Fabrication of modified-release custom-designed ciprofloxacin tablets via fused deposition modeling 3D printing

2020 ◽  
Vol 4 (1) ◽  
pp. 17-27
Author(s):  
Nasir Abbas ◽  
Nadia Qamar ◽  
Amjad Hussain ◽  
Sumera Latif ◽  
Muhammad Sohail Arshad ◽  
...  
Keyword(s):  
3D Printing ◽  
Drug Release ◽  
Fused Deposition Modeling ◽  
Structural Characteristics ◽  
Thermo Gravimetric Analysis ◽  
Gravimetric Analysis ◽  
Scanning Calorimetry ◽  
Ciprofloxacin Hydrochloride ◽  
Fused Deposition ◽  
Degradation Temperature

Aim: The aim of the present work was to fabricate customized tablets of ciprofloxacin hydrochloride through 3D printing for optimized dosing. Materials & methods: A hot melt extrusion technique was employed to produce polyvinyl alcohol filaments with differing strengths of ciprofloxacin hydrochloride. Drug-loaded filaments were characterized for mechanical strength, thermal behavior and structural characteristics prior to printing of tablets by varying the infill percentage. Final formulations were evaluated for drug release profiles. Results: The prepared formulations contained 15–20% drug. The drug release patterns of different formulations were found to be reliant on infill percentage. Differential scanning calorimetry and thermo-gravimetric analysis confirmed that degradation temperature of drug is way above the printing temperature. Conclusion: This work is potentially significant for optimized antibiotic dosing, which in turn leads to enhanced clinical outcome.

scholarly journals Lignin: A Biopolymer from Forestry Biomass for Biocomposites and 3D Printing

Materials ◽  
2019 ◽  
Vol 12 (18) ◽  
pp. 3006 ◽  
Author(s):  
Mihaela Tanase-Opedal ◽  
Eduardo Espinosa ◽  
Alejandro Rodríguez ◽  
Gary Chinga-Carrasco
Keyword(s):  
3D Printing ◽  
Radical Scavenging Activity ◽  
Matrix Material ◽  
Thermo Gravimetric Analysis ◽  
Radical Scavenging ◽  
Fused Deposition Modelling ◽  
Gravimetric Analysis ◽  
Scanning Calorimetry ◽  
Biobased Materials ◽  
Fused Deposition

Biopolymers from forestry biomass are promising for the sustainable development of new biobased materials. As such, lignin and fiber-based biocomposites are plausible renewable alternatives to petrochemical-based products. In this study, we have obtained lignin from Spruce biomass through a soda pulping process. The lignin was used for manufacturing biocomposite filaments containing 20% and 40% lignin and using polylactic acid (PLA) as matrix material. Dogbones for mechanical testing were 3D printed by fused deposition modelling. The lignin and the corresponding biocomposites were characterized in detail, including thermo-gravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction analysis (XRD), antioxidant capacity, mechanical properties, and scanning electron microscopy (SEM). Although lignin led to a reduction of the tensile strength and modulus, the reduction could be counteracted to some extent by adjusting the 3D printing temperature. The results showed that lignin acted as a nucleating agent and thus led to further crystallization of PLA. The radical scavenging activity of the biocomposites increased to roughly 50% antioxidant potential/cm2, for the biocomposite containing 40 wt % lignin. The results demonstrate the potential of lignin as a component in biocomposite materials, which we show are adequate for 3D printing operations.

scholarly journals Formulation and Evaluation of 3D Printed Pregabalin Tablets Targeted For Neuropathic Pain By Qbd Approach For Personalized Medicine

2021 ◽  
Vol 11 (6) ◽  
pp. 1-13
Author(s):  
Bhusnure omprakash Gadgeppa ◽  
Mule Shrikrishna Tukaram ◽  
Gholvesachin Baburo ◽  
Giram padamja Sidram ◽  
Gaurav Agarwal Prof.(Dr) ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
3D Printing ◽  
Drug Release ◽  
Thermo Gravimetric Analysis ◽  
Processing Condition ◽  
Gravimetric Analysis ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Fused Deposition ◽  
3D Printed

