scholarly journals QUANTIFICATION OF ANTICOAGULANTS DABIGATRAN, RIVAROXABAN, AND PRASUGREL BY CHROMATOGRAPHIC AND SPECTROMETRIC TECHNIQUES – REVIEW

2019 ◽  
pp. 1-8
Author(s):  
SATYA PRASAD B ◽  
JAYAKUMARI S
Keyword(s):  
Quantitative Analysis ◽  
Quantitative Determination ◽  
Analytical Techniques ◽  
Dosage Forms ◽  
Clinical Isolates ◽  
Advantages And Disadvantages

A review is presented on different analytical techniques used for quantitative analysis of selected anticoagulants dabigatran, rivaroxaban, and prasugrel. Efforts have been made to collate all the relevant references to the extent possible. The review discusses the advantages and disadvantages of the cited analytical techniques, which will help to give insights into the methods used for estimation of selected anticoagulants such as dabigatran, rivaroxaban, and prasugrel, from clinical isolates, and its dosage forms. The review highlights the basic as well as advanced techniques performed for estimating dabigatran, rivaroxaban, and prasugrel. The techniques illustrated here have been demonstrated to be useful for quantitative determination of selected anticoagulants and may find application in analyzing other related properties.

Quantification Of Novel Dpp4 Inhibitor - Vildagliptin By Spectrophotometric And Chromatographic Techniques: Brief Review

2021 ◽  
pp. 5603-5610
Author(s):  
Gnanasekaran D. ◽  
Gandhimathi R.
Keyword(s):  
Quantitative Analysis ◽  
Analytical Techniques ◽  
Dosage Forms ◽  
Major Focus ◽  
Pharmaceutical Dosage Forms ◽  
Dipeptidyl Peptidase 4 ◽  
Chromatographic Techniques ◽  
Dipeptidyl Peptidase 4 Inhibitor ◽  
Pros And Cons

A review is presented on different analytical techniques used for quantitative analysis of novel Dipeptidyl peptidase-4 inhibitor (DPP-4) - Vildagliptin. Endeavours have been made to examine all the pertinent references to the degree conceivable. The review discusses the pros and cons of the cited analytical techniques, which will aid to give understand into the methods used for determination of Vildagliptin, from clinical isolates and from its pharmaceutical dosage forms. The major focus of this review is the basic as well as advanced analytical techniques established for determination of Vildagliptin. The procedures outlined here have been exhibited to be helpful for assessment of Vildagliptin and may discover application in dissecting other related properties.

More-sensitive enzyme-multiplied immunoassay technique for procainamide and N-acetylprocainamide in plasma, serum, and urine.

1988 ◽  
Vol 34 (5) ◽  
pp. 957-960 ◽  
Author(s):  
P R Henry ◽  
R A Dhruv
Keyword(s):  
Quantitative Analysis ◽  
Plasma Concentration ◽  
Controlled Release ◽  
Quantitative Determination ◽  
Dosage Forms ◽  
Clinical Samples ◽  
Immunoassay Technique ◽  
Analytical Recovery ◽  
Serum And Urine

Abstract A commercially available (Syva Co.) enzyme-multiplied immunoassay technique (EMIT) for the quantitative determination of procainamide (PA) and N-acetylprocainamide (NAPA) was modified to allow automated quantitative analysis of approximately 100 samples per day, in a working range of 0.1 to 2.0 micrograms/mL. Such a test was needed to evaluate the pharmacokinetic characteristics of controlled-release dosage forms characterized by long half-lives at low plasma concentration. Analytical recovery of PA and NAPA from serum, plasma, and urine was satisfactory, but at extreme ratios for PA:NAPA the accuracy of determining the lower-concentration component became unsatisfactory. In fact, however, we found no such ratios in 5400 clinical samples assayed by this procedure.

Qualitative and quantitative determination of trace aldehydes and ketones in food preservative propionic acid for quality improvement

2021 ◽  
Author(s):  
Yiwen Cao ◽  
Shenjie Zhu ◽  
Lin Zhang ◽  
Qun Cui ◽  
Haiyan Wang
Keyword(s):  
Quality Improvement ◽  
Quantitative Analysis ◽  
Quantitative Determination ◽  
Propionic Acid ◽  
Qualitative And Quantitative Analysis ◽  
Food Preservative ◽  
Qualitative And Quantitative ◽  
Aldehydes And Ketones ◽  
Aldehyde Content

Aiming at the difficulty in qualitative and quantitative analysis of trace compositions in food preservative propionic acid, the trace compositions and the key components influencing the total aldehyde content in...

