scholarly journals PROTECTIVE EFFECT OF ETHANOLIC ROOT EXTRACT OF COMMIPHORA CAUDATA AGAINST DIABETIC-INDUCED RATS IN HIGH-FAT DIET-STREPTOZOTOCIN MODEL

2019 ◽  
pp. 563-566
Author(s):  
ANITHA K ◽  
SABAPATHI MOHANA LAKSHMI ◽  
SATYANARAYANA SV
Keyword(s):  
High Fat Diet ◽  
Histopathological Examination ◽  
Screening Method ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
High Density Lipoproteins ◽  
Phytochemical Analysis ◽  
Root Extract ◽  
High Fat ◽  
Standard Drug

Objective: The present study was to explore the phytochemical analysis and antidiabetic potential of the root of Commiphora caudata in high-fat diet (HFD) streptozotocin-induced diabetic rats. Methods: The ethanolic root extract of C. caudata at a dose of 400 mg/kg and 200 mg/kg was administered to diabetic rats. Glibenclamide (5 mg/kg) was used as standard drug. Results: The data were statistically assessed using one-way ANOVA followed by Dennett’s multiple comparison tests. To unfold the mechanism, we studied all the biochemical parameters glucose, total cholesterol, triglycerides (TG), high-density lipoproteins (HDL), low-density lipoproteins (LDL), and very LDL (VLDL) and histopathological examination of the pancreatic tissue section. The ethanolic extracts of root of C. caudata showed significant reduce of the level of cholesterol, TG, LDL, VLDL, and significant increase in the serum level of HDL at 400 mg/kg rather than 200 mg/kg. Conclusion: Further studies should look into the characterization and isolation of the constituents to know the exact mechanism of hypoglycemic activity. Statistical analyses of this screening method confirm that the proposed method is appropriate and it can be expected to improve basic idea to the researcher who is working in area-like antidiabetic activity.

scholarly journals ANTIHYPERLIPIDEMIC EFFECT OF ETHANOLIC SEED EXTRACT OF CANAVALIA ENSIFORMIS (L) IN HIGH FAT DIET-STREPTOZOTOCIN INDUCED RATS

2019 ◽  
Vol 11 (1) ◽  
pp. 99
Author(s):  
K. Anitha ◽  
Puthalapattu Ravikumar Yashoda
Keyword(s):  
High Fat Diet ◽  
Histopathological Examination ◽  
Screening Method ◽  
Diabetic Rats ◽  
Seed Extract ◽  
High Density Lipoproteins ◽  
High Fat ◽  
Canavalia Ensiformis ◽  
Antihyperlipidemic Activity ◽  
Liver Tissue Section

Objective: It was investigated to enlighten the phytochemical screening and antihyperlipidemic activity of seeds of Canavalia ensiformis (L.) in High fat diet Streptozotocin-induced diabetic rats.Methods: The ethanolic seed extract of Canavalia ensiformis (EECE) at a dose of 400 mg/kg and 200 mg/kg was administered to diabetic rats. Simvastatin (4 mg/kg) is used as a standard drug.Results: The statistics were assessed by using one way ANOVA followed by Dunnet’s multiple comparison tests. To unfold the mechanism we studied all the biochemical parameters like Total cholesterol (TC), Triglycerides (TG), high-density lipoproteins (HDL), low-density lipoproteins (LDL) and histopathological examination of Liver tissue section. The ethanolic extracts of seeds of Canavalia ensiformis showed significant reduce of the level of cholesterol, triglycerides, LDL, VLDL and a significant increase in the serum level of HDL at 400 mg/kg rather than 200 mg/kg.Conclusion: Further the characterization and isolation of the constituents could be done to know the exact mechanism of hyperlipidemic activity. Statistical analysis of this screening method conforms that the proposed method is appropriate and it can be useful, gives the basic idea to the researcher who is working in an area like Antihyperlipidemic activity. 

scholarly journals Extract ofSesbania grandifloraAmeliorates Hyperglycemia in High Fat Diet-Streptozotocin Induced Experimental Diabetes Mellitus

Scientifica ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Ghanshyam Panigrahi ◽  
Chhayakanta Panda ◽  
Arjun Patra
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Experimental Period ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Hepatic Glycogen ◽  
High Fat ◽  
Abdominal Girth ◽  
Standard Drug ◽  
Sesbania Grandiflora

