A Case of Anterior Uveitis in the Presence of Acute Lymphoblastic Leukemia

2020 ◽  
pp. 50-53
Author(s):  
A.V. Kolesnikov ◽  
◽  
I.V. Kirsanova ◽  
N.S. Tumanova ◽  
M.M. Averina ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Clinical Case ◽  
Complete Blood Count ◽  
Lymphoblastic Leukemia ◽  
Underlying Disease ◽  
Pathological Process ◽  
The Body ◽  
Cervical Lymph Nodes ◽  
Antiinflammatory Therapy ◽  
Ocular Manifestations

A clinical case of the development of a rare form of ocular manifestation of acute lymphoblastic leukemia, one of the most common oncological diseases in childhood, is described. A seven-year-old child initially had weakness, decreased appetite, and a single episode of subfebrile condition for two days without catarrhal symptoms. Further, an increase in the cervical lymph nodes was noticed. Then a hemorrhagic rash appeared all over the body. In the complete blood count (CBC) test: erythrocytes (RBC) – 3.8 * 1012 / l, hemoglobin (HGB) – 115 g/L, leukocytes (WBC) – 121*109/L, platelets (PLT) – 22*109/L. The child was admitted to the regional children’s clinical hospital. On examination, 90% of blast cells were detected in the myelogram. Against the background of a confirmed remission of the oncological disease, iridocyclitis of the left eye was diagnosed. It could not be stopped by standard antibacterial and antiinflammatory therapy. After a while, the right eye was also involved in the pathological process. Hematologists confirmed the recurrence of acute lymphoblastic leukemia after bone marrow puncture. The presented clinical case demonstrates the fact that the treatment of ocular manifestations of acute lymphoblastic leukemia can be effective only in the treatment of the underlying disease.

scholarly journals Клинический случай легочной формы мукормикоза у ребенка с острым лимфобластным лейкозом

2021 ◽  
Vol 2 (4) ◽  
pp. 38-47
Author(s):  
D. A. Kharagezov ◽  
Yu. N. Lazutin ◽  
E. A. Mirzoyan ◽  
A. G. Milakin ◽  
O. N. Stateshny ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Enzyme Immunoassay ◽  
Blood Count ◽  
Clinical Case ◽  
Lymphoblastic Leukemia ◽  
Underlying Disease ◽  
Main Diagnosis ◽  
X Ray ◽  
Pulmonary Mucormycosis ◽  
Stage Of Diagnosis

The article presents a clinical case of pulmonary mucormycosis in a 12‑year-old child at the stage of diagnosis of acute lymphoblastic leukemia. The first symptoms of the disease (headaches, malaise and weakness, pallor), changes in the general blood count (hyperleukocytosis up to 200 thousand cells/μl, single platelets). Based on the results of the examination, the main diagnosis was verified for acute lymphoblastic leukemia L2, IFT T-II, CD1a-. At the stage of diagnosis of acute lymphoblastic leukemia, the underlying disease was complicated by the development of right-sided pneumonia according to X-ray examination. To verify the etiology of infiltration of lung tissue, broncho-alveolar lavage was directed to microbiological diagnostics, which included studies: enzyme immunoassay, microscopic and cultural. On the aggregate of all the results obtained, invasive mucormycosis was diagnosed and antifungal therapy was started immediately.

scholarly journals A clinical case of pulmonary form of mucormycosis in a child with acute lymphoblastic leukemia

2021 ◽  
Vol 2 (4) ◽  
pp. 13-17
Author(s):  
Yu. Yu. Kozel ◽  
O. Yu. Kutsevalova ◽  
V. V. Dmitrieva ◽  
O. V. Kozyuk ◽  
L. B. Kushtova ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Clinical Case ◽  
Lymphoblastic Leukemia ◽  
Specific Treatment ◽  
Underlying Disease ◽  
Antifungal Drugs ◽  
High Dose ◽  
Main Diagnosis ◽  
Pulmonary Mucormycosis ◽  
Stage Of Diagnosis

