scholarly journals COMPARISON STUDY OF GRINDING AND SLURRY METHOD ON PHYSICOCHEMICAL CHARACTERISTIC OF ACYCLOVIR – SUCCINIC ACID COCRYSTAL

2017 ◽  
Vol 10 (3) ◽  
pp. 153
Author(s):  
Fauzi Rahman ◽  
Agnes Nuniek Winantari ◽  
Dwi Setyawan ◽  
Siswandono .
Keyword(s):  
Fourier Transform ◽  
Ir Spectroscopy ◽  
Succinic Acid ◽  
Physicochemical Characteristic ◽  
Fourier Transform Infrared ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Slurry Method ◽  
Dissolution Efficiency

ABSTRACTObjective: This study aimed to compare the characteristics of acyclovir (ACV)-succinic acid (SA) cocrystal with grinding and slurry method.Methods: Cocrystals were prepared using grinding and slurry methods. Physicochemical characterizations were performed using powder X-raydiffraction (PXRD), differential scanning calorimetry, Fourier transform infrared (IR) spectroscopy, scanning electron microscope (SEM), anddissolution test.Results: The study revealed that cocrystal of ACV-SA showed a decrease in the melting temperature, i.e., 175.10°C, respectively, in comparison with themelting point of the constituent materials (ACV 253.53°C and SA 187.29°C). PXRD diffractogram showed that cocrystal with grinding method exhibitednew diffraction peaks at angle 2θ=8.92°, 16.24°, and 17.14°, while PXRD diffractogram of cocrystal with slurry method exhibit new diffraction peaksat angle 2θ=16.25°, and 19.63°. Characterization with IR spectroscopy showed the disappearance of transmission peaks at 3441cm disappearance ofC=O stretch at 1584cm and 1612cm. Dissolution efficiency of each treatment group calculated the efficiency of dissolution in 15th minutes, grindingmethod cocrystal with grinding time 15 minutes give the dissolution efficiency were 54.23%. Slurry method cocrystal with solvent concentration12 ml/g gives the high value of the dissolution efficiency is 74.36%. SEM micrographs showed that cocrystals prepared by solvent evaporation methodhave differences crystal form at magnification 5000× magnification compared to pure ACV and physical mixture.Conclusion: The study concluded that cocrystals of ACV-SA were successfully formed using grinding and slurry methods. The formed cocrystalsof ACV-SA exhibited different physicochemical characteristics as compared to the constituent materials. The formed cocrystals prepared by slurrymethod have a high intensity of diffraction peak on X-ray diffraction and highest dissolution efficiency at 15 minutes rather than grinding methodcocrystal.Keywords: Cocrystal, Acyclovir, Succinic acid, Grinding, Slurry, Powder X-ray diffraction, Fourier transform infrared, Dissolution rate. 

PENINGKATAN LAJU DISOLUSI ACYCLOVIR DENGAN METODE SISTEM DISPERSI PADAT MENGGUNAKAN POLOXAMER 188

2016 ◽  
Vol 5 (1) ◽  
pp. 6
Author(s):  
Budi Setiawan ◽  
Erizal Zaini ◽  
Salman Umar
Keyword(s):  
Electron Microscopy ◽  
Thermal Analysis ◽  
Scanning Electron Microscopy ◽  
Fourier Transform ◽  
Differential Thermal Analysis ◽  
Fourier Transform Infrared ◽  
X Ray Diffraction ◽  
Poloxamer 188 ◽  
X Ray ◽  
Scanning Electron

Sebuah penelitian tentang sistem dispersi padat dari asiklovir dengan poloxamer 188 telah dilakukan formulasi dengan pencampuran secara fisika dengan rasio 1 : 1, 1 : 3, 1 : 5 dan dispersi padat 1 : 1, 1 : 3, 1 : 5 dan penggilingan 1:1 sebagai pembanding. Dispersi padat dibuat menggunakan metode pencairan (fusi), yang digabung dengan poloxamer 188 pada hotplate kemudian asiklovir dimasukkan ke dalam hasil poloxamer 188 lalu di kocok hingga membentuk masa homogen. Semua formula yang terbentuk termasuk asiklovir poloxamer 188 murni dianalisis karakterisasinya dengan Differential Thermal Analysis (DTA), X-ray Diffraction, Scanning Electron Microscopy (SEM), dan Fourier Transform Infrared (FTIR), kemudian pengambilan dilakukan  (penentuan kadar) mengunakan spektrofotometer UV pada panjang gelombang 257,08 nm dan uji laju disolusi dengan aquadest bebas CO2 menggunakan metode dayung. Hasil pengambilan  (penentuan kadar) menunjukkan bahwa semua formula memenuhi persyaratan farmakope Amerika edisi 30 dan farmakope Indonesia edisi 4 yaitu 95-110%. Sedangkan hasil uji laju disolusi untuk campuran fisik 1: 1, dan dispersi padat 1: 1, dan penggilingan 1: 1 menunjukkan peningkatan yang nyata dibandingkan asiklovir murni. Hal ini juga dapat dilihat dari hasil perhitungan statistik  menggunakan analisis varian satu arah  SPSS 17.

Biocidal activity of curcumin and cationic polymer possessing composites

2020 ◽  
Vol 35 (4-5) ◽  
pp. 389-398
Author(s):  
Tarık Eren ◽  
Gülay Baysal ◽  
Faik Doğan
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Fourier Transform ◽  
Curcuma Longa ◽  
Antibacterial Properties ◽  
Fourier Transform Infrared ◽  
Diffusion Method ◽  
X Ray Diffraction ◽  
X Ray ◽  
Scanning Electron

There is a growing interest in new type of biocidal compounds with antibacterial properties against bacteria. In this study, new antibacterial synthetic materials bearing curcumin and cationic polymers were synthesized. In the synthesis stage, the methacrylate functional cationic monomer was synthesized via the Michael addition route by using 3-acryloxy-2-hydroxypropyl methacrylate and 3-amino pyridine to obtain Monomer 1. Monomer 1 was further quaternized with hexyl bromide to obtain a cationic methacrylate functional monomer. Free-radical polymerization of Monomer 1 and methyl acrylate was conducted in the presence of azobisisobutyronitrile under dimethylformamide solvent. The composite formulation was conducted by using turmeric extract Curcuma longa (curcumin), hydroxyapatite, montmorillonite, and silver nitrate. The materials were analyzed by using the methods of X-ray diffraction, nuclear magnetic resonance, Fourier transform infrared spectroscopy, and scanning electron microscopy. The biocidal activities against the bacteria Escherichia coli, Listeria monocytogenes, Salmonella, and Staphylococcus aureus were analyzed using agar well diffusion method. From the Fourier transform infrared, X-ray diffraction, and scanning electron microscopy analysis results of the synthesized nanocomposites, it is seen that they form strong connections with the components added to the composites and form an exfoliated structure. According to the antibacterial analysis results, the nanocomposites obtained have showed a strong antibacterial resistance against E.coli, L.monocytogenes, Salmonella, and S. aureus bacteria, and the high inhibition zone areas were obtained.

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