Prediction of the Side Effects Perceived by Therapists in Psychotherapy (Preprint)

2021 ◽  
Author(s):  
Lijun Yao ◽  
Zhiwei Xu ◽  
Xudong Zhao ◽  
Yang Chen ◽  
Liang Liu ◽  
...  
Keyword(s):  
Machine Learning ◽  
Side Effects ◽  
Predictive Performance ◽  
Machine Learning Techniques ◽  
Cross Sectional ◽  
Psychological States ◽  
Learning Classifier ◽  
Psychological Activity ◽  
Client Side ◽  
Sectional Analysis

BACKGROUND Side effects in psychotherapy are sometimes unavoidable. Therapists play a significant role in the side effects of psychotherapy, but there have been few quantitative studies on the mechanisms by which therapists contribute to them. OBJECTIVE Using machine learning techniques to distinguish therapists with and without the perception of consulting side effects, and identify the predictive factors of therapists who could perceive client side effects in psychotherapy. METHODS We designed the Psychotherapy Side Effects Questionnaire-Therapist Version (PSEQ-T) and released it online through an official WeChat account, where 530 therapists participated in the cross-sectional analysis. The therapists were classified into groups with and without perceptions of clients’ side effects. A number of features were selected to distinguish the therapists by category. Six machine learning–based algorithms were selected and trained by our dataset to build classification models. To make the prediction model interpretable, we leveraged the Shapley Additive exPlanations (SHAP) method to quantify the importance of each feature to the therapist categories. RESULTS Our study demonstrated the following: 1) Of the therapists, 316 perceived the side effects of the clients in the ongoing psychotherapy sessions, with a 59.6% incidence of side effects. Among all 7 perception types of the side effects, the most common was “make the clients or patients feel bad” (49.8%). 2) A random forest–based machine-learning classifier offered the best predictive performance to distinguish the therapists with and without perceptions of clients’ side effects, with an F1 score of 0.722 and an AUC value of 0.717. 3) When “therapists’ psychological activity” was considered a possible cause of the side effects in psychotherapy by the therapists, it was the most relevant feature for distinguishing the therapist category. CONCLUSIONS Our study revealed that the therapist's mastery of the limitations of psychotherapy technology and theory, especially the awareness and construction of their own psychological states, was the most important factor in predicting the therapist's perception of the side effects of psychotherapy.

scholarly journals A Machine Learning-based Approach to Identify Therapists who can Perceive Client-Side Effects in Psychotherapy

2021 ◽  
Author(s):  
Lijun Yao ◽  
Zhiwei Xu ◽  
Xudong Zhao ◽  
Yang Chen ◽  
Liang Liu ◽  
...  
Keyword(s):  
Machine Learning ◽  
Side Effects ◽  
Predictive Performance ◽  
Cross Sectional ◽  
Psychological States ◽  
Learning Classifier ◽  
Auc Value ◽  
Psychological Activity ◽  
Client Side ◽  
Sectional Analysis

Abstract Background: Side effects in psychotherapy are sometimes unavoidable. Therapists play a significant role in the side effects of psychotherapy, but there have been few quantitative studies on the mechanisms by which therapists contribute to them. Methods: We designed the Psychotherapy Side Effects Questionnaire-Therapist Version (PSEQ-T) and released it online through an official WeChat account, where 530 therapists participated in the cross-sectional analysis. The therapists were classified into groups with and without perceptions of clients’ side effects. A number of features were selected to distinguish the therapists by category. Six machine learning–based algorithms were selected and trained by our dataset to build classification models. To make the prediction model interpretable, we leveraged the Shapley Additive exPlanations (SHAP) method to quantify the importance of each feature to the therapist categories.Results: Our study demonstrated the following: 1) Of the therapists, 316 perceived the side effects of the clients in the ongoing psychotherapy sessions, with a 59.6% incidence of side effects. Among all 7 perception types of the side effects, the most common type was “make the clients or patients feel bad” (49.8%). 2) A random forest–based machine-learning classifier offered the best predictive performance to distinguish the therapists with and without perceptions of clients’ side effects, with an F1 score of 0.722 and an AUC value of 0.717. 3) When “therapists’ psychological activity” was considered a possible cause of the side effects in psychotherapy by the therapists, it was the most relevant feature for distinguishing the therapist category.Conclusions: Our study revealed that the therapist's mastery of the limitations of psychotherapy technology and theory, especially the awareness and construction of their own psychological states, was the most important factor in predicting the therapist's perception of the side effects of psychotherapy.

