EFFECTIVENESS OF PROJECT-BASED LEARNING AND 5E LEARNING CYCLE INSTRUCTIONAL MODELS

This study was aimed at determining and comparing the effectiveness of project-based learning and 5E learning cycle instructional models in improving the acquisition of new biological knowledge related to the human immune system. This quasi experiment study with a pretest-posttest non-equivalent control group design was conducted in SMAN 1 and SMAN 8 Yogyakarta, Indonesia during the academic year 2018/2019. A cluster sampling technique was used to select 3 eleventh grade classes of natural science from each school. The criterion referenced essay test was used to measure the students’ learning achievements and the data collected were analyzed using SPSS version 23. The results show that both PjBL and 5E learning instructional models were effective to improve the students’ ability to acquire new biological knowledge related to the human immune system. PjBL model was more effective than 5E learning cycle model in improving the students’ ability to acquire new biological knowledge related to the human immune system.

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Project Based Learning (PjBL) Model on the Mathematical Representation Ability

Tadris Jurnal Keguruan dan Ilmu Tarbiyah ◽

10.24042/tadris.v3i1.2535 ◽

2018 ◽

Vol 3 (1) ◽

pp. 47 ◽

Cited By ~ 6

Author(s):

Nining Ratnasari ◽

Nilawati Tadjudin ◽

Muhamad Syazali ◽

Mujib Mujib ◽

Siska Andriani

Keyword(s):

Real Life ◽

Project Based Learning ◽

T Test ◽

Mathematical Representation ◽

Control Group ◽

Cluster Sampling ◽

Conventional Model ◽

Control Group Design ◽

Significance Level ◽

Quasi Experimental

This study aims to determine the comparison of students 'mathematical representation ability through the Project Based Learning (PjBL) Model and the students' mathematical representation ability through the conventional model. The PjBL model is a student-centered, innovative, project-based learning model and positioned teachers as effective facilitators in the contextual learning related to real life situation. This research employed quasi-experimental design. The research applied the posttest only non-equivalent control group design through randomized cluster sampling. The data collection technique used was test. The instrument used to collect the data was the essay test. Data analysis was conducted using independent sample t-test. The result of the data calculation through the Independent-Sample T-Test test obtained the significance level of 0.913 means that the students’ mathematical representation ability was better after the learning through Project Based Learning (PjBL) model was conducted compared to the students' mathematical representation ability through a conventional model. This means that the PjBL model is more influential on students' mathematical representation ability.

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PENGARUH MODEL PEMBELAJARAN LEARNING CYCLE 5E DISERTAI MIND MAP TERHADAP HASIL BELAJAR IPA BIOLOGI SISWA KELAS VIII SMP NEGERI 5 KARANGANYAR TAHUN PELAJARAN 2015/2016

BIO-PEDAGOGI ◽

10.20961/bio-pedagogi.v5i2.5420 ◽

2016 ◽

Vol 5 (2) ◽

pp. 21

Author(s):

Hargiono Hargiono ◽

Maridi Maridi ◽

Bowo Sugiharto

Keyword(s):

Learning Cycle ◽

Cognitive Domain ◽

Choice Test ◽

Control Group ◽

Cluster Sampling ◽

Learning Models ◽

Control Group Design ◽

Group Data ◽

Biology Learning ◽

Academic Year

The purpose of this research is to ascertain the influence of learning cycle 5E models accompanied mind map toward biology learning achievment of VIII grade students at SMP Negeri 5 Karanganyar academic year 2015/2016. This research was quasi experiment research which used posttest only nonequivalent control group design. This research applied learning cycle 5E learning models accompanied mind map in experimental group and direct instruction learning models in control group. The population of this research was all of VIII grade students at SMP Negeri 5 Karanganyar in academic year 2015/2016. Sampling techniques used cluster sampling that choosed VIII A, VIII B, and VIII G as experiment group, and VIII H as control group. Data was collected using multiple choice test, observation sheet, and document. The hypotheses analyzed by anova test. Result of data analysis using one way anova showed that experiment group with application of learning cycle 5E learning models accompanied mind map has different signification 0.000 with other experiment groups and Fstatisticwith value 7,436 is higher than F(α,df)with value 2,440.This research concluded that application of learning cycle 5E learning models accompanied mind map has real influential toward student’s biology learning achievement of VIII grade students at SMP Negeri 5 Karanganyar especially cognitive domain. Keywords : learning cycle 5E, mind map,learning achievment.

