scholarly journals Efektivitas Dan Keamanan Furosemid Continuous Infusion Dosis 10 dan 20 Mg/Jam pada Pasien Penyakit Ginjal Kronik Kondisi Fluid Overload Syndrome Disertai Hipoalbumin di RSUD Abdul Wahab Sjahranie

2021 ◽  
Vol 17 (1) ◽  
pp. 60
Author(s):  
Diga Albrian Setiadi
Keyword(s):  
Clinical Trial ◽  
Continuous Infusion ◽  
Randomized Clinical Trial ◽  
Fluid Overload ◽  
T Test ◽  
Single Blind

Furosemid continuous infusion merupakan obat pilihan pertama dalam mengatasi kondisi Fluid overload syndrome disertai hipoalbumin pada pasien Penyakit Ginjal Kronik (PGK). Namun pada kondisi tersebut, dosis furosemid yang digunakan oleh para klinisi yakni antara 10 dan 20 mg/jam. Belum ada penelitian yang membandingkan efektivitas dan keamanan furosemid dosis yang berbeda. Penelitian ini bertujuan mengevaluasi efektivitas dan keamanan furosemid dosis 10 dan 20 mg/jam yang diberikan secara continuous infusion pada pasien PGK dengan kondisi fluid overload syndrome disertai hipoalbumin. Metode penelitian Single blind, Randomized Clinical Trial yang dilakukan selama periode bulan Februari-April 2017 di ruang rawat inap RSUD Abdul Wahab Sjahranie. Pengolahan data dilakukan dengan uji analisis statistik yaitu uji parametrik Two Independent T Test untuk data yang terdistribusi normal dan yang tidak saling berkolerasi, sedangkan untuk data yang terdistribusi tidak normal dan yang tidak saling berkolerasi maka digunakan uji non-parametrik Mann Whitney dan Kruskal Willis. Outcome yang diteliti adalah volume urin tampung 24 jam, sesak napas, lama pemakaian oksigen, ronkhi dan keamanan terapi yang dilihat dari efek samping obat (hipotensi, hiperuricemia, hiperglikemia, hiponatremia, hipokalemia). Hasil penelitian, sebanyak 34 pasien PGK dengan kondisi fluid overload syndrome disertai hipoalbumin (2,5-3,0 g/dL) telah didaftarkan. Pada efektivitas terapi, tidak ada perbedaan secara signifikan pada volume urin tampung 24 jam (P=0,324; P>0,05; 95% CI=714,6-1017,8 ml kelompok 1; CI=818,0-1113,2 ml kelompok 2), sesak napas (P=0,781; P>0,05; 95% CI=0,68-1,32 kelompok 1; CI=0,72-1,40 kelompok 2), lama pemakaian oksigen (P=0,363; P>0,05; 95% CI=1,34-2,66 hari kelompok 1; CI=1,72-3,10 hari kelompok 2), ronkhi (P=0,692; P>0,05) dan tidak adanya kejadian efek samping obat (P=1,000; P>0,05) antara dua kelompok tersebut. Kesimpulan, furosemid dosis 10 dan 20 mg/jam memiliki efektivitas terapi yang sama dan furosemid memiliki kemanan terapi yang baik pada pasien PGK dengan kondisi fluid overload syndrome disertai hipoalbuminemia.

Effect of Daily Usage Time of 4% Hydrogen Peroxide on the Efficacy and Bleaching-induced Tooth Sensitivity: A Single-blind Randomized Clinical Trial

2021 ◽  
Author(s):  
RMO Terra ◽  
KL da Silva ◽  
L Vochikovski ◽  
E Sutil ◽  
M Rezende ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Hydrogen Peroxide ◽  
Patient Satisfaction ◽  
Randomized Clinical Trial ◽  
Color Change ◽  
T Test ◽  
Tooth Sensitivity ◽  
Anterior Teeth ◽  
Single Blind ◽  
At Home

Clinical Relevance Although color change was slightly lower in a 3-week 30-minutes/day protocol, than in the 120-minute protocol, this could be compensated by an extra week of bleaching. The advantage of the shorter protocol is the reduced daily application, making the procedure more comfortable for the patients. SUMMARY Objective: Compare the risk/intensity of tooth sensitivity (TS) and color change of a 30-minute vs. the recommended 120-minute application time of 4% hydrogen peroxide (HP) for at-home bleaching. Methods: A single-blind, parallel, randomized clinical trial was conducted with 92 adult patients with caries and restoration-free anterior teeth A2 or darker, randomly allocated to two groups. Bleaching trays containing 4% HP were used for three-weeks. A four-week regimen was also offered to the patients for the 30-min group after the end of the 3-week protocol. The color change was assessed with the Vita Classical (VITA Zahnfabrik, Bad Säckingen, Germany) and Vita Bleachedguide shade guides (VITA Zahnfabrik) and the Vita Easyshade spectrophotometer (VITA Zahnfabrik) at baseline, weekly, and 30 days after the bleaching. The absolute risk and the intensity of TS were assessed daily using the 0-10 visual analogue scale (VAS) and 5-point Numerical Rating Scale (NRS) scale, and patient satisfaction was recorded with a Likert 0-7 scale. Risk of TS (Fisher’s test), intensity of TS in NRS scale (Mann-Whitney test), VAS scale (t-test), and a color change (t-test) were compared. Results: The 30-minute group saw color change of around 1 SGU inferior to the 120-minute group in all-time assessments (p<0.05). After an extra week of bleaching, mean color change was similar (p>0.05). Patient satisfaction was high for both groups (p>0.05). Conclusions: A four-week protocol of at-home dental bleaching with 4% HP for 30 minutes/day whitened teeth similarly to the 120 minutes/day protocol, with low intensity of dental sensitivity and high patient satisfaction.

