scholarly journals Switching from biosimilar (Basalin) to originator (Lantus) insulin glargine is effective in Chinese patients with diabetes mellitus: a retrospective chart review

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 477 ◽  
Author(s):  
Xia Hu ◽  
Lei Zhang ◽  
Yanhu Dong ◽  
Chao Dong ◽  
Jikang Jiang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Insulin Glargine ◽  
Hospital Discharge ◽  
Chart Review ◽  
Insulin Dose ◽  
Retrospective Chart Review ◽  
Chinese Patients ◽  
Time Points ◽  
Patients With Diabetes

Background: This study investigated the effectiveness and safety of switching from Basalin® to Lantus® in Chinese patients with diabetes mellitus (DM). Methods:  A retrospective chart review conducted using the electronic medical records of patients hospitalized at the Qingdao Endocrine and Diabetes Hospital from 2005 to 2016. All patients were diagnosed with DM and underwent switching of insulin from Basalin to Lantus during hospitalization. Data collected included fasting (FBG), pre- and post-prandial whole blood glucose, insulin dose, reasons for insulin switching and hypoglycemia. Four study time points were defined as: hospital admission, Basalin initiation, insulin switching (date of final dose of Basalin), and hospital discharge. Blood glucose measurements were imputed as the values recorded closest to the dates of these four time points for each patient. Results: Data from 73 patients (70 patients with type 2 diabetes, 2 with type 1, and 1 undisclosed) were analyzed. At admission, mean glycated hemoglobin (HbA1c) and FBG were 8.9% (SD=1.75) and 9.98 (3.22) mmol/L, respectively. Between Basalin initiation and insulin switch, mean FBG decreased from 9.68 mmol/L to 8.03 mmol/L (p<0.0001), over a mean 10.8 (SD=6.85) days of Basalin treatment, and reduced further to 7.30 mmol/L at discharge (p=0.0116) following a mean 6.6 (7.36) days of Lantus. The final doses of Basalin and Lantus were similar (0.23 vs. 0.24 IU/kg/day; p=0.2409). Furthermore, reductions in pre- and post-prandial blood glucose were also observed between Basalin initiation, insulin switch and hospital discharge. The incidence of confirmed hypoglycemia was low during Basalin (2 [2.4%]) and Lantus (1 [1.2%]) treatment, with no cases of severe hypoglycemia. Conclusion: In this study population, switching from Basalin to Lantus was associated with further reductions in blood glucose, although the dose of insulin glargine did not increase. Further studies are required to verify these findings and determine the reason for this phenomenon.

Impact of Dosing Conversion From Basal Insulin to Follow-On Insulin Glargine

2019 ◽  
pp. 089719001985395
Author(s):  
Marina L. Maes ◽  
Emily J. Ashjian ◽  
Kellie A. Kippes ◽  
Vince Marshall ◽  
Nada Rida ◽  
...  
Keyword(s):  
Insulin Glargine ◽  
Basal Insulin ◽  
Medical Center ◽  
Insulin Dose ◽  
Academic Medical Center ◽  
Retrospective Chart Review ◽  
Secondary Outcome ◽  
Real World Data ◽  
Insulin Requirements ◽  
Patients With Diabetes

