scholarly journals First-Generation Vaccines against Human Papillomavirus

2005 ◽  
Vol 1 (2) ◽  
pp. 223-229
Author(s):  
Jorma Paavonen ◽  
Matti Lehtinen
Keyword(s):  
Human Papillomavirus ◽  
Sexually Transmitted Infection ◽  
First Generation ◽  
Preclinical Studies ◽  
Human Papillomavirus Vaccine ◽  
Transmitted Infection ◽  
Vaccine Candidates ◽  
Sexually Transmitted ◽  
The Past ◽  
Papillomavirus Vaccine

There has been considerable progress in the development of a prophylactic human papillomavirus vaccine in the past 10 years, since the discovery of human papillomavirus virus-like particles. Licensure of the human papillomavirus vaccine is probably not far away. This would make it the first licensed vaccine against a common sexually transmitted infection. Although hepatitis B is a sexually transmitted infection for which there is an effective prophylactic vaccine, it is often not perceived as such by individuals taking the vaccine. Preclinical studies have already produced attractive vaccine candidates and recent clinical trials have yielded strikingly promising results. The candidate vaccines are generally well tolerated, induce high titers of serum antibodies to the human papillomavirus types and effectively prevent acquisition of infection and early clinical disease caused by common human papillomavirus types.

scholarly journals Sexually Transmitted Infections and Male Circumcision: A Systematic Review and Meta-Analysis

ISRN Urology ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-42 ◽  
Author(s):  
Robert S. Van Howe
Keyword(s):  
Systematic Review ◽  
Human Papillomavirus ◽  
Sexually Transmitted Infections ◽  
Sexually Transmitted Infection ◽  
Positive Impact ◽  
Meta Analysis ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
General Populations ◽  
Simplex Virus

The claim that circumcision reduces the risk of sexually transmitted infections has been repeated so frequently that many believe it is true. A systematic review and meta-analyses were performed on studies of genital discharge syndrome versus genital ulcerative disease, genital discharge syndrome, nonspecific urethritis, gonorrhea, chlamydia, genital ulcerative disease, chancroid, syphilis, herpes simplex virus, human papillomavirus, and contracting a sexually transmitted infection of any type. Chlamydia, gonorrhea, genital herpes, and human papillomavirus are not significantly impacted by circumcision. Syphilis showed mixed results with studies of prevalence suggesting intact men were at great risk and studies of incidence suggesting the opposite. Intact men appear to be of greater risk for genital ulcerative disease while at lower risk for genital discharge syndrome, nonspecific urethritis, genital warts, and the overall risk of any sexually transmitted infection. In studies of general populations, there is no clear or consistent positive impact of circumcision on the risk of individual sexually transmitted infections. Consequently, the prevention of sexually transmitted infections cannot rationally be interpreted as a benefit of circumcision, and any policy of circumcision for the general population to prevent sexually transmitted infections is not supported by the evidence in the medical literature.

Papillomaviruses and polyomaviruses

2020 ◽  
pp. 877-885
Author(s):  
Raphael P. Viscidi ◽  
Chen Sabrina Tan ◽  
Carole Fakhry
Keyword(s):  
Human Papillomavirus ◽  
Sexually Transmitted Infection ◽  
Sexual Contact ◽  
Prophylactic Vaccine ◽  
Basal Cells ◽  
Anogenital Warts ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Surgical Methods ◽  
Flat Lesions

There are nearly 200 human papillomavirus types that infect epithelia of skin and mucous membranes. They infect only humans, and cause conditions including the following: skin warts and verrucas, which are caused by types 1 and 2; infection initiated when, after minor skin abrasions, for example, the basal cells of the epithelium come in contact with infectious virus; anogenital warts, which are caused by types 6 and 11; transmitted by direct sexual contact, these are the most common sexually transmitted infection; present clinically as multiple exophytic lesions or as subclinical flat lesions. They can be treated topically with podophyllin or imiquimod, or by ablative surgical methods. Recurrences are common. A highly efficacious prophylactic vaccine is available.

