scholarly journals FREE RADICAL QUENCHING EFFICACY OF VARIOUS EXTRACTS OF C.PICTUS TO COMBAT OXIDATIVE DAMAGE/STRESS: AN IN VITRO STUDY

2017 ◽  
Vol 10 (2) ◽  
pp. 178
Author(s):  
Amala Reddy ◽  
Ganesh Venkatayappa
Keyword(s):  
Hydrogen Peroxide ◽  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Free Radical ◽  
Ethyl Acetate ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Scavenging Activity ◽  
Polar Solvents ◽  
Standard Drug

Objectives: The objectives of this research article are to elucidate the antioxidant activity of the sequentially extracted fractions using solvents with a varying range of polarity from the leaves of Costus pictus (Zingiberaceae). The antioxidant efficacy to combat the oxidative stress was evaluated based on their superoxide, hydrogen peroxide, and nitric oxide (NO) scavenging activity of the leaf extract.Methods: Extraction was performed by sequential extraction methods with low to high polar solvents. Using hexane as a low polar, dichloromethane as medium polar, and ethyl acetate and methanol as high polar, based on their individual boiling points extraction was carried out. The extracts were then evaporated using a rotary evaporator under vacuum and stored in the dry container. Then, antioxidant activity of each extract was evaluated for superoxide, hydrogen peroxide, and NO scavenging activity, ascorbic acid was used as a standard drug for the study of antioxidant activity. The output was statistically interpreted, and the most significant concentration of the best extract with good antioxidant activity was evaluated.Results: As the methanolic solvent is highly polar and able to retrieve the active lead components from the plant material, was very well correlated with the higher degree of free radical scavenging efficacy. It also exhibited the most and significant inhibition in superoxide radical scavenging, hydrogen peroxide scavenging, and NO scavenging which was about 86±1.23, 94±0.34, and 86±1.87 at 250 µg/ml of extract, respectively. The results from our experiments were in par with the positive control chosen.Conclusions: The above results help us to substantially conclude that bioactive components are extracted well in high polar solvents such as methanol, which mainly includes flavonoids and related polyphenols. These compounds present in C. pictus may be an active lead for potent antioxidant activities which would need further investigations in molecular level.Keywords: Costus pictus, Hexane, Dichloromethane, Ethyl acetate, Methanol, Ascorbic acid.

Antioxidant Activities of Yinchenhao (Artemisiae Capillaris) Leaves

2020 ◽  
Vol 18 (4) ◽  
pp. 386-391
Author(s):  
Yonghun Kim ◽  
Ang Li ◽  
Junyu Wang ◽  
Wancong Yu ◽  
Fang Wan ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Free Radical ◽  
Ethyl Acetate ◽  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Therapeutic Effects ◽  
Scavenging Activity

Yinchenhao (Artemisia capillaris Thunb.) is a pharmaceutical agent that not only shows therapeutic effects against hepatobiliary diseases but also offers various physiological benefits. This study examined the extraction rates of antioxidant extracts from Yinchenhao leaves using different solvents. The extraction rates using different solvents were as follows: ethanol (12.1 ± 0.87%) > water (7.7 ± 0.45%) > n-butanol (1.3 ± 0.16%) ethyl acetate > (1.3 ± 0.14%) > n-hexane (1.1 ± 0.15%). The n-butanol and ethyl acetate extracts showed higher 1,1-Diphenyl-2 picrylhydrazyl radical free radical scavenging activity, 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulphonate) free radical scavenging activity and ferric ion reducing antioxidant activity, while n-hexane extracts showed weak antioxidant activity. In conclusion, Yinchenhao leaf has potential as a natural antioxidant, and n-butanol and ethyl acetate may be effective extraction solvents for studying its antioxidant activities.

scholarly journals Antioxidant and Anticancer Activities of Wampee (Clausena lansium(Lour.) Skeels) Peel

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
K. Nagendra Prasad ◽  
Jing Hao ◽  
Chun Yi ◽  
Dandan Zhang ◽  
Shengxiang Qiu ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Ethyl Acetate ◽  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Total Phenolic ◽  
Liver Carcinoma ◽  
Scavenging Activity ◽  
Anticancer Activities

