AbstractOur rigorously validated Computational Fluid Dynamics (CFD) model (Basha et al. 2016) was previously used to predict the effects of gas sparger designs and internals configurations on the local hydrodynamics in a pilot-scale and a conceptual large-scale slurry bubble column reactors (SBCRs) (Basha and Morsi 2018). In this study, the CFD model was used to predict the effect of incorporating the F-T reaction kinetics on the local hydrodynamics in the pilot-scale (0.3-m ID, 3-m height) and the overall performance of the pilot-scale and an industrial-scale (5.8-m ID, 42-m height) SBCRS, both operating under F-T conditions with iron catalyst.In the pilot-scale SBCR, the CFD simulations were carried out with catalyst concentrations of 5, 10 and 15 vol% and three H2/Co ratios of 1, 1.5 and 2, at temperature of 443 K, pressure of 20.5 bar and a superficial gas velocity of 0.24 m/s. The predictions showed that the presence of chemical reactions decreased the gas holdup and the Sauter mean bubble diameters along the reactor height by an average of 15.4 % and 17.63 %, respectively and strengthened the liquid circulations near the reactor wall. The predictions also showed that the CO and H2conversions increased with increasing the catalyst concentration, and the pilot scale SBCR could produce a maximum of 1.87 tons/day of C5+products at a catalyst concentration of 15 vol%.In the commercial-scale SBCR, the CFD simulations were conducted at a catalyst loading of 10 vol% at a temperature of 528 K, pressure of 29 bar and four superficial gas velocities of 0.12, 0.24, 0.3 and 0.4 m/s. The calculations were completed, however, the contours of the local hydrodynamics were not extracted due to computational and memory limitations associated with generating graphics of such a large and complex reactor geometry. The predictions showed that the CO conversions were 48 %, 59 %, 58 % and 55 %; the H2conversions were 36 %, 51 %, 56 % and 54 % and the C5+products yields were are 275, 576, 627 and 654 ton/day at the superficial gas velocities of 0.12, 0.24, 0.3 and 0.4 m/s, respectively. When comparing the CFD model predictions with those of the 1-D empirical model developed by Sehabiague et al. (Sehabiague et al. 2015) at a superficial gas velocity of 0.24 m/s and catalyst loading of 10 %, the CFD model was found to predict lower CO conversion, higher H2conversion and higher C5+yield.