A prospective cohort study of older colorectal cancer surgical patients: an association of post-operative clinical outcome with sarcopenia, frailty, and nutritional status [Protocol] (Preprint)

Mapping Intimacies ◽

10.2196/preprints.16846 ◽

2019 ◽

Author(s):

Nia Humphry

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Nutritional Status ◽

Significant Proportion ◽

The Elderly ◽

Operative Risk ◽

Surgical Patients ◽

Clinical Frailty Scale ◽

Colorectal Cancer Surgery ◽

Colorectal Cancer Resection

UNSTRUCTURED Older patients account for a significant proportion of patients undergoing colorectal cancer surgery, and are vulnerable to a number of pre-operative risk factors that are not often present in younger patients. Three pre-operative risk factors more prevalent in the elderly are frailty, sarcopenia, and malnutrition. Whilst each of these has been studied in isolation, there is little information on the interplay between them in older surgical patients. One particular area of increasing interest is the use of urine metabolomics for objective evaluation of dietary profiles and malnutrition. Herein we describe the design, cohort, and standard operating procedures of a planned prospective study of older surgical patients undergoing colorectal cancer resection across multiple institutions in the United Kingdom. These procedures include serial frailty evaluations (Clinical Frailty Scale and Groningen Frailty Indicator), functional assessments (with hand grip strength and 4-metre walk test), muscle mass evaluations using computerized tomography morphometric analysis and evaluation of nutritional status using analysis of urinary dietary biomarkers. As these are all areas of common derangement in the elderly surgical population, prospectively studying them in concert will allow for analysis of their interplay as well as the development of predictive models for those at risk for commonly tracked surgical complications and outcomes.

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Colorectal cancer surgery in the elderly: acceptable morbidity?

The American Journal of Surgery ◽

10.1016/j.amjsurg.2007.12.022 ◽

2008 ◽

Vol 195 (3) ◽

pp. 344-348 ◽

Cited By ~ 27

Author(s):

Evan S. Ong ◽

Mohamed Alassas ◽

Kelli Bullard Dunn ◽

Ashwani Rajput

Keyword(s):

Colorectal Cancer ◽

The Elderly ◽

Cancer Surgery ◽

Colorectal Cancer Surgery ◽

Surgery In The Elderly

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Risk Factors for Wound Infection in Colorectal Cancer Surgery

Nippon Daicho Komonbyo Gakkai Zasshi ◽

10.3862/jcoloproctology.66.330 ◽

2013 ◽

Vol 66 (5) ◽

pp. 330-334

Author(s):

Naruyuki Kobayashi ◽

Masatoshi Kubo ◽

Izuru Endo ◽

Hiroki Otani ◽

Tetsunobu Udaka

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Wound Infection ◽

Cancer Surgery ◽

Colorectal Cancer Surgery

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Status kesehatan mulut dan asupan makan sebagai faktor risiko underweight pada lansia

Jurnal Gizi Klinik Indonesia ◽

10.22146/ijcn.18367 ◽

2013 ◽

Vol 9 (4) ◽

pp. 188

Author(s):

Dian Isti Angraini ◽

Al Supartinah ◽

Deddy Nur Wachid

Keyword(s):

Risk Factors ◽

Health Status ◽

Oral Health ◽

Nutritional Status ◽

Significant Risk ◽

The Elderly ◽

Oral Health Status ◽

Gingival Index ◽

Missing Teeth ◽

Periodontal Index

Background: Oral health status and dietary intake contribute to nutritional status in elderly. Missing teeth cause chewing disorder that reduces quality and quantity of food intake, which finally makes the elderly have underweight nutritional status.Objective: To determine the risk factors for underweight in the elderly at Yogyakarta Municipality.Method: The study was observational with case control design on elderly at Yogyakarta Municipality. Subjects consisted of 210 elderly matched in age and gender. Sampling was done by multistage random sampling. Oral health status was assessed through dental health status (index of missing teeth) and periodontal status (gingival index, periodontal index and oral hygiene index), dietary intake was collected by using semi quantitative food frequency questionnaire (SQ-FFQ) and underweight nutritional status was based on body mass armspan (BMA). Data were analyzed by using tests of X2 Mc.Nemar, X2 Stuart Maxwell, and conditional logistic regression.Results: Bivariate analysis showed the number of missing teeth ≥ 21 (OR=3.67, p<0.05) and 16-20 (OR=3.53, p<0.05) as risk factors of underweight, whereas the gingival index, periodontal index and oral hygiene index were not. Less intake of energy (OR=6.3), protein (OR=7.83), fat (OR=5.67) and carbohydrates (OR=7.5) were risk factors of underweight (p<0.01). Income less than Rp 808.000,00 was also risk factor for underweight (OR=4.5; p<0.01). Multivariate analysis showed the significant risk factors for underweight were the missing teeth ≥ 21 (OR=8.76) and 16-20 (OR=6.04) which increased by income less than Rp 808.000,00 (OR=5.94), less fat intake (OR=4.88), and less carbohydrate intake (OR=5.48). Income was confounding factor in the risk of missing teeth and protein intake for becoming underweight.Conclusion: Significant risk factors of underweight in elderly were missing teeth ≥ 16, less intake of fat and carbohydrate, and income less than Rp 808.000,00.

