scholarly journals Local use of Muscomed in the treatment of patients with knee osteoarthritis

TRAUMA ◽  
2021 ◽  
Vol 22 (2) ◽  
pp. 28-33
Author(s):  
A.V. Makogonchuk ◽  
Yu.O. Bezsmertnyi ◽  
L.Ye. Atamanchuk
Keyword(s):  
Analogue Scale ◽  
Pain Syndrome ◽  
Knee Joints ◽  
Osteoarthritis Of The Knee ◽  
Efficacy And Safety ◽  
Safety And Efficacy ◽  
Womac Index ◽  
Inflammatory Drugs ◽  
Local Use

The article presents the literature data and the results of our own investigation on the efficacy and safety of Muscomed cream in the treatment of patients with osteoarthritis of the knee joint. The study included 20 women (mean age 62 years). The study design included clinical and radiological examination of patients and survey using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and the visual analogue scale at the beginning of treatment, on days 7 and 14 of using Muscomed cream. Muscomed cream was applied topically as a component of physiotherapeutic procedures as a part of a comprehensive conservative treatment. Two weeks after completing the course of treatment, there was a significant decrease in the intensity of pain syndrome and a decrease in the total WOMAC index in patients who used Muscomed cream locally. There was also a more pronounced decrease in the need for non-steroidal anti-inflammatory drugs in patients of the main group. The safety and efficacy of the Muscomed cream in the treatment of osteoarthritis of the knee joints were demonstrated, which resulted in a decrease in the severity of pain syndrome and an improvement in the functional activity and quality of life of such patients.

scholarly journals AB0599 EFFICACY AND SAFETY OF COMBINATION THERAPY WITH NSAIDS AND ANTICONVULSANT, COMPARED WITH NSAID MONOTHERAPY FOR CHRONIC PAIN IN PATIENTS WITH OSTEOARTHRITIS OF THE KNEE JOINTS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1336.1-1336
Author(s):  
E. Filatova ◽  
L. Alekseeva ◽  
E. Taskina ◽  
N. Kashevarova ◽  
A. Lila ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Knee Joints ◽  
Anxiety And Depression ◽  
Osteoarthritis Of The Knee ◽  
Efficacy And Safety ◽  
Womac Index ◽  
Group I ◽  
Group Ii ◽  
Pain At Rest

