scholarly journals Proinflammatory cytokines in patients with acute myocardial infarction against the background of chronic obstructive pulmonary disease

2020 ◽  
Vol 11 (3) ◽  
pp. 40-47
Author(s):  
A. V. Naumov ◽  
T. V. Prokofieva ◽  
O. S. Polunina ◽  
L. V. Saroyants ◽  
E. A. Polunina
Keyword(s):  
Myocardial Infarction ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Serum Levels ◽  
Cardiovascular Death ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Increased Risk ◽  
Independent Marker

Objective: To study and analyze serum levels of interleukins (IL): IL-1β, IL-2 and IL-6 in patients with myocardial infarction and chronic obstructive pulmonary disease.Materials and methods: In 85 people were examined: 28 patients with myocardial infarction, 37 patients with comorbid pathology (myocardial infarction and chronic obstructive pulmonary disease) and 20 somatically healthy volunteers as a control group. Determination of IL-1β, IL-2 and IL-6 levels was basing on enzyme immunoassay.Results: The median and inter-percentile range of IL-1β, IL-2 and IL-6 in the donors did not differ significantly from the data of the manufacturer. In the group of patients with myocardial infarction and in patients with comorbid pathology a statistically significant increase in the level of median and inter-percentile range of cytokines was revealing compared with the control group. The highest levels of IL-1β, IL-2 and IL-6 were detecting in the group of patients with comorbid pathology. IL-6 was found to be an independent marker of increased risk of STEMI and an increase in its concentration later than 12 hours after hospitalization is associated with the risk of future cardiovascular death or new myocardial infarction.Conclusion: Analysis of the dynamics of the level of IL-1β, IL-2 and IL-6 has a high prognostic value in patients with myocardial infarction and in patients with comorbid pathology.

scholarly journals Oral Corticosteroid Use and the Risk of Acute Myocardial Infarction in Chronic Obstructive Pulmonary Disease

2006 ◽  
Vol 13 (3) ◽  
pp. 134-138 ◽  
Author(s):  
Laetitia Huiart ◽  
Pierre Ernst ◽  
Xavier Ranouil ◽  
Samy Suissa
Keyword(s):  
Myocardial Infarction ◽  
Chronic Obstructive Pulmonary Disease ◽  
Acute Myocardial Infarction ◽  
Pulmonary Disease ◽  
Systemic Hypertension ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Increased Risk ◽  
Acute Exacerbations ◽  
Oral Corticosteroids

BACKGROUND: Given the limited efficacy of oral corticosteroids in treating chronic obstructive pulmonary disease (COPD), the possible cardiac side effects of oral corticosteroids are of particular concern in an elderly population. The impact of the use of oral corticosteroids on the risk of acute myocardial infarction (AMI) in a cohort of patients with COPD was studied.METHODS: The Saskatchewan health services databases were used to form a population-based cohort of 5648 patients aged 55 years or older who received a first treatment for COPD between 1990 and 1997. A nested case-control analysis was conducted: 371 cases presenting with a first myocardial infarction were matched with 1864 controls according to the length of follow-up, the date of cohort entry and age. Conditional logistic regression was used to adjust for sex, severity of COPD, systemic hypertension, diabetes and prior cardiovascular disease.RESULTS: Only the current use of corticosteroids was associated with an increased risk of AMI (adjusted RR=2.01 [95% CI 1.13 to 3.58]), particularly when the current dose was larger than 25 mg/day of prednisone or the equivalent (adjusted RR=3.22 [95% CI 1.42 to 7.34]). This observed increase in risk rapidly returned to baseline after the cessation of the medication, suggesting that the use of such high doses reflected the treatment of acute exacerbations of the disease.CONCLUSIONS: An association was found between the current use of oral corticosteroids and the occurrence of an AMI, suggesting that acute exacerbations of COPD are associated with an increased risk of acute coronary syndromes.

scholarly journals Role of signal-averaged electrocardiography and ventricular late potentials in patients with chronic obstructive pulmonary disease