Antioxidant activities of wampee peel extracts using five different solvents (ethanol, hexane, ethyl acetate, butanol and water) were determined by using in-vitro antioxidant models including total antioxidant capability, 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity, reducing power, and superoxide scavenging activity. Ethyl acetate fraction (EAF) exhibited the highest antioxidant activity compared to other fractions, even higher than synthetic antioxidant butylated hydroxyl toluene (BHT). In addition, the EAF exhibited strong anticancer activities against human gastric carcinoma (SGC-7901), human hepatocellular liver carcinoma (HepG-2) and human lung adenocarcinoma (A-549) cancer cell lines, higher than cisplatin, a conventional anticancer drug. The total phenolic content of wampee fraction was positively correlated with the antioxidant activity. This is the first report on the antioxidant and anticancer activities of the wampee peel extract. Thus, wampee peel can be used potentially as a readily accessible source of natural antioxidants and a possible pharmaceutical supplement.

scholarly journals Design, Synthesis, Antimicrobial, and Antioxidant Activities of Novel-{4, 5-(substituted diphenyl)-4H-1, 2, 4-triazol-3-ylthio} Acetyl Chloride

2017 ◽  
Vol 15 (2) ◽  
pp. 157-167
Author(s):  
Prabhakar Kumar VERMA ◽  
Mukesh KUMAR ◽  
Nelam MALIK ◽  
Priyanka DHIMAN ◽  
Anurag KHATAHAR
Keyword(s):  
Free Radical ◽  
Acetyl Chloride ◽  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Biologically Active ◽  
Free Radical Scavenging Activity ◽  
Scavenging Activity ◽  
Standard Drug

A series of 20 new biologically active derivatives of 2-{4, 5-(substituted diphenyl)-4H-1,2,4-triazol-3-ylthio}acetyl chloride has been synthesized, with the aim to investigate antimicrobial, free radical scavenging activity. All the synthesized compounds were characterized by spectroscopic data and elemental analysis. The final compounds were tested for antibacterial activity against Gram-positive bacteria: Staphylococcus aureus MTCC 3160, Bacillus subtilis MTCC 441; Gram-negative bacteria: Escherichia coli MTCC 443, and, for antifungal activity, against Candida albicans MTCC 227 and Aspergillus niger MTCC 281, taking ciprofloxacin as antibacterial and fluconazole as antifungal standard drugs. Compound 7a6 was found to be the most effective antibacterial (MIC = 3.12 µg/ml), and compounds 7a2 and 7d1 (MIC = 3.12 and 6.25 µg/ml) had the most effective antifungal effects on the selected strains, as compared to the standard drugs. The results of antioxidant studies revealed that compound 7b1 was found to be most active antioxidant, with 40.4±0.687 µg/ml, and compounds 7b3, 7d7, and 7d4 also showed promising free radical scavenging activity, as compared with the standard drug ascorbic acid.

scholarly journals Phytochemical screening and In-vitro antioxidant activity of Centella asiatica extracts

2017 ◽  
Vol 9 (4) ◽  
pp. 615
Author(s):  
Mukesh Kumar Yadav ◽  
Santosh Kumar Singh ◽  
JS Tripathi ◽  
YB Tripathi
Keyword(s):  
Hydrogen Peroxide ◽  
Antioxidant Activity ◽  
Free Radical ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Centella Asiatica ◽  
Free Radical Scavenging ◽  
Scavenging Activity ◽  
Phytochemical Screening