The 3D printing technology has been newly employed in the design and formulation of different dosage forms with the aim formulation and evaluation of 3D printed Pregabalin tablets for the treatment of neuropathic pain by QbD approach. Drug (Pregabalin) together with other excipients, were mixed and extruded into filaments by hot melt extrusion. Then with the help of fused deposition modeling these obtained filaments were printed into tablets. Due to the use of different polymers in the printed formulation different release profiles for the 3D printed tablets were obtained. Drug release characteristics change the infill or the size of the printed tablets, allowing the personalization of the tablets. Filaments and tablets were characterized by means of Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X- RAY powder diffraction (XRPD), and thermo gravimetric analysis (TGA). The results showed that after printing, the processing condition did not have a significant impact on the stability of the drug and the crystalline nature of the drug remained. FDM 3D printing makes it possible not only to formulate 3D printing Pregabalin tablets for the treatment of neuropathic pain but also to modify the potential of additive manufacturing in the development of personalized dose medicines. This study presents novel formulations containing Pregabalin for prevention of neuropathic pain and investigates 3D printing technology for personalized production of oral solid dosage from enabling adjustable dose as well as drug release properties.

scholarly journals Influence of Controlled Cooling on Crystallinity of Poly(L-Lactic Acid) Scaffolds after Hydrolytic Degradation

Materials ◽  
2020 ◽  
Vol 13 (13) ◽  
pp. 2943
Author(s):  
Javier Vazquez-Armendariz ◽  
Raquel Tejeda-Alejandre ◽  
Aida Rodriguez-Garcia ◽  
Yadira I. Vega-Cantu ◽  
Christian Mendoza-Buenrostro ◽  
...  
Keyword(s):  
Fused Deposition Modeling ◽  
Cooling System ◽  
Thermo Gravimetric Analysis ◽  
Hydrolytic Degradation ◽  
Degree Of Crystallinity ◽  
Gravimetric Analysis ◽  
Controlled Cooling ◽  
Scanning Calorimetry ◽  
Fused Deposition ◽  
Deposition Modeling

The use of hybrid manufacturing to produce bimodal scaffolds has represented a great advancement in tissue engineering. These scaffolds provide a favorable environment in which cells can adhere and produce new tissue. However, there are several areas of opportunity to manufacture structures that provide enough strength and rigidity, while also improving chemical integrity. As an advancement in the manufacturing process of scaffolds, a cooling system was introduced in a fused deposition modeling (FDM) machine to vary the temperature on the printing bed. Two groups of polylactic acid (PLA) scaffolds were then printed at two different bed temperatures. The rate of degradation was evaluated during eight weeks in Hank’s Balanced Salt Solution (HBSS) in a controlled environment (37 °C–120 rpm) to assess crystallinity. Results showed the influence of the cooling system on the degradation rate of printed scaffolds after the immersion period. This phenomenon was attributable to the mechanism associated with alkaline hydrolysis, where a higher degree of crystallinity obtained in one group induced greater rates of mass loss. The overall crystallinity was observed, through differential scanning calorimetry (DSC), thermo gravimetric analysis (TGA), and Fourier transformed infrared spectroscopy (FTIR) analysis, to increase with time because of the erosion of some amorphous parts after immersion.

scholarly journals Biocomposites of Bio-Polyethylene Reinforced with a Hydrothermal-Alkaline Sugarcane Bagasse Pulp and Coupled with a Bio-Based Compatibilizer

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2158
Author(s):  
Nanci Vanesa Ehman ◽  
Diana Ita-Nagy ◽  
Fernando Esteban Felissia ◽  
María Evangelina Vallejos ◽  
Isabel Quispe ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Water Absorption ◽  
Sugarcane Bagasse ◽  
Thermo Gravimetric Analysis ◽  
Decomposition Temperature ◽  
Gravimetric Analysis ◽  
Scanning Calorimetry ◽  
Cradle To Gate ◽  
Bagasse Pulp

