scholarly journals Modeling Sleep and Adiposity-Associated Cardiometabolic Disease Risk Factors: Protocol for the SLUMBRx Study (Preprint)

2021 ◽  
Author(s):  
Adam Knowlden ◽  
John Higginbotham ◽  
Michael Grandner ◽  
John Allegrante
Keyword(s):  
Risk Factors ◽  
Sleep Duration ◽  
Disease Risk ◽  
Cardiometabolic Disease ◽  
Health Issues ◽  
Short Sleep Duration ◽  
Short Sleep ◽  
Adiposity Indices ◽  
The Relationship ◽  
Cardiometabolic Disease Risk

BACKGROUND Obesity and short sleep duration are significant public health issues. Current evidence suggests these conditions are associated with cardiovascular disease, metabolic syndrome, inflammation, and premature mortality. Increased interest in the potential link between obesity and short sleep duration, and its health consequences, has been driven by: 1) the apparent parallel increase in prevalence of both conditions in recent decades; 2) their overlapping association with cardiometabolic outcomes; and 3) the potential causal connection between the two health issues. The Short Sleep Undermines Cardiometabolic Health (SLUMBRx) Study seeks to contribute to the development of a comprehensive adiposity-sleep model, while laying the groundwork for a future program of research that will be designed to prevent and treat adiposity and sleep-related cardiometabolic disease risk factors. OBJECTIVE SLUMBRx addresses four topics pertinent to the adiposity-sleep hypothesis: 1) the relationship between adiposity and sleep duration; 2) sex-based differences in the relationship between adiposity and sleep duration; 3) influence of adiposity indices and sleep duration on cardiometabolic outcomes; and 4) the role of socioecological factors as effect modifiers in the relationship between adiposity indices, sleep, and cardiometabolic outcomes. METHODS SLUMBRx will employ a large-scale survey (n=1,000) that recruits 159 participants (53 normal weight, 53 overweight, and 53 obese) to be assessed in two phases. RESULTS Phase 1, a lab-based study, will gather objective adiposity indices (air displacement plethysmography and anthropometrics) and cardiometabolic data (blood pressure, pulse wave velocity and pulse wave analysis, and blood-based biomarker). Phase 2, a one-week, home-based study, will gather sleep-related data (home sleep testing/sleep apnea, actigraphy, sleep diaries). During Phase 2, detailed demographic and socioecological data will be collected to contextualize hypothesized adiposity and sleep-associated cardiometabolic disease risk factors. Collection and analyses of these data will yield information necessary to customize future observational and intervention research. CONCLUSIONS Precise implementation of the SLUMBRx protocol promises to provide objective, empirical data on the interaction between body composition and sleep duration. The hypotheses that will be tested by SLUMBRx are important for understanding the pathogenesis of cardiometabolic disease and for developing future public health interventions to prevent its conception and treat its consequences. CLINICALTRIAL https://projectreporter.nih.gov/project_info_description.cfm?aid=9822114&icde=45818775

Relationship between short sleep duration and cardiovascular risk factors in a multi-ethnic cohort – the helius study

2015 ◽  
Vol 16 (12) ◽  
pp. 1482-1488 ◽  
Author(s):  
Kenneth Anujuo ◽  
Karien Stronks ◽  
Marieke B. Snijder ◽  
Girardin Jean-Louis ◽  
Femke Rutters ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Sleep Duration ◽  
Short Sleep Duration ◽  
Short Sleep ◽  
Helius Study

scholarly journals Inflammatory markers are altered in severe mental disorders independent of comorbid cardiometabolic disease risk factors – ERRATUM

2019 ◽  
Vol 49 (10) ◽  
pp. 1758-1758
Author(s):  
Ragni H. Mørch ◽  
Ingrid Dieset ◽  
Ann Færden ◽  
Elina J. Reponen ◽  
Sigrun Hope ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mental Disorders ◽  
Inflammatory Markers ◽  
Disease Risk ◽  
Cardiometabolic Disease ◽  
Severe Mental Disorders ◽  
Cardiometabolic Disease Risk

scholarly journals 0872 Sleep Duration and Cardiometabolic Disease Risk in Native Hawaiians

SLEEP ◽  
2018 ◽  
Vol 41 (suppl_1) ◽  
pp. A324-A324
Author(s):  
A Gilles ◽  
M Grandner
Keyword(s):  
Sleep Duration ◽  
Disease Risk ◽  
Native Hawaiians ◽  
Cardiometabolic Disease ◽  
Cardiometabolic Disease Risk

scholarly journals Hepatic fibrosis associates with multiple cardiometabolic disease risk factors: The Framingham Heart Study

Hepatology ◽  
2020 ◽  
Author(s):  
Michelle T. Long ◽  
Xiaoyu Zhang ◽  
Hanfei Xu ◽  
Ching‐Ti Liu ◽  
Kathleen E. Corey ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatic Fibrosis ◽  
Framingham Heart Study ◽  
Disease Risk ◽  
Cardiometabolic Disease ◽  
Heart Study ◽  
Cardiometabolic Disease Risk

Relationship between plasma vitamin D level and cardiometabolic disease risk factors