scholarly journals Influencing Factors and Machine Learning-Based Prediction of Side Effects in Psychotherapy

2020 ◽  
Vol 11 ◽  
Author(s):  
Lijun Yao ◽  
Xudong Zhao ◽  
Zhiwei Xu ◽  
Yang Chen ◽  
Liang Liu ◽  
...  
Keyword(s):  
Machine Learning ◽  
Side Effects ◽  
Random Forest ◽  
Influencing Factors ◽  
Prediction Performance ◽  
Psychotherapy Outcomes ◽  
Cross Sectional ◽  
Learning Classifier ◽  
Auc Value ◽  
Sectional Analysis

Background: Side effects in psychotherapy are a common phenomenon, but due to insufficient understanding of the relevant predictors of side effects in psychotherapy, many psychotherapists or clinicians fail to identify and manage these side effects. The purpose of this study was to predict whether clients or patients would experience side effects in psychotherapy by machine learning and to analyze the related influencing factors.Methods: A self-compiled “Psychotherapy Side Effects Questionnaire (PSEQ)” was delivered online by a WeChat official account. Three hundred and seventy participants were included in the cross-sectional analysis. Psychotherapy outcomes were classified as participants with side effects and without side effects. A number of features were selected to distinguish participants with different psychotherapy outcomes. Six machine learning-based algorithms were then chosen and trained by our dataset to build outcome prediction classifiers.Results: Our study showed that: (1) the most common side effects were negative emotions in psychotherapy, such as anxiety, tension, sadness, and anger, etc. (24.6%, 91/370); (2) the mental state of the psychotherapist, as perceived by the participant during psychotherapy, was the most relevant feature to predict whether clients would experience side effects in psychotherapy; (3) a Random Forest-based machine learning classifier offered the best prediction performance of the psychotherapy outcomes, with an F1-score of 0.797 and an AUC value of 0.804. These numbers indicate a high prediction performance, which allowed our approach to be used in practice.Conclusions: Our Random Forest-based machine learning classifier could accurately predict the possible outcome of a client in psychotherapy. Our study sheds light on the influencing factors of the side effects of psychotherapy and could help psychotherapists better predict the outcomes of psychotherapy.

Machine Learning-Based Scoring Functions. Development and Applications with SAnDReS.

2020 ◽  
Vol 27 ◽  
Author(s):  
Gabriela Bitencourt-Ferreira ◽  
Camila Rizzotto ◽  
Walter Filgueira de Azevedo Junior
Keyword(s):  
Machine Learning ◽  
Binding Affinity ◽  
Drug Targets ◽  
Computational Models ◽  
Factor Xa ◽  
Coagulation Factor ◽  
Predictive Performance ◽  
Machine Learning Techniques ◽  
Scoring Functions ◽  
Molegro Virtual Docker

Background: Analysis of atomic coordinates of protein-ligand complexes can provide three-dimensional data to generate computational models to evaluate binding affinity and thermodynamic state functions. Application of machine learning techniques can create models to assess protein-ligand potential energy and binding affinity. These methods show superior predictive performance when compared with classical scoring functions available in docking programs. Objective: Our purpose here is to review the development and application of the program SAnDReS. We describe the creation of machine learning models to assess the binding affinity of protein-ligand complexes. Method: SAnDReS implements machine learning methods available in the scikit-learn library. This program is available for download at https://github.com/azevedolab/sandres. SAnDReS uses crystallographic structures, binding, and thermodynamic data to create targeted scoring functions. Results: Recent applications of the program SAnDReS to drug targets such as Coagulation factor Xa, cyclin-dependent kinases, and HIV-1 protease were able to create targeted scoring functions to predict inhibition of these proteins. These targeted models outperform classical scoring functions. Conclusion: Here, we reviewed the development of machine learning scoring functions to predict binding affinity through the application of the program SAnDReS. Our studies show the superior predictive performance of the SAnDReS-developed models when compared with classical scoring functions available in the programs such as AutoDock4, Molegro Virtual Docker, and AutoDock Vina.