Background:In 20-44% of patients with osteoarthritis of the knee joints neuroplastic changes occur due to central sensitization (1,2), which is the rationale for complex therapy, including centrally acting drugs, for more effective pain control.Objectives:To evaluate the efficacy and safety of combination therapy with NSAID and anticonvulsant in comparison with NSAID monotherapy in patients with osteoarthritis of the knee joints and signs of central sensitization or nocyplastic painMethods:The study included 60 women with osteoarthritis of the knee joints (OAK) with signs of nocyplastic pain. Nocyplastic pain were revealed by neuropathic scales (DN4 questionnaire > 4 points), subject to the absence of patients lesions of the somatosensory nervous system. All patients were randomized into two age- and sex-matched groups: group I (n=30) received combination therapy with aceclofenac and pregabalin, group II (n=30) - monotherapy with aceclofenac. The observation period was 42 days and included three visits. All patients underwent a clinical and neurological examination, we assessed the overall WOMAC index, pain intensity at rest with the visual analogue scale (VAS), nocyplastic pain (DN4 and Pain DETECT questionnaires), anxiety and depression (HADS questionnaire) and the quality of life (EQ-5D questionnaire).Results:The intensity of pain at rest according to VAS in patients of group I significantly decreased after 14 days (visit 2) and even further after 42 days (visit 3) (64.0 [50.0; 72.0] vs 49.0 [33.0; 55.0] vs 33.5 [22.0; 49.0] p = 0.006). In group II the intensity of pain at rest also decreased after 14 days (visit 2) (63.0 [41.0; 72.0] vs 48.0 [35.0; 58.0] p <0.001), however, did not change significantly from visit 2 to 3 (48.0 [35.0; 58.0] vs 44.0 [35.0; 60.0]) (p = 0.57).The dynamics of neuropathic pain indicators according to the DN4 and Pain DETECT questionnaires was as follows: group I (visit 1-3) DN4 (6.0 [5.0; 7.0] vs 3.0[1.0; 4.0], p=0.001) and Pain DETECT (17.0 [16.0;20.0] vs 8.0 [5.0; 14.0], p=0.001). Group II DN4 (6.0[5.0;6.0] vs 5,0 [3,0; 6,0],p=0,05), Pain DETECT (17,0 [15,0; 19,0] vs 16.0 [14,0; 19,0],p=0,53).The overall WOMAC index decreased significantly in both groups.Significant positive dynamics in terms of the level of anxiety (9.0 [7.0;14.0] vs 7.0 [4.0;10.0], p=0.001), depression (8.0 [5.0;10.0] vs 6.5 [4.0;9.0], p= 0.03) and quality of life (0.52 [-0.02;0.52] vs 0.52 [0.52;0.59], p=0.01) was observed compared to baseline in group I but not in group II. Before the start of therapy, the groups were comparable in the studied parameters, however, after 42 days, anxiety (7.0 [4.0;10.0]vs 9.0 [7.0;12.0], p=0.02) and depression levels (6.5 [4.0;9.0] vs 8.0 [6.0;9.0], p=0.05) were statistically different. Moreover, the median anxiety and depression levels still exceeded 7 points in group II, indicating the presence of anxiety and depression.Conclusion:Combination therapy of chronic pain with signs of nocyplastic pain with pregabalin and aceclofenac in patients with knee osteoarthritis has been shown to be effective in terms of pain intensity, the presence of neuropathic descriptors and the severity of anxiety compared with aceclofenac alone.References:[1]Hochman JR, French MR, Bermingham SL, Hawker GA. The nerve of osteoarthritis pain. Arthritis Care Res (Hoboken). 2010;62:1019–23.[2]Hochman JR, Gagliese L, Davis AM, Hawker GA. Neuropathic pain symptoms in a community knee OA cohort. Osteoarthr Cartil. 2011;19:647–54.Disclosure of Interests:None declared.

scholarly journals Effects of isometric quadriceps muscle strengthening exercise on chronic osteoarthritis of the knee

2010 ◽  
Vol 36 (1) ◽  
pp. 20-22 ◽  
Author(s):  
Md. A. Shakoor ◽  
Md. Shahidur Rahman ◽  
Abul Kalam Azad ◽  
Md. Sadrul Islam
Keyword(s):  
Analogue Scale ◽  
Quadriceps Muscle ◽  
Exercise Group ◽  
Knee Joints ◽  
Osteoarthritis Of The Knee ◽  
Muscle Strengthening ◽  
Osteoarthritis Of Knee ◽  
Strengthening Exercise ◽  
Inflammatory Drugs ◽  
Day By Day

A total of 64 patients of osteoarthritis of the knee joints were studied to observe the effects of isometric quadriceps muscle strengthening exercise plus non-steroidal anti-inflammatory drugs (NSAIDs) on osteoarthritis of knee joints. Another 75 patients were treated with NSAIDs as control. They were assessed by visual analogue scale, OMAC scale and range of motion of the knee joints and followed-up weekly for six weeks. Improvement was found in both groups (p= 0.001) after treatment. In comparison, more improvement was found in the exercise group after four weeks (p= 009). Then improvement was gradually increased day by day and finally there was highly significant improvement (p=0.001). This study suggests that isometric quadriceps muscle strengthening exercise has its beneficial role to reduce symptoms in osteoarthritis knee.Online: 18 July 2010DOI: http://dx.doi.org/10.3329/bmrcb.v36i1.5502Bangladesh Med Res Counc Bull 2010; 36: 20-22

scholarly journals Therapeutic niche of hyaluronic acid derivatives in osteoarthritis