2012 ◽  
pp. BMP38
Author(s):  
Alaa Badawi ◽  
Bibiana Garcia-Bailo ◽  
Eman Sadoun ◽  
Laura Da Costa ◽  
Paul Arora ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Disease Risk ◽  
Cardiometabolic Disease ◽  
Plasma Vitamin ◽  
Cardiometabolic Disease Risk

scholarly journals Association between self-reported sleep duration and dietary quality in European adolescents

2013 ◽  
Vol 110 (5) ◽  
pp. 949-959 ◽  
Author(s):  
Sarah Bel ◽  
Nathalie Michels ◽  
Tineke De Vriendt ◽  
Emma Patterson ◽  
Magdalena Cuenca-García ◽  
...  
Keyword(s):  
Sleep Duration ◽  
Healthy Lifestyle ◽  
Dietary Diversity ◽  
Dietary Quality ◽  
Short Sleep Duration ◽  
Cross Sectional ◽  
Insufficient Sleep ◽  
Short Sleep ◽  
Relationship Of ◽  
The Relationship

Evidence has grown supporting the role for short sleep duration as an independent risk factor for weight gain and obesity. The purpose of the present study was to examine the relationship between sleep duration and dietary quality in European adolescents. The sample consisted of 1522 adolescents (aged 12·5–17·5 years) participating in the European multi-centre cross-sectional ‘Healthy Lifestyle in Europe by Nutrition in Adolescence’ study. Sleep duration was estimated by a self-reported questionnaire. Dietary intake was assessed by two 24 h recalls. The Diet Quality Index for Adolescents with Meal index (DQI-AM) was used to calculate overall dietary quality, considering the components dietary equilibrium, dietary diversity, dietary quality and a meal index. An average sleep duration of ≥ 9 h was classified as optimal, between 8 and 9 h as borderline insufficient and < 8 h as insufficient. Sleep duration and the DQI-AM score were positively associated (β = 0·027, r 0·130, P< 0·001). Adolescents with insufficient (62·05 (sd 14·18)) and borderline insufficient sleep (64·25 (sd 12·87)) scored lower on the DQI-AM than adolescents with an optimal sleep duration (64·57 (sd 12·39)) (P< 0·001; P= 0·018). The present study demonstrated in European adolescents that short sleep duration was associated with a lower dietary quality. This supports the hypothesis that the health consequences of insufficient sleep may be mediated by the relationship of insufficient sleep to poor dietary quality.

Food and plant bioactives for reducing cardiometabolic disease risk: an evidence based approach

2017 ◽  
Vol 8 (6) ◽  
pp. 2076-2088 ◽  
Author(s):  
Arrigo F. G. Cicero ◽  
Federica Fogacci ◽  
Alessandro Colletti
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cardiovascular Disease Risk Factors ◽  
Cardiometabolic Disease ◽  
Evidence Based ◽  
Cardiometabolic Disease Risk

Nutraceuticals active on the main cardiovascular disease risk factors.

scholarly journals Contribution of short sleep duration to ethnic differences in cardiovascular disease: results from a cohort study in the Netherlands

BMJ Open ◽  
2017 ◽  
Vol 7 (11) ◽  
pp. e017645 ◽  
Author(s):  
Kenneth Anujuo ◽  
Charles Agyemang ◽  
Marieke B Snijder ◽  
Girardin Jean-Louis ◽  
Bert-Jan van den Born ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
The Netherlands ◽  
Sleep Duration ◽  
Ethnic Differences ◽  
Urban Setting ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Short Sleep Duration ◽  
Short Sleep

ObjectivesWe analysed association between short sleep duration and prevalence of cardiovascular disease (CVD) in a multiethnic population living in the Netherlands, and the contribution of short sleep to the observed ethnic differences in the prevalence of CVD, independent of CVD risk factors.Methods20 730 participants (aged 18–71 years) of the HELIUS (Healthy Life in an Urban Setting) Study were investigated. Self-reported sleep duration was classified as: short (<7 hours/night) and healthy (7–9 hours/night). Prevalence of CVD was assessed using the Rose Questionnaire on angina pectoris, intermittent claudication and possible myocardial infarction. Association of short sleep duration with prevalent CVD and the contribution of short sleep to the observed ethnic differences in the prevalence of CVD were analysed using adjusted prevalence ratio(s) (PRs) with 95% CI.ResultsResults indicate that short sleep was associated with CVD among all ethnic groups with PRs ranging from 1.41 (95% CI 1.21 to 1.65) in Moroccans to 1.62 (95% CI 1.20 to 2.18) in Dutch after adjustment for age, sex and conventional CVD risk factors. The independent contributions of short sleep (in percentage) to ethnic differences in CVD compared with Dutch were 10%, 15%, 15%, 5% and 5% in South-Asian Surinamese, African-Surinamese, Ghanaian, Turkish and Moroccan, respectively.ConclusionShort sleep contributed to ethnic differences in CVD independent of well-known CVD risk factors particularly in Surinamese and Ghanaian groups. Reducing sleep deprivation may be a relevant entry point for reducing increased CVD risks among the various ethnic minority groups.

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