Mucormycosis of the lungs is a severe infectious complication in patients with acute lymphoblastic leukemia, which develops at the stage of high-dose cytostatic therapy. It is characterized by an extremely aggressive, rapidly progressive course and, without specific treatment, is fatal in a short time. Reliable verification of mucor is necessary due to its resistance to the most commonly used antifungal drugs, particularly to voriconazole.The article presents a clinical case of pulmonary mucormycosis in a 12‑year-old child at the stage of diagnosis of acute lymphoblastic leukemia. The first symptoms of the disease (headaches, malaise and weakness, pallor), changes in the general blood count (hyperleukocytosis up to 200 thousand cells/μl, single platelets). Based on the results of the examination, the main diagnosis was verified for acute lymphoblastic leukemia L2, IFT T-II, CD1a-. At the stage of diagnosis of acute lymphoblastic leukemia, the underlying disease was complicated by the development of right-sided pneumonia according to X-ray examination. To verify the etiology of infiltration of lung tissue, broncho-alveolar lavage was directed to microbiological diagnostics, which included studies: enzyme immunoassay, microscopic and cultural. On the aggregate of all the results obtained, invasive mucormycosis was diagnosed and antifungal therapy was started immediately.

PT07.5: Association Between the Body Mass Index and the Relapse Rate in Patients with B-Cell Precursor Acute Lymphoblastic Leukemia

2019 ◽  
Vol 38 ◽  
pp. S48
Author(s):  
C.O. Ramos-Peñafiel ◽  
A. Martínez-Tovar ◽  
E. Rozen-Fuller ◽  
M.P. Bejarano-Rosales ◽  
K. Alvarez-Altamirano ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Body Mass ◽  
Relapse Rate ◽  
Lymphoblastic Leukemia ◽  
The Body ◽  
Cell Precursor

Effective Induction of Apoptosis by Mistletoe Plant Extracts in an Acute Lymphoblastic Leukemia Model.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 1880-1880
Author(s):  
Georg Seifert ◽  
Patrick Jesse ◽  
Aram Prokop ◽  
Tobias Reindl ◽  
Stephan Lobitz ◽  
...  
Keyword(s):  
Cell Death ◽  
Body Weight ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
The Body ◽  
Induction Of Apoptosis ◽  
First Time ◽  
Over Time

Abstract Mistletoe (Viscum album) is one of the most used alternative cancer therapies applied as monotherapy or in combination with conventional therapies. Anti-tumor effects of mistletoe (MT) extracts were related to cytostatic and immunomodulatory effects observed in vitro. Aqueous MT extracts contain the three mistletoe lectins I, II and III as one predominant group of biologically active agents. The MT lectins inhibit protein biosynthesis by inactivating the 60S ribosomal subunit. Mistletoe lectin-I (ML-I) is one important apoptosis inducing compound. It is a heterodimer that consists of a cytotoxic A-chain (ribosome inactivating protein, RIP type 1) linked by a carbohydrate binding B-chain for cellular lectin uptake. However, although MT is widely used, there is a lack of scientific preclinical and clinical data. Here, we describe for the first time efficacy and mechanism of MT extracts against lymphoblastic leukemia in vitro and in vivo. For this purpose, we first investigated both the cytotoxic effect and mechanism of action of two standardized aqueous MT extracts (MT obtained from fir trees (MT-A); MT obtained from pine trees (MT-P)) and isolated ML-I, in three human acute lymphoblastic leukemia (ALL) cell lines (NALM-6, sup-B-15 and REH). MT-A, MT-P and ML-I clearly inhibited cell proliferation as determined by LDH reslease assays at very low concentrations (ML-I LD50 from 0,05 ng/ml to 10 ng/ml depending on the host tree) with MT-P being the most cytotoxic extract. The mechanism of cell death was determined by DNA-fragmentation assays. These indicated dose dependent induction of apoptosis as the main mechanism of cell death. Finally, we evaluated the efficacy of MT-A and MT-P in an in vivo SCID-model of pre-B ALL (NALM-6). For this purpose, mice (n=8/group) were injected i.v. with 1 × 106NALM6 cells and treated by intraperitoneal injections four times per week for 3 weeks (day 1–4; 7–11; 14–18) at varying doses (1, 5 and 50 mg/Kg (plant weight/body weight)). Mice (n=8) treated with PBS and cyclophosphamide (100 mg/kg, once on day 1) were used as negative and positive controls, respectively. Toxicity, peripheral blood counts, bodyweight and survival was determined over time. Interestingly, both MT extracts in all tested concentrations significantly improved survival (up to 55,4 days) in contrast to controls (34,6 days). Furthermore, no hematologic side effects were observed from this treatment as indicated by completely stable blood counts. Also the body weight of treated animals remained stable over time indicating a complete absence of systemic toxicity in the selected dose range. In summary, we demonstrate for the first time efficacy and mechanism of MT extracts against ALL in vitro and in vivo and hereby provide an important base line for the design of clinical trials with these compounds.