Application of Machine Learning Techniques to Predict Binding Affinity for Drug Targets: A Study of Cyclin-Dependent Kinase 2

2020 ◽  
Vol 28 (2) ◽  
pp. 253-265 ◽  
Author(s):  
Gabriela Bitencourt-Ferreira ◽  
Amauri Duarte da Silva ◽  
Walter Filgueira de Azevedo
Keyword(s):  
Machine Learning ◽  
Binding Affinity ◽  
Predictive Performance ◽  
Supervised Machine Learning ◽  
Machine Learning Techniques ◽  
Scoring Functions ◽  
Cyclin Dependent Kinase ◽  
Learning Models ◽  
Learning Techniques ◽  
Machine Learning Models

Background: The elucidation of the structure of cyclin-dependent kinase 2 (CDK2) made it possible to develop targeted scoring functions for virtual screening aimed to identify new inhibitors for this enzyme. CDK2 is a protein target for the development of drugs intended to modulate cellcycle progression and control. Such drugs have potential anticancer activities. Objective: Our goal here is to review recent applications of machine learning methods to predict ligand- binding affinity for protein targets. To assess the predictive performance of classical scoring functions and targeted scoring functions, we focused our analysis on CDK2 structures. Methods: We have experimental structural data for hundreds of binary complexes of CDK2 with different ligands, many of them with inhibition constant information. We investigate here computational methods to calculate the binding affinity of CDK2 through classical scoring functions and machine- learning models. Results: Analysis of the predictive performance of classical scoring functions available in docking programs such as Molegro Virtual Docker, AutoDock4, and Autodock Vina indicated that these methods failed to predict binding affinity with significant correlation with experimental data. Targeted scoring functions developed through supervised machine learning techniques showed a significant correlation with experimental data. Conclusion: Here, we described the application of supervised machine learning techniques to generate a scoring function to predict binding affinity. Machine learning models showed superior predictive performance when compared with classical scoring functions. Analysis of the computational models obtained through machine learning could capture essential structural features responsible for binding affinity against CDK2.

Arabic tweets sentiment analysis – a hybrid scheme

2016 ◽  
Vol 42 (6) ◽  
pp. 782-797 ◽  
Author(s):  
Haifa K. Aldayel ◽  
Aqil M. Azmi
Keyword(s):  
Machine Learning ◽  
Saudi Arabia ◽  
Hybrid Approach ◽  
Training Data ◽  
Machine Learning Techniques ◽  
Good Source ◽  
Learning Classifier ◽  
Learning Techniques ◽  
Semantic Orientation ◽  
F Measure

The fact that people freely express their opinions and ideas in no more than 140 characters makes Twitter one of the most prevalent social networking websites in the world. Being popular in Saudi Arabia, we believe that tweets are a good source to capture the public’s sentiment, especially since the country is in a fractious region. Going over the challenges and the difficulties that the Arabic tweets present – using Saudi Arabia as a basis – we propose our solution. A typical problem is the practice of tweeting in dialectical Arabic. Based on our observation we recommend a hybrid approach that combines semantic orientation and machine learning techniques. Through this approach, the lexical-based classifier will label the training data, a time-consuming task often prepared manually. The output of the lexical classifier will be used as training data for the SVM machine learning classifier. The experiments show that our hybrid approach improved the F-measure of the lexical classifier by 5.76% while the accuracy jumped by 16.41%, achieving an overall F-measure and accuracy of 84 and 84.01% respectively.

USING ACCURACY-BASED LEARNING CLASSIFIER SYSTEMS FOR ADAPTABLE STRATEGY GENERATION IN GAMES AND INTERACTIVE VIRTUAL SIMULATIONS

2009 ◽  
Vol 10 (04) ◽  
pp. 365-390
Author(s):  
ALEJANDRO JUAN ◽  
RICHARD W. PAZZI ◽  
AZZEDINE BOUKERCHE
Keyword(s):  
Machine Learning ◽  
Genetic Algorithm ◽  
Training Session ◽  
Learning Classifier Systems ◽  
Machine Learning Techniques ◽  
Knowledge Map ◽  
Classifier Systems ◽  
Learning Classifier System ◽  
Learning Classifier ◽  
Virtual Simulations