Bio-polyethylene (BioPE, derived from sugarcane), sugarcane bagasse pulp, and two compatibilizers (fossil and bio-based), were used to manufacture biocomposite filaments for 3D printing. Biocomposite filaments were manufactured and characterized in detail, including measurement of water absorption, mechanical properties, thermal stability and decomposition temperature (thermo-gravimetric analysis (TGA)). Differential scanning calorimetry (DSC) was performed to measure the glass transition temperature (Tg). Scanning electron microscopy (SEM) was applied to assess the fracture area of the filaments after mechanical testing. Increases of up to 10% in water absorption were measured for the samples with 40 wt% fibers and the fossil compatibilizer. The mechanical properties were improved by increasing the fraction of bagasse fibers from 0% to 20% and 40%. The suitability of the biocomposite filaments was tested for 3D printing, and some shapes were printed as demonstrators. Importantly, in a cradle-to-gate life cycle analysis of the biocomposites, we demonstrated that replacing fossil compatibilizer with a bio-based compatibilizer contributes to a reduction in CO2-eq emissions, and an increase in CO2 capture, achieving a CO2-eq storage of 2.12 kg CO2 eq/kg for the biocomposite containing 40% bagasse fibers and 6% bio-based compatibilizer.

Decellularized liver-regenerative 3D printing biomaterials for cell-based liver therapies via a designed procedure combined with papain-containing reagent treatments and supercritical fluids

2021 ◽  
pp. 1-8
Author(s):  
Ching-Cheng Huang
Keyword(s):  
3D Printing ◽  
Thermo Gravimetric Analysis ◽  
Extraction Process ◽  
Gravimetric Analysis ◽  
Collagen Scaffolds ◽  
Scanning Calorimetry ◽  
Porcine Liver ◽  
Good Thermal Stability ◽  
Decellularized Liver ◽  
Liver Collagen

BACKGROUND: The biologic scaffolds derived from decellularized tissues and organs have been successfully developed in a variety of preclinical and/or clinical studies. OBJECTIVE: The new decellularized liver-regenerative 3D printing biomaterials were designed and prepared for cell-based liver therapies. METHODS: An extraction process was employed to remove the tissue and cellular molecules from porcine liver via pretreatment of supercritical fluid of carbon dioxide (ScCO2). Varying porosities of the decellularized liver tissues were created using papain-containing reagent treatments after ScCO2. RESULTS: The resulting liver-regenerative 3D printing biomaterials of decellularized liver collagen scaffolds were characterized by Fourier transform infrared spectroscopy, thermo-gravimetric analysis, differential scanning calorimetry and scanning electron microscopy. CONCLUSIONS: The decellularized liver collagen scaffolds with good thermal stability (>150 °C) were obtained and employed as liver-regenerative 3D printing biomaterials for cell-based liver therapies.

Exploring tablet design options for tailoring drug release and dose via fused deposition modeling (FDM) 3D printing

2020 ◽  
Vol 591 ◽  
pp. 119987
Author(s):  
Guluzar Gorkem Buyukgoz ◽  
David Soffer ◽  
Jackenson Defendre ◽  
Gia M. Pizzano ◽  
Rajesh N. Davé
Keyword(s):  
3D Printing ◽  
Drug Release ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
Design Options

Synthesis and Characterization of the Bismaleimides Containing Aliphatic-ether Chain for Microelectronics Application

e-Polymers ◽  
2006 ◽  
Vol 6 (1) ◽  
Author(s):  
J. L. Feng ◽  
C. Y. Yue ◽  
K. S. Chian
Keyword(s):  
Chain Length ◽  
Thermo Gravimetric Analysis ◽  
Gravimetric Analysis ◽  
Scanning Calorimetry ◽  
Thermo Gravimetric ◽  
Degradation Temperature ◽  
Dielectric Thermal Analysis ◽  
Aliphatic Ether ◽  
Synthetic Reaction

AbstractThis project aims to develop and characterize a series of bismaleimide (BMI) polymers based on maleic anhydride and aliphatic-ether diamines. The effects of varying the chain length of aliphatic-ether diamines on the resultant bismaleimide systems were evaluated so that their suitability for microelectronics applications could be evaluated. The synthetic reaction and properties of the bismaleimide materials were investigated using Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Thermo- Gravimetric Analysis (TGA), Dielectric Thermal Analysis (DEA) and rheometry. Results showed that thermal, dielectric and rheological properties were all affected by the main chain length of BMI. The magnitude of the dielectric constant at 100 kHz increases with the increasing chain length. The curing peak temperature, curing heat and degradation temperature of BMI, all decrease with the increasing chain length.

