scholarly journals CYTOTOXICITY OF STRAWBERRY EXTRACT ON ORAL CANCER CELL LINE

2018 ◽  
Vol 11 (9) ◽  
pp. 353
Author(s):  
Ramya G ◽  
Vishnu Priya V ◽  
Gayathri R
Keyword(s):  
Oral Cancer ◽  
Cytotoxic Activity ◽  
Cell Line ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Neutral Red ◽  
Natural Medicine ◽  
Oral Cancer Cell ◽  
Oral Cancer Cell Line

Objective: Berries including strawberry may have beneficial effects against oxidative stress-mediated diseases such as cancer. The purpose of the present study was to investigate the cytotoxic effects of strawberry extract on oral cancer cell line.Methods: Strawberry methanolic extract (SBE) was prepared, and cytotoxic activity of different concentration of SBE on KB cell lines was determined by (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay and neutral red dye incorporation test.Results: Strawberry extract exhibits cytotoxic activity over the oral cancer cell lines. On administration of about 100 μg/ml of strawberry extract, about 50% of cell viability could be observed and assessed from the cell lines.Conclusion: Strawberries have a cytotoxic effect on oral cancer cell line due to the presence of anticancer constituents in the berries. These berries can be used as a natural medicine for cancer sufferers.

scholarly journals Effect of Ocimum sanctum on Oral Cancer Cell Line: An in vitro Study

2015 ◽  
Vol 16 (9) ◽  
pp. 709-714 ◽  
Author(s):  
Prachi Shivpuje ◽  
Renuka Ammanangi ◽  
Kishore Bhat ◽  
Sandeep Katti
Keyword(s):  
Oral Cancer ◽  
Cytotoxic Activity ◽  
Cell Line ◽  
Cancer Cell ◽  
Aqueous Extract ◽  
Cancer Cell Line ◽  
Ocimum Sanctum ◽  
Oral Cancer Cell ◽  
Oral Cancer Cell Line

ABSTRACT Background Cancer till today remains the leading cause of death in both developed and developing countries. Plants have been beacon of therapeutic sources for curing diseases from times immemorial. Hence, the present study aimed at evaluating the antiproliferative activity of extract of Ocimum sanctum leaves on oral cancer cell line. Objectives: • To evaluate the antiproliferative effect and to analyze dose dependent cytotoxic activity of aqueous extract of O. sanctum leaves on KB mouth cell line. • To compare the effectiveness among different variety of O. sanctum. Materials and methods KB cells (Mouth Epidermal Carcinoma Cells) were used for the present study. Aqueous and dry extract of O. sanctum with both dark (Krishna Tulsi) and light (Rama Tulsi) leaves were prepared in the institution. The antiproliferative and cytotoxic activity on KB cell line was evaluated by MTT assay. Statistical analysis with Mann-Whitney U-test and Wilcoxon matched pairs test was carried out. Results The aqueous extract of O. sanctum of both the leaves exhibited significant cytotoxic effect against oral cancer cell line. Conclusion Aqueous extract of O. sanctum leaves was effective as an antiproliferative agent which caused apoptosis in oral cancer cell line. Clinical significance Ocimum sanctum herb which is abundantly grown in India can be used for its anticancer properties for treating oral cancer. This will not only be cost-effective but will also have less or no side effects. How to cite this article Shivpuje P, Ammanangi R, Bhat K, Katti S. Effect of Ocimum sanctum on Oral Cancer Cell Line: An in vitro Study. J Contemp Dent Pract 2015;16(9):709-714.

scholarly journals Ornithine Decarboxylase Antizyme Induces Hypomethylation of Genome DNA and Histone H3 Lysine 9 Dimethylation (H3K9me2) in Human Oral Cancer Cell Line

PLoS ONE ◽  
2010 ◽  
Vol 5 (9) ◽  
pp. e12554 ◽  
Author(s):  
Daisuke Yamamoto ◽  
Kaori Shima ◽  
Kou Matsuo ◽  
Takashi Nishioka ◽  
Chang Yan Chen ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cell Line ◽  
Ornithine Decarboxylase ◽  
Cancer Cell ◽  
Histone H3 ◽  
Cancer Cell Line ◽  
Oral Cancer Cell ◽  
Oral Cancer Cell Line

scholarly journals Dentin Sialophosphoprotein (DSPP) Gene-Silencing Inhibits Key Tumorigenic Activities in Human Oral Cancer Cell Line, OSC2

PLoS ONE ◽  
2010 ◽  
Vol 5 (11) ◽  
pp. e13974 ◽  
Author(s):  
Rajeshree Joshi ◽  
Amany Tawfik ◽  
Nneka Edeh ◽  
Veronica McCloud ◽  
Stephen Looney ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Gene Silencing ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Dentin Sialophosphoprotein ◽  
Oral Cancer Cell ◽  
Oral Cancer Cell Line

scholarly journals 7. Gene transfer using ultrasonic irradiation into the oral cancer cell line

2004 ◽  
Vol 58 (4) ◽  
pp. 125
Author(s):  
Kenjiro Iwanaga ◽  
Kazuhiro Tominaga ◽  
Kozo Yamamoto ◽  
Miho Sukedai ◽  
Toshiyuki Tsujisawa ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Oral Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Ultrasonic Irradiation ◽  
Cancer Cell Line ◽  
Oral Cancer Cell ◽  
Oral Cancer Cell Line

scholarly journals Evaluation and comparison of anti-cancer activity of dapagliflozin and canagliflozin in oral cancer cell line: an in vitro study

2019 ◽  
Vol 8 (3) ◽  
pp. 473 ◽  
Author(s):  
Nenavath Vinay ◽  
Darling Chellathai David
Keyword(s):  
Oral Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Sglt2 Inhibitors ◽  
Cytotoxic Assay ◽  
Oral Cancer Cell ◽  
Oral Cancer Cell Line

Background: Cancer is rapidly evolving life-threatening ailment in the mankind due to changes in daily food intake and lifestyle changes. Oral carcinoma is 6th major cause of cancer death in the world and it is third major reason of cancer mortality in India. Every cell in the human body requires glucose for its metabolic energy. Besides normal cell, cancer cells also require the glucose for its endurance and multiplication. SGLT2 inhibitors which are aimed at diabetes therapy exhibited anticancer properties also in colon and pancreatic cancer lines. Present study aim is to evaluate the anticancer activity of SGLT2 inhibitors against oral cancer cell by MTT Assay.Methods: To evaluate the anticancer activity of SGLT2 inhibitors MTT Cytotoxic assay is performed as per standard protocols. Cancer cells were plated in 24-well plates and incubated at 370C with 5% CO2 condition. After convergence, samples are added to the plates in various concentrations and allowed to incubate then they are detached from the plates and cleansed with the reagents. The wells are coated with the dye and incubated. Later samples are analysed in UV-spectrophotometer.Results: Cytotoxic assay showed decrease in cell viability with increasing dose of SGLT2 inhibitors. IC50 values were determined graphically. The IC50 value of dapagliflozin is 400µg/ml and canagliflozin is 250µg/ml respectively after 24 hours of Assessment.Conclusions: The results of the current study give us an evidence that SGLT2 inhibitors dapagliflozin and canagliflozin exhibits anticancer property in Oral Cancer cell line.

Sign in / Sign up

Export Citation Format

Share Document