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Risk Factors for Postoperative Urinary Tract Infection and Urinary Retention in Patients Undergoing Surgery for Colorectal Cancer

The American Surgeon ◽

10.1177/000313481207801020 ◽

2012 ◽

Vol 78 (10) ◽

pp. 1100-1104 ◽

Cited By ~ 23

Author(s):

Celeste Y. Kang ◽

Obaid O. Chaudhry ◽

Wissam J. Halabi ◽

Vinh Nguyen ◽

Joseph C. Carmichael ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Urinary Tract Infection ◽

Logistic Regression ◽

Urinary Tract ◽

Tract Infection ◽

Hospital Mortality ◽

Urinary Retention ◽

Surgical Patients ◽

Independent Risk Factors

The aim of this study was to analyze risk factors for postoperative urinary tract infection (UTI) and urinary retention (UR) in patients with colorectal cancer. Using Nationwide Inpatient Sample 2006–2009, a retrospective analysis of surgical patients with colorectal cancer was conducted. Patients were stratified into groups, with or without UTI/UR. The LASSO algorithm for logistic regression identified independent risk factors. A total of 93,931 surgical patients with colorectal cancer were identified. The incidences of UTI and UR were 5.91 and 2.52 per cent, respectively. Overall in-hospital mortality was 2.68 per cent. The UTI group demonstrated significantly higher in-hospital mortality rates compared with those without. Both UTI and UR groups were associated with prolonged hospital stay and increased hospital charge. Multivariate logistic regression analysis revealed age older than 60 years, females, anemia, congestive heart failure, coagulopathy, diabetes with chronic complications, fluid and electrolyte, paralysis, pulmonary circulation disorders, renal failure, and weight loss were independent risk factors of UTI. Age older than 60 years, male gender, rectal and rectosigmoid cancers, and postoperative anastomotic leakage and ileus were independent risk factors for UR. Postoperative UTI increases in-house mortality. Postoperative UTI/UR in patients with colorectal cancer increases length of stay and hospital charges. Knowledge of these specific risk factors for UTI and UR is needed to counsel patients and prevent these complications in this high-risk population.

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Analysis of factors influencing the results of colorectal cancer surgery in the elderly

BMC Surgery ◽

10.1186/1471-2482-13-s1-a44 ◽

2013 ◽

Vol 13 (Suppl 1) ◽

pp. A44

Author(s):

M Saracco ◽

A Esposito ◽

DG Palmieri ◽

N Carlomagno ◽

A Renda

Keyword(s):

Colorectal Cancer ◽

The Elderly ◽

Cancer Surgery ◽

Colorectal Cancer Surgery ◽

Factors Influencing ◽

Surgery In The Elderly

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Incidence and risk factors of portomesenteric venous thrombosis after colorectal surgery for cancer in the elderly population

World Journal of Surgical Oncology ◽

10.1186/s12957-019-1739-9 ◽

2019 ◽

Vol 17 (1) ◽

Cited By ~ 1

Author(s):

Michele Manigrasso ◽

Marco Milone ◽

Nunzio Velotti ◽

Sara Vertaldi ◽

Pietro Schettino ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Abdominal Pain ◽

Colorectal Surgery ◽

Venous Thrombosis ◽

Ct Scan ◽

Elderly Population ◽

The Elderly ◽

Duration Of Surgery ◽

Portomesenteric Venous Thrombosis

Abstract Background Although it is known that portomesenteric venous thrombosis (PMVT) is associated with total colectomy and proctocolectomy in young patients with inflammatory bowel disease, little is known about incidence and risk factors of PMVT among the elderly population undergoing colorectal surgery for cancer. Methods Data of elderly patients (> 70 years) undergoing surgery for colorectal cancer were retrospectively registered. The occurrence of PMVT was correlated with the patients’ characteristics and operative variables. Data collected included age, sex, obesity, ASA score, tumor degree, type of surgical resection, surgical approach (laparoscopic or open), and duration of surgery (from skin incision to the application of dressings). Results A total of 137 patients > 70 years who underwent surgery for colorectal cancer and developed an acute intraabdominal process with suggestive symptoms, needing a CT scan, were included. Three of these patients (2.1%) had portomesenteric venous thrombosis during the study period, which was proved with CT scan. There were no significant patients’ characteristics or operative variables between patients with or without the occurrence of PMVT after surgery. Of interest, only operative time was significantly higher in patients with PMVT after surgery (256 ± 40 vs 140 ± 41, p < 0.001). Conclusions PMVT as a cause of abdominal pain after colorectal surgery for cancer in the elderly population is uncommon. An index of suspicion for PMVT in an elderly postoperative colorectal cancer patient with sudden onset of abdominal pain must be maintained.

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