2015 ◽  
Vol 53 (2) ◽  
pp. 133-139 ◽  
Author(s):  
C.A. Buzea ◽  
G.A. Dan ◽  
Anca Rodica Dan ◽  
Caterina Delcea ◽  
M.I. Balea ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Ventricular Arrhythmias ◽  
Control Group ◽  
Chronic Obstructive ◽  
Late Potentials ◽  
Obstructive Pulmonary Disease ◽  
Ventricular Late Potentials ◽  
Copd Patients ◽  
Increased Risk

Abstract Patients with chronic obstructive pulmonary disease (COPD) have an increased risk for cardiac arrhythmias. Ventricular late potentials (VLP) on signal-averaged electrocardiography (SAECG) are associated with an increased risk for malignant ventricular arrhythmias. Our aim is to investigate the modifications of SAECG parameters and the presence of VLP as possible indicators of proarrhythmic substrate in patients with COPD. We prospectively enrolled 41 consecutive patients in the COPD group and 63 patients without any history of pulmonary disease, matched for age and hypertension history, in the control group. Pulmonary function tests, arterial blood gases, echocardiography, 24-hour Holter monitoring and SAECG were performed. We measured total filtered QRS duration (QRSf), duration of high frequency, low-amplitude signals < 40 V (HFLA40), and root mean square voltage in the last 40 ms (RMS40). VLP were considered if at least two of these parameters were abnormal. Results. We did not register any significant differences in QRSf, HFLA40 or RMS40 between the two groups. In the COPD group there was a non-significant higher percentage of patients with VLP in comparison with the control group. In the COPD patients we registered a significantly higher number of isolated premature ventricular beats and of combined complex ventricular arrhythmias, consisting of polymorphic PVC, couplets, triplets or nonsustained ventricular tachycardias. None of these arrhythmic parameters correlated with SAECG variables or with the presence of VLP. Conclusion. In COPD patients parameters measured on signal-averaged electrocardiography and ventricular late potentials analysis have little value in risk stratification for ventricular arrhythmias.

scholarly journals Informativeness of cytokine profile in predicting complications in patients with myocardial infarction on background of chronic obstructive pulmonary disease

2019 ◽  
Vol 3 (22) ◽  
pp. 33-36
Author(s):  
A. V. Naumov ◽  
L. V. Saroyants ◽  
T. V. Prokofyeva ◽  
O. S. Polunina ◽  
E. A. Polunina
Keyword(s):  
Myocardial Infarction ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Left Ventricular ◽  
Cytokine Profile ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Main Indicator ◽  
Complications Of Myocardial Infarction

Objective. To determine the information content of the cytokine profile (IL-1β, IL-2 and IL-6) in predicting complications in patients with myocardial infarction (MI) against the background of chronic obstructive pulmonary disease (COPD).Materials and methods. In 85 people were examined: 28 patients with myocardial infarction, 37 patients with comorbid pathology (MI + COPD) and 20 somatically healthy volunteers as a control group. Determination of IL-1β, IL-2 and IL-6 levels was basing on enzyme immunoassay.Results. When assessing the cytokine profile in patients with MI and MI against the background of COPD, the most pronounced differences between groups of patients were observed in the levels of IL-6. Analyzing the association of the level of IL-6 with the presence of early complications of MI, it was found that the level of IL-6 in patients with complicated MI was significantly higher than in patients with uncomplicated course. The highest level of IL-6 was recorded in the subgroup of patients with complicated myocardial infarction during COPD. Studying the levels of IL-6 depending on the type of complications of myocardial infarction showed that the highest values of IL-6 were recorded in the group of comorbid patients with cardiogenic shock and pulmonary edema.Conclusion. When determining the cytokine status in patients with myocardial infarction on the background of COPD, the level of IL-6 should be considered as the main indicator. This cytokine can be considered a marker of left ventricular that developed in the acute period in patients with myocardial infarction on the background of COPD.

scholarly journals COPD significantly increases cerebral and cardiovascular events in hypertensives

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria Perticone ◽  
Raffaele Maio ◽  
Benedetto Caroleo ◽  
Edoardo Suraci ◽  
Salvatore Corrao ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Chronic Obstructive Pulmonary Disease ◽  
Essential Hypertension ◽  
Pulmonary Disease ◽  
Cardiovascular Events ◽  
Cardiovascular Death ◽  
Major Adverse Cardiovascular Events ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