2021 ◽  
pp. 123-132
Author(s):  
I. G. Krasivina ◽  
L. N. Dolgova ◽  
N. V. Dolgov
Keyword(s):  
Hyaluronic Acid ◽  
Pain Syndrome ◽  
Reduction Of Pain ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Viscoelastic Substances ◽  
Local Use ◽  
Point Of Intersection ◽  
Therapeutic Doses

Osteoarthritis (OA) is a widespread disease of synovial joints, the treatment of which determines a significant number of tactical and strategic directions. Currently, there is experience in the local use of so-called synovial fluid (SF) prostheses, which are viscoelastic substances that improve the cushioning properties of the native intra-articular environment. The overwhelming majority of viscoelastic additives are represented by hyaluronic acid (HA) derivatives, a natural component of SF, whose biological role consists in maintaining the rheological properties of fluid and the presence of anti-inflammatory, anti-nociceptive and chondro-protective properties. In the development of HA drugs, the main goals are the sustained and controlled release of therapeutic doses of the drug, taking into account the choice of carrier, drug molecule and target articular tissue. Assessing the quality and physiological feasibility of introducing a particular viscoelastic drug into the joint involves determining the so-called crossover frequency - the point of intersection of the viscosity modulus G’ and the elastic modulus G” (G’/G”), which reflects changes in the viscoelastic properties of the SF with increasing load frequency when transitioning from walking to running. Physiological range of frequencies out of the majority of investigated medical products corresponds to a single one, among which there are also variants of domestic production. Numerous studies of local application of some HA drugs in patients with OA confirm their effectiveness and safety, in particular, reduction of pain syndrome, reduction of the need for nonsteroidal anti-inflammatory drugs, improvement of the quality of life. However, unfortunately, most HA drugs available on the market have not undergone full-fledged clinical trials, so there is a need to study the comparative effectiveness of drugs of this group approved for use and determine their place in the treatment of OA with different variants of the course.

scholarly journals Many years of experience in using a combination of glucosamine and chondroitin in clinical practice

2020 ◽  
pp. 113-119
Author(s):  
I. S. Dydykina ◽  
P. S. Kovalenko ◽  
A. A. Kovalenko
Keyword(s):  
Clinical Evidence ◽  
Knee Joints ◽  
Osteoarthritis Of The Knee ◽  
Lower Back ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Timely Administration ◽  
Nuclear Factor Kb

The article presents the main approaches to choosing the treatment of osteoarthritis and the main links in the pathogenesis of this disease. The effects of glucosamine and chondroitin on the main pathogenetic mechanisms of osteoarthritis that prevent its progression are described. There are discussed an effectiveness and safety of treatment of the disease with a focus on the use of a combination of glucosamine hydrochloride and chondroitin sulfate (Arthra), as well as their combination with methylsulfonylmethane and sodium hyaluronic acid (Arthra MSM). Methylsulfonylmethane reduces pain, it is involved in the processes of maintaining and regeneration of connective tissue, in the synthesis of sulfated glycosaminoglycans and collagen. It is suggested that this compound may have analgesic and anti-inflammatory properties due to the inhibition of the nuclear factor kB signaling pathway, which allows to reduce the local and systemic inflammatory response, as well as suppressing the expression of proinflammatory cytokines and much more. This article also presents experimental and clinical evidence of the effectiveness and safety of these compounds. It has been convincingly demonstrated the possibility with these drugs to reduce joint pain and the need for analgesics and non-steroidal anti-inflammatory drugs, to improve the quality of life. Currently, symptomatic slow-acting drugs, which include the discussed ones, are recommended to be prescribed as first-line drugs for the treatment of osteoarthritis. Timely administration of symptomatic slow-acting drugs, their long-term use contributes not only to reducing the progression of the disease, but also makes it possible to avoid or delay endoprosthetics. In this article there is indicated the contribution of Russian scientists to obtaining evidence of the effectiveness and safety of Arthra and Arthra MSM in the application of various treatment modes in osteoarthritis of the knee joints and lower back pain.

Which NSAID to choose for treatment of pain syndrome in polymorbid patients?