<p><em>Centella asiatica</em> also known as <em>mandukparni </em>or Indian pennywort or <em>jalbrahmi</em>, which has been used as a medicine in the Ayurveda from ancient times and mentioned in many classical texts of Ayurveda. <em>Centella asiatica</em> has long been used to improve memory and cognitive function.</p><p>The study aimed to identify the phytochemicals present in different solvent extracts of <em>Centella asiatica </em>(i.e. PECA- Petroleum ether extract of <em>C. asiatica, </em>CCA- Chloroform extract of <em>C. asiatica, </em>EACA- Ethyl acetate extract of <em>C. asiatica,</em> ECA- Ethanolic extract of <em>C. asiatica, </em>HACA- Hydro-alcoholic extract of <em>C. asiatica</em>)<em> </em>and evaluate the respective in-vitro antioxidant potentials. <em></em></p><p>The phytochemical screening of extracts was done with standardized procedures and the antioxidant potential of different solvent extracts of <em>Centella asiatica</em> was assessed by its free radical scavenging activity 2, 2-diphenyl -1- picrylhydrazyl (DPPH) as well as hydrogen peroxide scavenging assay respectively for reducing capability.</p><p>In all different solvent extracts of <em>C. asiatica</em> revealed excellent free radical scavenging activity as revealed by 2-2- diphenyl-1-picryl-hydrazyl (DPPH) assay with  EC<sub>50</sub> values for ECA=128.752±1.85 μg/ml, HACA=274.884±1.21 μg/ml and hydrogen peroxide assay against the standard (Butylated hydroxytoluene) BHT, with the EC<sub>50</sub> values ECA=429.69±0.92 μg/ml HACA=458.08±0.58 μg/ml while rest solvent extracts shown very less antioxidant activity.</p><p> The present study indicates that the <em>Centella asiatica</em> extracts have good antioxidant activity which can be used in stress and anxiety and also a good source to be used as natural drugs.</p>

Phytochemical and antioxidant activity of Cadaba farinosa Forssk stem bark extracts

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Emmanuel M. Halilu ◽  
Abdullahi M. Abdurrahman ◽  
Sylvester N. Mathias ◽  
Chinenye J. Ugwah-Oguejiofor ◽  
Muntaka Abdulrahman ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Free Radical ◽  
Ethyl Acetate ◽  
Total Phenolic Content ◽  
Phenolic Content ◽  
Radical Scavenging ◽  
Stem Bark ◽  
Free Radical Scavenging ◽  
Total Phenolic

Abstract Cadaba farinosa is used in traditional medicine for treatment of cancer, diabetes, and rheumatism. The research was aimed at evaluating the phytochemical and antioxidant activity of the extracts. The powdered stem bark was extracted successively with the aid of Soxhlet extractor using n-hexane, ethyl acetate, and methanol. The resulting extracts were concentrated on rotary evaporator and the percentage yields were calculated. The phytochemical and TLC profiles of the extracts were studied. The antioxidant activity of the extracts and ascorbic acid (standard) were determined using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay. The total phenolic content of the extracts and tannic acid (standard) were evaluated using Folin–Ciocalteu reagent. The percentage yields of n-hexane, ethyl acetate, and methanol extracts were found to be 1.19, 1.37, and 13.93%, respectively. The phytochemical screening revealed the presence of tannins, flavonoids, saponins, cardiac glycosides, alkaloids, and triterpenoids. The TLC profiles of the extracts revealed the presence of compounds as evidenced from their R f values. The total phenolic content of ethyl acetate and methanol extracts were found to be 135 and 112 mg, respectively. The free radical scavenging activity demonstrated by the extracts was comparable to ascorbic acid. The ethyl acetate extract had higher phenolic content and demonstrated the highest free radical scavenging with IC50 31.07 mg/mL. The results of research have provided strong preliminary evidence of antioxidant activity which may be because of phenolic compounds in the extracts.

Antioxidant Properties of Cashew Apple Wine (CAW)

2011 ◽  
Vol 396-398 ◽  
pp. 1645-1651 ◽  
Author(s):  
Qiu Ping Zhong ◽  
Yong Cheng Li
Keyword(s):  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Free Radical ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Scavenging Activity ◽  
Total Antioxidant Activity ◽  
Total Antioxidant ◽  
Reducing Capacity

In this study, total polyphenols content (TPC) and ascorbic acid content (AAC) in CAW were quantified. Total antioxidant activity, reducing capacity, and free radical scavenging activity of CAW were assayed. The TPC and AAC were 160 mg GAE /100ml and 132 mg/100 ml，respectivity. CAW exhibited effective antioxidant activities in the employed in vitro experiments, including total antioxidant activity, reducing capacity, and free radical scavenging activity, which indicates that phenolic compounds and ascorbic acid may play a key role in the antioxidant function of CAW.

