Methylphenidate in a Patient with Depression and Respiratory Insufficiency

2001 ◽  
Vol 31 (4) ◽  
pp. 443-449 ◽  
Author(s):  
Danusa Céspedes Guizzo Ayache ◽  
Renério Fráguas Júnior
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Insufficiency ◽  
Initial Dose ◽  
Respiratory Function ◽  
Severe Depression ◽  
Critically Ill Patient ◽  
Medical Complications ◽  
Case Description ◽  
Antidepressant Response ◽  
Ventilatory Insufficiency

Objective: We report a case of severe depression in an elderly and critically ill patient with multiple medical complications who was treated with a combination of methylphenidate and sertraline. The objective of this report is to outline the usefulness of methylphenidate as an antidepressant in a patient with respiratory insufficiency. Method: Case description. Results: The patient had a positive clinical response with initial mental confusion due to methylphenidate. An initial dose of 2.5 mg/day allowed antidepressant response and improvement of respiratory function permitting the removal of mechanical ventilation. Conclusion: Methylphenidate may be useful for patients with severe medical conditions including ventilatory insufficiency.

Percorso assistenziale e scelte terapeutiche nella Sclerosi Laterale Amiotrofica (SLA) / Care pathway and therapeutics choices for Amyiotrophic Lateral Sclerosis (ALS)

2018 ◽  
Vol 67 (2) ◽  
pp. 157-174
Author(s):  
Mario Sabatelli
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Failure ◽  
Respiratory Function ◽  
Care Pathway ◽  
Muscular Weakness ◽  
Sulla Base ◽  
Novel Technology ◽  
Sclerosi Laterale Amiotrofica ◽  
Lateral Sclerosis ◽  
Critical Aspects

La Sclerosi laterale amiotrofica (SLA) è una malattia devastante caratterizzata da una paralisi progressiva dei muscoli scheletrici compresi quelli degli arti, della deglutizione, della fonazione e della respirazione. La morte si verifica entro 3-5 anni nella gran parte dei casi e in un contesto di grande sofferenza a causa dei sintomi della insufficienza respiratoria. La introduzione di tecnologie innovative per supportare la funzione respiratoria con la ventilazione meccanica ha cambiato notevolmente l’approccio assistenziale alle persone con SLA. Il presente contributo intende approfondire, sulla base dell’esperienza maturata presso il Centro Clinico NeMOFondazione Policlinico Universitario A. Gemelli - IRCCS, alcuni aspetti problematici nel percorso assistenziale e delle relative scelte terapeutiche per i pazienti affetti da SLA. ---------- Amyiotrophic Lateral Sclerosis (ALS) is a devastating disease characterized by progressive muscular weakness, leading to limb palsy, difficulties in swallowing, speaking and breathing. Death occurs within 3-5 years in most patients in the context of significant suffering due to symptoms of respiratory failure. The availability of novel technology to support respiratory function by mechanical ventilation has profoundly changed the management of people with ALS. The present article addresses some critical aspects of both care pathway and the related therapeutics choices for patients with ALS on the basis of the experience of the Centro Clinico NeMO-Fondazione Policlinico Universitario A. Gemelli - IRCCS.

scholarly journals Moderation of antidepressant response by the serotonin transporter gene

2009 ◽  
Vol 195 (1) ◽  
pp. 30-38 ◽  
Author(s):  
Patricia Huezo-Diaz ◽  
Rudolf Uher ◽  
Rebecca Smith ◽  
Marcella Rietschel ◽  
Neven Henigsberg ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Severe Depression ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Antidepressant Response ◽  
Therapeutic Drugs ◽  
Noradrenaline Reuptake ◽  
Antidepressant Effects ◽  
And Gender