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E-STEM project-based learning in teaching science to increase ICT literacy and problem solving

International Journal of Evaluation and Research in Education (IJERE) ◽

10.11591/ijere.v10i4.21942 ◽

2021 ◽

Vol 10 (4) ◽

pp. 1386

Author(s):

Syarifah Rahmiza Muzana ◽

Jumadi Jumadi ◽

Insih Wilujeng ◽

Bagus Endri Yanto ◽

Abdul Aziz Mustamin

Keyword(s):

Problem Solving ◽

Junior High School ◽

Learning Model ◽

Project Based Learning ◽

Teaching Science ◽

Control Group ◽

Cluster Sampling ◽

Ict Literacy ◽

Control Group Design ◽

Quasi Experimental

The aim of the research was to determine the effectivity of implementation of e-learning science, technology, engineering, and mathematics (E-STEM) project-based learning model in teaching science to improve information, communication, and technology (ICT) literacy and problem solving. The study adopted quasi-experimental non-equivalent control group design. E-STEM project-based learning model was applied in experimental classroom, while the control classroom applied conventional teaching. The sample was 46 students who was selected using cluster sampling method. They were in grade VIII academic year 2020/2021 which representing the population students of Junior High School 8, in Aceh Besar, Indonesia. The data were collected using test instrument and questionnaires. Validity verification of instrument measured based on Aiken index, while instrument reliability was determined based on Cronbach’s alpha coefficient. The data were analyzed using Manova and descriptive quantitative. The result of the study showed that there is meaningful difference of ICT literacy and problem solving mean score based on the difference of both teaching approach. It is concluded that the implementation of E-STEM project-based learning model and problem solving in teaching science has significant impact in increasing ICT literacy and problem solving.

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Penerapan Model Pembelajaran Learning Cycle 5e Sebagai Upaya Untuk Meningkatkan Kemampuan Komunikasi Matematis Siswa

Jurnal Derivat: Jurnal Matematika dan Pendidikan Matematika ◽

10.31316/j.derivat.v4i2.154 ◽

2019 ◽

Vol 4 (2) ◽

pp. 8-16

Author(s):

Nia Yuniarti ◽

Nerru Pranuta Murnaka

Keyword(s):

Sampling Technique ◽

Skill Learning ◽

Learning Cycle ◽

Control Group ◽

Cluster Sampling ◽

Model Learning ◽

Mathematical Communication ◽

Control Group Design ◽

Communication Ability ◽

Quasi Experiment

Mathematical communication ability is an important ability to have students. This is because by having these abilities, students can communicate ideas or mathematical ideas both orally and in writing. However, based on preliminary studies in the form of mathematical communication and class observation tests conducted by researchers in one class at SMP Negeri 8 Kota Tangerang Selatan showed that students' mathematical communication ability is still low. The efforts that can be done is to apply a model of learning that can train and cultivate students' mathematical communication ability by applying the learning cycle 5e model. The purpose of this study is to determine whether the average of improvement mathematical communication skills of students who get a learning model learning cycle 5e higher than students who obtain conventional learning. This type of research is quasi experiment. The research design used is a nonequivalent control group design. The population in this research are the students of class VII.1, VII.2, and VII.3 SMP Negeri 8 Kota Tangerang Selatan and the sample is the students of class VII.2 as the experimental class and class VII.3 as the control class. The sampling technique used random cluster sampling. Hypothesis testing of research done by the parametric test (t-test). In this research, it can be concluded that the average improvement mathematical communication ability of students who get the learning cycle 5e model is higher than students who get conventional learning. Keywords: Mathematical communication skill, learning cycle 5e model, quasi-experiment

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Effects of pesticide exposure on the human immune system

Human & Experimental Toxicology ◽

10.1177/0960327108094509 ◽

2008 ◽

Vol 27 (9) ◽

pp. 671-680 ◽

Cited By ~ 75

Author(s):

E Corsini ◽

J Liesivuori ◽

T Vergieva ◽

H Van Loveren ◽

C Colosio

Keyword(s):

Immune System ◽

Pesticide Exposure ◽

Prognostic Significance ◽

Control Group ◽

Limited Data ◽

Human Immune System ◽

Epidemiological Evidence ◽

Exposure Data ◽

Exposure Levels ◽

Human Immune

Epidemiological evidence from Western countries indicates that the prevalence of diseases associated with alterations in the immune response, such as asthma, certain autoimmune diseases and cancer, are increasing to such an extent that it cannot be attributed to improved diagnostics alone. There is some concern that this trend could be, at least, partially attributable to new or modified patterns of exposures to chemicals, including pesticides. The purpose of this article is to review the evidence on pesticide immunotoxicity in humans. Overall, the available data are inadequate to draw firm conclusions on the immunotoxic risk associated with pesticide exposure. The available studies on the effects of pesticides on the human immune system have several limitations, including limited data on exposure levels, heterogeneity of the applied methods, and difficulties in assessing the prognostic significance of observed slight changes and in the interpretation of the reported findings. Further studies are needed and preferably as prospective studies, comparing pre- and post-exposure data in the same group of subjects and including an appropriate non-exposed control group. More knowledge is required regarding the prognostic significance of the small changes observed.