AbstractEssential hypertension and chronic obstructive pulmonary disease often coexist in the same patient. The aim of this study was to evaluate whether the addition of chronic obstructive pulmonary disease modifies the risk of cardiovascular events in hypertensives. We enrolled 1728 hypertensives. Study outcomes included fatal and non-fatal cardiovascular stroke and myocardial infarction, and cardiovascular death. During a mean follow-up of 57 months there were 205 major adverse cardiovascular events (2.47 per 100 pts/yr): cardiac (n117; 1.41 per 100 pts/yr) and cerebrovascular (n = 77; 0.93 per 100 pts/yr). In hypertensives with chronic obstructive pulmonary disease we observed a greater number of cardiovascular events than in hypertensives without respiratory disease (133 [5.55 per 100 pts/yr) vs 72 [1.22 per 100 pts/yr], respectively. The addition of chronic obstructive pulmonary disease to hypertension increased the incidence of total and non-fatal stroke of more than nine- (2.42 vs 0.32 per 100 pts/yr) and 11-fold (2.09 vs 0.22 per 100 pts/yr), respectively. The same trend was observed for total (2.88 vs 0.81 per 100 pts/yr) and non-fatal (2.67 vs 0.79 per 100 pts/y) myocardial infarction. The presence of chronic obstructive pulmonary disease in hypertensives significantly increases the risk of stroke, myocardial infarction and major adverse cardiovascular events.

scholarly journals Detection of alpha-1 antitrypsin gene mutations by polymerase chain reaction in patients with chronic obstructive pulmonary disease

2019 ◽  
Vol 72 (5-6) ◽  
pp. 148-153
Author(s):  
Jelena Stojcevic-Maletic ◽  
Katarina Baculov ◽  
Vanesa Sekerus ◽  
Natasa Vucinic ◽  
Borko Milanovic ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Protease Inhibitor ◽  
Pulmonary Disease ◽  
Serum Levels ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Lung Emphysema ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin

Introduction. The alpha-1 antitrypsin deficiency is the best described genetic cause of chronic obstructive pulmonary disease. The study of the alpha-1 antitrypsin deficiency, as the most important genetic risk factor for chronic obstructive pulmonary disease, is an important step in developing a strategy for the prevention and treatment of this disease. The aim of the study was detection of homozygous and heterozygous deficient gene alleles (protease inhibitor Z and protease inhibitor S) for alpha-1 antitrypsin in the group of patients with chronic obstructive pulmonary disease with the predominance of lung emphysema, as well as determination of a positive correlation between the serum levels of alpha-1 antitrypsin and the corresponding alpha-1 antitrypsin genotype. Material and Methods. The study included 90 patients, mutually unrelated individuals, hospitalized due to lung emphysema. The control group included 10 subjects, with no clinical signs of lung emphysema, but with a family history of chronic obstructive pulmonary disease. We attempted to identify the most common deficient alleles (protease inhibitor Z and protease inhibitor S) and the concentration of alpha-1 antitrypsin in the serum of the examinees. The polymorphism between the two allelic forms, protease inhibitor Z and protease inhibitor S, was detected by real-time polymerase chain reaction. Results. Protease inhibitor MM genotype alpha-1 antitrypsin was present in all 90 patients with the diagnosis of pulmonary emphysema, and the serum levels of alpha-1 antitrypsin were within the range of reference values. In the control group, there were two cases with mutated protease inhibitor MZ genotype, and in these 2 subjects the serum level of alpha-1 antitrypsin was at the lower limit of reference values. Conclusion. In patients diagnosed with lung emphysema, protease inhibitor MM genotype of alpha-1 antitrypsin and normal serum alpha-1 antitrypsin levels, the genetically- determined deficiency of alpha-1 antitrypsin is not responsible for the development of chronic obstructive pulmonary disease.

scholarly journals Association of serum deiodinase type 2 level with chronic obstructive pulmonary disease in the Polish population

2019 ◽  
Author(s):  
Elżbieta Gałecka ◽  
Anna Kumor-Kisielewska ◽  
Paweł Górski
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Healthy Subjects ◽  
Serum Levels ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Protein Levels