scholarly journals Recurrent perichondritis as a debut «mask» of acute lymphoblastic leukemia in a young child (clinical case)

2019 ◽  
pp. 83-88
Author(s):  
N.G. Chumachenko ◽  
◽  
T.L. Marushko ◽  
O.V. Golovchenko ◽  
V.N. Fisun ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Young Child ◽  
Clinical Case ◽  
Lymphoblastic Leukemia

scholarly journals On importance of correct interpretation of complete blood count

2019 ◽  
Vol 3 (22) ◽  
pp. 68-70
Author(s):  
N. A. Sokolova ◽  
M. I. Savina ◽  
O. S. Shokhina
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Antiviral Therapy ◽  
Blood Count ◽  
Complete Blood Count ◽  
Lymphoblastic Leukemia ◽  
Correct Interpretation

We would like to present the case the manifestation of acute lymphoblastic leukemia in 2-year-old and 11-month child was treated with antiviral therapy during several month. We retrospectively analyzed hemogram’s values of the child and the importance of correct and timely interpretation of complete blood count is once again evidently demonstrated.

scholarly journals Diagnosis and treatment of acute lymphoblastic leukemia in a patient with niimegen syndrome first diagnosed in adulthood

2020 ◽  
Vol 65 (1) ◽  
pp. 39-51
Author(s):  
K. I. Zarubina ◽  
E. N. Parovnikova ◽  
A. V. Kokhno ◽  
O. A. Gavrilina ◽  
V. V. Troitskaya ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Clinical Case ◽  
De Novo ◽  
Lymphoblastic Leukemia ◽  
Autosomal Recessive Disorder ◽  
Nijmegen Breakage Syndrome ◽  
Diagnosis And Treatment ◽  
Genetic Syndromes ◽  
Cell Acute Lymphoblastic Leukemia

Background. Nijmegen breakage syndrome is a rare hereditary autosomal recessive disorder characterized by microcephaly, combined primary immunodeficiency, sensitivity to radioactive radiation and liability to tumours of various nature (in particular, those developing in the lymphatic tissue). This syndrome is part of a group of diseases characterized by chromosomal instability. This disease develops as a result of mutations in the NBS1 gene, which is responsible for repairing DNA double-stranded breaks.Aim. To describe a clinical case of the diagnosis and treatment of T-cell acute lymphoblastic leukemia in a patient with Nijmegen syndrome, which was first diagnosed in adulthood.General findings. A clinical case of the diagnosis and treatment of Nijmegen syndrome in a young man with de novo T-cell acute lymphoblastic leukemia is presented. The difficulty of early diagnosis of hereditary genetic syndromes is demonstrated. The genetic character of such conditions is revealed over time, when children and young adults begin to develop long-term complications, in particular tumours of various origins. Early detection of hereditary genetic syndromes in children is of great importance.