2021 ◽  
pp. 41-46
Author(s):  
A. P. Pereverzev
Keyword(s):  
Chronic Pain ◽  
Odds Ratio ◽  
Pain Syndrome ◽  
Moderate Pain ◽  
Efficacy And Safety ◽  
First Line ◽  
Increased Risk ◽  
Inflammatory Drugs ◽  
First Line Treatment

A polymorbid patient is a patient with several diseases occurring simultaneously at different stages and phases of their development. Patients with polymorbid pathology have a statistically significant almost 2.5 times higher risk (odds ratio [OR] = 2.41; p = 0.01) of pain syndrome and other diseases (for example, depression, arterial hypertension, etc.), which will contribute to the progression of polymorbidity. Individuals with chronic pain have a significantly increased risk of all causes’ death (hazard ratio [HR] = 1.95; 95 % confidence interval [CI]: 1.26–3.03) and cardiovascular causes (RR = 2.72; 95 % CI: 1.41–5.26) compared to patients without chronic pain. Therefore, in order to improve the prognosis and quality of life of the patient, both acute and chronic pain must be treated with non-pharmacological (exercise therapy, taping, virtual reality, etc.) and pharmacological methods. Non-steroidal anti-inflammatory drugs (NSAIDs) are the first-line treatment for mild to moderate pain. The rational choice of NSAIDs in polymorbid patients can be difficult due to the presence of pathologies that limit their use or conditions that are risk factors of complications of drug therapy. In this article, the author present approaches to choosing the optimal NSAID in polymorbid patients, and justify efficacy and safety of administration of original meloxicam in these individuals (Movalis®, Boehringer Ingelheim International).

scholarly journals Comparative analysis of different methods of anesthesia in patients with acute pancreatitis using pain scales

2016 ◽  
Vol 97 (2) ◽  
pp. 217-221
Author(s):  
V N Shilenok ◽  
E V Nikitina
Keyword(s):  
Acute Pancreatitis ◽  
Comparative Analysis ◽  
Visual Analogue Scale ◽  
Pain Intensity ◽  
Epidural Anesthesia ◽  
Analogue Scale ◽  
Pain Syndrome ◽  
Opioid Analgesics ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Aim. To conduct a comparative analysis of used anesthesia methods in patients with acute pancreatitis in intensive care units settings using pain scales.Methods. Depending on the anesthesia type, 44 patients with acute pancreatitis were divided into three groups: the first group received intramuscular injections of nonsteroidal anti-inflammatory drugs and spasmolytics, the second group - intramuscular injections of non-steroidal anti-inflammatory drugs and opioid analgesics, the third group - epidural anesthesia with local anesthetics. Comparative analysis of pain character, intensity was conducted, its dynamics in patients of all groups amid anesthesia was evaluated using a visual analogue scale, verbal rating scale, verbal descriptor scale, McGill pain questionnaire.Results. Baseline pain intensity in patients of all groups was high. Patients estimated this pain as «very strong». The time and the level of pain intensity reduction for various anesthesia types had differences. Pain syndrome was eliminated slower in patients of the second group. By the end of the 1st day, patients of this group continued to complain of «strong» pain. Pain intensity decreased only on the 2nd day - patients reported «moderate» pain. Pain syndrome was not completely eliminated in these patients for 2 days of anesthesia. 97.7% of patients reported that the visual analogue scale is the most acceptable pain assessment scale for them.Conclusion. In patients with acute pancreatitis, the most optimal anesthesia types are intramuscular nonsteroidal anti-inflammatory drugs with spasmolytics and prolonged epidural anesthesia with local anesthetics; intramuscular administration of opioid analgesics with non-steroidal anti-inflammatory drugs is less effective in relieving pain.