Historically, the artificial intelligence (AI) of interactive virtual simulations or games is usually driven by pre-defined static scripts. One of the disadvantages of such scripted opponents is that they can be deciphered and countered by an intelligent user. Thus, the user has the opportunity to find weaknesses and an easy solution against the virtual simulation, which diminishes the efficiency aspect of a training session or entertaining value drastically. While randomization can be used to mask the static behaviour of a scripted AI, it is possible to develop much richer solutions by applying Learning Classifier System (LCS) techniques to create agents with intelligent-like behaviors. Learning Classifier Systems are rule-based machine learning techniques that rely on a Genetic Algorithm to discover a knowledge map used to classify an input space into a set of actions. In this paper, we propose the use of an unsupervised machine learning technique called Accuracy-based Learning Classifier Systems (XCS) for adaptable strategy generation that can be used in virtual simulations or games. XCS use a Genetic Algorithm to evolve a knowledge base in the form of rules. The performance and adaptability of the strategies and tactics developed with the XCS is analyzed by facing these against scripted opponents on a real time strategy game. According to our experiments, the rulesets are able to adapt to a wide array of behaviors from its opponents, as opposed to a linear game script, which is limited in its ability to adapt to its environment.

scholarly journals INGOT-DR: an interpretable classifier for predicting drug resistance in M. tuberculosis

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Hooman Zabeti ◽  
Nick Dexter ◽  
Amir Hosein Safari ◽  
Nafiseh Sedaghat ◽  
Maxwell Libbrecht ◽  
...  
Keyword(s):  
Machine Learning ◽  
Drug Resistance ◽  
Predictive Accuracy ◽  
Group Testing ◽  
Predictive Performance ◽  
Machine Learning Techniques ◽  
Evaluation Metrics ◽  
Lower Accuracy ◽  
Unseen Data ◽  
The One

Abstract Motivation Prediction of drug resistance and identification of its mechanisms in bacteria such as Mycobacterium tuberculosis, the etiological agent of tuberculosis, is a challenging problem. Solving this problem requires a transparent, accurate, and flexible predictive model. The methods currently used for this purpose rarely satisfy all of these criteria. On the one hand, approaches based on testing strains against a catalogue of previously identified mutations often yield poor predictive performance; on the other hand, machine learning techniques typically have higher predictive accuracy, but often lack interpretability and may learn patterns that produce accurate predictions for the wrong reasons. Current interpretable methods may either exhibit a lower accuracy or lack the flexibility needed to generalize them to previously unseen data. Contribution In this paper we propose a novel technique, inspired by group testing and Boolean compressed sensing, which yields highly accurate predictions, interpretable results, and is flexible enough to be optimized for various evaluation metrics at the same time. Results We test the predictive accuracy of our approach on five first-line and seven second-line antibiotics used for treating tuberculosis. We find that it has a higher or comparable accuracy to that of commonly used machine learning models, and is able to identify variants in genes with previously reported association to drug resistance. Our method is intrinsically interpretable, and can be customized for different evaluation metrics. Our implementation is available at github.com/hoomanzabeti/INGOT_DR and can be installed via The Python Package Index (Pypi) under ingotdr. This package is also compatible with most of the tools in the Scikit-learn machine learning library.

scholarly journals Modern machine learning outperforms GLMs at predicting spikes

2017 ◽  
Author(s):  
Ari S. Benjamin ◽  
Hugo L. Fernandes ◽  
Tucker Tomlinson ◽  
Pavan Ramkumar ◽  
Chris VerSteeg ◽  
...  
Keyword(s):  
Machine Learning ◽  
Neural Activity ◽  
Linear Models ◽  
Feedforward Neural Networks ◽  
Predictive Performance ◽  
Machine Learning Techniques ◽  
Machine Learning Methods ◽  
Learning Techniques ◽  
Neural Spiking ◽  
Modern Machine

AbstractNeuroscience has long focused on finding encoding models that effectively ask “what predicts neural spiking?” and generalized linear models (GLMs) are a typical approach. It is often unknown how much of explainable neural activity is captured, or missed, when fitting a GLM. Here we compared the predictive performance of GLMs to three leading machine learning methods: feedforward neural networks, gradient boosted trees (using XGBoost), and stacked ensembles that combine the predictions of several methods. We predicted spike counts in macaque motor (M1) and somatosensory (S1) cortices from standard representations of reaching kinematics, and in rat hippocampal cells from open field location and orientation. In general, the modern methods (particularly XGBoost and the ensemble) produced more accurate spike predictions and were less sensitive to the preprocessing of features. This discrepancy in performance suggests that standard feature sets may often relate to neural activity in a nonlinear manner not captured by GLMs. Encoding models built with machine learning techniques, which can be largely automated, more accurately predict spikes and can offer meaningful benchmarks for simpler models.

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