Background: Several basal insulins have recently come to market including follow-on insulin glargine (Basaglar®). Currently, there is no real-world data published on the implications of conversion to Basaglar on dosing or glycemic control. Objective: To identify differences in basal insulin dosing requirements, hemoglobin A1c (HbA1c), and incidence of hypoglycemia or weight gain when converting a patient to Basaglar from another basal insulin. Methods: Single-center, retrospective chart review at an academic medical center. All patients prescribed Basaglar between December 15, 2016, and August 31, 2017 were included for review if converted from another basal insulin. Primary outcome: Difference in basal insulin requirements in both units/d and units/kilogram (kg)/d after conversion to Basaglar. Secondary outcome: Change in HbA1c and weight. Results: Mean basal insulin dose was 38.4 ± 26.3 units/d pre-conversion and 40.5 ± 29.8 units/d post-conversion (P = .031). Results were significant for patients with type 2 diabetes mellitus (T2DM; pre-conversion basal dose 34.6 ± 24.3 units/d; post-conversion basal dose 37.6± 29.0 units/d; P = .009). Weight-based dosing changed from 0.37 ± 0.25 units/kg/d pre-conversion to 0.39 ± 0.29 units/kg/d post-conversion (P = .056) and was significant for patients with T2DM (P = .040). A nonsignificant decrease in HbA1c was seen (−0.14% ± 1.24%; P = .142). There was no difference seen in weight (111.6 ± 46.3 kg vs 111.7 ± 46.9 kg; P = .662). Conclusion: Patients with diabetes require similar basal insulin doses upon conversion to Basaglar. Clinicians should monitor blood glucose closely during basal insulin transition.

Self-monitoring of blood glucose and perceived obstacles in Turkish patients with diabetes mellitus

2014 ◽  
Author(s):  
Ozlem Turhan Iyidir ◽  
Mustafa Unubol ◽  
Bulent Ogun Hatipoglu ◽  
Ceyla Konca Degertekin
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Self Monitoring ◽  
Patients With Diabetes ◽  
Turkish Patients

Neuropathy in the gut. Gut motility disorders in patients with diabetes mellitus

2012 ◽  
Vol 153 (16) ◽  
pp. 607-614
Author(s):  
Tibor Wittmann
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Treatment Modalities ◽  
Clinical Aspects ◽  
Gut Motility ◽  
Motility Disorders ◽  
The Everyday ◽  
Patients With Diabetes ◽  
Leading Symptom ◽  
Different Parts

The extent and severity of motility disorders remains heterogeneous in the different parts of the gut, and in most cases failures in gut motility do not correspond with the severity of the symptoms. If diarrhea or fecal incontinence is the leading symptom, or the blood glucose level varies frequently and considerably despite the treatment efforts, the motility of the stomach and bowels is seriously disturbed. The clinical aspects, detailed pathogenesis, diagnostic approach and treatment modalities of gastrointestinal motility disorders in diabetes mellitus are reviewed to help and improve the everyday medical practice. Orv. Hetil., 2012, 153, 607–614.

scholarly journals PENGARUH JUS LIDAH BUAYA TERHADAP KADAR GLUKOSA DARAH PUASA DAN 2 JAM PP(Post Prandial) PADA PENDERITA DIABETES MELITUS

2019 ◽  
Vol 10 (1) ◽  
pp. 77
Author(s):  
Febria Syafyu Sari ◽  
Ridhyalla Afnuhazi
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Sugar ◽  
Fasting Blood Glucose ◽  
Aloe Vera ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Patients With Diabetes ◽  
Paired T Test ◽  
Diabetes Melitus

