Examining the Validity of Mobile-based Nutrient Assessment Tools for Chinese Patients with Diabetes (Preprint)

2021 ◽  
Author(s):  
Qianzhi Jiang ◽  
Zeyi He ◽  
Qiong Chen ◽  
Haojia Jing
Keyword(s):  
Blood Glucose ◽  
Assessment Tools ◽  
Chinese Patients ◽  
Nutrient Analysis ◽  
Chinese Populations ◽  
Control Blood Glucose ◽  
Analysis Tools ◽  
Patients With Diabetes ◽  
Positive Correlations ◽  
Dietary Tracking

BACKGROUND Chinese patients with diabetes do not receive adequate education in dietary management to control blood glucose. Technology-based tools can help them track their dietary intake. However, limited research examined mobile dietary tracking tools with dish-based composition database for Chinese populations. OBJECTIVE The study aimed to examine the validity of mobile-based nutrient analysis tools against nutrient analysis conducted by dietitians on assessment of Chinese dishes. METHODS Registered Dietitian (RD)-performed nutrient analysis was used as the reference. Two mobile-based nutrient analysis tools were selected for the comparison: BD Diabetes Health Coach (an Artificial Intelligence (AI) Coach developed in the current study upon a dish composition database) and Boohoo App (a popular open-access dietary tracking tool in China). Both RDs and mobile-based tools conducted nutrient analysis of the same dishes commonly consumed in China regarding total calories, carbohydrate, fat, and protein content. Descriptive statistics were analyzed. Paired t-tests, Wilcoxon signed rank tests, linear regression and Bland-Altmanwere used to compare results between the RDs and the mobile tools. RESULTS Strong positive correlations between AI Coach- and RD-performed analyses results and moderate positive correlations between Boohoo-performed and RD-performed analyses results were observed for energy and all macronutrients. Bland-Altman plots showed small bias and narrow limit of agreement between AI Coach- and RD-performed analyses, indicating AI Coach-performed analysis is comparable to RD-performed analysis. CONCLUSIONS The AI Coach tool developed in the current study supported by a dish composition database consisting of commonly consumed Chinese dishes was an effective alternative to dietitians in total calorie and macronutrient analysis. This is promising in helping patients with diabetes manage blood glucose through dietary tracking.

scholarly journals Switching from biosimilar (Basalin) to originator (Lantus) insulin glargine is effective in Chinese patients with diabetes mellitus: a retrospective chart review

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 477 ◽  
Author(s):  
Xia Hu ◽  
Lei Zhang ◽  
Yanhu Dong ◽  
Chao Dong ◽  
Jikang Jiang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Insulin Glargine ◽  
Hospital Discharge ◽  
Chart Review ◽  
Insulin Dose ◽  
Retrospective Chart Review ◽  
Chinese Patients ◽  
Time Points ◽  
Patients With Diabetes

Background: This study investigated the effectiveness and safety of switching from Basalin® to Lantus® in Chinese patients with diabetes mellitus (DM). Methods:  A retrospective chart review conducted using the electronic medical records of patients hospitalized at the Qingdao Endocrine and Diabetes Hospital from 2005 to 2016. All patients were diagnosed with DM and underwent switching of insulin from Basalin to Lantus during hospitalization. Data collected included fasting (FBG), pre- and post-prandial whole blood glucose, insulin dose, reasons for insulin switching and hypoglycemia. Four study time points were defined as: hospital admission, Basalin initiation, insulin switching (date of final dose of Basalin), and hospital discharge. Blood glucose measurements were imputed as the values recorded closest to the dates of these four time points for each patient. Results: Data from 73 patients (70 patients with type 2 diabetes, 2 with type 1, and 1 undisclosed) were analyzed. At admission, mean glycated hemoglobin (HbA1c) and FBG were 8.9% (SD=1.75) and 9.98 (3.22) mmol/L, respectively. Between Basalin initiation and insulin switch, mean FBG decreased from 9.68 mmol/L to 8.03 mmol/L (p<0.0001), over a mean 10.8 (SD=6.85) days of Basalin treatment, and reduced further to 7.30 mmol/L at discharge (p=0.0116) following a mean 6.6 (7.36) days of Lantus. The final doses of Basalin and Lantus were similar (0.23 vs. 0.24 IU/kg/day; p=0.2409). Furthermore, reductions in pre- and post-prandial blood glucose were also observed between Basalin initiation, insulin switch and hospital discharge. The incidence of confirmed hypoglycemia was low during Basalin (2 [2.4%]) and Lantus (1 [1.2%]) treatment, with no cases of severe hypoglycemia. Conclusion: In this study population, switching from Basalin to Lantus was associated with further reductions in blood glucose, although the dose of insulin glargine did not increase. Further studies are required to verify these findings and determine the reason for this phenomenon.

scholarly journals PENGARUH BAWANG MERAH TERHADAP PENURUNAN KADAR GULA DARAH PADA PENDERITA DIABETES MELLITUS DI DESA SIDORAHARJO KECAMATAN KEDAMEAN KABUPATEN GRESIK

