scholarly journals EXTEMPORANEOUS COMPOUNDING PRACTICE BY PHARMACISTS: A SYSTEMATIC REVIEW

Author(s):  
Susi Ari Kristina ◽  
Chairun Wiedyaningsih ◽  
Niken Nur Widyakusuma ◽  
Hardika Aditama

<p><strong>Objective: </strong>To identify the frequency and scope of extemporaneous compounding practice reported in community and hospital pharmacies.</p><p><strong>Method</strong><strong>s</strong><strong>:</strong><strong> </strong>A systematic literature review was undertaken to identify the prevalence of extemporaneous compounding practice in community and hospital pharmacies, including the reasons of providing compounding services.</p><p><strong>Results: </strong>Nine studies were identified and evaluated in which extemporaneous products prepared by pharmacist could be identified. Most of the studies record that prevalence of extemporaneous compounding practice is very low (less than 5%). Prescribing of compounded medicines occurs more frequently in paediatrics and for special patients’ need. The major types of extemporaneous compounding products were dermatological dosage forms and followed by oral solutions and oral suspensions. Reasons for providing compounding practice were to make a customised products that not available commercially and to provide full pharmaceutical care to patients. Issues about the stability of compounded products, accuracy in dose strength and lack of standardised protocol in extemporaneous compounding need to be addressed.</p><p><strong>Conclusion: </strong>Extemporaneous compounding practice are an essential part of pharmacist’ competency. These unique skills need to be preserved and regulations that cover rationalised compounding practice is necessary.</p>

2013 ◽  
Vol 21 (02) ◽  
pp. 123-151 ◽  
Author(s):  
MICHAEL LORZ ◽  
SUSAN MUELLER ◽  
THIERRY VOLERY

The majority of studies that analyze the impact of entrepreneurship education on entrepreneurial attitudes, intentions, and venture activities report positive influences. However, several scholars have recently cast doubts about research methods and the generalizability of entrepreneurship education impact studies. In this study, we conducted a systematic literature review of the methods used in entrepreneurship education impact studies. Our results uncover significant methodological deficiencies and question the overwhelmingly positive impact of entrepreneurship education. Based on this evidence, we propose a series of recommendations to improve the reliability and validity of entrepreneurship education impact studies and we outline promising topics which are currently under-researched.


2021 ◽  
pp. 30-48
Author(s):  
Andrei Anatolevich Mudrov ◽  
Aleksandr Yur’evich Titov ◽  
Mariyam Magomedovna Omarova ◽  
Sergei Alekseevich Frolov ◽  
Ivan Vasilevich Kostarev ◽  
...  

Despite the large number of available surgical interventions aimed at the treatment of rectovaginal fistulas, the results of their use remain extremely disappointing, associated with the high recurrence rate of the disease reaching 80 %, as well as the lack of a single tactic to minimize the risk of anal incontinence and the need for colostomy. Objective: to conduct a systematic literature review in order to summarize information related to the rectovaginal fistulas surgery. The systematic review includes the results of an analysis of 97 clinical trials selected from 756 publications found in databases. Inclusion criteria: a full-text article, the presence of at least 5 patients in the study, as well as data on the outcome of surgery. Clinical trials with different surgical treatments were identified and classified into the following categories: elimination of the rectovaginal septal defect with a displaced flap (rectal and vaginal); Martius surgery; gracilis muscle transposition; transperineal procedure; abdominal procedure including endoscopic and laparoscopic methods; use of biological or biocompatible materials. Treatment outcomes vary significantly from 0 % to > 80 %. None of the studies were randomized. Due to the low quality of the identified studies, comparison of results and meta-analysis conduction were not possible. Conclusion: as a result of the systematic review, data for the analysis and development of any strategic and tactical algorithms for the treatment of RVF were not obtained. The most important questions still remain open: what and when surgical method to choose, is it necessary to form a disconnecting stoma?


2000 ◽  
Vol 56 (1) ◽  
pp. 3-6 ◽  
Author(s):  
M. Papadopoulos ◽  
P. Rheeder

Physiotherapists, whether serving individual patients or populations, always have to sought to base their decisions and actions on the best possible evidence. In making choices, health professionals may benefit from structured summaries of the options and outcomes, systematic reviews of the evidence and recommendations regarding the best choices. The aim of this paper is to present guidelines on how to conduct a systematic review. The structure and content of a systematic review are being discussed, following a step-by-step approach.


Mathematics ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 146
Author(s):  
Lili Nemec Zlatolas ◽  
Luka Hrgarek ◽  
Tatjana Welzer ◽  
Marko Hölbl

Social networking sites (SNSs) are used widely, raising new issues in terms of privacy and disclosure. Although users are often concerned about their privacy, they often publish information on social networking sites willingly. Due to the growing number of users of social networking sites, substantial research has been conducted in recent years. In this paper, we conducted a systematic review of papers that included structural equations models (SEM), or other statistical models with privacy and disclosure constructs. A total of 98 such papers were found and included in the analysis. In this paper, we evaluated the presentation of results of the models containing privacy and disclosure constructs. We carried out an analysis of which background theories are used in such studies and have also found that the studies have not been carried out worldwide. Extending the research to other countries could help with better user awareness of the privacy and self-disclosure of users on SNSs.