scholarly journals UJI PENANGKAPAN RADIKAL 2,2-difenil-1-pikrilhidrazil (DPPH) OLEH EKSTRAK ETANOL BUNGA KECOMBRANG (Nicolaia speciosa (Bl.) Horan) DAN BUAH TALOK (M. calabura L. )

2019 ◽  
Vol 12 (1) ◽  
pp. 41-53
Author(s):  
Tatang Irianti ◽  
Hari Purnomo ◽  
Kuswandi Kuswandi ◽  
Sindu Nuranto ◽  
Damiana Nitya Kanistri ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Free Radical ◽  
Ethyl Acetate ◽  
Carbonyl Group ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Natural Antioxidants ◽  
The Body ◽  
Scavenging Activity ◽  
Muntingia Calabura

ABSTRACT The process of excessive free radicals  in our body plays a major part in the development of chronic and degenerative illness such as cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, cardiovascular and neurodegenerative diseases. The recently study reported that free radical and oxidants play a dual role as both toxic and beneficial compounds, since they can be either harmful or helpful to the body. Therefore, natural antioxidants can be explored to prevent degenerative diseases and in the present paper we have investigated antioxidant activity of extracts from Nicolaia speciose (Bl.) Horan flower and Muntingia calabura L.  fruit for its free radical scavenging activity using 2,2-diphenyl, 1-picryl hydrazil (DPPH) radical scavenging activity. The results revealed that both ethyl acetate fractions of N.  speciaose and M. calabura have the highest antioxidant activitiy with IC50 29.81 and 14.48 µg/ml respectively.   The antioxidant activity of both ethanolic extracts were more potent than hexan and water fractions with IC50 39.27 and 137.20 µg/ml respectively. The investigation of IC50 values indicated that the antioxidant activity show moderate to very active. Active compounds were identified using thin layer chromatography with FeCl3, AlCl3, 2,4-DNPH and anisaldehide-H2SO4 spray reagents. Chromatogram of ethylacetate fraction showed that spots on the hRf 12 and 56 were thought to contain phenolic compounds with a carbonyl group, while the hRf 37 was suspected flavone compounds with 3-OH group and the hRf 50 was alleged the ortho-dihydroxy flavone or ortho hydroxy and free carbonyl. Chromatogram of ethyl acetate of talok fruits fraction showed that spots on the hRf 19.31 and 44 were suspected flavone compounds with ortho-hydroxy-carbonyl group and or ortho-hydroxy. ABSTRAK Radikal bebas berlebih dalam tubuh dapat memicu tumbuhnya sel kanker, penyumbatan pembuluh jantung, kerusakan oksidatif otak dan penuaan dini. Hal ini menyebabkan penelitian tentang potensi antioksidan terus mengalami peningkatan, terutama antioksidan alami dari tanaman. Bunga kecombrang (Nicolaia speciosa (BI.) Horan) dan buah talok (Muntingia Calabura L.) dilaporkan aktif sebagai antioksidan dan mengandung senyawa aktif dengan tingkat kepolaran yang berbeda. Oleh karena itu, penelitian ini bertujuan untuk menguji aktivitas dengan penangkapan radikal bebas fraksi-fraksi ekstrak bunga kecombrang dan buah talok serta karakterisasi golongan senyawa aktifnya. Hasil fraksinasi ekstrak diuji dengan larutan DPPH 0,4 mM dan diukur dengan spektrofotometer UV-Vis pada panjang gelombang 517 nm. Hasil absorbansi sampel dan kontrol diolah untuk mendapatkan persen penangkapan radikal DPPH dan aktivitas antioksidan dievaluasi melalui nilai IC50. Senyawa aktif diidentifikasi menggunakan kromatografi lapis tipis dengan penampak bercak FeCl3, AlCl3, 2,4-DNPH dan anisaldehid-H2SO4.  Fraksi-fraksi ekstrak bunga kecombrang dan buah talok menunjukkan tingkat kekuatan antioksidan antara sedang sampai sangat aktif. Fraksi etil asetat bunga kecombrang serta buah talok memiliki aktivitas penangkapan radikal bebas tertinggi dengan IC50 sebesar 29,81 µg/ml dan 14,48 µg/ml. Pada fraksi etil asetat ini, buah talok mempunyai potensi aktivitas antioksidan dua kali lipatnya dari bunga kecombrang.  Fraksi air, ekstrak etanol serta fraksi heksan bunga kecombrang memiliki IC50 sebesar 39,27 µg/ml, 44,08 µg/ml, dan 135,36 µg/ml. Sedangkan ekstrak etanol, fraksi air serta fraksi heksan buah talok memiliki IC50 sebesar 137,20 µg/ml, 282,47 µg/ml, dan 2611,70 µg/ml. Hasil KLT fraksi etil asetat buah kecombrang menunjukkan bahwa bercak pada hRf 12 dan 56 mengandung senyawa fenolik dengan gugus karbonil, sedangkan hRf 37 diduga senyawa flavon dengan gugus 3-OH dan pada hRf 50 merupakan flavon dengan o-dihidroksi dan atau o-hidroksi karbonil bebas. Kemudian hasil KLT fraksi etil asetat buah talok menunjukkan bahwa bercak dengan nilai hRf  19, 31, dan 44 merupakan flavon dengan gugus o-hidroksi karbonil dan atau gugus o-dihidroksi. Bercak pada hRf 31 juga mengindikasikan adanya senyawa terpenoid.    