scholarly journals ANGKA KEJADIAN DIARE PADA ANAK DENGAN LEUKEMIA LIMFOBLASTIK AKUT DI RSUP PROF. DR. R. D. KANDOU MANADO PERIODE TAHUN 2011-2015

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Fatmawati Latamu ◽  
Jeanette I. Ch. Manoppo ◽  
Max F. J. Mantik
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Medical Records ◽  
Lymphoblastic Leukemia ◽  
Transmitted Disease ◽  
The Body ◽  
Induction Phase ◽  
Inclusion Criteria ◽  
Cross Sectional ◽  
Common Cause ◽  
Foreign Objects

ABSTRACTBackground : Leukemia is a type of non-transmitted disease that cause death with a large number of cases, especially in children. Leukemia is the most common childhood cancer. Acute Lymphoblastic Leukemia (ALL) is approximately 75% of all cases. One of the main consequences of leukemia is inability of the immune system defending the body from the invasion of foreign objects. As a result of infection or bleeding is the most common cause of death in patient with leukemia. Diarrhea is one of the infections that can be found in children with Acute Lymphoblastic Leukemia. Diarrhea in children with Acute Lymphoblastic Leukemia can occur either from the disease itself or due to chemotherapy. The purpose of this study is to describe the incidence of diarrhea in children with acute lymphoblastic leukemia in Prof. R. D. Kandou Hospital Manado year period 2011-2015.Methods : This study is a descriptive retrospective, with cross sectional approach by collecting data medical records of pediatric patient with ALL in RSUP Prof. Dr. R. D. Kandou Manado then describe the incidence of diarrhea. Samples were 60.Results : The result obtained 60 patients who met the inclusion criteria, and 17 patients had diarrhea. Diarrhea in children with ALL is more common in induction phase, and the duration of diarrhea more to less than 7 days (acute diarrhea).Conclusion : From this result, it can be concluded that the incidence of diarrhea in children with Acute Lymphoblastic Leukemia in Prof. DR. R. D. Kandou Hospital Manado year period 2011-2015 is low enough.Keywords : Acute Lymphoblastic Leukemia (ALL), Diarrhea, ChildABSTRAKLatar Belakang : Leukemia merupakan jenis penyakit tidak menular yang menyebabkan kematian dengan jumlah kasus yang tidak sedikit khususnya pada anak-anak. Leukemia adalah kanker anak yang paling sering. Leukemia Limfoblastik Akut (LLA) berjumlah kira-kira 75% dari semua kasus. Salah satu konsekuensi utama dari Leukemia adalah ketidakmampuan sistem imum mempertahankan tubuh dari invasi benda asing. Akibatnya infeksi atau perdarahan hebat adalah penyebab tersering kematian pada pasien leukemia. Diare merupakan salah satu infeksi yang dapat dijumpai pada anak dengan Leukemia Limfoblastik Akut. Diare pada anak dengan Leukemia Limfoblastik Akut dapat terjadi baik akibat dari Leukemia Limfoblastik Akut itu sendiri maupun akibat dari kemoterapi yang diberikan.Metode : Penelitian ini bersifat retrospektif deskriptif, dengan pendekatan potong lintang dengan cara mengumpulkan rekam medik pasien anak dengan LLA di RSUP Prof. Dr. R. D. Kandou Manado, kemudian mendeksripsikan kejadian diare.Hasil : Didapatkan 60 pasien yang memenuhi kriteria inklusi, dan 17 pasien mengalami diare. Diare pada anak dengan LLA lebih sering terjadi pada fase induksi, dan lamanya diare lebih banyak pada < 7 hari (diare akut).Kesimpulan : Angka kejadian diare pada anak dengan Leukemia Limfoblastik Akut di RSUP Prof. DR. R. D. Kandou periode tahun 2011-2015 cukup rendah.Kata Kunci : Leukemia Limfoblastik Akut (LLA), Diare, Anak

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