GLC Determination of the Optical Isomers of Amphetamine

1970 ◽  
Vol 53 (1) ◽  
pp. 113-115
Author(s):  
Clyde E Wells
Keyword(s):  
Quantitative Determination ◽  
Calibration Curve ◽  
Collaborative Study ◽  
Isomeric Ratio ◽  
Dosage Forms ◽  
Optical Isomers ◽  
Standard Calibration ◽  
Tablet Dosage

Abstract A method is described for the quantitative determination of the ratio of d- and l-amphetamine stereoisomers by GLC. A derivative formed with N-trifluoroacetyl-(l)-prolyl chloride is chromatographed and the isomeric ratio is read from a standard calibration curve. The method is applicable to crystalline salts of amphetamine and to commercial tablet dosage forms. It is recommended that this method be subjected to collaborative study.

scholarly journals Pharmaceutical Application of Tablet Film Coating

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 853
Author(s):  
Ki-Soo Seo ◽  
Rajiv Bajracharya ◽  
Sang Hoon Lee ◽  
Hyo-Kyung Han
Keyword(s):  
Computational Modeling ◽  
Analytical Techniques ◽  
Film Coating ◽  
Dosage Forms ◽  
Coating Process ◽  
Coating Materials ◽  
Coating Technology ◽  
Advantages And Disadvantages ◽  
Pharmaceutical Application

Tablet film coating is a common but critical process providing various functionalities to tablets, thereby meeting diverse clinical needs and increasing the value of oral solid dosage forms. Tablet film coating is a technology-driven process and the evolution of coated dosage forms relies on advancements in coating technology, equipment, analytical techniques, and coating materials. Although multiple coating techniques are developed for solvent-based or solvent-free coating processes, each method has advantages and disadvantages that may require continuous technical refinement. In the film coating process, intra- and inter-batch coating uniformity of tablets is critical to ensure the quality of the final product, especially for active film coating containing active pharmaceutical ingredients in the coating layer. In addition to experimental evaluation, computational modeling is also actively pursued to predict the influence of operation parameters on the quality of the final product and optimize process variables of tablet film coating. The concerted efforts of experiments and computational modeling can save time and cost in optimizing the tablet coating process. This review provides a brief overview of tablet film coating technology and modeling approaches with a focus on recent advancements in pharmaceutical applications.

scholarly journals Spectrophotometric Determination of Ritodrine and Isoxsuprine Hydrochlorides Using 4-Aminoantipyrine

2000 ◽  
Vol 83 (6) ◽  
pp. 1440-1445 ◽  
Author(s):  
Hosakere D Revanasiddappa ◽  
Bochhe Gowda Manju
Keyword(s):  
Quantitative Determination ◽  
Rapid Method ◽  
Spectrophotometric Determination ◽  
Dosage Forms ◽  
Oxidizing Agent ◽  
Ritodrine Hydrochloride ◽  
Colored Product

Abstract A simple, accurate, and rapid method for the quantitative determination of ritodrine hydrochloride (RTH) and isoxsuprine hydrochloride (ISH) in both pure and dosage forms, is described. The method is based on the development of pink colored product as a result of the condensation of 4-aminoantipyrine with phenols in the presence of an alkaline oxidizing agent. The resulting products are measured at 510 nm for both drugs, with molar absorptivities of 0.98 × 104 and 1.20 × 104 L/mol·cm for RTH and ISH, respectively. A study of the effect of commonly associated excipients revealed that they did not cause interference.

scholarly journals Aflatoxin species: their health effects and determination methods in different foodstuffs

2012 ◽  
Vol 10 (3) ◽  
pp. 675-685 ◽  
Author(s):  
Sezgin Bakırdere ◽  
Selin Bora ◽  
E. Bakırdere ◽  
Fırat Aydın ◽  
Yasin Arslan ◽  
...  
Keyword(s):  
Health Effects ◽  
Analytical Techniques ◽  
The Other ◽  
Advantages And Disadvantages ◽  
Time Period ◽  
Long Time ◽  
Sensitive Determination ◽  
Determination Methods ◽  
And Storage

AbstractCarcinogenic and mutagenic properties of aflatoxin species are known in literature. Their intake over a long time period might be health-dangerous for human even at trace levels. It is well known that different foodstuffs can be contaminated by aflatoxin species through growing and storage. Due to the serious health effects, sensitive determination of aflatoxin species in any matrices related with the human being is very crucial at trace levels. In literature, there are sensitive techniques to analyze the different samples for the contents of their aflatoxin species. Each technique has some advantages and disadvantages over the other techniques. This review aims to summarize the different health effects of aflatoxin species, development of analytical techniques and applications of developed techniques in a variety of matrices.

Sign in / Sign up

Export Citation Format

Share Document