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Pengaruh Model Problem Based Learning (PBL) dan Project Based Learning (PjBL) Terhadap Hasil Belajar Biologi Pada Materi Pencemaran Lingkungan Siswa Sekolah Menengah Atas

Jurnal Pendidikan Biologi ◽

10.24114/jpb.v6i2.6550 ◽

2017 ◽

Vol 6 (2) ◽

Author(s):

Eka Prihartini

Keyword(s):

Learning Outcomes ◽

Model Problem ◽

Problem Based Learning ◽

Sampling Technique ◽

Project Based Learning ◽

Control Group ◽

Cluster Sampling ◽

Control Group Design ◽

Biology Learning ◽

Level Of Significance

This research was aimed to determine: the effect of model problem based learning (PBL), project based learning (PjBL) and conventional learning to: biology learning outcomes of students in the matter of environmental pollution in SMA Negeri 2 Kota Tebingtinggi. A quasi-experiment research used pretest-posttest control group design. Samples were selected using random cluster sampling technique and divided into experiment and control classes. The tenth class of sains-2 was applied with conventional learning (control), the tenth class of sains-3 was applied with problem based learning (PBL), and the tenth class of sains-4 was applied with project based learning (PjBL). Data were analyzed using Analysis Covarian (anacova) at the level of significance α = 0.05 and followed by Tukey’s test with SPSS ver 21.0. The results showed that: There was an effect of learning model to biology learning outcomes (P= 0,025). Biology learning outcomes that learned with problem based learning (81,46 ± 6,59) was higher than the project based learning (81,43 ± 10,14) and conventional learning (65,43 ± 7,10). Based on the results showed that problem based learning (PBL) is better than project based learning (PjBL) and conventional learning.

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Faculty Opinions recommendation of The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725390605.793505391 ◽

2015 ◽

Author(s):

Toshihiro Nakajima ◽

Satoko Aratani

Keyword(s):

Immune System ◽

Genetic Architecture ◽

Human Immune System ◽

Disease Pathogenesis ◽

System A ◽

Human Immune

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721 AT1412, a patient-derived CD9 antibody in preclinical development promoting tumor immune infiltration and inducing tumor rejection

Journal for ImmunoTherapy of Cancer ◽

10.1136/jitc-2020-sitc2020.0721 ◽

2020 ◽

Vol 8 (Suppl 3) ◽

pp. A763-A763

Author(s):

Remko Schotte ◽

Julien Villaudy ◽

Martijn Kedde ◽

Wouter Pos ◽

Daniel Go ◽

...

Keyword(s):

T Cells ◽

Immune System ◽

T Cell ◽

Tumor Cells ◽

Tumor Rejection ◽

Human Immune System ◽

Preclinical Development ◽

High Affinity ◽

Human Immune ◽

A375 Melanoma

BackgroundAdaptive immunity to cancer cells forms a crucial part of cancer immunotherapy. Recently, the importance of tumor B-cell signatures were shown to correlate with melanoma survival. We investigated whether tumor-targeting antibodies could be isolated from a patient that cured (now 13 years tumor-free) metastatic melanoma following adoptive transfer of ex vivo expanded autologous T cells.MethodsPatient‘s peripheral blood B cells were isolated and tested for the presence of tumor-reactive B cells using AIMM’s immmortalisation technology. Antibody AT1412 was identified by virtue of its differential binding to melanoma cells as compared to healthy melanocytes. AT1412 binds the tetraspanin CD9, a broadly expressed protein involved in multiple cellular activities in cancer and induces ADCC and ADCP by effector cells.ResultsSpontaneous immune rejection of tumors was observed in human immune system (HIS) mouse models implanted with CD9 genetically-disrupted A375 melanoma (A375-CD9KO) tumor cells, while A375wt cells were not cleared. Most notably, no tumor rejection of A375-CD9KO tumors was observed in NSG mice, indicating that blockade of CD9 makes tumor cells susceptible to immune rejection.CD9 has been described to regulate integrin signaling, e.g. LFA-1, VLA-4, VCAM-1 and ICAM-1. AT1412 was shown to modulate CD9 function by enhancing adhesion and transmigration of T cells to endothelial (HUVEC) cells. AT1412 was most potently enhancing transendothelial T-cell migration, in contrast to a high affinity version of AT1412 or other high affinity anti-CD9 reference antibodies (e.g. ALB6). Enhanced immune cell infiltration is also observed in immunodeficient mice harbouring a human immune system (HIS). AT1412 strongly enhanced CD8 T-cell and macrophage infiltration resulting in tumor rejection (A375 melanoma). PD-1 checkpoint blockade is further sustaining this effect. In a second melanoma model carrying a PD-1 resistant and highly aggressive tumor (SK-MEL5) AT1412 together with nivolumab was inducing full tumor rejection, while either one of the antibodies alone did not.ConclusionsThe safety of AT1412 has been assessed in preclinical development and is well tolerated up to 10 mg/kg (highest dose tested) by non human primates. AT1412 demonstrated a half-life of 8.5 days, supporting 2–3 weekly administration in humans. Besides transient thrombocytopenia no other pathological deviations were observed. No effect on coagulation parameters, bruising or bleeding were observed macro- or microscopically. The thrombocytopenia is reversible, and its recovery accelerated in those animals developing anti-drug antibodies. First in Human clinical study is planned to start early 2021.Ethics ApprovalStudy protocols were approved by the Medical Ethical Committee of the Leiden University Medical Center (Leiden, Netherlands).ConsentBlood was obtained after written informed consent by the patient.

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