2018 ◽  
Vol 10 (2) ◽  
Author(s):  
Siti Aminah Hidayat ◽  
Chilyatiz Zahroh
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Rank Test ◽  
Control Blood Glucose ◽  
Alternative Intervention ◽  
Patients With Diabetes ◽  
Decrease Blood Glucose ◽  
Signed Rank Test

People living in Desa Sidoraharjo were more familiar with oral medication to control glucose level ini the blood, namely oral anti-diabetic drugs (OADs) than herbal medicine onion. The purpose of this study was to know the effect of onion toward decrease blood glucose levels in people with Diabetes Mellitus. The study using preexperimental one group pretest-posttest involved population taken from all people found with Diabetes Mellitus, totaling 15 patients. The samples chosen using simple random sampling technique were 14 patients in total. The independent variable was onions, whereas the dependent variable was blood glucose level. The instrument used in this study was autocheck self-monitoring of capillary blood glucose. Moreover, the data were analyzed using Wilcoxon signed-rank test with level of significance α = 0,05. The result of study showed that blood glucose level on average before consuming onions was 278,93 mg/dL, whereas after onions treatment, the average blood glucose level decreased to 251,64 mg/dL. The result of Wilcoxon signed-rank test showed that the level significance ρ=(0,001<α) so that the use of onions brought effects to the decrease of blood glucose level. The use of onions as herbal medication can decrease blood glucose level as another alternative intervention to control blood glucose level of the patients with Diabetes Mellitus. besides consuming onions, those patients are also expected to visit medical workers periodically to prevent hypoglycemia. Keywords: Diabetes Mellitus, blood glucose level, onion> <α) so that the use of onions brought effects to the decrease of blood glucose level. The use of onions as herbal medication can decrease blood glucose level as another alternative intervention to control blood glucose level of the patients with Diabetes Mellitus. Besides consuming onions, those patients are also expected to visit medical workers periodically to prevent hypoglycemia.

Self-monitoring of blood glucose and perceived obstacles in Turkish patients with diabetes mellitus

2014 ◽  
Author(s):  
Ozlem Turhan Iyidir ◽  
Mustafa Unubol ◽  
Bulent Ogun Hatipoglu ◽  
Ceyla Konca Degertekin
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Self Monitoring ◽  
Patients With Diabetes ◽  
Turkish Patients

Neuropathy in the gut. Gut motility disorders in patients with diabetes mellitus

2012 ◽  
Vol 153 (16) ◽  
pp. 607-614
Author(s):  
Tibor Wittmann
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Treatment Modalities ◽  
Clinical Aspects ◽  
Gut Motility ◽  
Motility Disorders ◽  
The Everyday ◽  
Patients With Diabetes ◽  
Leading Symptom ◽  
Different Parts

The extent and severity of motility disorders remains heterogeneous in the different parts of the gut, and in most cases failures in gut motility do not correspond with the severity of the symptoms. If diarrhea or fecal incontinence is the leading symptom, or the blood glucose level varies frequently and considerably despite the treatment efforts, the motility of the stomach and bowels is seriously disturbed. The clinical aspects, detailed pathogenesis, diagnostic approach and treatment modalities of gastrointestinal motility disorders in diabetes mellitus are reviewed to help and improve the everyday medical practice. Orv. Hetil., 2012, 153, 607–614.

Examining Sensor Agreement in Neural Network Blood Glucose Prediction

2021 ◽  
pp. 193229682110182
Author(s):  
Aaron P. Tucker ◽  
Arthur G. Erdman ◽  
Pamela J. Schreiner ◽  
Sisi Ma ◽  
Lisa S. Chow
Keyword(s):  
Neural Network ◽  
Blood Glucose ◽  
Patient Specific ◽  
Sensor Location ◽  
Effective Care ◽  
Freestyle Libre ◽  
Patients With Diabetes ◽  
Interstitial Glucose ◽  
Continuous Glucose Monitors ◽  
Glucose Prediction

Successful measurements of interstitial glucose are a key component in providing effective care for patients with diabetes. Recently, there has been significant interest in using neural networks to forecast future glucose values from interstitial measurements collected by continuous glucose monitors (CGMs). While prediction accuracy continues to improve, in this work we investigated the effect of physiological sensor location on neural network blood glucose forecasting. We used clinical data from patients with Type 2 Diabetes who wore blinded FreeStyle Libre Pro CGMs (Abbott) on both their right and left arms continuously for 12 weeks. We trained patient-specific prediction algorithms to test the effect of sensor location on neural network forecasting ( N = 13, Female = 6, Male = 7). In 10 of our 13 patients, we found at least one significant ( P < .05) increase in forecasting error in algorithms which were tested with data taken from a different location than data which was used for training. These reported results were independent from other noticeable physiological differences between subjects (eg, height, age, weight, blood pressure) and independent from overall variance in the data. From these results we observe that CGM location can play a consequential role in neural network glucose prediction.