ABSTRAK Diabetes Melitus merupakan penyakit yang paling menonjol yang disebabkan oleh gagalnya pengaturan gula darah. Lidah buaya berkhasiat untuk menurunkan kadar gula dalam darah bagi penderita diabetes dan dapat mengontrol tekanan darah. Tujuan penelitian untuk mengetahui pengaruh jus lidah buaya (AloeBarbadensis Miller) terhadap penurunan glukosa darah puasa GDP) dan 2 Jam PP (Post Prendial) pada penderita DM (Diabetes Melitus). Desain penelitian merupakan Quasi Eksperimental dengan pendekatan one group pretest – postest design. Sampel terbagi menjadi 14 responden. Data dianalisis dengan paired t-test. Hasil menunjukan rata-rata penurunan glukosa darah puasa pada intervensi (28,42 gr/dl) dan glukosa darah 2 jam pp pada intervensi (40,57 gr/dl). Untuk analisis bivariat terdapat perbedaan antara glukosa puasa dan 2 jam pp dengan glukosa darah puasa GDP) dan 2 Jam PP (Post Prendial) pada penderita DM (Diabetes Melitus). Kesimpulan didapatkanlidah buaya dapat menurunkan kadar glukosa darah.Berdasarkan hasil penelitian jus lidah buaya dapat menjadi salah satu alternatif keperawatan non farmakologi dalam penyakit diabetes melitus. Kata Kunci : Lidah Buaya ; Diabetes Mellitus THE EFFECT OF VEGETABLE VOCATIONAL JUICE ON FAST BLOOD GLUCOSE LEVELS AND 2 HOURS OF PP (Post Prandial) IN DIABETES MELLITUS  ABSTRACT Diabetes mellitus is the most prominent disease caused by the failure of blood sugar regulation. Aloe vera is efficacious can to  reduce blood sugar levels for diabetics and can control blood pressure. The purpose of this study was to determine the effect of Aloe Barbadensis Miller on the reduction of fasting blood glucose GDP and 2 hours of PP (post prendial) in patients with diabetes mellitus. The research design is Experimental Quasi with one group pretest - postest design approach. The sample is divided into 14 respondents. Data were analyzed by paired t-test. The results showed an average decrease in fasting blood glucose at intervention (28.42 gr / dl) and 2 hours pp blood glucose at intervention (40.57 gr / dl). For bivariate analysis there was a difference between fasting glucose and 2 hours pp with fasting blood glucose GDP) and 2 hours PP (Post Prendial) in patients with diabetes mellitus. The conclusion is that aloe vera can reduce blood glucose levels. Based on the results of research on aloe vera juice can be an alternative non-pharmacological nursing in diabetes mellitus. Keywords: Aloe Vera ; Diabetes Mellitus

scholarly journals Insulin Glargine and Acarbose in the treatment of elderly patients with diabetes

2019 ◽  
Vol 35 (3) ◽  
Author(s):  
Jing Li ◽  
Jinzhi Ji ◽  
Fuyan Liu ◽  
Lingling Wang
Keyword(s):  
Quality Of Life ◽  
Blood Glucose ◽  
Elderly Patients ◽  
Insulin Glargine ◽  
Adverse Reactions ◽  
Postprandial Blood Glucose ◽  
Control Group ◽  
Observation Group ◽  
Patients With Diabetes

Objective: To investigate the clinical efficacy of insulin glargine combined with acarbose in the treatment of elderly patients with diabetes. Methods: One hundred and forty-four elderly patients with diabetes who received treatment between December 2016 and December 2017 in Binzhou People’s Hospital, China, were selected and divided into a control group and an observation group, 72 each, using random number table. The control group was treated with insulin glargine, while the observation group was treated with insulin glargine combined with acarbose. The therapeutic effect, improvement of quality of life and adverse reactions were compared between the two groups. Results: After treatment, fasting blood glucose (FBG), 2h postprandial blood glucose (PBG) and glycosylated hemoglobin (Hb Alc) of the two groups were lower than those before treatment, and the decrease degree of the observation group was significantly larger than that of the control group (P<0.05). The time needed for blood glucose reaching the standard level and daily insulin dosage of the observation group were significantly lower than that of the control group, and the differences were statistically significant (P<0.05). SF-36 scale score of the observation group was significantly better than the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The combination of insulin Glargine and Acarbose can significantly control the blood glucose level of elderly patients with diabetes, improve the biochemical indicators, and enhance the quality of life. It is worth promotion in clinical practice. doi: https://doi.org/10.12669/pjms.35.3.86 How to cite this:Li J, Ji J, Liu F, Wang L. Insulin Glargine and Acarbose in the treatment of elderly patients with diabetes. Pak J Med Sci. 2019;35(3):---------. doi: https://doi.org/10.12669/pjms.35.3.86 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Examining the Validity of Mobile-based Nutrient Assessment Tools for Chinese Patients with Diabetes (Preprint)