Efficacy and safety of Alflutop in the treatment of patients with osteoarthritis of the knee joints: multicenter open-label randomized clinical trial

Pharmateca ◽  
2020 ◽  
Vol 13_2020 ◽  
pp. 87-95
Author(s):  
E.P. Sharapova Sharapova ◽  
L.I. Alekseeva Alekseeva ◽  
E.A. Taskina Taskina ◽  
N.G. Kashevarova Kashevarova ◽  
S.G. Anikin Anikin ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Knee Joints ◽  
Osteoarthritis Of The Knee ◽  
Efficacy And Safety ◽  
Open Label

A patient with osteoarthritis at an outpatient appointment. Unresolved problems

2021 ◽  
Author(s):  
Ю.А. Лушпаева
Keyword(s):  
Quality Of Life ◽  
Primary Care ◽  
Clinical Practice ◽  
Knee Osteoarthritis ◽  
Marine Fish ◽  
Routine Clinical Practice ◽  
Knee Joints ◽  
Osteoarthritis Of The Knee ◽  
Outpatient Basis

Целью исследования было выявление возможных проблем диагностики, междисциплинарного взаимодействия и причины дефектов терапии пациентов с остеоартритом на амбулаторном приеме, а также оценка эффективности и безопасности применения в рутинной клинической практике у пациентов с остеоартритом коленных суставов препарата, основой которого является биоактивный концентрат мелких морских рыб. Проанализированы результаты амбулаторного приема ревматолога и истории болезни 2312 пациентов с направительным диагнозом «остеоартрит» различной локализации. Оказалось, что из всех обратившихся к ревматологу пациентов с направительным диагнозом «остеоартрит» 47% направлений можно расценить как безосновательные. Было обнаружено, что 45% пациентов даже при установленном достоверном диагнозе «остеоартрит» на амбулаторном приеме терапия назначалась не в полном объеме и не соответствовала рекомендациям по ведению данной категории больных. После двух курсов (в течение года) лечения препаратом на основе биоактивного концентрата мелких морских рыб эффектом от терапии были удовлетворены 67% пациентов с остеоартритом коленных суставов, отметившие снижение интенсивности боли, улучшение функции суставов и качества жизни. В группе наблюдения не было зарегистрировано нежелательных явлений. Несмотря на то, что в настоящее время проблема остеоартрита хорошо освещена, в реальной клинической практике на этапе первичного звена врачи нередко сталкиваются со сложностями решения как диагностических, так и терапевтических задач. В связи с этим возникает острая необходимость в пересмотре и адаптации к рутинной амбулаторной практике междисциплинарных алгоритмов ведения больных остеоартритом, с определением порога вмешательства врача первичного звена и специалиста. Существует также необходимость в разработке и внедрении в рутинную клиническую практику оптимизированных шкал/опросников для динамической оценки качества жизни пациентов с остеоартритом коленных суставов. Проведенное исследование демонстрирует достаточно высокую эффективность, безопасность и доступность препарата на основе биоактивного концентрата мелких морских рыб, а лечение данным препаратом может широко применяться в комплексной терапии остеоартрита коленных суставов. The purpose of the study was to identify the problems of diagnosis, interdisciplinary interaction and the causes of defects in the treatment of patients with osteoarthritis on an outpatient basis, as well as to assess the efficacy and safety of using the medicine from bioactive concentrate of small marine fish, in routine clinical practice in patients with knee osteoarthritis. The results of an out-patient reception hours with a rheumatologist and case histories of 2312 patients with a referral diagnosis of osteoarthritis of various localization were analyzed. It turned out that 47% of all referrals to a rheumatologist with a referral diagnosis of osteoarthritis can be regarded as unfounded. It was found that 45% of patients, even with an established reliable diagnosis of osteoarthritis, on an outpatient basis, therapy was not prescribed in full and did not comply with the recommendations for the management of this category of patients. After 2 courses (within a year) of treatment with a drug based on a bioactive concentrate of small marine fish, 67% of patients with osteoarthritis of the knee joints were satisfied with the effect of therapy, noting a decrease in pain intensity, an improvement in knee joint function and quality of life. No adverse events were reported in the observation group. Despite the fact that at present the problem of osteoarthritis is well covered, in real clinical practice at the stage of primary care physicians often face difficulties in solving both diagnostic and therapeutic problems. In this regard, there is an urgent need to revise and adapt to the routine outpatient practice of interdisciplinary algorithms for managing patients with osteoarthritis, with the determination of the intervention threshold of a primary care physician and a specialist physician. However, there is a need to develop and introduce into routine clinical practice optimized scales/questionnaires for dynamic assessment of the quality of life of patients with knee osteoarthritis. The study demonstrates a fairly high efficacy, safety and availability of a drug based on a bioactive concentrate of small marine fish, and treatment with this drug can be widely used in the complex therapy of osteoarthritis of the knee joints.