scholarly journals Sam68 promotes hepatic gluconeogenesis via CRTC2

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Aijun Qiao ◽  
Junlan Zhou ◽  
Shiyue Xu ◽  
Wenxia Ma ◽  
Chan Boriboun ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Therapeutic Target ◽  
Rna Binding ◽  
Adaptor Protein ◽  
Diabetic Mouse ◽  
Mrna Levels ◽  
Hepatic Gluconeogenesis ◽  
Kinase Substrate ◽  
Glucose Levels ◽  
Patients With Diabetes

AbstractHepatic gluconeogenesis is essential for glucose homeostasis and also a therapeutic target for type 2 diabetes, but its mechanism is incompletely understood. Here, we report that Sam68, an RNA-binding adaptor protein and Src kinase substrate, is a novel regulator of hepatic gluconeogenesis. Both global and hepatic deletions of Sam68 significantly reduce blood glucose levels and the glucagon-induced expression of gluconeogenic genes. Protein, but not mRNA, levels of CRTC2, a crucial transcriptional regulator of gluconeogenesis, are >50% lower in Sam68-deficient hepatocytes than in wild-type hepatocytes. Sam68 interacts with CRTC2 and reduces CRTC2 ubiquitination. However, truncated mutants of Sam68 that lack the C- (Sam68ΔC) or N-terminal (Sam68ΔN) domains fails to bind CRTC2 or to stabilize CRTC2 protein, respectively, and transgenic Sam68ΔN mice recapitulate the blood-glucose and gluconeogenesis profile of Sam68-deficient mice. Hepatic Sam68 expression is also upregulated in patients with diabetes and in two diabetic mouse models, while hepatocyte-specific Sam68 deficiencies alleviate diabetic hyperglycemia and improves insulin sensitivity in mice. Thus, our results identify a role for Sam68 in hepatic gluconeogenesis, and Sam68 may represent a therapeutic target for diabetes.

scholarly journals Glycemic variability and cardiovascular disease in patients with type 2 diabetes

2021 ◽  
Vol 9 (1) ◽  
pp. e002032
Author(s):  
Marcela Martinez ◽  
Jimena Santamarina ◽  
Adrian Pavesi ◽  
Carla Musso ◽  
Guillermo E Umpierrez
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Glycated Hemoglobin ◽  
Glucose Monitoring ◽  
Glycemic Variability ◽  
Cardiovascular Complications ◽  
Glucose Levels ◽  
Increased Risk ◽  
Patients With Diabetes

Glycated hemoglobin is currently the gold standard for assessment of long-term glycemic control and response to medical treatment in patients with diabetes. Glycated hemoglobin, however, does not address fluctuations in blood glucose. Glycemic variability (GV) refers to fluctuations in blood glucose levels. Recent clinical data indicate that GV is associated with increased risk of hypoglycemia, microvascular and macrovascular complications, and mortality in patients with diabetes, independently of glycated hemoglobin level. The use of continuous glucose monitoring devices has markedly improved the assessment of GV in clinical practice and facilitated the assessment of GV as well as hypoglycemia and hyperglycemia events in patients with diabetes. We review current concepts on the definition and assessment of GV and its association with cardiovascular complications in patients with type 2 diabetes.

scholarly journals Variability in preventive care practices among US adults with diabetes mellitus

2021 ◽  
Vol 9 (1) ◽  
pp. e001861
Author(s):  
Lorena Baccaglini ◽  
Adams Kusi Appiah ◽  
Mahua Ray ◽  
Fang Yu
Keyword(s):  
Blood Glucose ◽  
Diabetes Care ◽  
Target Population ◽  
Care Practice ◽  
Behavioral Risk ◽  
Cross Sectional ◽  
Complex Sampling ◽  
Patients With Diabetes ◽  
Care Practices ◽  
Diabetic Care

IntroductionPatients with diabetes are advised to follow standard medical care including daily blood glucose and foot checks, eye examinations with pupil dilation, and cholesterol checks to prevent diabetes-related complications. It is unclear how these practices currently vary across different US population subgroups. The objective of this study was to assess variation in overall and individual diabetes care practices and identify specific factors associated with differences in these practices in a representative sample of US diabetic adults.Research design and methodsCross-sectional data were from the 2017 Behavioral Risk Factor Surveillance System. Survey logistic regression was used to account for the complex sampling design.ResultsAmong 30 780 eligible participants, 8957 (equivalent to 28% of the target population) followed all four diabetes care practices. Insulin-dependent participants had higher adjusted odds (adjusted OR=2.95; 95% CI 2.62 to 3.31) of following all four diabetic care practices compared with those who did not. Cost-related variables (having healthcare coverage and/or a personal doctor) were positively associated with diabetes care practices, with the strongest association observed for adherence to more costly practices (annual eye examination and cholesterol check) versus less costly ones (daily blood glucose check, daily foot check).ConclusionsOur findings suggest the need for diabetes care practice-specific and population subgroup-specific public health interventions to encourage early adherence to diabetic care practices and reduce complications.

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