scholarly journals Terapi Akupresur Dapat Menurunkan Keluhan Mual Muntah Akut Akibat Kemoterapi Pada Pasien Kanker: Randomized Clinical Trial

2011 ◽  
Vol 14 (2) ◽  
pp. 133-140
Author(s):  
Hilman Syarif ◽  
Elly Nurachmah ◽  
Dewi Gayatri
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Nursing Intervention ◽  
T Test ◽  
Nausea And Vomiting ◽  
Control Group ◽  
Acute Nausea ◽  
Patients With Cancer ◽  
Acute Cinv ◽  
Single Blind

AbstrakAkupresur merupakan salah satu terapi komplementer pada pasien yang mengalami mual muntah akut akibat kemoterapi.Tujuan riset ini untuk membuktikan pengaruh akupresur terhadap mual muntah akut pada pasien kanker di dua RS di Jakarta.Penelitian ini merupakan randomized clinical trial dengan metode single blind. Pengambilan sampel dengan cara consecutivesampling dan penentuan kelompok intervensi dan kontrol dengan randomisasi alokasi subjek sederhana. Sampel penelitianberjumlah 44 responden, terdiri dari 22 responden sebagai kelompok intervensi yang dilakukan terapi akupresur sebanyak tigakali sehari, dan 22 responden sebagai kelompok kontrol. Pengujian perbedaan penurunan rerata skor mual, muntah, dan mualmuntah pada kelompok intervensi dan kelompok kontrol menggunakan uji T test. Hasil penelitian menunjukkan penurunanrerata mual muntah akut setelah akupresur pada kelompok intervensi signifikan lebih besar dibanding dengan kelompok kontrol(p= 0,000; α= 0,05). Akupresur secara signifikan dapat menurunkan mual muntah akut akibat kemoterapi pada pasien kankeryang dilakukan akupresur dibandingkan dengan kelompok kontrol. Akupresur direkomendasikan dapat diterapkan sebagaibagian dari intervensi keperawatan dalam pemberian asuhan keperawatan pada pasien yang mengalami mual muntah akutakibat kemoterapi.Kata kunci: akupresur, kemoterapi, mual muntah akutAbstractAcupressure is one of the complementary theraphies for patients with acute chemotherapy-induced nausea and vomiting(CINV). The objective of the study was to prove the effect of acupressure to acute CINV on patients with cancer at two hospitalsin Jakarta. The research used randomized clinical trial with single blind method. A consecutive sampling was used as thesample collection method and simple randomization allocation subject was used to identify samples in the intervention orcontrol group. The number of samples was 44 respondents, consisted of 22 subjects who were given an acupressure theraphy,three times a day; and the remaining was the control group. A t-test was used to examine the differences of the mean nauseaand vomiting scores between the intervention and control groups. The result indicated that there is a signifant decrease of themean acute nausea and vomiting scores after acupressure between the two groups (p= 0.000; α= 0.05). It was concluded thatthe acupressure can significantly decrease acute CINV on patients with cancer in the intervention group if compared withcontrol group. Based on the findings, recommendation is directed to hospital management especially nursing management toapply acupressure as a nursing intervention to patients with acute CINV.Keywords: acupressure, chemotherapy, acute nausea and vomiting

Longitudinal effect of curcumin-photodynamic antimicrobial chemotherapy in adolescents during fixed orthodontic treatment: a single-blind randomized clinical trial study

2014 ◽  
Vol 30 (8) ◽  
pp. 2059-2065 ◽  
Author(s):  
Marco Aurélio Paschoal ◽  
Cíntia Maria Zanin Moura ◽  
Fabiano Jeremias ◽  
Juliana Feltrin Souza ◽  
Vanderlei S. Bagnato ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Antimicrobial Chemotherapy ◽  
Orthodontic Treatment ◽  
Photodynamic Antimicrobial Chemotherapy ◽  
Single Blind

scholarly journals The Analgesic Effects of Bupivacaine and Magnesium Sulfate Combination, Bupivacaine, and Adrenaline Combination and Bupivacaine Alone on Post-cesarean Section Pain: A Randomized Clinical Trial

