Clinical case of neonatal acute lymphoblastic leukemia

A clinical case of the development of a rare form of ocular manifestation of acute lymphoblastic leukemia, one of the most common oncological diseases in childhood, is described. A seven-year-old child initially had weakness, decreased appetite, and a single episode of subfebrile condition for two days without catarrhal symptoms. Further, an increase in the cervical lymph nodes was noticed. Then a hemorrhagic rash appeared all over the body. In the complete blood count (CBC) test: erythrocytes (RBC) – 3.8 * 1012 / l, hemoglobin (HGB) – 115 g/L, leukocytes (WBC) – 121*109/L, platelets (PLT) – 22*109/L. The child was admitted to the regional children’s clinical hospital. On examination, 90% of blast cells were detected in the myelogram. Against the background of a confirmed remission of the oncological disease, iridocyclitis of the left eye was diagnosed. It could not be stopped by standard antibacterial and antiinflammatory therapy. After a while, the right eye was also involved in the pathological process. Hematologists confirmed the recurrence of acute lymphoblastic leukemia after bone marrow puncture. The presented clinical case demonstrates the fact that the treatment of ocular manifestations of acute lymphoblastic leukemia can be effective only in the treatment of the underlying disease.

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Diagnosis and treatment of acute lymphoblastic leukemia in a patient with niimegen syndrome ﬁrst diagnosed in adulthood

Hematology and Transfusiology ◽

10.35754/0234-5730-2020-65-1-39-51 ◽

2020 ◽

Vol 65 (1) ◽

pp. 39-51

Author(s):

K. I. Zarubina ◽

E. N. Parovnikova ◽

A. V. Kokhno ◽

O. A. Gavrilina ◽

V. V. Troitskaya ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

T Cell ◽

Clinical Case ◽

De Novo ◽

Lymphoblastic Leukemia ◽

Autosomal Recessive Disorder ◽

Nijmegen Breakage Syndrome ◽

Diagnosis And Treatment ◽

Genetic Syndromes ◽

Cell Acute Lymphoblastic Leukemia

Background. Nijmegen breakage syndrome is a rare hereditary autosomal recessive disorder characterized by microcephaly, combined primary immunodeﬁciency, sensitivity to radioactive radiation and liability to tumours of various nature (in particular, those developing in the lymphatic tissue). This syndrome is part of a group of diseases characterized by chromosomal instability. This disease develops as a result of mutations in the NBS1 gene, which is responsible for repairing DNA double-stranded breaks.Aim. To describe a clinical case of the diagnosis and treatment of T-cell acute lymphoblastic leukemia in a patient with Nijmegen syndrome, which was ﬁrst diagnosed in adulthood.General ﬁndings. A clinical case of the diagnosis and treatment of Nijmegen syndrome in a young man with de novo T-cell acute lymphoblastic leukemia is presented. The difﬁculty of early diagnosis of hereditary genetic syndromes is demonstrated. The genetic character of such conditions is revealed over time, when children and young adults begin to develop long-term complications, in particular tumours of various origins. Early detection of hereditary genetic syndromes in children is of great importance.

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Клинический случай легочной формы мукормикоза у ребенка с острым лимфобластным лейкозом

South Russian Journal of Cancer ◽

10.37748/2686-9039-2021-2-4-5 ◽

2021 ◽

Vol 2 (4) ◽

pp. 38-47

Author(s):