scholarly journals Phenolics and Carotenoids Contribute to Antioxidant Activity in Navel Orange

HortScience ◽  
2006 ◽  
Vol 41 (4) ◽  
pp. 1000A-1000
Author(s):  
G.K. Jayaprakasha ◽  
Clark Wilson ◽  
Bhimanagouda S. Patil
Keyword(s):  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Ethyl Acetate ◽  
Antioxidant Capacity ◽  
Fruits And Vegetables ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Navel Orange ◽  
Scavenging Activity ◽  
Freeze Dried

Consumption of fruits and vegetables has been associated with reduced risk of disease, such as neurodegenerative disorders and certain forms of cancer, and aging. Antioxidants prevent the damage to macromolecules and cells by interfering with the free radicals. Several natural compounds that posses antioxidant activity have been reported from plant sources and are commercially promoted as nutraceuticals. Citrus fruits contain certain bioactive compounds such as phenolics, flavonoids, limonoids, carotenoids, and ascorbic acid. In this context, navel oranges were freeze-dried and extracted with five different solvents, such as hexane, ethyl acetate, acetone, methanol, and 8 methanol: 2 water. The extracts were dried under vacuum and screened for their radical scavenging activity using the 1,1-diphenyl-2-picrylhydrazyl method at 250, 500, and 1000 ppm. The methanol: water and methanol extracts of navel orange were found to be maximum (92.9%) and minimum (63.89%) radical scavenging activity at 1000 ppm. Furthermore, the antioxidant capacity of all extracts was assayed through the phosphomolybdenum method and expressed as equivalent to ascorbic acid (μmol/g of the extract). The order of antioxidant capacity for navel orange extracts was found to be ethyl acetate > acetone > methanol: water > methanol > hexane. It seems that the antioxidant capacity of the extracts is in accordance with the amount of phenolics/lycopene present in each fraction and may provide a good source of antioxidants. This project is based upon work supported by the USDA–CSREES under Agreement USDA IFAFS #2001-52102-02294 and USDA #2005-34402-14401 “Designing Foods for Health” through the Vegetable and Fruit Improvement Center.

scholarly journals PHYTOCHEMICAL ANALYSIS AND IN VITRO FREE RADICAL SCAVENGING ACTIVITY OF SUCCESSIVE EXTRACTS OF ALYSICARPUS VAGINALIS VAR. NUMMULARIFOLIUS (DC.) MIQ