Background. Sesbania grandiflorahas been traditionally used as antidiabetic, antioxidant, antipyretic, and expectorant and in the management of various ailments.Materials and Methods.The study evaluates the antidiabetic activity of methanolic extract ofSesbania grandiflora(MESG) in type 2 diabetic rats induced by low dose streptozotocine and high fat diet. Diabetic rats were given vehicle, MESG (200 and 400 mg/kg, p.o.), and the standard drug, metformin (10 mg/kg), for 28 days. During the experimental period, body weight, abdominal girth, food intake, fasting serum glucose, urine analyses were measured. Insulin tolerance test was carried out on 25th day of drug treatment period. Serum analyses for lipid profile and SGOT and SGPT and serums creatinine, urea, protein, SOD, and MDA were also carried out. At the end of the experiment, animals were euthanized, the liver and pancreas were immediately dissected out, and the ratio of pancreas to body weight and hepatic glycogen were calculated.Results.MESG (200 and 400 mg/kg, p.o.) induced significant reduction (P<0.05) of raised blood glucose levels in diabetic rats and also restored other parameters to normal level.Conclusion.Therefore, it is concluded that MESG has potential antihyperglycemic and antihyperlipemic activities and alleviate insulin resistance conditions.

scholarly journals EVALUATION OF EFFECT 0F SITAGLIPTIN AND COMBINATION THERAPY OF SITAGLIPTIN AND METFORMIN ON HIGH DENSITY LIPOPROTEIN(HDL) AND LOW DENSITY LIPOPROTEIN(LDL) IN DIABETIC RATS

2021 ◽  
pp. 9-10
Author(s):  
Yasmeen A Maniyar ◽  
Siddarameshwar C Bidarurmath
Keyword(s):  
High Fat Diet ◽  
Wistar Rats ◽  
Low Dose ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Low Density ◽  
High Fat ◽  
Standard Drug ◽  
System Disorder

Diabetes mellitus is a multi system disorder leading to multiple complications.Dyslipedemia plays central role in most of the complications.HDL,LDL levels are amongst the parameters which are used to asses dyslipidemia .This study aims to evaluate the effect of sitagliptin and combination of sitagliptin and metformin on HDL,LDL levels in diabetes induced Albino Wistar rats. Albino Wistar rats were divided into 4 groups . Diabetes was induced by high fat diet and low dose streptozotocin . Metformin was used as standard drug. Rats were administered sitagliptin and combination of both metformin and sitagliptin for 21 days.After treatment LDL and HDL levels were evaluated. It was found that in groups treated with metformin, sitagliptin and combination of both drugs there was significant increase in HDL and reduction in LDL levels.

scholarly journals Effect of Bergenin on the Kidney of C57BL/6J Mice with High Fat-Diet Induced Oxidative Stress

2016 ◽  
Vol 54 ◽  
pp. 58-65 ◽  
Author(s):  
Sagadevan Ambika ◽  
Ramalingam Saravanan
Keyword(s):  
Lipid Peroxidation ◽  
Plasma Glucose ◽  
High Fat Diet ◽  
Histopathological Examination ◽  
Intragastric Administration ◽  
Standard Diet ◽  
Lipid Peroxidation Product ◽  
High Fat ◽  
Standard Drug ◽  
Peroxidation Product

The present study evaluated the protective effect of bergenin on high fat diet (HFD) induced diabetic mice. C57BL/6J mice were segregated in two groups, one fed standard diet (NC) and the other fed HFD for 16 weeks. Mice were fed continuously with high fat diet for 16 weeks and subjected to intragastric administration of bergenin (10, 20 and 40 mg/kg body weight (BW)), metformin (25 mg/kg BW) 9 to 16 weeks. At the end of the treatment nephritic markers, lipid peroxidation product, antioxidant and histopathological examination were carried out to assess the efficacy of the treatment. HFD fed mice showed increased plasma glucose, insulin, altered nephritic markers, antioxidant and histopathological abnormalities. Oral Treatment with bergenin (40 mg/kg BW) showed near normalized levels of plasma glucose, lipid peroxidation product, antioxidants, improved insulin and reduced kidney damage. The effects of bergenin were comparable with standard drug, metformin. These data suggest that bergenin protect kidney from deleterious effect of glucose.

scholarly journals Evaluation of antidiabetic activity of bud and flower of Avaram Senna (Cassia auriculata L.) In high fat diet and streptozotocin induced diabetic rats

2018 ◽  
Vol 108 ◽  
pp. 1495-1506 ◽  
Author(s):  
Gayathri Nambirajan ◽  
Kaleshkumar Karunanidhi ◽  
Arun Ganesan ◽  
Rajaram Rajendran ◽  
Ruckmani Kandasamy ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
High Fat ◽  
Cassia Auriculata

scholarly journals Evaluation of antihyperlipidemic activity of ethanolic root extract of Glycyrrhiza glabra Linn.