D. A. Kharagezov ◽

Yu. N. Lazutin ◽

E. A. Mirzoyan ◽

A. G. Milakin ◽

O. N. Stateshny ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Enzyme Immunoassay ◽

Blood Count ◽

Clinical Case ◽

Lymphoblastic Leukemia ◽

Underlying Disease ◽

Main Diagnosis ◽

X Ray ◽

Pulmonary Mucormycosis ◽

Stage Of Diagnosis

The article presents a clinical case of pulmonary mucormycosis in a 12‑year-old child at the stage of diagnosis of acute lymphoblastic leukemia. The first symptoms of the disease (headaches, malaise and weakness, pallor), changes in the general blood count (hyperleukocytosis up to 200 thousand cells/μl, single platelets). Based on the results of the examination, the main diagnosis was verified for acute lymphoblastic leukemia L2, IFT T-II, CD1a-. At the stage of diagnosis of acute lymphoblastic leukemia, the underlying disease was complicated by the development of right-sided pneumonia according to X-ray examination. To verify the etiology of infiltration of lung tissue, broncho-alveolar lavage was directed to microbiological diagnostics, which included studies: enzyme immunoassay, microscopic and cultural. On the aggregate of all the results obtained, invasive mucormycosis was diagnosed and antifungal therapy was started immediately.

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TROMBOSIS OF MESENTERIAL VESSELS IN ACUTE LYMPHOBLASTIC LEUKEMIA (CASE REPORT)

Wiadomości Lekarskie ◽

10.36740/wlek201901126 ◽

2019 ◽

Vol 72 (1) ◽

pp. 133-136

Author(s):

Veronika M. Dudnyk ◽

Irina I. Andrikevych ◽

Hennadiy M. Rudenko ◽

Tetiana G. Korol ◽

Kateryna V. Khromykh

Keyword(s):

Case Report ◽

Surgical Treatment ◽

Acute Lymphoblastic Leukemia ◽

Thrombolytic Therapy ◽

Successful Treatment ◽

Clinical Case ◽

Lymphoblastic Leukemia ◽

Diagnostic Problems ◽

Mesenteric Vessels ◽

Leukemia In Children

The article presents data on classification, diagnostic problems, treatment of acute lymphoblastic leukemia in children. Remaining unresolved problems of protocol chemotherapy complications of acute lymphoblastic leukemia. The presented clinical case of successful treatment of thrombosis of mesenteric vessels in a child with acute lymphoblastic leukemia, which included the stages of thrombolytic therapy and surgical treatment for resection of necrotized part of the ileum.

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A clinical case of pulmonary form of mucormycosis in a child with acute lymphoblastic leukemia

South Russian Journal of Cancer ◽

10.37748/10.37748/2686-9039-2021-2-4-2 ◽

2021 ◽

Vol 2 (4) ◽

pp. 13-17

Author(s):

Yu. Yu. Kozel ◽

O. Yu. Kutsevalova ◽

V. V. Dmitrieva ◽

O. V. Kozyuk ◽

L. B. Kushtova ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Clinical Case ◽

Lymphoblastic Leukemia ◽

Specific Treatment ◽

Underlying Disease ◽

Antifungal Drugs ◽

High Dose ◽

Main Diagnosis ◽

Pulmonary Mucormycosis ◽

Stage Of Diagnosis

Mucormycosis of the lungs is a severe infectious complication in patients with acute lymphoblastic leukemia, which develops at the stage of high-dose cytostatic therapy. It is characterized by an extremely aggressive, rapidly progressive course and, without specific treatment, is fatal in a short time. Reliable verification of mucor is necessary due to its resistance to the most commonly used antifungal drugs, particularly to voriconazole.The article presents a clinical case of pulmonary mucormycosis in a 12‑year-old child at the stage of diagnosis of acute lymphoblastic leukemia. The first symptoms of the disease (headaches, malaise and weakness, pallor), changes in the general blood count (hyperleukocytosis up to 200 thousand cells/μl, single platelets). Based on the results of the examination, the main diagnosis was verified for acute lymphoblastic leukemia L2, IFT T-II, CD1a-. At the stage of diagnosis of acute lymphoblastic leukemia, the underlying disease was complicated by the development of right-sided pneumonia according to X-ray examination. To verify the etiology of infiltration of lung tissue, broncho-alveolar lavage was directed to microbiological diagnostics, which included studies: enzyme immunoassay, microscopic and cultural. On the aggregate of all the results obtained, invasive mucormycosis was diagnosed and antifungal therapy was started immediately.

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