Backgrounds: Deiodinase type 2 (DIO2) is a selenoenzyme involved in the synthesis of thyroid hormones. Chemerin is a newly investigated adipokine known also as novel chemokine. Both molecules have been recently expected and found to play an important role in inflammation and immunity. DIO2, for example, is upregulated during acute and chronic inflammation. In addition, inflammation-induced expression of DIO2 in macrophages has been confirmed, while chemerin modulates the activation and chemotaxis of immune cells. It is widely known that chronic obstructive pulmonary disease (COPD) – the most common lung disease in the world – is accompanied by an inflammatory process and immune activation. There are no studies demonstrating an association between DIO2, chemerin and COPD. The aim of this study was to estimate DIO2 and chemerin concentration in serum collected from patients suffering from COPD and to compare it with healthy subjects, as well as to correlate with basic and clinical characteristics. Methods: The study group included 50 patients with COPD and 30 healthy subjects. DIO2 and chemerin serum levels as well as c-reactive protein levels were determined in all the subjects using commercial enzyme-linked immunosorbent assay kits. The association between serum DIO2 and chemerin with sociodemographic and clinical variables was assessed. Results: DIO2 serum levels were significantly higher in the patients with COPD as compared to the control group (50.3±23.2 U/L vs. 13.3±13.1; p<0.00001). No differences were observed in serum chemerin levels between the patients and controls (107.559±86.695.6 vs. 100.701±53.805; p=0.54). Furthermore, there was no association between DIO2 and chemerin levels and other variables, and no correlation between both molecules. Conclusions: This study demonstrated that DIO2 levels were higher in the patients with COPD than in the control subjects. The examined molecules should be further investigated if they are intended to be considered markers of processes involved in COPD mechanisms.

scholarly journals Clinical and diagnostic significance of apoptosis markers in myocardial infarction in the setting of chronic obstructive pulmonary disease

2021 ◽  
Vol 12 (4) ◽  
pp. 46-53
Author(s):  
A. V. Naumov ◽  
T, V. Prokofieva ◽  
O. S. Polunina ◽  
L. V. Saroyants ◽  
E. A. Polunina
Keyword(s):  
Myocardial Infarction ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Annexin V ◽  
Control Group ◽  
Chronic Obstructive ◽  
Healthy Individuals ◽  
Obstructive Pulmonary Disease ◽  
St Segment Elevation ◽  
St Segment

Objective: To study the levels of heat shock protein 70 (HSP70) and annexin V-dependent apoptosis of cells in myocardial infarction (MI) with a different course of the disease and in the setting of chronic obstructive pulmonary disease (COPD).Materials and Methods: Sixty-five patients with MI were examined; 37 of them developed MI in the setting of COPD, and 28 patient had MI without COPD. The subjects were divided into subgroups depending on the presence of ST segment elevation. The control group included 30 somatically healthy individuals.Results: In all examined patients with MI and in patients with MI with COPD, the number of annexin V-associated apoptotic cells and the level of HSP70 was statistically significantly higher than in healthy individuals. The value of the studied biomarkers was statistically significantly higher than in patients without COPD. In patients with MI with ST segment elevation, the values of the studied biomarkers were statistically significantly higher in patients without ST segment elevation in all the examined patients.Conclusions: Higher values of the studied biomarkers in the group of comorbid patients compared with those with MI without COPD may be associated with intensified apoptosis in the setting of chronic systemic inflammation, which worsens the clinical course of both diseases. The greater significance of the levels of HSP70 and annexin V-dependent cell apoptosis in patients with MI with ST segment elevation compared with patients without ST segment elevation is due to the volume of myocardial lesion.

scholarly journals Clinical and functional correlations in patients with myocardial infarction on background of chronic obstructive pulmonary disease with various phenotypes

2020 ◽  
pp. 11-14
Author(s):  
B. Yu. Kuzmichev ◽  
T. V. Prokofievа ◽  
O. S. Polunina ◽  
E. A. Polunina ◽  
K. Yu. Kuzmichyov ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Chronic Obstructive Pulmonary Disease ◽  
Chronic Bronchitis ◽  
Pulmonary Disease ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Ventricular Ejection Fraction