Review of Evidence and Recommendation for Human Papillomavirus (HPV) Vaccination of Canadian Males Over the Age of 26 Years

2020 ◽  
Vol 24 (3) ◽  
pp. 285-291 ◽  
Author(s):  
Alex Derstenfeld ◽  
Kyle Cullingham ◽  
Zhuo Cai Ran ◽  
Ivan V. Litvinov
Keyword(s):  
Human Papillomavirus ◽  
Sexually Transmitted Infection ◽  
Hpv Vaccine ◽  
Hpv Vaccination ◽  
Older Men ◽  
Hpv Infection ◽  
Transmitted Infection ◽  
Vaccination Programs ◽  
Sexually Transmitted ◽  
Control And Prevention

Human papillomavirus (HPV) remains the most common sexually transmitted infection with a lifetime incidence of over 75%. Based on US data from the Centers for Disease Control and Prevention (CDC), 64% of invasive HPV-associated cancers are attributable to HPV 16 or 18 (65% for females; 63% males) and may be prevented by vaccination with either the quadrivalent or nonavalent HPV vaccine. Public HPV vaccination programs are now the norm for women aged 9-45 years and men aged 9-26 years in Canada. Yet, only recently have guidelines begun to consider vaccination of men older than 26 years of age. There now exist compelling reasons to recommend vaccination against HPV amongst males >26 years of age. Recognizing that the risks posed by HPV infection persist beyond 26 years of age, that the vaccination of men aged 26-45 years with HPV vaccine confers immunogenicity at levels demonstrably efficacious against HPV-related diseases, and that the Food and Drug Administration recently expanded the HPV vaccination to include older men, it is argued that HPV vaccination in men older than 26 years of age should be routinely recommended.

Intention of college students to receive the human papillomavirus vaccine

2016 ◽  
Vol 116 (4) ◽  
pp. 342-355 ◽  
Author(s):  
Keith Richards
Keyword(s):  
College Students ◽  
Human Papillomavirus ◽  
Information Seeking ◽  
Hpv Vaccine ◽  
Human Papillomavirus Vaccine ◽  
Transmitted Infection ◽  
Content Type ◽  
Sexually Transmitted ◽  
The Usa ◽  
To Receive

Purpose – The purpose of this paper is to better understand what influences the intentions of college students to receive the human papillomavirus (HPV) vaccine. HPV is the most common sexually transmitted infection in the USA and cancers related to HPV are on the rise. Design/methodology/approach – A 2×2 experimental design was used to predict the intentions. Messages were created that manipulated the level of severity and vulnerability to determine which would increase intentions to receive the HPV vaccine. Each of the 278 participants viewed a message that contained one severity message (high or low) and one vulnerability message (high or low). Findings – Regression was used to determine that elements of the protection motivation theory such as vulnerability and fear, along with norms, and information seeking explained a significant portion of the variance in intent to be vaccinated (R2=0.40, F(4, 268)=44.47, p < 0.001). Norms had the most influence on intention (β=0.42, p < 0.001), next was vulnerability (β=0.21, p < 0.001) then fear (β=0.16, p=0.002), and finally information seeking (β=0.10, p=0.01). Originality/value – The current college age population did not have the opportunity to be vaccinated early and the recent (2011) recommendation that males get vaccinated makes this research valuable to those designing vaccination messages. The current study shows that norms were the most influential variable in regards to increasing intent to get vaccinated. This means that if the participant believed their friends would support or endorse their intent to get vaccinated they were more likely to say they would follow through and get vaccinated. This finding should be highlighted in any future campaign.

scholarly journals Preparations for implementing human papillomavirus vaccination should begin

2005 ◽  
Vol 10 (37) ◽  
Author(s):  
M Lehtinen
Keyword(s):  
Human Papillomavirus ◽  
World Health Organization ◽  
Sexually Transmitted Infection ◽  
Hpv Vaccination ◽  
World Health ◽  
Human Papillomavirus Vaccination ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
National Programmes ◽  
Health Organization

At a World Health Organization meeting, the latest developments in human papillomavirus (HPV) vaccination were discussed. The leading theme that emerged was how to implement within national programmes the concept of vaccinating adolescents both against a common sexually transmitted infection

scholarly journals Human Papillomavirus Infection in a Male Population Attending a Sexually Transmitted Infection Service

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e54375 ◽  
Author(s):  
Marta Elena Álvarez-Argüelles ◽  
Santiago Melón ◽  
Maria Luisa Junquera ◽  
Jose Antonio Boga ◽  
Laura Villa ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Sexually Transmitted Infection ◽  
Male Population ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection
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