2018 ◽  
Vol 8 (6-s) ◽  
pp. 120-124 ◽  
Author(s):  
Priya Tyagi ◽  
Satish Kumar Sharma ◽  
Pawan Kumar
Keyword(s):  
High Fat Diet ◽  
Wistar Rats ◽  
Conventional Medicine ◽  
Glycyrrhiza Glabra ◽  
Root Extract ◽  
Dependent Manner ◽  
High Fat ◽  
Standard Drug ◽  
Antihyperlipidemic Activity ◽  
Ethanolic Extracts

Glycyrrhiza glabra Linn. is an Indian medicinal plant demonstrated to exert multiple health cures. This plant grows naturally in tropical, subtropical and temperate regions. It is traditionally used as anti-acne, anti-arthritic, anti-convulsant, anti-diabetic, anti-microbial, anti inflammatory, wound healing, anti-oxidant, anti-platelet, anti-stress and nootropic, anti-viral, diuretic and gastroprotective. The antihyperlipidemic effect of ethanolic root extracts of Glycyrrhizaglabrawas studied in wistar rats using High Fat Diet (FD) induced hyperlipidemic model, at the doses of 400 mg/kg body weight. The efficacy of extract was compared with standard drug simvastatin. The ethanolic extracts, significantly decreased the serum lipid profile level in a dose dependent manner in wistar rats. Ethanolic extracts at 400 mg/kg have shown significant antihyperlipidemic action. These results support the fact that this plant is used traditionally as antihyperlipidemic. The study will help in exploring new plant source as an antihyperlipiedemic agent which can minimize the risk and side effects as compared to that of conventional medicine.  Keywords: Glycyrrhizaglabra, Antihyperlipidemic Activity, Simvastatin, High Fat Diet (FD) induced hyperlipidemic model.

scholarly journals HEPATOPROTECTIVE EFFECT OF PERILLYL ALCOHOL (POH) ON HIGH-FAT DIET-LOW-DOSE STREPTOZOTOCIN-INDUCED TYPE 2 DIABETES IN EXPERIMENTAL RATS

2019 ◽  
pp. 266-270
Author(s):  
TOWSEEF HASSAN ◽  
ELANCHEZHIYAN C ◽  
INSHA NASEER
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Low Dose ◽  
Perillyl Alcohol ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Hepatoprotective Effect ◽  
High Fat ◽  
Standard Drug ◽  
Histopathological Studies

Objective: The aim of the present study was to investigate the hepatoprotectivity effect of perillyl alcohol in high-fat diet (HFD)-low-dose streptozotocin (STZ)-induced diabetic rats. Methods: Diabetes was induced in male albino Wistar rats by 4 weeks diet manipulation followed by a low single intraperitoneal injection of STZ (35 mg/kg body weight). Perillyl alcohol was administered orally (50 mg/kg body weight and 100 mg/kg body weight) for 30 days. Glibenclamide was used as a standard drug and given orally 6 mg/kg body weight. At the end of treatment period, levels of alkaline phosphatase (ALP), aspartate transaminase (AST) alanine transaminase (ALT), and bilirubin and serum protein were measured in serum of experimental rats. Histopathological studies of liver were also done with microscope. Results: The levels of ALP, AST ALT, and bilirubin were increased significantly in HFD-STZ-induced diabetic rats. Perillyl alcohol-treated diabetic rats showed marked restoration in the activity of ALP, AST, ALT, and bilirubin when compared with diabetic control rats. Perillyl alcohol and glibenclamide drug-treated rats showed reversible tissue regeneration with prominent hepatocytes. Conclusion: The present results clearly indicate that the perillyl alcohol has a potent efficacy for hepatoprotective effect in HFD- low-dose STZ-induced diabetic rats.