Objective. To identify clinical and functional correlations in patients with myocardial infarction against the background of the chronic obstructive pulmonary disease with various phenotypes.Materials and methods. 188 patients were examined, from which the following groups were formed: control group – 50 patients, group 1–50 patients with myocardial infarction (MI), group 2–25 patients with MI against the background of the chronic obstructive pulmonary disease (COPD) with emphysematous phenotype, group 3–20 patients with MI + COPD with chronic bronchitis phenotype, group 4–22 patients with MI + COPD with mixed phenotype and group 5–21 patients with MI + COPD with the phenotype with eosinophilia and bronchial asthma. Clinical examination of patients included assessment of complaints, medical history and history of life. Spirography on apparatus SP-100 Schiller (Switzerland) was used for the assessment of respiratory function. Echocardiography was performed on Acuson-Sequoia 512 echo scanner (Siemens). Statistical analyses were performed using Statistica 12.0 (Stat Soft).Results. The highest frequency of symptoms such as chest pain, nausea/vomiting, fatigue, tachycardia, cough with sputum was observed among patients with MI + COPD with chronic bronchitis phenotype. In this group of patients, the level of systolic blood pressure in the pulmonary artery and the left ventricular ejection fraction were the lowest.Conclusion. Chronic bronchitis phenotype of COPD in patients with MI is the most prognostically unfavorable. It is associated with the severity of clinical manifestations, with signs of pulmonary hypertension and dysfunction of the left heart, that makes necessary to take into account the phenotypes of COPD in the care of patients with MI against the background of COPD and the allocation of chronic bronchitis phenotype as a criterion for an unfavorable prognosis of MI.

Oral and Oropharyngeal Sensory Function in Adults With Chronic Obstructive Pulmonary Disease

2020 ◽  
Vol 29 (2) ◽  
pp. 864-872
Author(s):  
Fernanda Borowsky da Rosa ◽  
Adriane Schmidt Pasqualoto ◽  
Catriona M. Steele ◽  
Renata Mancopes
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Oral Cavity ◽  
Pulmonary Disease ◽  
Thermal Sensation ◽  
Sensory Function ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Age Related ◽  
Copd Patients

Introduction The oral cavity and pharynx have a rich sensory system composed of specialized receptors. The integrity of oropharyngeal sensation is thought to be fundamental for safe and efficient swallowing. Chronic obstructive pulmonary disease (COPD) patients are at risk for oropharyngeal sensory impairment due to frequent use of inhaled medications and comorbidities including gastroesophageal reflux disease. Objective This study aimed to describe and compare oral and oropharyngeal sensory function measured using noninstrumental clinical methods in adults with COPD and healthy controls. Method Participants included 27 adults (18 men, nine women) with a diagnosis of COPD and a mean age of 66.56 years ( SD = 8.68). The control group comprised 11 healthy adults (five men, six women) with a mean age of 60.09 years ( SD = 11.57). Spirometry measures confirmed reduced functional expiratory volumes (% predicted) in the COPD patients compared to the control participants. All participants completed a case history interview and underwent clinical evaluation of oral and oropharyngeal sensation by a speech-language pathologist. The sensory evaluation explored the detection of tactile and temperature stimuli delivered by cotton swab to six locations in the oral cavity and two in the oropharynx as well as identification of the taste of stimuli administered in 5-ml boluses to the mouth. Analyses explored the frequencies of accurate responses regarding stimulus location, temperature and taste between groups, and between age groups (“≤ 65 years” and “> 65 years”) within the COPD cohort. Results We found significantly higher frequencies of reported use of inhaled medications ( p < .001) and xerostomia ( p = .003) in the COPD cohort. Oral cavity thermal sensation ( p = .009) was reduced in the COPD participants, and a significant age-related decline in gustatory sensation was found in the COPD group ( p = .018). Conclusion This study found that most of the measures of oral and oropharyngeal sensation remained intact in the COPD group. Oral thermal sensation was impaired in individuals with COPD, and reduced gustatory sensation was observed in the older COPD participants. Possible links between these results and the use of inhaled medication by individuals with COPD are discussed.

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