Experience of the Use of Chondroitin Sulfate in the Recovery Treatment of Posttraumatic Chondropathy of the Knee in Athletes Playing Sports

10.12737/7270 ◽  
2014 ◽  
Vol 21 (4) ◽  
pp. 61-67
Author(s):  
Сахарова ◽  
M. Sakharova ◽  
Капустина ◽  
N. Kapustina ◽  
Смоленский ◽  
...  
Keyword(s):  
Knee Joint ◽  
Chondroitin Sulfate ◽  
Pain Syndrome ◽  
Main Group ◽  
Knee Joints ◽  
Osteoarthritis Of The Knee ◽  
Isokinetic Testing ◽  
Deficit Reduction ◽  
Recovery Treatment ◽  
Angular Velocities

The article presents results of research on the effectiveness of comprehensive rehabilitation treatment of athletes with post-traumatic chondropathies of knee joints by means of chondro-protective therapy (chondroitin sulfate injections). The study involved 60 athletes playing sports. Athletes were examined through a survey questionnaire Knee injury and osteoarthritis outcome score - Scale Exodus of injury and osteoarthritis of the knee joint, as well as clinical examination, ultrasound examination of the knee joints, bilateral isokinetic testing of the muscles of the flexor-extensor of the knee joint. 2 groups of 30 athletes (the main group and the comparison group) had course of treatment: physical therapy by alternating magnetic field, therapeutic physical training, massage. Athletes of the main group was additionally applied intramuscularly drug chondroitin-sulfate (Astragal). The study showed greater efficacy of the treatment of athletes in the main group, this is confirmed by a significant decrease of pain syndrome, improving of functional status of the knee joints, increase sporting activity and improving the quality of life of athletes according to the survey; improving the biomechanical characteristics of the periarticular muscles and deficit reduction extensor tibiae between damaged and intact limb at angular velocities of 60 and 180 0/с, the positive dynamics of the ultrasonic examination of the knee joints.

scholarly journals Evaluation of efficacy and safety of new high-density dyes for chromovitrectomy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Valerio Piccirillo ◽  
Sandro Sbordone ◽  
Francesco Sorgente ◽  
Adele Ragucci ◽  
Antonello Iovine ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Central Macular Thickness ◽  
Efficacy And Safety ◽  
Safety And Efficacy ◽  
Macular Surgery ◽  
Ocular Coherence Tomography ◽  
Before And After

AbstractThe purpose of this study is to evaluate the safety and efficacy of two novel heavy dyes for macular surgery: DoubledyneTM and TwinTM. One eye from each of 144 patients undergoing surgery for macular hole or macular pucker was included in the study. The eyes were randomly divided into two groups according to the dye used during surgery. Best correct visual acuity (BCVA), intraocular pressure (IOP) and retinal morphology assessed by ocular coherence tomography (OCT) were evaluated before and 1, 3, 6 and 12 months after surgery. Only one surgeon performed each operation and provided a score ranging from 1 (poor) to 10 (excellent) for quality of staining and comfort in surgery. Statistical analysis was carried out with SPSS to compare parameters before and after surgery and between the two groups. No statistical differences were recorded in quality of staining (p = 0.11), in surgery comfort (p = 0.17) and total time of surgery (p = 0.44) between the two groups. BCVA statistically improved and central macular thickness (CMT) statistically decreased after surgery in both groups (p < 0.05). No toxic dye-related complications or long-term ones affecting the retina were observed in either group. According to this data, although confirmation in further studies with larger populations and longer follow up is required, DoubledyneTM and TwinTM proved to be safe and effective dyes for macular surgery.

Sign in / Sign up

Export Citation Format

Share Document