2018 ◽  
Vol 9 (4) ◽  
pp. 284-290
Author(s):  
Zinatossadat Bouzari ◽  
Seyedeh Rabeeh Rouhani ◽  
Ebrahim Alijanpour ◽  
Shahla Yazdani ◽  
Bahman Hasannasab ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cesarean Section ◽  
Magnesium Sulfate ◽  
Randomized Clinical Trial ◽  
Normal Saline ◽  
Repeated Measures ◽  
The Other ◽  
Hemodynamic Parameters ◽  
Analgesic Effects ◽  
Single Blind

Objectives: The present study was performed to compare the analgesic effects of bupivacaine and magnesium sulfate combination on post-cesarean (C) section pain. Materials and Methods: The present single-blind randomized clinical trial was conducted on 160 C-section candidates. The participants were randomly divided into four groups. When the fascia healed, the first group received 20 mL of 0.25% bupivacaine and the second group received 20 mL of 0.25% bupivacaine combined with subcutaneous adrenaline. In addition, both groups received 50 mL of intravenous normal saline. Further, the third group received subcutaneous bupivacaine and 50 mg/kg of magnesium sulfate and the fourth group received subcutaneous and intravenous normal saline as a placebo. The pain intensity was assessed 2, 6, 12, 18, and 24 hours after spinal anesthesia using the visual analogue scale (VAS) for pain. The dose of pethidine (as a standard analgesic) and hemodynamic parameters (i.e., heart rate [HR] and blood pressure [BP]) was recorded as well. The obtained data were then analyzed utilizing ANOVA, Tukey’s HSD, and repeated measures ANOVA tests. Results: The intensity of pain and the dose of pethidine decreased significantly in the combination of bupivacaine with magnesium compared to the other groups at all times (P < 0.001). However, diastolic BP significantly increased in the bupivacaine + adrenaline group in comparison with the other groups (P = 0.02). Conclusions: Overall, bupivacaine combination with magnesium sulfate is suitable for controlling post-cesarean section pain.

scholarly journals Effect of Acupressure on Stress and Anxiety of Patients with Multiple Sclerosis: A Sham-controlled Randomized Clinical Trial

2020 ◽  
Vol 10 (3) ◽  
pp. 270-283
Author(s):  
Mohammad Ali Nahayati ◽  
◽  
Seyed Abolfazl Vaghar Seyyedin ◽  
Hamid Reza Bahrami-Taghanki ◽  
Zahra Rezaee ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Test Scores ◽  
Sham Group ◽  
Applied Pressure ◽  
Intervention Group ◽  
T Test ◽  
Significant Difference ◽  
The Mean

Objective: Stress and anxiety are common in patients with Multiple Sclerosis (MS). These complications exacerbate the symptoms of MS. This study aims to evaluate the effect of acupressure on stress and anxiety of MS patients. Methods: In this randomized clinical trial, participants were 106 MS Patients referred to Multiple Sclerosis Society in Mashhad, Iran. After signing an informed consent form, they completed a demographic form and stress, and the Depression Anxiety Stress Scale - 42 items (DASS-42). Then, they were randomly assigned into intervention and sham groups by tossing a coin. Participants in the intervention group were asked apply a pressure on the Shenmen and Yin Tang acupoints for one month (once per day for 15 minutes), while the sham group applied pressure 2.5 cm below the Shenmen acupoint and 3 cm above the Yin Tang acupoint. Participants in each group were then completed the DASS-42 again one hour after the final session. Data were analyzed using chi-square test, Kolmogorov-Smirnov test, independent t-test, and Paired t-test. Results: In the intervention and sham groups, there was no statistically significant difference between the mean pre-test scores of stress (34.73±5.80 vs. 33.06±6.42) and anxiety (27.09±6.99 vs. 25.31±6.88), and neither between the mean post-test scores of stress (29.20±6.21 vs. 33.73±9.44) and anxiety (22.79±5.68 vs. 25.21±6.72) (P>0.05). However, comparison of DASS-42 scores between groups showed that the mean scores of stress and anxiety in the intervention group were significantly lower than in the sham group (P< 0.05). Conclusion: It seems that acupressure can be used along with other therapeutic and pharmacological interventions to reduce stress and anxiety in patients with MS.

Evaluation of the genotoxic potential of different delivery methods of at-home bleaching gels: a single-blind, randomized clinical trial

2018 ◽  
Vol 23 (5) ◽  
pp. 2199-2206 ◽  
Author(s):  
Marcílio Jorge Fernandes Monteiro ◽  
Jéssica Bruna Corrêa Lindoso ◽  
Nikeila Chacon de Oliveira Conde ◽  
Luciana Mendonça da Silva ◽  
Alessandro D. Loguercio ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Delivery Methods ◽  
Genotoxic Potential ◽  
Bleaching Gels ◽  
Single Blind ◽  
At Home
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