scholarly journals Medical-Grade PCL Based Polyurethane System for FDM 3D Printing—Characterization and Fabrication

Materials ◽  
2019 ◽  
Vol 12 (6) ◽  
pp. 887 ◽  
Author(s):  
Agnieszka Haryńska ◽  
Justyna Kucinska-Lipka ◽  
Agnieszka Sulowska ◽  
Iga Gubanska ◽  
Marcin Kostrzewa ◽  
...  
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Extrusion Process ◽  
C2c12 Cells ◽  
Hexamethylene Diisocyanate ◽  
Scanning Calorimetry ◽  
Thermoplastic Polyurethanes ◽  
Fused Deposition ◽  
Medical Grade

The widespread use of three-dimensional (3D) printing technologies in medicine has contributed to the increased demand for 3D printing materials. In addition, new printing materials that are appearing in the industry do not provide a detailed material characterization. In this paper, we present the synthesis and characterization of polycaprolactone (PCL) based medical-grade thermoplastic polyurethanes, which are suitable for forming in a filament that is dedicated to Fused Deposition Modeling 3D (FDM 3D)printers. For this purpose, we synthesized polyurethane that is based on PCL and 1,6-hexamethylene diisocyanate (HDI) with a different isocyanate index NCO:OH (0.9:1, 1.1:1). Particular characteristics of synthesized materials included, structural properties (FTIR, Raman), thermal (differential scanning calorimetry (DSC), thermogravimetric analysis (TGA)), mechanical and surfaces (contact angle) properties. Moreover, pre-biological tests in vitro and degradation studies were also performed. On the basis of the conducted tests, a material with more desirable properties S-TPU(PCL)0.9 was selected and the optimization of filament forming via melt-extrusion process was described. The initial biological test showed the biocompatibility of synthesized S-TPU(PCL)0.9 with respect to C2C12 cells. It was noticed that the process of thermoplastic polyurethanes (TPU) filaments forming by extrusion was significantly influenced by the appropriate ratio between the temperature profile, rotation speed, and dosage ratio.

scholarly journals Fused Deposition Modeling of Polyamides: Crystallization and Weld Formation

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2980
Author(s):  
Andrea Costanzo ◽  
Umberto Croce ◽  
Roberto Spotorno ◽  
Seif Eddine Fenni ◽  
Dario Cavallo
Keyword(s):  
3D Printing ◽  
Crystallization Kinetics ◽  
Fused Deposition Modeling ◽  
Degree Of Crystallinity ◽  
Temperature History ◽  
Weld Strength ◽  
Processing Conditions ◽  
Scanning Calorimetry ◽  
Fused Deposition ◽  
Deposition Modeling

International newspapers and experts have called 3D printing the industrial revolution of this century. Among all its available variants, the fused deposition modeling (FDM) technique is of greater interest since its application is possible using simple desktop printers. FDM is a complex process, characterized by a large number of parameters that influence the quality and final properties of the product. In particular, in the case of semicrystalline polymers, which afford better mechanical properties than amorphous ones, it is necessary to understand the crystallization kinetics as the processing conditions vary, in order to be able to develop models that allow having a better control over the process and consequently on the final properties of the material. In this work it was proposed to study the crystallization kinetics of two different polyamides used for FDM 3D printing and to link it to the microstructure and properties obtained during FDM. The kinetics are studied both in isothermal and fast cooling conditions, thanks to a home-built device which allows mimicking the quenching experienced during filament deposition. The temperature history of a single filament is then determined by mean of a micro-thermocouple and the final crystallinity of the sample printed in a variety of conditions is assessed by differential scanning calorimetry. It is found that the applied processing conditions always allowed for the achievement of the maximum crystallinity, although in one condition the polyamide mesomorphic phase possibly develops. Despite the degree of crystallinity is not a strong function of printing variables, the weld strength of adjacent layers shows remarkable variations. In particular, a decrease of its value with printing speed is observed, linked to the probable development of molecular anisotropy under the more extreme printing conditions.

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