Author(s):  
Helio Aisenberg Ferenhof ◽  
Susanne Durst ◽  
Paulo Mauricio Selig

In this paper, we are interested in the knowledge that is “wasted” in organizations, that is existing relevant knowledge that is overlooked in the process of knowledge conversion. Given the competitive pressure firms are facing in today´s business environment, a waste of knowledge is not only costly but also dangerous. This means that we consider knowledge from a knowledge at risk perspective. Having this in mind, the purpose of this paper is to review research on knowledge waste in organizations to establish our current body of knowledge regarding this topic. The study consists of a systematic review of 51 peer-reviewed articles addressing knowledge waste in organizations. To the best of the authors’ knowledge, no systematic literature review on this topic has previously been published or presented. The topic seems to be a promising field for intensive research and offers a variety of future research avenues. In view of practitioners, the study´s finding may enable an increased awareness towards the areas where existing knowledge is at the mercy of “waste”. This can assist practitioners to better cope with risks related to this waste and, therefore, better exploit the (limited) knowledge base available.


2020 ◽  
Vol 8 (1) ◽  
pp. 18
Author(s):  
Juanda Syafita Sari ◽  
Fitria Fitria ◽  
Esitra Esitra

<p>Latar Belakang: Masalah utama zat besi pada kehamilan adalah kepatuhan, karena perempuan sering gagal untuk mengambil suplemen secara teratur seperti anjuran tenaga kesehatan karena faktor bervariasi dan ini diduga menjadi potensi untuk meningkatkan prevalensi tinggi anemia pada ibu hamil. Tujuan dari systematic review ini adalah untuk mengetahui faktor-faktor yang berhubungan dengan kepatuhan ibu hamil terhadap konsumsi zat besi.<br />Metode: Studi apprasial menggunakan Joana Briggs Institute (JBI), dan metode sintesis menggunakan modifikasi PEOS.<br />Hasil: Hasil dari lima jurnal yang memenuhi kriteria inklusi didapatkan faktor-faktor yang mempengaruhi kepatuhan ibu hamil mengonsumsi suplemen zat besi yaitu usia, pendidikan, pekerjaan, pengetahuan, sosio ekonomi, dan kunjungan ANC.<br />Simpulan: Terdapat hubungan kepatuhan ibu hamil mengonsumsi tablet Fe dengan usia, pendidikan, pengetahuan, kunjungan ANC, pekerjaan paritas, dan paritas. Faktor yang paling berhubungan dengan kepatuhan ibu hamil mengonsumsi tablet Fe adalah frekuensi ANC.<br /><br /></p>


2021 ◽  
pp. 1-8
Author(s):  
Jonathan Rychen ◽  
Adrian Madarasz ◽  
Michael Murek ◽  
Philippe Schucht ◽  
Mirjam R. Heldner ◽  
...  

OBJECTIVE Postoperative internal carotid artery (ICA) intimal flap (IF) is a potential complication after carotid endarterectomy (CEA) for carotid artery stenosis. There are no clear recommendations in the current literature on the management of this condition due to sparse evidence. Some authors advocate carotid stent placement or reoperation, while others suggest watchful waiting. The aim of this study was to analyze incidence and management strategies of postoperative ICA-IF, and moreover, to put these findings into context with a systematic literature review. METHODS The authors retrospectively reviewed all consecutive CEA cases performed at the University Hospital of Bern over a decade (January 2008 to December 2018). The incidence of postoperative ICA-IF, risk factors, management strategies, and outcomes were analyzed. These results were put into context with a systematic review following the PRISMA guidelines. RESULTS A total of 725 CEAs were performed between January 2008 and December 2018. Postoperative ICA-IF was detected by routine duplex neurovascular ultrasound (NVUS) in 13 patients, corresponding to an incidence rate of 1.8% (95% CI 1.0%–3.1%). There were no associated intraluminal thrombi on the detected IF. Intraoperative shunt placement was used in 5.6% and one or more intima tack sutures were performed in 42.5% of the 725 cases. There was no significant association between intraoperative shunt placement and the occurrence of an IF (p > 0.99). Two patients (15.4%) with IF experienced a transient postoperative neurological deficit (transient ischemic attack). In these cases, the symptoms resolved spontaneously without any interventions or change in the antiplatelet regimen. All other cases (84.6%) with IF were asymptomatic. In 1 patient (7.7%) with IF, the antiplatelet treatment was switched from a mono- to a dual-antiaggregating regimen because the IF led to a stenosis > 70%; this patient remained asymptomatic. All cases of IFs were managed conservatively with close radiological follow-up evaluations, without reoperation or stenting of the ICA. All 13 IFs vanished spontaneously after a mean duration of 6.9 months (median 1.5 months, range 0.5–48 months). A systematic literature review revealed a postoperative ICA-IF incidence of 3.0% (95% CI 2.1%–4.1%) with relatively heterogenous management strategies. CONCLUSIONS Postoperative ICA-IF is a rare finding after CEA. Conservative therapy with close NVUS follow-up evaluations appears to be an acceptable and safe management strategy for asymptomatic IFs without associated intraluminal thrombi.