2021 ◽  
Author(s):  
Qianzhi Jiang ◽  
Zeyi He ◽  
Qiong Chen ◽  
Haojia Jing
Keyword(s):  
Blood Glucose ◽  
Assessment Tools ◽  
Chinese Patients ◽  
Nutrient Analysis ◽  
Chinese Populations ◽  
Control Blood Glucose ◽  
Analysis Tools ◽  
Patients With Diabetes ◽  
Positive Correlations ◽  
Dietary Tracking

BACKGROUND Chinese patients with diabetes do not receive adequate education in dietary management to control blood glucose. Technology-based tools can help them track their dietary intake. However, limited research examined mobile dietary tracking tools with dish-based composition database for Chinese populations. OBJECTIVE The study aimed to examine the validity of mobile-based nutrient analysis tools against nutrient analysis conducted by dietitians on assessment of Chinese dishes. METHODS Registered Dietitian (RD)-performed nutrient analysis was used as the reference. Two mobile-based nutrient analysis tools were selected for the comparison: BD Diabetes Health Coach (an Artificial Intelligence (AI) Coach developed in the current study upon a dish composition database) and Boohoo App (a popular open-access dietary tracking tool in China). Both RDs and mobile-based tools conducted nutrient analysis of the same dishes commonly consumed in China regarding total calories, carbohydrate, fat, and protein content. Descriptive statistics were analyzed. Paired t-tests, Wilcoxon signed rank tests, linear regression and Bland-Altmanwere used to compare results between the RDs and the mobile tools. RESULTS Strong positive correlations between AI Coach- and RD-performed analyses results and moderate positive correlations between Boohoo-performed and RD-performed analyses results were observed for energy and all macronutrients. Bland-Altman plots showed small bias and narrow limit of agreement between AI Coach- and RD-performed analyses, indicating AI Coach-performed analysis is comparable to RD-performed analysis. CONCLUSIONS The AI Coach tool developed in the current study supported by a dish composition database consisting of commonly consumed Chinese dishes was an effective alternative to dietitians in total calorie and macronutrient analysis. This is promising in helping patients with diabetes manage blood glucose through dietary tracking.

Antidiabetic and Antidyslipidemic activity of Secang (Caesalpinia sappan L.) Wood extract on Diabetic Rat

2021 ◽  
pp. 2800-2806
Author(s):  
Diana Holidah ◽  
Ika Puspita Dewi ◽  
Fransiska Maria Christianty ◽  
Noer Sidqi Muhammadiy ◽  
Nur Huda
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Blood Glucose ◽  
Diabetic Rat ◽  
Level Increase ◽  
Patients With Diabetes ◽  
Potential Activity ◽  
Wood Extract ◽  
Antidyslipidemic Activity

Diabetes mellitus is a syndrome due to disorders of carbohydrate, lipid, and protein metabolism due to decreased insulin secretion or reduced insulin sensitivity. The number of people with diabetes mellitus is increasing every year. However, diabetes mellitus is a major cause of cardiovascular disease, blindness, kidney failure, and amputation due to gangrene. Patients with diabetes mellitus have a possibility of 2-3 times higher cardiovascular disease than non diabetic. Sappan wood containing brazilin that have antioxidant activity and had a potential activity to lower the incidence of type 2 diabetes mellitus. Objective of this research was to determine the activity of secang wood extract as an antidiabetic and antidyslipidemic on diabetic rat. Diabetic rat induced by alloxan and given extract once daily for 14 days. At 15th day, blood glucose level, lipid profile was determine, pancreas was harvested and processed to hystopathological examination. Secang wood extract decreased blood glucose, cholesterol, triglyceride, and LDL level, increase HDL level, and repair the histology of pancreas on diabetic rat after 14 days treatment. Based on the result, secang wood extract had antidiabetic and antidyslipidemic activity on diabetic rat.

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