of sensitivity to antibacterial drugs was performed for all patients before treatment and in dynamics. In MA, there was a suppression of the growth of certain types of bacteria and an increase in the number of species resistant to this antibiotic. In the framework of the OA, when prescribing antibiotics, the results were comparable. With N/S implants, growth inhibition of a number of species present at the beginning of treatment was noted. In multi-stage operations, we consider it reasonable to use beta-lactamase-protected drugs, or drugs of another group that include representatives of parodontopathogenic species and potential carriers of multiple resistance genes in their spectrum of action.

Functional analysis of chondroitin 4 sulfate constituting osseointegration

Impact ◽  
2019 ◽  
Vol 2019 (8) ◽  
pp. 18-20
Author(s):  
Shuhei Tsuchiya
Keyword(s):  
Functional Analysis ◽  
Extracellular Matrix ◽  
Dental Implants ◽  
Maxillofacial Surgery ◽  
The Body ◽  
Oral And Maxillofacial Surgery ◽  
Direct Connection ◽  
Tooth Replacement ◽  
Living Bone ◽  
Natural Tooth

Osseointegration can be defined as a direct connection, both structural and functional, between living bone and the surface of an artificial implant. Indeed, the word comes from the Greek term for 'bone' and 'to make whole'. In dentistry, once dental implants are placed, the body will react with osseointegration, enabling the implants to become a permanent part of the jaw. There are many benefits to this type of implant, compared with traditional tooth replacement options, not least that dental implants mimic the strength and functionality of a natural tooth. Dr Shuhei Tsuchiya is a researcher based in the Division of Oral and Maxillofacial Surgery at Nagoya University, Japan, who is interested in a range of areas, including regenerative medicine and the extracellular matrix. One of his key preoccupations, though, is shedding light on osseointegration. He and his team are working to unravel the mysteries of the mechanism.

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