2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Rola Imad Fanousse ◽  
Dilupa Nakandala ◽  
Yi-Chen Lan

PurposeThis article provides the first systematic review of literature on effective organisational practices for reducing innovation project uncertainties to promote project performance. Innovation is the lifeblood of organisations, while simultaneously being one of the most challenging processes to manage. This systematic review seeks to examine best practice for reducing uncertainties and thus mitigate the high failure rates in innovation projects.Design/methodology/approachThis paper provides a systematic review of the literature on innovation project management and encourages an understanding of how intra-organisational collaboration reduces uncertainty and thus increases project performance.FindingsBased on an analysis of the systematic literature review findings, the impact of intra-organisational collaboration in reducing uncertainties in innovation projects is uncovered. Three types of project uncertainties were found to be dominant in the context of innovation project management: task, technological and market uncertainties. Five dimensions of intra-organisational collaboration are also identified, namely collaborative relationship, collaborative leadership, communicating and sharing information, trust formation and joint decision-making.Originality/valueThe authors situate five intra-organisational collaboration dimensions as key mechanisms that yield organisational learning as an outcome. On the other hand, they also uncovered that organisational learning is a key enabler in the relationship between intra-organisational collaboration and task, market and technological uncertainties reduction. Therefore, intra-organisational collaboration is identified as a critical practice in enhancing the performance of innovation projects. The study proposes a multi-dimensional conceptual model, providing a mechanism for furthering a research agenda for improving the performance of innovation projects.


2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Qian Chen ◽  
Daniel Mark Hall ◽  
Bryan Tyrone Adey ◽  
Carl Thomas Haas

PurposeManaging stakeholders' reciprocal interdependencies is always a challenging issue. Stakeholders need to find out different ways to communicate information and coordinate material flows during the supply chain processes. Many recent studies have advanced construction supply chain coordination from multiple perspectives. However, the field still lacks a comprehensive analysis to summarize existing research, to explicitly identify all the possible enablers for coordination and to investigate how the enablers can be carried out at the supply chain interfaces. To fill the gap, this study aims to conduct a systematic review in order to examine the relevant literature.Design/methodology/approachA systematic literature review process was conducted to identify and synthesize relevant publications (published in the past 20 years) concerning the coordination of construction supply chain functions. These publications were coded to link main research findings with specific enabler categories. In addition, how these enablers can be used at the interfaces across supply chain processes was reviewed with an in-depth analysis of reciprocal communications between stakeholders at design-to-production, production-to-logistics and production-to-site-assembly phases.FindingsThe coordination enablers were classified into three categories: (1) contractual enablers (including subtopics on relational contracts and incentive models), (2) procedural enablers (including subtopics on multiagent knowledge sharing systems and the last planner system) and (3) technological enablers (including subtopics on linked databases for design coordination, design for manufacturing software platforms and automated monitoring technologies). It was found that interfacing different functions requires a certain level of integration of stakeholders for quick response and feedback processes. The integration of novel contractual forms with digital technologies, such as smart contracts, however, was not adequately addressed in the state of the art.Research limitations/implicationsThe scope of the systematic review is limited to the static analysis of selected publications. Longitudinal studies should be further included to sharpen the inductions of enablers considering organizational changes and process dynamics in construction projects.Practical implicationsDifferent enablers for coordination were summarized in a concise manner, which provides researchers and project stakeholders with a reinforced understanding of various ways to manage reciprocal interdependencies at different supply chain interfaces.Originality/valueThis study constitutes an important input for research on the construction supply chain by illuminating the thematic topic of coordination from inductively developed review processes, which included a holistic framing of the emerging coordination enablers and their use across supply chain functions. Consequently, it closes some identified knowledge gaps and offers additional insights to improve the supply chain performance of construction projects.


2010 ◽  
Vol 17 (6) ◽  
pp. E95-E97 ◽  
Author(s):  
Aaron Kornblith ◽  
Kennon Heard

Databases are used to screen for warfarin-medication interactions. We measured the reliability and validity of 5 databases. Databases were queried for 30 medications identified as having varying degrees of interactions with warfarin in a recent systematic literature review. Reliability was measured by the percentage agreement between the databases for each interaction and validity was measured by agreement between each database and the systematic literature review. All of the databases and the systematic review agreed on 14 medications (47%). There were 5 medications (17%) where all databases reported an interaction, but no interaction was noted by the systematic review. The databases did not agree on the remaining 11 medications (37%). Four of these interactions were of moderate or greater clinical significance. These commonly used databases frequently do not agree on the occurrence of warfarin-medications interactions, and some interactions identified by the best clinical evidence were not identified in several databases.


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