2017 ◽  
Vol 9 (6) ◽  
pp. 231
Author(s):  
Susan Kurian ◽  
Leenamma Joseph ◽  
Josekumar V. S.
Keyword(s):  
Nitric Oxide ◽  
Hydrogen Peroxide ◽  
Free Radical ◽  
Ethyl Acetate ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Phytochemical Analysis ◽  
Scavenging Activity

Objective: The present study was carried to evaluate free radical scavenging activity and phytochemical analysis of successive extraction with hexane (AVH), ethyl acetate (AVE) and methanol (AVM) of Alysicarpus vaginalis var. nummularifolius (DC.) MIQ., a herb used in home remedies.Methods: The entire plant was dried and powdered, successively extracted (soxhlet apparatus) and concentrated using rotary vacuum evaporator. The extracts were quantitatively analyzed for phytochemicals like total phenolic, flavonoids, alkaloids and carbohydrates following standard methods. The free radical scavenging activity was evaluated with DPPH (1, 1-diphenyl-2-picrylhydrazyl), nitric oxide radical and hydrogen peroxide scavenging reactions.Results: The quantitative phytochemical studies of the crude extracts showed that AVM extract with highest phenolic, flavonoid, alkaloid and carbohydrate content which is followed by AVE and AVH. The IC50 values of AVH, AVE and AVM for scavenging DPPH, nitric oxide and hydrogen peroxide were 589.21±0.09 µg/ml, 254.65±0.08 µg/ml and 261.40±0.08 µg/ml; 533.81±0.09 µg/ml, 362.07±0.09 µg/ml and 456.36±0.08 µ/ml; 464.66±0.08 µg/ml, 380.29±0.08 µg/ml and 367.6±0.08 µg/ml respectively. Conclusion: The present study revealed that AVM extracts having high polyphenolic compounds when compared with AVE and AVH. The free radical scavenging reaction was greater in ethyl acetate and methanol extracts. This suggests that due to the high antioxidant reactions, these extracts can be useful for the treatment of oxidative stress–related diseases.

Free Radical Scavenging Activity of Some Legumes Hulls Extract and Its Efficacy on Oil Oxidative Stability

2020 ◽  
Author(s):  
Alaa ElDein El-Beltagy ◽  
Salman Alharthi
Keyword(s):  
Antioxidant Activity ◽  
Free Radical ◽  
Ethyl Acetate ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Ethanol Extract ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Scavenging Activity ◽  
Protection Factor

Abstract Background Synthetic antioxidants have toxigenic effects, there is therefore growing interest in substituting them with natural antioxidants. Attention is being focused on extracting them from agricultural industry residuals to minimize costs. Legume seed hulls could be cheap sources of such natural antioxidants. Objective This study aims to unravel potential free radical scavenging activity, antioxidant activity, and total phenolic and flavonoid contents of some legumes’ hulls extracted by different solvents and evaluate their efficacy to enhance sunflower oil stability. Method Legume hulls extracted by different solvents were evaluated for their antioxidant activity coefficient (AAC), free radical scavenging activity [by 2,2-diphenyl-1- picrylhydrazyl (DPPH)], and phenolic and flavonoids contents. The protection factor and induction periods (rancimat test) of the highest activity extracts were evaluated. Results Sunflower seed hull ethyl acetate extract, lupine seed hull ethanol extract, and mung bean hull petroleum ether extract exhibited stronger DPPH scavenging activity, AAC, and protection factor values than other solvents. Ethyl acetate extracts of sunflower seed hulls showed an antioxidant and scavenging activity close (P&gt;0.05) to that detected for α-tocopherol. Conclusions Legume hulls may possess strong free radical scavenging and antioxidant activity. The analogous effect between sunflower hull extract and α-tocopherol make it a potential, cheaper substitute of α-tocopherol in food systems. Highlights The analogous effect between sunflower hull extract and α-tocopherol give it the potency to allow substitution at a concentration of 0.5% of sunflower hull ethyl acetate or 1% of lupine hull ethanol extract instead of 0.5% α-tocopherol to enhance induction periods and protection factors of sunflower oil.

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