BackgroundThere have been conflicting reports on whether the length polymorphism in the promoter of the serotonin transporter gene (5-HTTLPR) moderates the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs). We hypothesised that the pharmacogenetic effect of 5-HTTLPR is modulated by gender, age and other variants in the serotonin transporter gene.AimsTo test the hypothesis that the 5-HTTLPR differently influences response to escitalopram (an SSRI) compared with nortriptyline (a noradrenaline reuptake inhibitor).MethodThe 5-HTTLPR and 13 additional markers across the serotonin transporter gene were genotyped in 795 adults with moderate-to-severe depression treated with escitalopram or nortriptyline in the Genome Based Therapeutic Drugs for Depression (GENDEP) project.ResultsThe 5-HTTLPR moderated the response to escitalopram, with long-allele carriers improving more than short-allele homozygotes. A significant three-way interaction between 5-HTTLPR, drug and gender indicated that the effect was concentrated in males treated with escitalopram. The single-nucleotide polymorphism rs2020933 also influenced outcome.ConclusionsThe effect of 5-HTTLPR on antidepressant response is SSRI specific conditional on gender and modulated by another polymorphism at the 5' end of the serotonin transporter gene.

Chant and Be Happy: The Effects of Chanting on Respiratory Function and General Well-Being in Individuals Diagnosed with Depression

2005 ◽  
Vol 15 (1) ◽  
pp. 61-64
Author(s):  
Molly Kenny ◽  
Raphael Bernier ◽  
Carey DeMartini
Keyword(s):  
Pilot Study ◽  
Beck Depression Inventory ◽  
Respiratory Function ◽  
Effective Means ◽  
Severe Depression ◽  
Extended Period ◽  
Well Being ◽  
Output Level ◽  
Preliminary Screening ◽  
Before And After

The effects of chanting on respiratory function and general well-being in individuals with mild to severe depression were tested in this pilot study. A total of 10 women and 1 man participated in this 8-week-long chanting program. All of the participants had been previously diagnosed with mild to severe depression. Several testing measures were employed. All subjects filled out a preliminary screening questionnaire and took the Beck Depression Inventory at the beginning of the study prior to their first chanting class and at the last meeting before chanting started. A 5-point Likert Scale Questionnaire was administered before and after each session. Spirometry was used to evaluate subjects' FVC, FEV, and FET. Each subject also self-administered pre and post peak/flow tests, taking the best of three forced exhalations before and after each chanting session. At the end of 8 weeks, our results showed that participants increased their breath control and overall expiratory output level. Additionally, 10 of our 11 subjects surveyed showed an increase in their overall mood on the Beck Depression Inventory. The score for one participant remained the same. Preliminary results from this pilot study indicate that chanting is an effective means of increasing people's moods in the immediate present, as well as over an extended period of time in which chanting is performed at least once per week.

scholarly journals Daytime mechanical ventilation in chronic respiratory insufficiency

1997 ◽  
Vol 10 (12) ◽  
pp. 2840-2846 ◽  
Author(s):  
B. Schönhofer ◽  
M. Geibel ◽  
M. Sonneborn ◽  
P. Haidl ◽  
D. Köhler
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Insufficiency ◽  
Chronic Respiratory Insufficiency

scholarly journals Efektivitas Ventilator dalam Proses End of Life dan Tinjauannya Menurut Pandangan Islam

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Yulya Mauliddina ◽  
Ferryal Basbeth ◽  
Muhammad Arsyad
Keyword(s):  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Intensive Care ◽  
Respiratory Failure ◽  
Medical Record ◽  
Medical Records ◽  
Respiratory Function ◽  
Sampling Techniques ◽  
Mechanical Ventilator ◽  
Probability Sampling

Background: A mechanical ventilator is a device used to help with respiratory function. Its use is indicated for patients with hypoxemia, severe hypercapnia and respiratory failure. Mechanical ventilator is one of the important and widely used aspects for critical patient care in the Intensive Care Unit (ICU). Methods: This research was conducted with non-probability sampling techniques. Non-probability sampling techniques was determined by purposive method, which is to determine the criteria first, then the samples are taken according to predetermined criteria. Results: As much as 98 medical records taken from the Juwita Bekasi Hospital ICU from  2013-2017  showed  that 3 patients showed effective results for ventilator installation and 95 patients showed ineffective results. Conclusion: Based on medical record in Juwita Bekasi Hospital from 2013 to 2017, The mechanical ventilation installation was not effective and only has 1% effectivity.

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