scholarly journals ANTIDIABETIC EFFECTS OF [10]-GINGEROL IN STREPTOZOTOCIN- AND HIGH-FAT DIET-INDUCED DIABETIC RATS

2019 ◽  
pp. 77-80
Author(s):  
ASHUTOSH KUMAR YADAV ◽  
REETU ◽  
ARUN GARG
Keyword(s):  
Type 2 Diabetes ◽  
Body Weight ◽  
Blood Glucose ◽  
High Fat Diet ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Control Group ◽  
High Fat ◽  
Antidiabetic Effects

Objective: India is the “diabetes capital of the world” with 62.4 million Indians having type 2 diabetes in 2011. A major risk factor for insulin resistance is obesity, which is generally caused by regular physical inactivity and high-fat diet (HFD). Obesity and diabetes are closely related to each other as about 80% of diabetics are obese. Obesity is a common finding in type 2 diabetes. The objective of the study was to investigate the antidiabetic effects of [10]-gingerol in streptozotocin (STZ)- and HFD-induced diabetic rats. Methods: Wistar rats were used for the study. Animals were divided into six groups. The six groups in this study were, Group I (normal control), Group II (diabetic control), Group III (glibenclamide at 5 mg/kg p.o.), Group IV (orlistat at 60 mg/kg p.o.), Group V ([10]-gingerol at 15 mg/kg p.o.), and Group VI [10]-gingerol (30 mg/kg p.o.), respectively. The antidiabetic activity was assessed using blood glucose level, body weight, and various biochemical parameters such as serum total cholesterol (TC) level, triglyceride (TG) level, high-density lipoproteins (HDLs), total protein (TP), serum alanine transaminase, and aspartate aminotransferase (serum glutamic-oxaloacetic transaminase), respectively. Results: [10]-gingerol exhibited an antidiabetic effect by significantly decreased the level of blood glucose, body weight, TC, TG, TP, and increase HDL. The results of the study demonstrated that the treatment with [10]-gingerol significantly (p<0.05) and dose dependently prevented STZ- and HFD-induced diabetic rats. Conclusions: The findings of the study suggest that [10]-gingerol possesses potential antidiabetic activity as it lowers serum glucose level.

Effects of Maternal Flaxseed Supplementation on Female Offspring of Diabetic Rats in Serum Concentration of Glucose, Insulin, and Thyroid Hormones

2019 ◽  
Vol 89 (1-2) ◽  
pp. 45-54
Author(s):  
Akemi Suzuki ◽  
André Manoel Correia-Santos ◽  
Gabriela Câmara Vicente ◽  
Luiz Guillermo Coca Velarde ◽  
Gilson Teles Boaventura
Keyword(s):  
Thyroid Hormones ◽  
High Fat Diet ◽  
Female Offspring ◽  
Flaxseed Oil ◽  
Diabetic Rats ◽  
High Fat ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Flaxseed Flour ◽  
Maternal Consumption

Abstract. Objective: This study aimed to evaluate the effect of maternal consumption of flaxseed flour and oil on serum concentrations of glucose, insulin, and thyroid hormones of the adult female offspring of diabetic rats. Methods: Wistar rats were induced to diabetes by a high-fat diet (60%) and streptozotocin (35 mg/kg). Rats were mated and once pregnancy was confirmed, were divided into the following groups: Control Group (CG): casein-based diet; High-fat Group (HG): high-fat diet (49%); High-fat Flaxseed Group (HFG): high-fat diet supplemented with 25% flaxseed flour; High-fat Flaxseed Oil group (HOG): high-fat diet, where soya oil was replaced with flaxseed oil. After weaning, female pups (n = 6) from each group were separated, received a commercial rat diet and were sacrificed after 180 days. Serum insulin concentrations were determined by ELISA, the levels of triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) were determined by chemiluminescence. Results: There was a significant reduction in body weight at weaning in HG (−31%), HFG (−33%) and HOG (44%) compared to CG (p = 0.002), which became similar by the end of 180 days. Blood glucose levels were reduced in HFG (−10%, p = 0.044) when compared to CG, and there was no significant difference between groups in relation to insulin, T3, T4, and TSH after 180 days. Conclusions: Maternal severe hyperglycemia during pregnancy and lactation resulted in a microsomal offspring. Maternal consumption of flaxseed reduces blood glucose levels in adult offspring without significant effects on insulin levels and thyroid hormones.

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